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Figure 11-35
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY Figure 11-35 UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY A: Undifferentiated NB for which immunohistochemistry was needed for classification shows extensive cytoplasmic staining for synaptophysin with a slightly granular aspect. B More about this image found in UNDIFFERENTIATED NEUROBLASTOMA: IMMUNOHISTOCHEMISTRY A: Undifferentiated N...
Images
Figure 11-12
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...
Images
Figure 11-16
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION Figure 11-16 UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stage 3 NB in a 5-year-old girl was not pretreated and showed this peculiar undifferentiated spindle cell morphology without presence of neuropil More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stag...
Images
Figure 11-17
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY Figure 11-17 UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was originally diagnosed as malignant rhabdoid tumor on the basis of morphology and loss of BRG1 immunostaining, until resection showed foci of ganglion cell More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was or...
Images
Figure 11-27
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA Figure 11-27 UNDIFFERENTIATED NEUROBLASTOMA This tumor could not be diagnosed by morphology only, but was shown to be a NB on the basis of positive cytoplasmic staining of chromogranin A (shown here), synaptophysin, and tyrosine hydroxylase, and nuclear staining More about this image found in UNDIFFERENTIATED NEUROBLASTOMA This tumor could not be diagnosed by morpho...
Images
Figure 11-11
Published: 01 December 2024
SMALL BLUE ROUND CELL TUMOR Figure 11-11 SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to be undifferentiated NB. The cellular tumor is composed of undifferentiated cells with atypical nuclei and scant cytoplasm. No stroma or ganglion cell differentiation is present. More about this image found in SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to...
Images
Figure 11-34
Published: 01 December 2024
NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Figure 11-34 NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undifferentiated NB with numerous apoptotic bodies and a few potential mitotic figures, illustrating the approach to mitosis karyorrhexis counting. More about this image found in NEUROBLASTOMA WITH NUMEROUS MITOTIC AND APOPTOTIC FIGURES Area of undiffer...
Images
Figure 11-13
Published: 01 December 2024
STROMA-POOR NEUROBLASTOMA Figure 11-13 STROMA-POOR NEUROBLASTOMA A: The tumor cells are separated by pale pink fibrillary material representing neuritic cell processes. The tumor was largely undifferentiated, with only rare cells showing early ganglion cell differentiation. B: A different tumor More about this image found in STROMA-POOR NEUROBLASTOMA A: The tumor cells are separated by pale pink fi...
Images
Figure 11-5
Published: 01 December 2024
). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...NEUROBLASTOMA AND GANGLIONEUROBLASTOMA Neuroblastoma (NBL) is a primitive neoplasm of neuroectodermal origin that arises in anatomic sites corresponding to the distribution of the sympathoadrenal autonomic nervous system. It is subdivided into three subtypes: undifferentiated, poorly...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the epithelioid undifferentiated morphology and frequent expression of synaptophysin. With metastatic small cell lung tumors or other neuroendocrine neoplasms producing ectopic ACTH, there is also hyper-secretion of cortisol. In that unusual situation there may be recognizable hyperplasia of residual adrenal...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... nasopharyngeal carcinoma is distinctive, demonstrating a differentiated squamous cell, basaloid, or undifferentiated carcinomatous component with an associated desmoplastic stroma and striking mononuclear inflammatory cell infiltrate, hence the term “lymphoepithelial carcinoma” ( fig. 8-11 ). EBV...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 53-1 GENES IMPLICATED IN CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA MDM2 CDKN2A/B PDGFRA PDGFRB EGFR PIK3CA ACOX2 FH CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-8 CARDIAC...
Images
Figure 21-8
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... DIFFERENTIATION A: Amelanotic spindle cell melanoma shows focally osseous differentiation. B: The same tumor also showed focal cartilaginous differentiation. UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Agaimy   A , Specht   K , Stoehr   R , et al . Metastatic malignant melanoma with complete loss of differentiation markers (undifferentiated/dedifferentiated melanoma): analysis of 14 patients emphasizing phenotypic plasticity and the value of molecular testing as surrogate diagnostic marker...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... antigens, however, does not exclude a LMM with an undifferentiated invasive melanoma component. The diagnosis of LM or LMM is usually established or excluded confidently by a microscopic review of hematoxylin and eosin (H&E)-stained sections and clinical context. Immunohistochemistry may be necessary...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... have large epithelioid and fusiform melanocytes ( 2 ). Nuclear debris and necrosis are commonly observed. Some tumors are sarcomatoid, displaying undifferentiated features with loss of labeling for S-100 protein or SOX10, or rhabdomyosarcomatous differentiation ( fig. 20-6 ) ( 35 ). Spitz and Spitzoid...
Images
Figure 53-1
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-1 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Computerized tomographic (CT) reconstruction shows a low-density mass invading the left atrium (yellow arrow). Right: Axial CT fused with fluorodeoxyglucose (FDG)-positron emission More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Computerized tomographi...
Images
Figure 53-2
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU Figure 53-2 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU This left atrial tumor (yellow asterisk) is growing within the dome of the left atrium and infiltrating its wall. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU This left atrial tumo...