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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 53-1 GENES IMPLICATED IN CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA MDM2 CDKN2A/B PDGFRA PDGFRB EGFR PIK3CA ACOX2 FH CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES...
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<span class="search-highlight">UNDIFFERENTIATED</span> MELANOMA  An amelanotic <span class="search-highlight">undifferentiated</span> malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... presence of expression of S-100 protein, SOX10, and other differentiation antigens supporting melanocytic differentiation). In problematic cases, molecular studies (e.g., UV signature mutation, detection of driver mutations associated with melanoma) are helpful. UNDIFFERENTIATED MELANOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... epithelioid cell melanomas need to be distinguished from poorly differentiated carcinoma, atypical fibroxanthoma/undifferentiated sarcoma, or large cell lymphoma. Metastatic spindle cell melanoma may be confused with sarcomas or sarcomatoid carcinoma. Benign soft tissue tumors, such as cellular neurothekeomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... neurovascular bundles. LMM needs to be distinguished from LM colliding with other tumors, such as atypical fibroxanthoma, pleomorphic dermal sarcoma, or poorly differentiated carcinoma. Ancillary studies are usually necessary to exclude a collision scenario from an amelanotic pleomorphic or undifferentiated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the background nevus as a distinctly different mass characterized by much higher cell density, nuclear pleomorphism, undifferentiated cytologic features, and a high mitotic rate ( figs. 20-3 – 20-5 ). NODULAR MELANOMA ASSOCIATED WITH A LARGE CONGENITAL MELANOCYTIC NEVUS Figure 20-3 NODULAR MELANOMA ASSOCIATED...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are immunoreactive for S-100 protein. In mixed DM, the nondesmoplastic tumor component, especially if it displays an epithelioid cell morphology, may be positive for Mart1/Melan-A, tyrosinase, MITF, or HMB-45. A rare undifferentiated DM may be negative for, or only minimally positive, for all melanocyte markers...
Images
CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA  Left: Computerized tomographi...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-1 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Computerized tomographic (CT) reconstruction shows a low-density mass invading the left atrium (yellow arrow). Right: Axial CT fused with fluorodeoxyglucose (FDG)-positron emission tomogra... More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Computerized tomographi...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA IN SITU  This left atrial tumo...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU Figure 53-2 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU This left atrial tumor (yellow asterisk) is growing within the dome of the left atrium and infiltrating its wall. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA IN SITU This left atrial tumo...
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SURGICALLY RESECTED CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA (UPS)  Lef...
Published: 15 November 2023
SURGICALLY RESECTED CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA (UPS) Figure 53-3 SURGICALLY RESECTED CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA (UPS) Left: A left atrial UPS has both myxoid and fibrotic areas. Right: This surgically resected left atrial myxoma has a variegated appearance, im... More about this image found in SURGICALLY RESECTED CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA (UPS) Lef...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: ENDOCARDIAL GROWTH  Left: Thi...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: ENDOCARDIAL GROWTH Figure 53-4 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: ENDOCARDIAL GROWTH Left: This polypoid left atrial mass consists of dense endocardial cellularity growing on the luminal surface, with a somewhat fibrous interior. Right: Th... More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: ENDOCARDIAL GROWTH Left: Thi...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA  There is a dense proliferatio...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-5 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA There is a dense proliferation of large pleomorphic tumor cells, with minimal spindling. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA There is a dense proliferatio...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: CELLULAR PLEOMORPHISM  A: The...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: CELLULAR PLEOMORPHISM Figure 53-6 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: CELLULAR PLEOMORPHISM A: The markedly pleomorphic, noncohesive cells are visible even at medium power. Note also the acute inflammatory infiltrate. B: Numerous clusters o... More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: CELLULAR PLEOMORPHISM A: The...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA  Numerous mitotic figures are ...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-7 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Numerous mitotic figures are present, with a brisk acute inflammatory infiltrate in the background. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Numerous mitotic figures are ...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA  Surface fibrin is seen on thi...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-8 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Surface fibrin is seen on this collection of discohesive and pleomorphic tumor cells. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Surface fibrin is seen on thi...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: VASCULARITY  Left: The tumor ...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: VASCULARITY Figure 53-9 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: VASCULARITY Left: The tumor often exhibits a delicate vascular network throughout the malignant cells, most evident in the myxoid areas. Right: There may be thick smooth muscle cel... More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: VASCULARITY Left: The tumor ...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: STROMA  Left: A myxoid backgr...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STROMA Figure 53-10 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STROMA Left: A myxoid background is commonly present, at least focally, as in other cardiac tumors. Right: The stroma may also be somewhat fibrotic (collagenized). More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STROMA Left: A myxoid backgr...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: STORIFORM ARCHITECTURE  Left:...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STORIFORM ARCHITECTURE Figure 53-11 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STORIFORM ARCHITECTURE Left: The storiform architecture as well as the marked cellular pleomorphism are evident in this example. Right: The storiform architecture is pr... More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: STORIFORM ARCHITECTURE Left:...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA  Left: Inflammation and cellul...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Figure 53-12 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Inflammation and cellular pleomorphism are seen in this example with scattered tumor giant cells. Right: Bone formation is focal and not indicative of osteosarcoma. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA Left: Inflammation and cellul...
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CARDIAC <span class="search-highlight">UNDIFFERENTIATED</span> PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES ...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES Figure 53-13 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES A smooth muscle actin stain shows reactivity primarily within the tumor vasculature and focal reactivity in the lesional cells. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES ...