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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the oxymoron of “malignant nevus” ( 3 ). Another fitting term is BLUE melanoma (blue nevus-associated uveal melanoma equivalent in the skin), reflecting shared genetic drivers and phenotypes with uveal melanoma ( 3 ). The resemblance to a blue nevus is a more subjective parameter and yields a more...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... be of diagnostic help ( 36 – 40 ). The detection of multiple chromosomal copy number changes, especially types of aberrations known to be associated with melanoma, strongly favors melanoma. Melanoma arising in association with CBN shares genomic similarities with uveal melanoma. Thus, it is not surprising...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... a  One BAP1-TPDS tumor and first- or second-degree relative with BAP1-TPDS Confirmed BAP1-TPDS–associated neoplasms (in descending order of association with the syndrome):  BAP1-inactivated melanocytic tumors (BIMT)  Uveal melanoma  Mesothelioma  Cutaneous melanoma  Renal cell carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... in the nonasbestos textile sector. Gender ratio is inversely correlated with the mortality rate ( 17 ). Genetic Predisposition. In 2010, somatic mutations in BRCA1-associated protein 1 gene (BAP1) were found to be associated with metastatic uveal melanoma ( 18 ), with one mutation found...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 9
Published: 01 November 2021
10.55418/9781933477176-2
ISBN-10: 1-933477-17-2
ISBN: 978-1-933477-17-6
... sclerosis TSC1, TSC2 Angiomyolipomas, angiomyofibromas, cerebral cortex dysplasia, astrocytoma, lymphangioleiomyomatosis and more BAP1 tumor predisposition BAP1 Uveal and cutaneous melanomas, mesothelioma MITF tumor predisposition MITF Melanomas Cowden...
Images
<span class="search-highlight">UVEAL</span> MELANOMA WITH EXTRAOCULAR EXTENSION  Left: This <span class="search-highlight">uveal</span> melanoma involv...
Published: 01 February 2021
UVEAL MELANOMA WITH EXTRAOCULAR EXTENSION Figure 8-17 UVEAL MELANOMA WITH EXTRAOCULAR EXTENSION Left: This uveal melanoma involves the choroid and ciliary body, with multiple areas of extraocular extension through the sclera. The retina is detached, with a protein-rich eosinophilic exudate in the... More about this image found in UVEAL MELANOMA WITH EXTRAOCULAR EXTENSION Left: This uveal melanoma involv...
Images
PROLIFERATION AS PROGNOSTIC FACTOR IN <span class="search-highlight">UVEAL</span> MELANOMA  Left: It is customary...
Published: 01 February 2021
PROLIFERATION AS PROGNOSTIC FACTOR IN UVEAL MELANOMA Figure 8-19 PROLIFERATION AS PROGNOSTIC FACTOR IN UVEAL MELANOMA Left: It is customary to report the number of mitotic figures identified in 40 high-power fields at X40 magnification. A mitotic figure is seen in the center. Right: This tumor s... More about this image found in PROLIFERATION AS PROGNOSTIC FACTOR IN UVEAL MELANOMA Left: It is customary...
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Images
POSTERIOR <span class="search-highlight">UVEAL</span> (CHOROIDAL) INVASION BY RETINOBLASTOMA  A: Cut section of a...
Published: 01 February 2021
POSTERIOR UVEAL (CHOROIDAL) INVASION BY RETINOBLASTOMA Figure 9-25 POSTERIOR UVEAL (CHOROIDAL) INVASION BY RETINOBLASTOMA A: Cut section of an eye with massive choroidal invasion (over 3 mm) by retinoblastoma. Note the dissolution of the RPE and the replacement of the choroid by tumor in the righ... More about this image found in POSTERIOR UVEAL (CHOROIDAL) INVASION BY RETINOBLASTOMA A: Cut section of a...
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NEUROINVASIVE <span class="search-highlight">UVEAL</span> MELANOMA  A: An enucleated eye of a patient with choroi...
Published: 01 February 2021
NEUROINVASIVE UVEAL MELANOMA Figure 10-11 NEUROINVASIVE UVEAL MELANOMA A: An enucleated eye of a patient with choroidal melanoma (CM) in the equator of the eye. This eye had been treated with a radiation plaque and developed radiation retinopathy with bleeding (vitreous hemorrhage in front of the... More about this image found in NEUROINVASIVE UVEAL MELANOMA A: An enucleated eye of a patient with choroi...
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SARCOIDOSIS OF <span class="search-highlight">UVEAL</span> TRACT AND VITREOUS  Left: The specimen is cellular, wi...
Published: 01 February 2021
SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Figure 11-11 SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Left: The specimen is cellular, with occasional well-formed granulomas (center) and scattered lymphocytes and histiocytes (arrow) in the background. Right: A poorly formed granuloma with mainly epithelio... More about this image found in SARCOIDOSIS OF UVEAL TRACT AND VITREOUS Left: The specimen is cellular, wi...
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SECONDARY INVOLVEMENT OF THE <span class="search-highlight">UVEAL</span> TRACT  The ciliary body (CB), choroid (C...
Published: 01 February 2021
SECONDARY INVOLVEMENT OF THE UVEAL TRACT Figure 11-13 SECONDARY INVOLVEMENT OF THE UVEAL TRACT The ciliary body (CB), choroid (Ch), and retina are involved by non-Hodgkin B-cell chronic lymphocytic leukemia/chronic lymphocytic lymphoma with extraocular extension into the inferior oblique muscle (... More about this image found in SECONDARY INVOLVEMENT OF THE UVEAL TRACT The ciliary body (CB), choroid (C...
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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch08
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
... MELANOMA Figure 8-15 CHOROIDAL MELANOMA This pigmented mass arises from the choroid. The dome-shaped lesion is confined to the choroid and has not ruptured through Bruch membrane. (Courtesy of Drs. J. H. Francis and D. H. Abramson, New York, NY.) UVEAL MELANOMA WITH EXTRAOCULAR EXTENSION Figure 8-17...
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GROSS EXAMINATION OF EYES FROM WHICH TISSUE WAS REMOVED  A: In eyes from wh...
Published: 01 February 2021
GROSS EXAMINATION OF EYES FROM WHICH TISSUE WAS REMOVED Figure 1-6 GROSS EXAMINATION OF EYES FROM WHICH TISSUE WAS REMOVED A: In eyes from which fresh tissue for special studies has been harvested, ink is applied to the vortex veins before opening the eye. The long vortex veins, inferior temporal... More about this image found in GROSS EXAMINATION OF EYES FROM WHICH TISSUE WAS REMOVED A: In eyes from wh...
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FINE-NEEDLE ASPIRATION BIOPSY (FNAB) OF INTRAOCULAR TUMORS  A: Transvitreal...
Published: 01 February 2021
FINE-NEEDLE ASPIRATION BIOPSY (FNAB) OF INTRAOCULAR TUMORS Figure 1-10 FINE-NEEDLE ASPIRATION BIOPSY (FNAB) OF INTRAOCULAR TUMORS A: Transvitreal biopsy performed using an operating microscope allows visualization of the intraocular structures. B: A 25-gauge needle (left) is entering the partial... More about this image found in FINE-NEEDLE ASPIRATION BIOPSY (FNAB) OF INTRAOCULAR TUMORS A: Transvitreal...
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INTERIOR OF THE EYE  A: Cutting the first calotte allows the pathologist to...
Published: 01 February 2021
INTERIOR OF THE EYE Figure 1-8 INTERIOR OF THE EYE A: Cutting the first calotte allows the pathologist to visualize the interior of the eye. At the top, the cornea, anterior chamber, and lens are without pathologic alteration. The pathology appears in the posterior portion of the eye with a detac... More about this image found in INTERIOR OF THE EYE A: Cutting the first calotte allows the pathologist to...
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INVASIVE CONJUNCTIVAL CARCINOMA WITH INTRAOCULAR INVOLVEMENT  A: A white li...
Published: 01 February 2021
INVASIVE CONJUNCTIVAL CARCINOMA WITH INTRAOCULAR INVOLVEMENT Figure 2-19 INVASIVE CONJUNCTIVAL CARCINOMA WITH INTRAOCULAR INVOLVEMENT A: A white limbal mass is associated with corneal edema and retrocorneal gray-white material (arrow), suggestive of intraocular invasion by the tumor. The surface ... More about this image found in INVASIVE CONJUNCTIVAL CARCINOMA WITH INTRAOCULAR INVOLVEMENT A: A white li...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch10
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
... of the edge of the optic nerve (ON) and the choroidal melanoma (CM) shows invasion of the partially pigmented tumor (arrow) into the optic nerve at the edge with the meninges (Men) and the tumor in the sclera involving the meninges focally (arrows). NEUROINVASIVE UVEAL MELANOMA Figure 10-11 NEUROINVASIVE...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch01
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
... the eye. The long vortex veins, inferior temporal and inferior nasal (arrows), are seen. B: The eye is transilluminated to generate a shadow of the uveal melanoma. The tumor invests into the draining vortex vein (arrow). C: The veins can be resected with small scissors cutting flush to the sclera (arrow...