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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter discusses unusual morphologic variants of primary cutaneous melanomas that have not been discussed elsewhere in the Fascicle. The purpose of commenting on these variants is for the practicing pathologist to be aware of the morphologic spectrum of melanomas, and to consider...
Images
MATURING <span class="search-highlight">VARIANT</span> OF NEVOID MELANOMA  A: Dermal plaque-like silhouette of th...
Published: 01 February 2024
MATURING VARIANT OF NEVOID MELANOMA Figure 17-3 MATURING VARIANT OF NEVOID MELANOMA A: Dermal plaque-like silhouette of the tumor. B: Analysis of the tumor cells by single nucleotide polymorphism (SNP) array revealed multiple segmental chromosomal aberrations. C: The melanocytes are almost enti... More about this image found in MATURING VARIANT OF NEVOID MELANOMA A: Dermal plaque-like silhouette of th...
Images
MATURING <span class="search-highlight">VARIANT</span> OF NEVOID MELANOMA  A: Small diameter lesion with predomin...
Published: 01 February 2024
MATURING VARIANT OF NEVOID MELANOMA Figure 17-5 MATURING VARIANT OF NEVOID MELANOMA A: Small diameter lesion with predominantly intradermal growth of melanocytes displays the silhouette of a nevus. B: There is evidence of maturation. However, there is architectural disorder of melanocytes and as... More about this image found in MATURING VARIANT OF NEVOID MELANOMA A: Small diameter lesion with predomin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...), dysplastic nevus (dysplastic nevus-like melanoma), blue nevus (blue nevus-like melanoma), deep penetrating nevus (deep penetrating nevus-like melanoma), or other nevus variants. Table 17-1 FEATURES OF NEVOID MELANOMA a Clinical Features  Wide age range  Usually small...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for nodular melanoma when their invasive tumor cells have extended in the horizontal plane to or beyond the edge of the melanoma in situ. Accordingly, nodular melanoma does not represent a unique melanoma variant with a distinct histology or molecular pathway. Rather, it represents a shared microscopic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... dermis. B: A few scattered large epithelioid (spitzoid) melanocytes are present in the lymphocytic infiltrate. Histopathologic Variants of Spitz Nevi. A number of histopathologic variants of Spitz nevus have been reported ( Table 7-1 ). Table 7-1 HISTOPATHOLOGIC VARIANTS OF SPITZ NEVUS...
Images
MUCINOUS CARCINOMA, HYPOCELLULAR <span class="search-highlight">VARIANT</span>  A: Low-power image reveals large ...
Published: 01 January 2024
MUCINOUS CARCINOMA, HYPOCELLULAR VARIANT Figure 8-47 MUCINOUS CARCINOMA, HYPOCELLULAR VARIANT A: Low-power image reveals large pools of stromal mucin with scant epithelial cells. B: At intermediate power, small clusters of epithelial cells can be seen “floating” in the mucin pools. C: At higher... More about this image found in MUCINOUS CARCINOMA, HYPOCELLULAR VARIANT A: Low-power image reveals large ...
Images
MUCINOUS CARCINOMA, HYPERCELLULAR <span class="search-highlight">VARIANT</span>  A: At low power, this mucinous c...
Published: 01 January 2024
MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT Figure 8-48 MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT A: At low power, this mucinous carcinoma is considerably more cellular than that seen in fig. 8-47 , with large sheets of tumor cells surrounded by stromal mucin. B: At higher power, the tumor cells ... More about this image found in MUCINOUS CARCINOMA, HYPERCELLULAR VARIANT A: At low power, this mucinous c...
Images
MYOFIBROBLASTOMA, MYXOID <span class="search-highlight">VARIANT</span>  A: This core needle biopsy sample shows a...
Published: 01 January 2024
MYOFIBROBLASTOMA, MYXOID VARIANT Figure 11-2 MYOFIBROBLASTOMA, MYXOID VARIANT A: This core needle biopsy sample shows a bland spindle cell lesion with a myxoid stroma, admixed collagen, and scattered adipocytes. B: At high power, these features are better appreciated. More about this image found in MYOFIBROBLASTOMA, MYXOID VARIANT A: This core needle biopsy sample shows a...
Images
MYOFIBROBLASTOMA, LIPOMATOUS <span class="search-highlight">VARIANT</span>  A: Low-power view shows a mixed lipom...
Published: 01 January 2024
MYOFIBROBLASTOMA, LIPOMATOUS VARIANT Figure 11-3 MYOFIBROBLASTOMA, LIPOMATOUS VARIANT A: Low-power view shows a mixed lipomatous and spindle cell lesion. B: High power shows the bland spindle cell component, interspersed between adipocytes. Scattered mast cells offer a clue to the correct diagno... More about this image found in MYOFIBROBLASTOMA, LIPOMATOUS VARIANT A: Low-power view shows a mixed lipom...
Images
MYOFIBROBLASTOMA, CELLULAR <span class="search-highlight">VARIANT</span>  This intermediate power view illustrate...
Published: 01 January 2024
MYOFIBROBLASTOMA, CELLULAR VARIANT Figure 11-5 MYOFIBROBLASTOMA, CELLULAR VARIANT This intermediate power view illustrates the characteristic pattern of myofibroblasts with interspersed bundles of collagen. The cellularity is greater than is typically seen. More about this image found in MYOFIBROBLASTOMA, CELLULAR VARIANT This intermediate power view illustrate...
Images
MYOFIBROBLASTOMA, PALISADED <span class="search-highlight">VARIANT</span>  A: Low-power view shows a well circums...
Published: 01 January 2024
MYOFIBROBLASTOMA, PALISADED VARIANT Figure 11-6 MYOFIBROBLASTOMA, PALISADED VARIANT A: Low-power view shows a well circumscribed tumor with compact rows of myofibroblasts that characterize the palisaded variant. B,C: At intermediate (B) and high (C) power, the interspersed hypocellular or “Veroc... More about this image found in MYOFIBROBLASTOMA, PALISADED VARIANT A: Low-power view shows a well circums...
Images
DESMOID FIBROMATOSIS, KELOIDAL <span class="search-highlight">VARIANT</span>  A: This core needle biopsy sample o...
Published: 01 January 2024
DESMOID FIBROMATOSIS, KELOIDAL VARIANT Figure 11-12 DESMOID FIBROMATOSIS, KELOIDAL VARIANT A: This core needle biopsy sample of the keloidal variant of fibromatosis shows the presence of thick collagen fibers, a mimic for myofibroblastoma or scar. B: At higher power, bland spindle cells are seen... More about this image found in DESMOID FIBROMATOSIS, KELOIDAL VARIANT A: This core needle biopsy sample o...
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ANGIOSARCOMA  A: Low-power image of a subtle <span class="search-highlight">variant</span> of angiosarcoma mimick...
Published: 01 January 2024
ANGIOSARCOMA Figure 11-29 ANGIOSARCOMA A: Low-power image of a subtle variant of angiosarcoma mimicking radiation dermatitis. The cells of concern are seen at the left hand side of the field. B: High-power view shows the scattered highly atypical endothelial cells of angiosarcoma. C: Another hi... More about this image found in ANGIOSARCOMA A: Low-power image of a subtle variant of angiosarcoma mimick...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... clinically manifest as bluish patches, named for the anatomic skin region involved. A number of variants have been described, including Mongolian spot, nevus of Ota, nevus fuscocaeruleus zygomaticus (acquired nevus of Ota-like macules), nevus of Ito, and the “dermal melanocyte hamartoma” ( 2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytes ( 10 – 13 ). Combinations of blue and Spitz nevi are also reported ( 14 ). Sometimes more than two nevus phenotypes are seen, especially in context with a congenital melanocytic nevus ( Table 10-1 ). Table 10-1 VARIANTS OF COMBINED NEVI Combined deep penetrating nevus Combined inverted...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Desmoplastic melanoma (DM) is characterized microscopically by the association of invasive tumor with dense fibrous stroma ( 1 ). In pure variants, the tumor is a fibrous stroma-rich and cell-poor lesion, with individual tumor cells dispersed throughout in an abundant fibrous matrix ( 2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or spitzoid melanomas. Other, much less common variants of melanomas in young children include those associated with large or giant congenital melanocytic nevi. Rarely, a young child develops a conventional (adult-type) melanoma. In teenagers, by contrast, most melanomas are of adult type ( 2 ). CLINICAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... form in large plaque lesions. A speckled nevus (nevus spilus) of congenital onset ranges in size from 1 to 10 cm. The congenital variant of this nevus typically presents as a café-au-lait-like lightly pigmented patch at birth or early childhood. Later in childhood or during adolescence, secondary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... deep downward growth to the reticular dermis and/or superficial subcutis, often displaying a wedge (inverted triangle-like) shape ( figs. 9-1 – 9-3 ) ( 1 – 7 ). However, small superficial variants exist, in which the tumor cells are confined to the upper and mid reticular dermis ( fig. 9-4 ). Fascicles...