PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-40 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy associated with virilization, classified as benign behavior by means of the Wieneke score. The cut surface was homogeneously brown, with no evidence of necrosis or hemor... More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy...

PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-41 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progressively higher magnification. It lacks necrosis and signs of invasion and showed low mitotic and proliferation indexes. Final Wieneke score was 0. (Same case as fig. 6-4... More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progre...

PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-43 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1 (A). Ki-67 index (B) was 5 percent, whereas p53 was expressed in rare nuclei (C). (Same case as figs. 6-40 and 6-41 .) More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1...

CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...

CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...

SMALL BLUE ROUND CELL TUMOR Figure 11-11 SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to be undifferentiated NB. The cellular tumor is composed of undifferentiated cells with atypical nuclei and scant cytoplasm. No stroma or ganglion cell differentiation is present. More about this image found in SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to...

TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Figure 2-15 TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY A: Tumor cells are arranged in lobules and solid sheets, with some intervening fibrous stroma. A ... More about this image found in TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDR...

TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Figure 2-16 TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Individual cells have distinct cell borders and rounded nuclei, often with one or two eccentric nucleoli. Many cells contain coarse, granular pigment, which is lipofuscin. More about this image found in TESTICULAR TUMOR IN CONGENITAL ADRENAL HYPERPLASIA Individual cells have d...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 4-27 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile smooth borders that compress adjacent adrenal parenchyma and expand the adrenal capsule. B: The borders of the adenoma are sharply demarcated from the adjacent cor... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile ...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-11 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA On cross section, the tumor is sharply demarcated and appears encapsulated, particularly where it expands the contours of the adrenal capsule. The tumor measured 1 cm in diameter and is a uni... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA On cross section, the tumor...

ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-18 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clear (upper right) and compact cells (left). More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clea...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-25 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells have compact eosinophilic cytoplasm and contain eosinophilic hyaline globules. More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells ...

“BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-44 “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Tumor cells express steroidogenic factor 1 (SF1, A), Melan-A (red, B), and a low Ki-67 labeling index (red, C). More about this image found in “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Tumor cells express s...

ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-45 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: The tumor cells contain small to medium-sized electron-dense granules, which represent lipofuscin. Some cells contain sparse lipid droplets. B: Stacks of rough endoplasmic reticulum and promi... More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: The tumor cells contain sm...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-47 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have much smooth endoplasmic reticulum and a few lipid droplets, which vary in size. Microvillous cytoplasmic extensions are evident along the cell borders. Mitochondria ha... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have muc...

“BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-49 “BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells contain abundant lipofuscin and have only sparse lipid droplets. Microvillous projections are seen along the cytoplasmic borders. More about this image found in “BLACK” ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells contain a...

ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Figure 6-11 ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may be extremely variable, with patterns including the solid (A), “insular” (B), or large trabecular (C), frequently present within the same lesion. More about this image found in ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may ...

ADRENAL CORTICAL CARCINOMA Figure 6-15 ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coarse cytoplasmic vacuoles, which distend many cells and displace the nucleus to the periphery. Some cells have a “signet ring” appearance. More about this image found in ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coars...

ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT Figure 6-27 ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circumscribed within the adrenal (A). It has a pure storiform architectural pattern (B) and consists of spindle cells (B) expressing SF1 (C) and Melan-A (D). More about this image found in ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circums...