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PITUITARY NEUROENDOCRINE <span class="search-highlight">TUMOR</span> (PitNET)  PitNET is readily diagnosed on an ...
Published: 01 November 2022
PITUITARY NEUROENDOCRINE TUMOR (PitNET) Figure 1-12 PITUITARY NEUROENDOCRINE TUMOR (PitNET) PitNET is readily diagnosed on an H&E-stained section. The cells are all uniform. There is loss of the normal acinar architecture. There are no acidophilic or basophilic cells admixed with the sheets o... More
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MYELOLIPOMA  Left: Myelolipoma is a <span class="search-highlight">tumor</span>-like condition developing commonl...
Published: 01 November 2022
MYELOLIPOMA Figure 4-22 MYELOLIPOMA Left: Myelolipoma is a tumor-like condition developing commonly in the adrenal gland. It is composed of mature adipose tissue and hematopoietic elements. Right: Myelolipoma with hematopoietic elements, including megakaryocytes and erythroid precursors. More
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ISLET CELL HYPERPLASIA  Islet cell <span class="search-highlight">tumor</span> and adjacent islet cell hyperplasi...
Published: 01 November 2022
ISLET CELL HYPERPLASIA Figure 5-8 ISLET CELL HYPERPLASIA Islet cell tumor and adjacent islet cell hyperplasia. (Left: H&E; right: chromogranin immunohistochemistry.) More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... is a marker of paraneurons ( 6 ). Fujita noted that chromogranin immunopositivity is particularly helpful in identifying these cells, because other non-neuroendocrine cells can ectopically produce bioactive peptides or amines. The DNES is composed of cells and tumors with secretory granules that commonly...
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MEDULLARY THYROID CARCINOMA  Left: Medullary thyroid carcinoma is composed ...
Published: 01 November 2022
MEDULLARY THYROID CARCINOMA Figure 3-40 MEDULLARY THYROID CARCINOMA Left: Medullary thyroid carcinoma is composed of spindle and epithelioid cells. Right: Calcitonin immunostain is strong in the tumor cells. More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
..., fibroblasts, mast cells, and rare lymphocytes are present in the interstitium. Immunohistochemistry Keratins. Parathyroid tissue is positive for cytokeratins (CK) 7, 8, 18, and 19 ( 26 ). CAM5.2 is also positive in parathyroid tissue, and is the most useful keratin in identifying epithelial origin in tumors...
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HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE  The parathyroid glands can ...
Published: 01 November 2022
HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE Figure 2-8 HYPERCELLULAR PARATHYROID GLAND: CYSTIC CHANGE The parathyroid glands can show hemorrhage and cystic change, particularly in larger glands and in those with hyperparathyroidism-jaw tumor–associated disease more so than sporadic hyperparath... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... related to antigen retrieval methodologies. In a study by Zhang et al. ( 65 ), BCL2 immunoreactivity was detected focally in only 20 percent of adrenal cortical tumors but more diffusely in 86 percent of pheochromocytomas and in normal adrenal medullae. The β-catenin target gene, known as DAX1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... that of the sellar pituitary gland, the pharyngeal pituitary does not contribute meaningfully to hormone production ( 10 ). It is important, however, to recognize that ectopic pituitary neuroendocrine tumors (PitNETs) (formerly, pituitary adenoma) may arise from these rests of ectopic pituitary tissue ( 11...
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PARATHYROID HYPERPLASIA  These parathyroid glands show degenerative edemato...
Published: 01 November 2022
PARATHYROID HYPERPLASIA Figure 2-7 PARATHYROID HYPERPLASIA These parathyroid glands show degenerative edematous changes (left, right). More
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ADRENAL ATROPHY  The adrenal medulla appears more prominent with decreased ...
Published: 01 November 2022
ADRENAL ATROPHY Figure 4-12 ADRENAL ATROPHY The adrenal medulla appears more prominent with decreased thickness of the cortex. More
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HASHIMOTO THYROIDITIS  Focal squamous metaplasia of the follicular cells is...
Published: 01 November 2022
HASHIMOTO THYROIDITIS Figure 3-22 HASHIMOTO THYROIDITIS Focal squamous metaplasia of the follicular cells is common in longstanding Hashimoto thyroiditis. More
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HASHITOXICOSIS  Features of both Graves disease and Hashimoto thyroiditis, ...
Published: 01 November 2022
HASHITOXICOSIS Figure 3-29 HASHITOXICOSIS Features of both Graves disease and Hashimoto thyroiditis, with lymphoid follicles and germinal centers, are present. More
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PITUITARY HYPERPLASIA  Hyperplasia is associated with expansion in the size...
Published: 01 November 2022
PITUITARY HYPERPLASIA Figure 1-11 PITUITARY HYPERPLASIA Hyperplasia is associated with expansion in the size of the acinar nests. Importantly, the reticulin framework is not disrupted. More
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HASHIMOTO THYROIDITIS  Hurthle cell (oxyphil cell) metaplasia is usually a ...
Published: 01 November 2022
HASHIMOTO THYROIDITIS Figure 3-21 HASHIMOTO THYROIDITIS Hurthle cell (oxyphil cell) metaplasia is usually a prominent feature in Hashimoto thyroiditis. More
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UNTREATED GRAVES DISEASE  The follicles have convoluted and irregular conto...
Published: 01 November 2022
UNTREATED GRAVES DISEASE Figure 3-26 UNTREATED GRAVES DISEASE The follicles have convoluted and irregular contours. There is extensive colloid scalloping. More
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NODULAR HYPERPLASIA  Multiple nodules of predominantly lipid-rich cells are...
Published: 01 November 2022
NODULAR HYPERPLASIA Figure 4-19 NODULAR HYPERPLASIA Multiple nodules of predominantly lipid-rich cells are seen in a gland with nodular hyperplasia. More
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CALCIUM OXALATE IN COLLOID  Refractile calcium oxalate crystals are readily...
Published: 01 November 2022
CALCIUM OXALATE IN COLLOID Figure 3-12 CALCIUM OXALATE IN COLLOID Refractile calcium oxalate crystals are readily found in the colloid of thyroid tissues. More
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RIEDEL THYROIDITIS  The normal lobular pattern is obliterated. Dense “keloi...
Published: 01 November 2022
RIEDEL THYROIDITIS Figure 3-31 RIEDEL THYROIDITIS The normal lobular pattern is obliterated. Dense “keloid-like” collagen fibers are commonly present. More
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GRANULOMATOUS HYPOPHYSITIS  The well-formed compact granuloma is a clue to ...
Published: 01 November 2022
GRANULOMATOUS HYPOPHYSITIS Figure 1-9 GRANULOMATOUS HYPOPHYSITIS The well-formed compact granuloma is a clue to the diagnosis of sarcoid, despite the presence of background lymphocytic inflammation. More