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FEATURES OF MATURATION  A: Epithelioid (<span class="search-highlight">type</span> A) melanocytes with pink cytop...
Published: 01 February 2024
FEATURES OF MATURATION Figure 3-9 FEATURES OF MATURATION A: Epithelioid (type A) melanocytes with pink cytoplasm arranged in nests tend to be located in the superficial dermis of a nevus. B: With descent into the mid dermis, type B melanocytes may display lymphocyte-like features characterized b... More about this image found in FEATURES OF MATURATION A: Epithelioid (type A) melanocytes with pink cytop...
Images
PLAQUE-<span class="search-highlight">TYPE</span> BLUE NEVUS  A: A broad plaque of pigmented melanocytes in the d...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS Figure 8-22 PLAQUE-TYPE BLUE NEVUS A: A broad plaque of pigmented melanocytes in the dermis and subcutis involves the skin of the scalp. B: Individual tumor cells show features typical of common BN. They follow neurovascular bundles. More about this image found in PLAQUE-TYPE BLUE NEVUS A: A broad plaque of pigmented melanocytes in the d...
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PLAQUE-<span class="search-highlight">TYPE</span> BLUE NEVUS INVOLVING BREAST TISSUE  A: Diffuse involvement of t...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE Figure 8-23 PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE A: Diffuse involvement of the stroma of the breast by pigmented melanocytes. B: The melanocytes display spindle, epithelioid, and dendritic features and are cytologically bland. More about this image found in PLAQUE-TYPE BLUE NEVUS INVOLVING BREAST TISSUE A: Diffuse involvement of t...
Images
PLAQUE-<span class="search-highlight">TYPE</span> BLUE NEVUS WITH CELLULAR NODULES  A: Plaque-like multinodular g...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES Figure 8-24 PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular growth of melanocytes involving the eyelid. B: The superficial portion of the lesion shows features of pigmented and paucimelanotic common BN. C: The deeper portion ... More about this image found in PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular g...
Images
COMBINED INVERTED <span class="search-highlight">TYPE</span> A NEVUS  A: Silhouette of an intradermal melanocytic...
Published: 01 February 2024
COMBINED INVERTED TYPE A NEVUS Figure 10-6 COMBINED INVERTED TYPE A NEVUS A: Silhouette of an intradermal melanocytic nevus with variable pigmentation. B: Most of the nevus cells display small conventional epithelioid cell features (arrow), but there is a minor subpopulation of larger pigmented ... More about this image found in COMBINED INVERTED TYPE A NEVUS A: Silhouette of an intradermal melanocytic...
Images
COMBINED DEEP PENETRATING NEVUS  A: Silhouette of a congenital nevus with a...
Published: 01 February 2024
COMBINED DEEP PENETRATING NEVUS Figure 10-2 COMBINED DEEP PENETRATING NEVUS A: Silhouette of a congenital nevus with a dual population of conventional and pigmented melanocytes. B: Juxtaposition of the pigmented spindle and epithelioid melanocytes (*) and conventional type B (arrow) melanocytes ... More about this image found in COMBINED DEEP PENETRATING NEVUS A: Silhouette of a congenital nevus with a...
Images
COMBINED DEEP PENETRATING NEVUS  A: Silhouette of an intradermal melanocyti...
Published: 01 February 2024
COMBINED DEEP PENETRATING NEVUS Figure 10-3 COMBINED DEEP PENETRATING NEVUS A: Silhouette of an intradermal melanocytic nevus with a predominant population of conventional melanocytes superficially (arrows) and a second population of pigmented melanocytes (*) in the mid-reticular dermis surroundi... More about this image found in COMBINED DEEP PENETRATING NEVUS A: Silhouette of an intradermal melanocyti...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... type A nevus Combined blue nevus Combined spitzoid nevus a Combined desmoplastic nevus Combined neurotized nevus Combined balloon cell nevus Combined pigmented epithelioid melanocytoma Combined blue and Spitz nevus Multiphenotypic nevus b...
