ISLET CELLS Figure 1-20 ISLET CELLS Islet cells are polygonal with round nuclei and pale, well-defined amphophilic cytoplasm on air dried Diff Quik stain. More about this image found in ISLET CELLS Islet cells are polygonal with round nuclei and pale, well-def...

DUCTAL ADENOCARCINOMA Figure 7-25 DUCTAL ADENOCARCINOMA The large gland pattern can be very well differentiated, as in this example, mimicking a cystic or intraductal neoplasm. More about this image found in DUCTAL ADENOCARCINOMA The large gland pattern can be very well differentia...

WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Figure 7-32 WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Crowded nuclei in a flat sheet (hematoxylin and eosin [H&E] stain). More about this image found in WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Crowded nuclei in a flat sheet (...

WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Figure 7-33 WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Left: “Drunken honeycomb” pattern (H&E). Right: Nuclear crowding and irregular nuclear contours (H&E). More about this image found in WELL-DIFFERENTIATED DUCTAL ADENOCARCINOMA Left: “Drunken honeycomb” patter...

DUCTAL ADENOCARCINOMA Figure 7-35 DUCTAL ADENOCARCINOMA The drunken honeycomb appearance of well-differentiated adenocarcinoma (top) is juxtaposed with duoden al contaminants (bottom) (Papanicolaou stain). More about this image found in DUCTAL ADENOCARCINOMA The drunken honeycomb appearance of well-differentia...

ACINAR CELL CARCINOMA Figure 9-26 ACINAR CELL CARCINOMA Left: Ultrastructurally, well-polarized cells have abundant rough endoplasmic reticulum in the basal cytoplasm and round electron-dense zymogen granules in the apex near the lumen. Right: Large irregular fibrillary granules are elongated an... More about this image found in ACINAR CELL CARCINOMA Left: Ultrastructurally, well-polarized cells have a...

PANCREATOBLASTOMA Figure 10-1 PANCREATOBLASTOMA Left: The neoplasm is well circumscribed, yellow to tan, and lobulated. Right: Areas of central fibrosis with necrosis and hemorrhage are present in the fleshy tumor. More about this image found in PANCREATOBLASTOMA Left: The neoplasm is well circumscribed, yellow to tan,...

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-9 PANCREATIC NEUROENDOCRINE TUMOR Smaller PanNETs are well circumscribed and displace the pancreatic duct (left). They are often tan to yellow and moderately firm (right). More about this image found in PANCREATIC NEUROENDOCRINE TUMOR Smaller PanNETs are well circumscribed and...

CYSTIC PANCREATIC NEUROENDOCRINE TUMOR Figure 12-14 CYSTIC PANCREATIC NEUROENDOCRINE TUMOR Left: The tumor is well circumscribed and has a single, central cystic cavity. The pancreatic duct is not involved. Right: The cyst lining is smooth and hemorrhagic. Only a thin rim of preserved tumor tiss... More about this image found in CYSTIC PANCREATIC NEUROENDOCRINE TUMOR Left: The tumor is well circumscrib...

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-17 PANCREATIC NEUROENDOCRINE TUMOR Smaller tumors are well circumscribed (A) and some are surrounded by a fibrous pseudocapsule (B), but infiltration into adjacent tissues is common (C). More about this image found in PANCREATIC NEUROENDOCRINE TUMOR Smaller tumors are well circumscribed (A) ...

DESMOPLASTIC SMALL ROUND CELL TUMOR Figure 13-26 DESMOPLASTIC SMALL ROUND CELL TUMOR Left: The cells are arranged in well-defined and variably sized nests and broad bands separated by a striking desmoplastic stroma. Right: The neoplasm is composed of small, uniform, round cells with scant cytopl... More about this image found in DESMOPLASTIC SMALL ROUND CELL TUMOR Left: The cells are arranged in well-d...

LEIOMYOSARCOMA Figure 13-28 LEIOMYOSARCOMA Leiomyosarcoma is well circumscribed, firm, and yellow to tan. More about this image found in LEIOMYOSARCOMA Leiomyosarcoma is well circumscribed, firm, and yellow to t...

WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR, CLEAR CELL TYPE Figure 14-5 WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR, CLEAR CELL TYPE The clear cells are filled with numerous microvesicles, producing a foamy appearance, in contrast to the complete clearing in renal cell carcinoma. More about this image found in WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR, CLEAR CELL TYPE The clear cells ...

METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR Figure 14-6 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR The renal cell carcinoma (top) has clear cell features whereas the neuroendocrine t... More about this image found in METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTI...

HAMARTOMA Figure 15-41 HAMARTOMA The well-circumscribed white lesion has a solid and cystic cut surface. (Courtesy of Dr. E. Dankoweit-Timpe, Hannover, Germany) More about this image found in HAMARTOMA The well-circumscribed white lesion has a solid and cystic cut s...

HEPATIC BILE DUCT ADENOMA Figure 7-41 HEPATIC BILE DUCT ADENOMA Low- (left) and high- (right) magnification views demonstrate a well-demarcated lesion composed of well-differentiated tubular glands lined by uniform nonmucinous cuboidal epithelial cells. More about this image found in HEPATIC BILE DUCT ADENOMA Low- (left) and high- (right) magnification view...

DUCTAL ADENOCARCINOMA Figure 7-31 DUCTAL ADENOCARCINOMA Electron micrograph of ductal adenocarcinoma showing well-polarized cells with a lumen lined by blunt microvilli. More about this image found in DUCTAL ADENOCARCINOMA Electron micrograph of ductal adenocarcinoma showing...

SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-29 SOLID PSEUDOPAPILLARY NEOPLASM Cercariform cells (cells with “tails”) help distinguish the neo plasm from a well-differentiated neuroendocrine tumor. More about this image found in SOLID PSEUDOPAPILLARY NEOPLASM Cercariform cells (cells with “tails”) help...

CYSTIC PANCREATIC NEUROENDOCRINE TUMOR Figure 12-7 CYSTIC PANCREATIC NEUROENDOCRINE TUMOR CT of a central unilocular cyst present in a well-circum-scribed tumor involving the pancreatic tail. More about this image found in CYSTIC PANCREATIC NEUROENDOCRINE TUMOR CT of a central unilocular cyst pre...

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-11 PANCREATIC NEUROENDOCRINE TUMOR Left: In this patient with MEN1, there are multiple well-circumscribed tumors (large arrows) associated with numerous microtumors (small arrows). Right: There is nodular extension into the spleen. More about this image found in PANCREATIC NEUROENDOCRINE TUMOR Left: In this patient with MEN1, there are...