SPECIMENS TYPES TO EXCLUDE INTRAOCULAR LYMPHOMA Figure 11-3 SPECIMENS TYPES TO EXCLUDE INTRAOCULAR LYMPHOMA Undiluted vitreous usually is 1 mm or less, but it is the purest and most concentrated of the specimens. The cytology slide for triaging should be made from this sample because it has the m... More about this image found in SPECIMENS TYPES TO EXCLUDE INTRAOCULAR LYMPHOMA Undiluted vitreous usually...

SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Figure 11-11 SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Left: The specimen is cellular, with occasional well-formed granulomas (center) and scattered lymphocytes and histiocytes (arrow) in the background. Right: A poorly formed granuloma with mainly epithelio... More about this image found in SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Left: The specimen is cellular, wi...

RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS Figure 9-7 RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS A: Central pupil-optic nerve section of an eye with endophytic retinoblastoma that grows from the retina into the vitreous and seeds the head of the optic nerve with tumor. B: High magnification of an endophyt... More about this image found in RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS A: Central pupil-optic nerve section...

ADVANCED SARCOIDOSIS OF EYE Figure 11-10 ADVANCED SARCOIDOSIS OF EYE A: Macroscopic view of the anterior segment of the eye with white-tan granulomatous infiltrates in the ciliary body (CB) and choroid extending into the vitreous (V) and pulling the retina (R) in a funnel-shaped retinal detachmen... More about this image found in ADVANCED SARCOIDOSIS OF EYE A: Macroscopic view of the anterior segment of...

SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Figure 8-3 SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Starting from the bottom of the figure, first seen is the densely eosinophilic sclera. The loose fibrovascular connective tissue between the sclera ... More about this image found in SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Start...

RETINOBLASTOMA: EXTENSIVELY NECROTIC (OVER 95 PERCENT) Figure 9-12 RETINOBLASTOMA: EXTENSIVELY NECROTIC (OVER 95 PERCENT) A: CT image of a 2-year-old child who experienced eyelid edema and inflammation, accompanied by conjunctival edema (chemosis), pain, and proptosis. The cornea was opaque. The ... More about this image found in RETINOBLASTOMA: EXTENSIVELY NECROTIC (OVER 95 PERCENT) A: CT image of a 2-...

PRIMARY VITREORETINAL LYMPHOMA Figure 11-4 PRIMARY VITREORETINAL LYMPHOMA A: Cytology specimens may be paucicellular, with few atypical large cells (arrow) in a background of apoptotic cells, macrophages, and condensed vitreous. B: A more cellular specimen with more atypical cells (arrow). C: M... More about this image found in PRIMARY VITREORETINAL LYMPHOMA A: Cytology specimens may be paucicellular,...

RETINOBLASTOMA: CLOUD-TYPE TUMOR SEEDS Figure 9-9 RETINOBLASTOMA: CLOUD-TYPE TUMOR SEEDS Left: A cloud-type seed occupies most of the anterior vitreous behind the lens. Small sphere-type seeds are at the edge of the cloud (arrow). Right: The cloud-type seed is made predominantly by necrotic cell... More about this image found in RETINOBLASTOMA: CLOUD-TYPE TUMOR SEEDS Left: A cloud-type seed occupies mo...

ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA Figure 9-30 ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA A: Cut surface of the eye with retinoblastoma that has invaded the anterior chamber (AC), angle (*) posterior chamber (between iris and ciliary body [CB]), and anterior vitreous. B: Histologic cor... More about this image found in ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA A: Cut surface of the eye with...

RETINOBLASTOMA Figure 9-6 RETINOBLASTOMA A: Scanning magnification view of an eye containing a retinoblastoma tumor that fills the vitreous cavity. The tumor is tan-gray, partially translucent, with geographic yellow-white areas corresponding to areas of tumor necrosis (t.n.). B: Higher-power vi... More about this image found in RETINOBLASTOMA A: Scanning magnification view of an eye containing a retin...

