VIRAL MORPHOLOGY USING ELECTRON MICROSCOPY Figure 1-8 VIRAL MORPHOLOGY USING ELECTRON MICROSCOPY Selected viral pathogens are shown. (Courtesy of the CDC Public Health Image Library [PHIL]) More about this image found in VIRAL MORPHOLOGY USING ELECTRON MICROSCOPY Selected viral pathogens are sh...

CNS VIRAL INCLUSIONS Figure 3-51 CNS VIRAL INCLUSIONS CNS viral inclusions mirror those in other tissues, such as the nuclear enlargement and binucleation of cytomegalovirus (CMV) infection (A), and the typical intranuclear inclusions in adenovirus infection (B). (Courtesy of the CDC PHIL) More about this image found in CNS VIRAL INCLUSIONS CNS viral inclusions mirror those in other tissues, s...

RABIES VIRAL INCLUSIONS Figure 3-12 RABIES VIRAL INCLUSIONS Neurons show the round intracytoplasmic rabies viral inclusions, known as Negri bodies (arrows). More about this image found in RABIES VIRAL INCLUSIONS Neurons show the round intracytoplasmic rabies vir...

RABIES VIRAL PARTICLES Figure 3-13 RABIES VIRAL PARTICLES A,B: Electron microscopy confirms the typical bullet or elongated morphology of rabies viral particles in intracytoplasmic inclusions: lower (A) and higher (B) power electron photomicrographs. (Courtesy of the CDC PHIL) More about this image found in RABIES VIRAL PARTICLES A,B: Electron microscopy confirms the typical bulle...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-28 SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show more striking diffuse microgliosis than tight localized microglial clusters, as illustrated here in the cortex of an SSPE case at autopsy. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show ...

VIRAL ENCEPHALITIS Figure 3-49 VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and include perivascular cuffing by mononuclear cells and glial nodules, as seen in this mild case of herpes simplex encephalitis (A: courtesy of the CDC PHIL) and enterovirus encephalitis (B: courtesy ... More about this image found in VIRAL ENCEPHALITIS The histopathologic findings are nonspecific and includ...

VIRAL ENCEPHALITIS Figure 3-52 VIRAL ENCEPHALITIS Immunohistochemical assays confirm the etiology of viral encephalitis, as in this case of enterovirus (A) and Nipah virus (B) infection. (Courtesy of the CDC IDPB) More about this image found in VIRAL ENCEPHALITIS Immunohistochemical assays confirm the etiology of vira...

ACUTE VIRAL HEPATITIS Figure 5-2 ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, and more extensive confluent necrosis at top right. Note the dark eosinophilic cytoplasm and pyknotic nuclei of the degenerated liver cells. B,C: Degeneration of large numbers of adjacent hep... More about this image found in ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, an...

ACUTE VIRAL HEPATITIS DUE TO HERPES SIMPLEX VIRUS Figure 5-3 ACUTE VIRAL HEPATITIS DUE TO HERPES SIMPLEX VIRUS A: Typical mottled macroscopic appearance of the liver, with circumscribed pale necrotic foci surrounded by irregular congested and hemorrhagic zones. B: Microscopy reveals extensive co... More about this image found in ACUTE VIRAL HEPATITIS DUE TO HERPES SIMPLEX VIRUS A: Typical mottled macro...

INFLAMMATION IN CHRONIC VIRAL HEPATITIS C INFECTION Figure 5-5 INFLAMMATION IN CHRONIC VIRAL HEPATITIS C INFECTION A: HCV cirrhosis with septal and periseptal mononuclear inflammation. B–D: Active inflammation shows lymphocyte extension into regenerating nodular liver parenchyma (B), with associ... More about this image found in INFLAMMATION IN CHRONIC VIRAL HEPATITIS C INFECTION A: HCV cirrhosis with ...

VIRAL IMMUNOHISTOCHEMISTRY Figure 5-13 VIRAL IMMUNOHISTOCHEMISTRY A: Liver tissue shows hepatocyte and Kupffer cell positivity in yellow fever. B: Lung tissue in severe dengue with prominent macrophage staining. (Courtesy of the CDC IDPB) More about this image found in VIRAL IMMUNOHISTOCHEMISTRY A: Liver tissue shows hepatocyte and Kupffer ce...

NIPAH VIRUS INFECTION Figure 3-48 NIPAH VIRUS INFECTION Patterns of immunohistochemical staining in CNS neurons: abundant viral antigen in neurons and associated processes (A), discrete staining of intracytoplasmic viral inclusions (B), and fine granular cytoplasmic positivity in retracted neuron... More about this image found in NIPAH VIRUS INFECTION Patterns of immunohistochemical staining in CNS neur...

HANTAVIRUS ULTRASTRUCTURE Figure 4-18 HANTAVIRUS ULTRASTRUCTURE Transmission electron microscopy of hantavirus (A) and schematic of viral components (B). (A: courtesy of the CDC PHIL) More about this image found in HANTAVIRUS ULTRASTRUCTURE Transmission electron microscopy of hantavirus (...

JC VIRUS Figure 3-41 JC VIRUS Oligodendrocytes immunostain with antibodies directed against SV40, due to significant viral homology with this simian virus. More about this image found in JC VIRUS Oligodendrocytes immunostain with antibodies directed against SV4...