ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Figure 6-24 ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Large eosinophilic cells with abundant granular cytoplasm (A) and nuclear atypia with prominent nucleoli (B) are characteristic of this variant. More about this image found in ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Large eosinophilic cells wit...

ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Figure 6-25 ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Intratumoral lymphocytes are frequently seen. More about this image found in ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Intratumoral lymphocytes are...

ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT Figure 6-26 ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT A–C: Myxoid stromal changes are variably in extent and distribution. Neoplastic cells are usually small, grow in cords or thin trabeculae, and have less pronounced cytologic atypia. More about this image found in ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT A–C: Myxoid stromal changes are...

ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT Figure 6-27 ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circumscribed within the adrenal (A). It has a pure storiform architectural pattern (B) and consists of spindle cells (B) expressing SF1 (C) and Melan-A (D). More about this image found in ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circums...

ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT Figure 7-2 ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT The adrenal mass (A) is composed of a peripheral benign macronodular component (A, upper left), and is associated with a central component made of eosinophilic cells (B, lower right) showing malignancy-related features, including increased mitotic activity (B, red circle) for a total Weiss score of 4. More about this image found in ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLI...

ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GERMLINE MUTATION Figure 7-9 ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GERMLINE MUTATION The patient had a previous diagnosis of prostate cancer. The adrenal lesion showed predominant features of the myxoid variant. More about this image found in ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GE...

MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE Figure 10-1 MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a documented pathogenic germline SDHB variant, was diagnosed with a right carotid body tumor. B,C: ⁶⁸Ga-DOTATATE PET/CT also showed multiple lesions in his retroperitoneum. (A–C: courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a document...

SDH-DEFICIENT PARAGANGLIOMA Figure 10-5 SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained positivity in vascular endothelium serving as an internal positive control. More about this image found in SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient w...

IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE Figure 2-7 IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amyloid plaque on immunohistochemical staining. (Courtesy of the Armed Forces Institute of Pathology) B: Synaptic pattern of PrP^SC immunohistochemical staining. More about this image found in IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amylo...

AMYLOID PLAQUES Figure 2-6 AMYLOID PLAQUES A: Typical amyloid plaque in human spongiform encephalopathy. B: Variant Creutzfeldt-Jakob disease shows a plaque in the center of spongiform change (identifiable on a routine hematoxylin and eosin [H&E] stain). (Courtesy of Dr. J. Arango, Universit... More about this image found in AMYLOID PLAQUES A: Typical amyloid plaque in human spongiform encephalopat...