ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-39 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells in a diffuse pattern of growth with prominent nucleoli. More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells i...

ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-40 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A: The oncocytic adrenal cortical adenoma weighed 12 g and measured 3 cm. It was discovered incidentally on abdominal CT scan in a 67-year-old man who underwent surgical resection of a colonic adenocarci... More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A: The oncocytic adrenal cortical...

ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-41 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A nonfunctioning lesion, well circumscribed, with peritumoral adrenal cortex that is not atrophic (A), is composed of large eosinophilic cells in a lobular architecture with rare intratumoral lymphocytes... More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A nonfunctioning lesion, well cir...

ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 10-2 ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A: The adrenal gland has diffuse medullary hyperplasia as well as multiple nodules that represent pheochromocytomas. B,C: The nodules of adr... More about this image found in ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A:...

PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) Figure 10-3 PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) A: The adrenal gland contains a pheochromocytoma. B: The morphology of the tumor is not distinct from sporadic pheochromocytomas. More about this image found in PHEOCHROMOCYTOMA IN NEUROFIBROMATOSES TYPE 1 (NF1) A: The adrenal gland co...

MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13 MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) The adrenal gland contains a dominant pheochromocytoma as well as two smaller nodules (top) and an expanded pal... More about this image found in MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TY...

MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Figure 1-1 MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gonadal pathways are shown. Functions distinguishing the adrenal cortical zones from each other and from the gonads are determined by differential expression of steroi... More about this image found in MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...

ADRENAL CORTICAL ADENOMA WITH MYELOLIPOMA Figure 5-16 ADRENAL CORTICAL ADENOMA WITH MYELOLIPOMA A 7.5-cm lesion with a peripheral cortical cell component is associated with a prominent myelolipomatous component with hemorrhage and infarct-type necrosis. More about this image found in ADRENAL CORTICAL ADENOMA WITH MYELOLIPOMA A 7.5-cm lesion with a periphera...

NORMAL CAROTID BODY Figure 9-7 NORMAL CAROTID BODY A: This developing carotid body in an early second trimester stillborn fetus (same case as in figs. 9-3 and 9-4 ), shows more complex architecture and greater admixture of cell types than the abdominal paraganglia. B: Tyrosine hydroxylase exp... More about this image found in NORMAL CAROTID BODY A: This developing carotid body in an early second tri...

ABDOMINAL PARAGANGLIOMA Figure 9-39 ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin receptor 2A, an inexpensive stain, can triage patients for somatostatin receptor imaging and peptide receptor radionuclide therapy (PRRT). This very sensitive positron emission tomography (PET)/computerized tomography (CT) imaging uses ⁶⁸Ga, a positron emitter, chelated to a bifunctional “DOTA” compound that is also linked to a somatostatin analog. The most widely used analog is octreotate, which has high affinity for SSTR type 2, hence, the term “DOTAtate” scan. This modality is more sensitive and faster than octreotide scans, which have been available for decades and use ¹¹¹in, a single photon emitter, as the radioactive tracer. For PRRT, ⁶⁸Ga is replaced by ¹⁷⁷Lu, which emits cytotoxic medium energy beta particles, or by ⁹⁰Y, a high energy beta emitter that may be preferable for larger tumors [ ref. 111 ]. The immunohistochemical stain for SSTR2A in this figure corresponds to one of the lesions in the PET/CT image. More about this image found in ABDOMINAL PARAGANGLIOMA Immunohistochemical staining for somatostatin rece...