RETINOBLASTOMA: SPHERE-TYPE TUMOR SEEDS Figure 9-8 RETINOBLASTOMA: SPHERE-TYPE TUMOR SEEDS A: Stereoscopic microscope at high magnification shows a cluster of sphere-type tumor seeds floating in the vitreous. Some seeds have a center that is white while others are translucent. B: The seeds are o... More about this image found in RETINOBLASTOMA: SPHERE-TYPE TUMOR SEEDS A: Stereoscopic microscope at high...

ADENOCARCINOMA OF THE RETINAL PIGMENT EPITHELIUM Figure 9-35 ADENOCARCINOMA OF THE RETINAL PIGMENT EPITHELIUM A: Bleached section shows nests and tubules of neoplastic RPE invading the choroid (the sclera is at the left). The insert shows the PAS-rich stroma between the tumor cells. B: The pupil... More about this image found in ADENOCARCINOMA OF THE RETINAL PIGMENT EPITHELIUM A: Bleached section shows...

NEUROINVASIVE UVEAL MELANOMA Figure 10-11 NEUROINVASIVE UVEAL MELANOMA A: An enucleated eye of a patient with choroidal melanoma (CM) in the equator of the eye. This eye had been treated with a radiation plaque and developed radiation retinopathy with bleeding (vitreous hemorrhage in front of the... More about this image found in NEUROINVASIVE UVEAL MELANOMA A: An enucleated eye of a patient with choroi...

PRIMARY CHOROIDAL EXTRANODAL MARGINAL B-CELL LYMPHOMA (MALT TYPE) Figure 11-8 PRIMARY CHOROIDAL EXTRANODAL MARGINAL B-CELL LYMPHOMA (MALT TYPE) A: Low-power view in an evisceration for a perforated eye shows detached retina (R) and cloudy vitreous (V) (acute endophthalmitis secondary to perforati... More about this image found in PRIMARY CHOROIDAL EXTRANODAL MARGINAL B-CELL LYMPHOMA (MALT TYPE) A: Low-p...

MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Figure 9-1 MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Left: Macroscopic view under stereoscopic dissecting microscope. Note the inner most portion the transparent translucent vitreous body, the white translucent neurosensory retina with the red... More about this image found in MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Left: Macroscopic view und...

POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA Figure 9-23 POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA A: Top left: Systemic chemotherapy produces regression of the tan-gray lesion (RT) with large chunky calcifications (Ca++). In this eye there are also chorioretinal scars (circle) left by local treatment (laser or cryotherapy). A, top right: histopathology of the regressed tumor (RT) shows a retinocytoma-like lesion with neuronal or photoreceptor differentiation and an absence of mitoses or apoptosis. A, bottom left: chunky large calcifications (Ca++) in the regressed tumor. A, bottom right: histopathology of the same area with large chunky calcifications (Ca++) in a gliotic tissue. B: Radiotherapy effect in an eye with retinoblastoma. B, top left: the pupil-optic nerve section of this eye with a regressed tumor (RT) features calcifications and a funnel-shaped, totally detached retina at the center. B, bottom left: postradiation treatment shows areas of vitreous, retinal, and subretinal hemorrhages (*) with a detached retina and extensively calcified tumor (Ca++). B, right panel: epiretinal and tumor neovascular membrane. C: Effects after intra-arterial chemotherapy. C, left panel: gross photograph of a chorioretinal scar with RPE migration into the retina. C, right panel: histologic section of the same area with the RPE migration encircled. In eyes that have undergone local therapy, including laser photocoagulation, cryotherapy, or plaque radiation, large areas of chorioretinal scarring with RPE dispersion and proliferation into the retina are seen. Retinal atrophy and gliotic attachment to the RPE layer. D: A mostly regressed tumor with several multinucleated foreign body type cells (arrows) with fiber-like blue-gray material in the cytoplasm. D, top right: high-power view of a foreign body-type giant cell in the choroid. D, bottom right: polarization discloses birefringent polarizable foreign material (arrow). More about this image found in POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA A: Top left:...