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urothelial

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METASTASIS BY RETROGRADE LYMPHATIC SPREAD  Left: Metastatic high-grade urot...
Published: 15 November 2023
METASTASIS BY RETROGRADE LYMPHATIC SPREAD Figure 52-2 METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urothelial carcinoma forms a microscopic metastasis that cannot be seen grossly, but the intense fibrinous pericarditis is a direct consequence of the lymphatic involvement.... More about this image found in METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urot...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... Neurofibromatosis type 1 NF1 Negative regulation of RAS IBC, NST (also invasive lobular) CNS Lynch syndrome Various DNA mismatch repair More likely grade 3 TIL rich Low PR ER positive and triple negative reported Gyn GI/hepatobilliary Urothelial a Adapted from reference 28 . b IBC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch23
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 23-1 IMMUNE CHECKPOINT INHIBITORS a Inhibitor Target Malignancies Ipilimumab CTLA-4 Melanoma, renal cell carcinoma Nivolumab PD-1 Melanoma, non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, colorectal carcinoma Pembrolizumab PD-1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch50
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma . Am J Surg Pathol   2006 ; 30 : 1502 - 12 . 2. de Winkel   N , Becker   K , Vogt   M...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of the lung (primary tumor, white arrow) has invaded the structures of the superior mediastinum (black asterisk) and is directly invading the wall of the trachea. METASTASIS BY RETROGRADE LYMPHATIC SPREAD Figure 52-2 METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urothelial carcinoma...
Images
OVARIAN SURFACE IMPLANTATION OF HIGH-GRADE <span class="search-highlight">UROTHELIAL</span> CARCINOMA  The patien...
Published: 01 August 2023
OVARIAN SURFACE IMPLANTATION OF HIGH-GRADE UROTHELIAL CARCINOMA Figure 9-13 OVARIAN SURFACE IMPLANTATION OF HIGH-GRADE UROTHELIAL CARCINOMA The patient had an ipsilateral high-grade noninvasive urothelial carcinoma of ureter. No Brenner components are present. More about this image found in OVARIAN SURFACE IMPLANTATION OF HIGH-GRADE UROTHELIAL CARCINOMA The patien...
Images
BORDERLINE BRENNER TUMOR  Blunt intracystic papillae (A,B) and bland nuclea...
Published: 01 August 2023
BORDERLINE BRENNER TUMOR Figure 9-9 BORDERLINE BRENNER TUMOR Blunt intracystic papillae (A,B) and bland nuclear features with maturation from base to lumen (B,C) are seen. These features are similar to noninvasive low-grade papillary urothelial carcinoma or urothelial papillary neoplasm of low ma... More about this image found in BORDERLINE BRENNER TUMOR Blunt intracystic papillae (A,B) and bland nuclea...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-09
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
...Transitional cell tumors of the ovary resemble urothelial neoplasms of the urinary tract. Broad undulating papillae containing cells with severe nuclear atypia are considered reminiscent of high-grade urothelial carcinomas, whereas papillary tumors containing stratified cells with nuclear...
Images
TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE  Broad papillae resembling t...
Published: 01 August 2023
TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE Figure 5-6 TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE Broad papillae resembling those of urothelial carcinoma (“transitional-like) (A–C) often coexists with microcystic pattern (D,E). More about this image found in TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE Broad papillae resembling t...
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BORDERLINE BRENNER TUMOR WITH INTRAEPITHELIAL CARCINOMA AND MICROINVASION  ...
Published: 01 August 2023
BORDERLINE BRENNER TUMOR WITH INTRAEPITHELIAL CARCINOMA AND MICROINVASION Figure 9-10 BORDERLINE BRENNER TUMOR WITH INTRAEPITHELIAL CARCINOMA AND MICROINVASION A,B: The general architecture of borderline Brenner tumor is retained, but tumor cells are cytologically malignant. No stromal invasion i... More about this image found in BORDERLINE BRENNER TUMOR WITH INTRAEPITHELIAL CARCINOMA AND MICROINVASION ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... is common in high-grade serous carcinoma and should not lead to a diagnosis of a mixed carcinoma with an undifferentiated component. TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE Figure 5-6 TRANSITIONAL-LIKE AND MICROCYSTIC ARCHITECTURE Broad papillae resembling those of urothelial carcinoma...
Images
SECONDARY PAGET DISEASE OF <span class="search-highlight">UROTHELIAL</span> ORIGIN  The presence of acantholysis ...
Published: 01 February 2023
SECONDARY PAGET DISEASE OF UROTHELIAL ORIGIN Figure 5-48 SECONDARY PAGET DISEASE OF UROTHELIAL ORIGIN The presence of acantholysis and clefting between malignant cells and squamous epithelium is more often seen with spread of a urothelial primary (left). Nonetheless, the lesion may bear close res... More about this image found in SECONDARY PAGET DISEASE OF UROTHELIAL ORIGIN The presence of acantholysis ...
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<span class="search-highlight">UROTHELIAL</span> CARCINOMA METASTATIC TO THE CERVIX  Left: In this case, spread o...
Published: 01 February 2023
UROTHELIAL CARCINOMA METASTATIC TO THE CERVIX Figure 3-77 UROTHELIAL CARCINOMA METASTATIC TO THE CERVIX Left: In this case, spread occurred in a pagetoid fashion, and was initially interpreted as an HSIL of the cervix. Right: The primary lesion in the bladder, depicted here, shows identical feat... More about this image found in UROTHELIAL CARCINOMA METASTATIC TO THE CERVIX Left: In this case, spread o...
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PAPILLARY SQUAMOTRANSITIONAL CARCINOMA  Filiform papillae lined by a cellul...
Published: 01 February 2023
PAPILLARY SQUAMOTRANSITIONAL CARCINOMA Figure 3-24 PAPILLARY SQUAMOTRANSITIONAL CARCINOMA Filiform papillae lined by a cellular stratified proliferation without overt squamous maturation mimic urothelial differentiation. More about this image found in PAPILLARY SQUAMOTRANSITIONAL CARCINOMA Filiform papillae lined by a cellul...
Images
SQUAMOUS CELL CARCINOMA: SQUAMOTRANSITIONAL TYPE  Left: This lesion feature...
Published: 01 February 2023
SQUAMOUS CELL CARCINOMA: SQUAMOTRANSITIONAL TYPE Figure 4-10 SQUAMOUS CELL CARCINOMA: SQUAMOTRANSITIONAL TYPE Left: This lesion features prominent papillary growth highly resembling a low-grade urothelial neoplasm on low-power examination. Right: Higher-power examination shows a stratified, nonk... More about this image found in SQUAMOUS CELL CARCINOMA: SQUAMOTRANSITIONAL TYPE Left: This lesion feature...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-2
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... cases in one series reported) and true microglandular hyperplasia of the cervix (retained in all 24 cases) ( 51 ). GATA3. This marker is positive in a number of different tumor types. It stains trophoblastic neoplasia ( 57 ), benign and malignant mesonephric lesions ( 58 ), urothelial neoplasia ( 59...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... malignancies by immunohistochemistry is often needed. Papillary Squamous or Squamotransitional. These tumors are characterized by filiform papillae lined by neoplastic cells identical to HSIL or with features resembling transitional cell carcinoma of urothelial origin. The term “transitional” is based...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... and shows a distinctive p53 staining pattern as described above. Pagetoid HSIL must be distinguished from Paget disease as well as rare involvement of the vulvar mucosa by a urothelial carcinoma ( 46 ) (described later in this chapter). Tangential sectioning of HSIL involving skin appendages...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... with features of both squamous and urothelial mucosa ( fig. 4-10 ). There is an association with HPV infection, particularly high-risk types ( 46 ). The immunohistochemical profile (CK7 positive and CK20 negative) and the detection of HPV type 16 support its close relationship to conventional squamous cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... is expressed in most breast and urothelial carcinomas ( 70 ). Other neuroendocrine tumors do not express GATA3, although some folliculogenic thyroid and adrenal cortical tumors show infrequent GATA3 expression ( 70 ). CDX2 is helpful in identifying neuroendocrine tumors from the gastrointestinal tract...