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MELANOMA ARISING IN ASSOCIATION WITH A PLAQUE BLUE NEVUS  A: A densely cell...
Published: 01 February 2024
MELANOMA ARISING IN ASSOCIATION WITH A PLAQUE BLUE NEVUS Figure 18-4 MELANOMA ARISING IN ASSOCIATION WITH A PLAQUE BLUE NEVUS A: A densely cellular nodule is present in the subcutis in association with a portion of a broad plaque-type blue nevus. B: Areas highlighted from the benign blue nevus p... More about this image found in MELANOMA ARISING IN ASSOCIATION WITH A PLAQUE BLUE NEVUS A: A densely cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... recognized: conventional adult-type melanoma, Spitz melanoma, and melanoma associated with a large or giant congenital melanocytic nevus ( 1 , 2 ). EPIDEMIOLOGY Less than 1 percent of all melanomas occur in the pediatric population ( 3 ). Factors associated with an increased risk...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... features of BN. The peculiar cytoplasmic features are usually seen in larger blue nevi, often plaque-type lesions. Blue Nevus with Epithelioid Cell Features. A BN may contain a population of melanocytes displaying epithelioid cell features characterized by round or oval nuclei with a relatively...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Pigmented epithelioid melanocytoma (PEM) is a heavily pigmented melanocytic tumor composed of large epithelioid, fusiform, and dendritic melanocytes admixed with macrophages ( 1 , 2 ). Prior to the introduction of the term PEM, tumors with similar features were reported as “animal-type...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... measure more than 1 cm in diameter at the time of diagnosis and display a bluish-gray or brown color. MICROSCOPIC FINDINGS Melanoma Associated with a Common Blue Nevus. In one series of 23 blue nevus-associated melanomas, six blue nevi were of the common type ( 6 ). In this scenario, the melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., LMNA X-linked (EMD and FHL1); AD a and AR (LMNA) Dilated, arrhythmias Limb-girdle muscular dystrophy  Type 2 FKRP, DYSF, SGCB AR Dilated  Type 1 MYOT, LMNA, LMNC, CAV1 AD Dilated Myotonic dystrophy  Type 1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., the distinction of nodular melanoma or other type of melanoma with a dominant invasive tumor nodule is best made on an excisional specimen that permits three-dimensional review of the epidermis surrounding the tumor nodule. We caution against subtyping a melanoma as nodular on a partial biopsy. It is often...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in the stroma. Often this is accompanied by a morphologic change from large epithelioid melanocytes superficially to small epithelioid lymphocyte-like and fusiform schwannian (neural) ones at the base. These various cytomorphologies have been designated as type A (epithelioid), type B (lymphocyte like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with epidermotropic Merkel cell carcinoma. Since small cell melanoma tends to lack melanin pigment, intradermal (nodular) small cell melanomas usually require immunohistochemical studies for diagnosis and distinction from sarcoma or neuroendocrine carcinoma. Another type of small cell melanoma is melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... refers to a melanoma simulating, at first glance, the appearance of an ordinary acquired or small congenital melanocytic nevus ( Table 17-1 ). However, as any type of nevus can be mistaken for melanoma, the annotation “nevoid” may also be applied to melanomas simulating a Spitz nevus (spitzoid melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Peutz-Jeghers Syndrome: aut dom, STK11/LKB1 mutation  Mucosal (usually oral/labial) and cutaneous lentigines  Hamartomatous gastrointestinal polyps Carney Complex: aut dom, PRKAR1A mutation  1. Carcinocutaneous type (LAMB syndrome)   Lentigines   Atrial Myxomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... features, some are atypical, for which Clark et al. ( 12 – 14 ) coined the term atypical melanocytic nevus of genital type (AMNGT). Atypical nevi typically display junctional nests varying in size and shape ( fig. 5-4 ). Some of the nests are large and closely opposed to one another. In some...