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SINONASAL UNDIFFERENTIATED CARCINOMA Figure 1-41 SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely positive for pancytokeratin. B: Squamous markers like p40 are negative, or at most, focally positive. Diffuse staining excludes sinonasal undifferentiated carcinoma. C More about this image found in SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely posit...

INTESTINAL-TYPE ADENOCARCINOMA Figure 1-46 INTESTINAL-TYPE ADENOCARCINOMA A: This tumor has a prominent papillary growth pattern. B: This case, however, is mucinous or colloid, with tumor nests floating within extruded mucin. C: The tumor strongly resembles colorectal adenocarcinoma More about this image found in INTESTINAL-TYPE ADENOCARCINOMA A: This tumor has a prominent papillary gro...

INTESTINAL-TYPE ADENOCARCINOMA Figure 1-47 INTESTINAL-TYPE ADENOCARCINOMA A,B: CK7 is consistently negative (A), while CK20 is positive (B). C,D: Intestinal markers such as CDX2 (C) and SATB2 (D) are also positive in this tumor. More about this image found in INTESTINAL-TYPE ADENOCARCINOMA A,B: CK7 is consistently negative (A), whil...

DESMOID-TYPE FIBROMATOSIS Figure 1-107 DESMOID-TYPE FIBROMATOSIS A coronal CT shows a left maxillary sinus opacification by a soft tissue density mass (white arrow). More about this image found in DESMOID-TYPE FIBROMATOSIS A coronal CT shows a left maxillary sinus opacif...

DESMOID-TYPE FIBROMATOSIS Figure 1-108 DESMOID-TYPE FIBROMATOSIS A–D: No matter where identified, there is a purposeful, large, sweeping fascicular architecture, with vessels arranged parallel to the direction of the proliferation. The amount of collagen deposition varies. More about this image found in DESMOID-TYPE FIBROMATOSIS A–D: No matter where identified, there is a purp...

DESMOID-TYPE FIBROMATOSIS Figure 1-109 DESMOID-TYPE FIBROMATOSIS A,B: The neoplastic cells are elongated and spindled, separated by a collagenized stroma. The cellularity varies from hypercellular (A) to hypocellular (B). C: The vessels may be thin and collapsed. D: The neoplastic cells More about this image found in DESMOID-TYPE FIBROMATOSIS A,B: The neoplastic cells are elongated and spin...

DESMOID-TYPE FIBROMATOSIS Figure 1-110 DESMOID-TYPE FIBROMATOSIS A,B: There is a strong nuclear β-catenin immunoreactivity, although not all cells are reactive. More about this image found in DESMOID-TYPE FIBROMATOSIS A,B: There is a strong nuclear β-catenin immunor...

BIPHENOTYPIC SINONASAL SARCOMA Figure 1-127 BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity for both S-100 protein (A) and SMA (B), although the extent of staining is variable. More about this image found in BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity...

MENINGIOMA Figure 1-160 MENINGIOMA A: Meningothelial type with whorls of spindled and epithelioid cells. B: The whorls of meningothelial cells have an epithelioid quality. C: Islands of meningioma with intranuclear cytoplasmic inclusions. A psammoma body is present (black arrow). D: A fibrous More about this image found in MENINGIOMA A: Meningothelial type with whorls of spindled and epithelioid ...

KERATINIZING TYPE (HPV-INDEPENDENT) OROPHARYNGEAL SQUAMOUS CELL CARCINOMA Figure 2-22 KERATINIZING TYPE (HPV-INDEPENDENT) OROPHARYNGEAL SQUAMOUS CELL CARCINOMA The carcinoma shows angulated nests of eosinophilic tumor cells in a fibrotic (desmoplastic) stroma. More about this image found in KERATINIZING TYPE (HPV-INDEPENDENT) OROPHARYNGEAL SQUAMOUS CELL CARCINOMA ...

OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CLASSIC TYPE Figure 2-38 OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CLASSIC TYPE A: Low magnification of a classic polymorphous adenocarcinoma shows cords, trabeculae, and cribriform nests of tumor cells in a whorling pattern around foci of perineural More about this image found in OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CLASSIC TYPE A: Low magnificati...

OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CRIBRIFORM TYPE Figure 2-39 OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CRIBRIFORM TYPE The carcinoma has large nests with irregular cribriform growth, glomeruloid areas, cells with eosinophilic cytoplasm, and nuclei with open chromatin. More about this image found in OROPHARYNGEAL POLYMORPHOUS ADENOCARCINOMA, CRIBRIFORM TYPE The carcinoma h...

VASCULAR VOCAL CORD NODULE/POLYP Figure 6-9 VASCULAR VOCAL CORD NODULE/POLYP This type of vocal cord nodule/polyp has prominent small vessels in a loose stroma, often with extensive hemorrhage. The vascular component is not as developed or prominent as would be seen in a true hemangioma. More about this image found in VASCULAR VOCAL CORD NODULE/POLYP This type of vocal cord nodule/polyp has ...

LARYNGEAL SQUAMOUS CELL CARCINOMA Figure 6-42 LARYNGEAL SQUAMOUS CELL CARCINOMA Well-differentiated keratinizing-type SCC is often very mature so that the surface tumor and even the overtly invasive nests look like benign epithelium except for their markedly increased thickness, pattern More about this image found in LARYNGEAL SQUAMOUS CELL CARCINOMA Well-differentiated keratinizing-type SC...

SQUAMOUS CELL CARCINOMA Figure 6-49 SQUAMOUS CELL CARCINOMA Cytology in keratinizing-type SCC classically shows on Papanicolaou-stained smears cells with at least moderately pleomorphic nuclei and densely orangeophilic keratinized cells, some of which have very tapered shapes (“tadpole” cells). More about this image found in SQUAMOUS CELL CARCINOMA Cytology in keratinizing-type SCC classically show...

ADULT-TYPE RHABDOMYOMA Figure 6-93 ADULT-TYPE RHABDOMYOMA The smooth-edged tumor is brightly eosinophilic and somewhat vacuolated. There is little stroma or obvious vasculature. More about this image found in ADULT-TYPE RHABDOMYOMA The smooth-edged tumor is brightly eosinophilic and...

ADULT-TYPE RHABDOMYOMA Figure 6-94 ADULT-TYPE RHABDOMYOMA The cells of rhabdomyoma are large, with abundant eosinophilic cytoplasm and round nuclei, some with prominent nucleoli. This image shows occasional “spider cells” where the vacuolization leaves the periphery of the cells with apparent More about this image found in ADULT-TYPE RHABDOMYOMA The cells of rhabdomyoma are large, with abundant e...

ADULT-TYPE RHABDOMYOMA Figure 6-95 ADULT-TYPE RHABDOMYOMA At high magnification, with the condenser turned down, the striations in the tumor cells, just as in normal adult skeletal muscle, are seen. This is a pathognomonic histologic feature. More about this image found in ADULT-TYPE RHABDOMYOMA At high magnification, with the condenser turned do...

NUCHAL-TYPE FIBROMA Figure 7-45 NUCHAL-TYPE FIBROMA A: Low-power view of a typical nuchal fibroma showing involvement from dermal to subcutaneous tissue by a densely eosinophilic and poorly circumscribed lesion. B: At medium to high power, nuchal fibroma consists of dense, hyalinized collagen More about this image found in NUCHAL-TYPE FIBROMA A: Low-power view of a typical nuchal fibroma showing ...

FIRST BRANCHIAL CLEFT ANOMALY, WORK TYPE II Figure 8-10 FIRST BRANCHIAL CLEFT ANOMALY, WORK TYPE II A: Cartilage is seen adjacent to a fistula tract. B: Several cartilaginous islands are in the soft tissues near the fistula. Debris is seen in the lumen. More about this image found in FIRST BRANCHIAL CLEFT ANOMALY, WORK TYPE II A: Cartilage is seen adjacent ...