PULMONARY COCCIDIOIDOMYCOSIS Figure 21-8 PULMONARY COCCIDIOIDOMYCOSIS Confluent well-formed granulomatous foci have prominent foreign body-type multinucleated giant cells (A), and prominent necrosis with secondary cavitation (B). (Courtesy of the CDC PHIL) More about this image found in PULMONARY COCCIDIOIDOMYCOSIS Confluent well-formed granulomatous foci have...

PARACOCCIDIOIDOMYCOSIS Figure 21-17 PARACOCCIDIOIDOMYCOSIS A: Well-formed epithelioid cell granulomas with associated multinucleated giant cells and surrounding lymphocyte infiltrate. (Both: courtesy of G. Varela, Hospital Pablo Tobón Uribe, Medellín, Columbia) B: Weakly refractive round to oval Paracoccidioides yeasts (arrow) can be visualized in the granulomas on a routine H&E stain. More about this image found in PARACOCCIDIOIDOMYCOSIS A: Well-formed epithelioid cell granulomas with ass...

CUTANEOUS LEISHMANIASIS Figure 28-2 CUTANEOUS LEISHMANIASIS An ulcerated nodule has well-delineated elevated borders and a central depression. (Courtesy of Dr. L. M. Gomez, Pontificia Bolivariana University, Medellín, Colombia) More about this image found in CUTANEOUS LEISHMANIASIS An ulcerated nodule has well-delineated elevated b...

MALASSEZIA FOLLICULITIS Figure 24-53 MALASSEZIA FOLLICULITIS A dense intraluminal and perifollicular neutrophil infiltrate, as well as scant admixed basophilic detritus (right). More about this image found in MALASSEZIA FOLLICULITIS A dense intraluminal and perifoll...

RICKETTSIAL POX Figure 14-34 RICKETTSIAL POX There is a central eschar with epidermal and underlying dermal necrosis, as well as dermal perivascular inflammation. (Courtesy of the CDC IDPB) More about this image found in RICKETTSIAL POX There is a central eschar with epidermal and underlying de...

POXVIRUS Figure 6-8 POXVIRUS Electron microphotograph of a negative stain (A) and transmission electron microphotograph (B) of poxviruses, as well as a schematic of viral components (C). (A,B: courtesy of the CDC PHIL) More about this image found in POXVIRUS Electron microphotograph of a negative stain (A) and transmission...

LIVER HISTOPATHOLOGY IN LASSA FEVER Figure 10-8 LIVER HISTOPATHOLOGY IN LASSA FEVER Portal tract inflammatory infiltrate and foci of necrosis (A), as well as apoptotic hepatocytes (B) are seen. (Courtesy of the CDC IDPB) More about this image found in LIVER HISTOPATHOLOGY IN LASSA FEVER Portal tract inflammatory infiltrate a...

NIPAH VIRUS INFECTION Figure 3-47 NIPAH VIRUS INFECTION Typical changes in the CNS include perivascular and vascular inflammation (A,C) as well as associated cellular changes (B,D). (Courtesy of the CDC IDPB) More about this image found in NIPAH VIRUS INFECTION Typical changes in the CNS include perivascular and ...

DIAGNOSING HUMAN HERPESVIRUS INFECTION Figure 6-7 DIAGNOSING HUMAN HERPESVIRUS INFECTION Human herpesvirus infection can be diagnosed using direct immunofluorescence (A) as well as a Tzanck preparation (B). (Courtesy of the CDC PHIL) More about this image found in DIAGNOSING HUMAN HERPESVIRUS INFECTION Human herpesvirus infection can be ...

GIARDIASIS Figure 26-21 GIARDIASIS Trichrome stain of a stool specimen highlights a characteristic cyst (A) with visible nuclei and median body, as well as a trophozoite (B) with two anterior nuclei and characteristic pear shape. (Courtesy of the CDC PHIL) More about this image found in GIARDIASIS Trichrome stain of a stool specimen highlights a characteristic...

PARACOCCIDIOIDOMYCOSIS Figure 21-15 PARACOCCIDIOIDOMYCOSIS Juvenile form involving the skin (A), and chronic adult form showing lesions of the eye and tongue, as well as a destructive lesion that spans the mouth and nose (B). Note the granular “mulberry”-like appearance of the mucosa. (Courtesy o... More about this image found in PARACOCCIDIOIDOMYCOSIS Juvenile form involving the skin (A), and chronic a...

GRANULOMATOUS AMEBIC ENCEPHALITIS Figure 25-15 GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with associated mononuclear inflammation (A), as well as typical protozoan trophozoites and cysts (B,D, Acanthamoeba; C,E, Balamuthia). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with a...

CYTOMEGALOVIRUS (CMV) COLITIS Figure 5-17 CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon shows a patchy hemorrhagic mucosa and scattered well-circumscribed deep ulcers. (Courtesy of Dr. A. E. van der Hoven, University of Pretoria, Pretoria, South Africa) More about this image found in CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon show...

DISSEMINATED CLASSIC HISTOPLASMOSIS Figure 23-2 DISSEMINATED CLASSIC HISTOPLASMOSIS There are typical ulcerated mucosal (A) and skin (B) lesions, as well as reticulonodular pulmonary infiltrates seen on chest X-ray (C). (Courtesy of the Centers for Disease Control and Prevention [CDC] Public Heal... More about this image found in DISSEMINATED CLASSIC HISTOPLASMOSIS There are typical ulcerated mucosal (A...

EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-8 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural distortion (A) with focal capsular permeation by lymphoid cells (top), a polymorphic mononuclear infiltrate (B) with associated plasma cells (C) and focal mitotic activity (cen... More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural dist...

DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Figure 6-6 DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Parenchymal organs, such as the adrenal gland, liver, and others, can be involved. Note the prominent necrosis and hemorrhage (A), as well as multiple intranuclear viral inclusions (B). (Courtesy of t... More about this image found in DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Parenchymal organs, such as the...

SARS-CoV-2 MACROSCOPIC CHANGES Figure 4-9 SARS-CoV-2 MACROSCOPIC CHANGES The lung from an autopsy was significantly enlarged, with prominent pulmonary edema, patchy intra-alveolar hemorrhage, and vascular changes, as well as associated organizing pneumonia (bottom and right). (Courtesy of PA T. M... More about this image found in SARS-CoV-2 MACROSCOPIC CHANGES The lung from an autopsy was significantly ...

ENTEROHEMORRHAGIC E. COLI (EHEC) INFECTION Figure 13-7 ENTEROHEMORRHAGIC E. COLI (EHEC) INFECTION Colon biopsies of EHEC infection show prominent surface epithelial degeneration, lamina propria red blood cell extravasation, and isolated mucosal microthrombi (A,B), as well as crypt withering, ulceration, and submucosal edema with red cell extravasation (C). Some of these microscopic features may be indistinguishable from localized or regional acute ischemia. More about this image found in ENTEROHEMORRHAGIC E. COLI (EHEC) INFECTION Colon biopsies...