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Book Chapter

Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... or InlB) that attaches to cell receptors (E-cadherin or Met) on goblet, trophoblastic, and other cells ( 4 ). When internalized through phagocytosis, the bacteria disrupt the vacuole membrane by using listeriolysin O. In the host cell cytosol, Listeria organisms disrupt the normal cellular...
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Book Chapter

Systemic Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... (smooth or rough) ( fig. 14-3 ). The bacteria then replicate extensively inside vacuoles (called brucellosomes) of macrophages, dendritic cells, and trophoblast, although they can also replicate in many other cells ( 6 ). Brucellosis is the most common bacterial zoonosis worldwide ( 2 ). It is endemic...
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Images
Figure 5-10

TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Transdifferen...

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in High-Grade Serous Carcinoma > Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Figure 5-10 TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Transdifferentiation, with formation of syncytiotrophoblast and cytotrophoblast, in an otherwise typical high-grade serous carcinoma. More about this image found in TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Transdifferen...
Images
Figure 16-49

GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A...

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in Neoplasms of the Fallopian Tube and Broad Ligament > Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE Figure 16-49 GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A,B: Choriocarcinoma in a patient with a significantly elevated serum hCG. C: Complete hydatidiform mole. (Courtesy of Dr. S. Stolnicu More about this image found in GESTATIONAL TROPHOBLASTIC DISEASE AND GERM CELL TUMORS IN FALLOPIAN TUBE A...
Book Chapter

Neoplasms of the Fallopian Tube and Broad Ligament

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... neuroectodermal tumor of central nervous system type is illustrated in figure 16-48 . METASTATIC CENTRAL-TYPE PRIMITIVE NEUROECTODERMAL TUMOR Figure 16-48 METASTATIC CENTRAL-TYPE PRIMITIVE NEUROECTODERMAL TUMOR GERM CELL AND TROPHOBLASTIC TUMORS Teratomas of the fallopian tube have been described...
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Book Chapter

Clear Cell Tumors

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., express synaptophysin, inhibin, and Melan-A, unlike clear cell carcinoma. The intermediate trophoblastic tumors, placentalsite trophoblastic tumor and epithelioid trophoblastic tumor, may simulate clear cell carcinoma; epithelioid trophoblastic tumor, in particular, exhibits growth...
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Book Chapter

High-Grade Serous Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... histotypes of ovarian carcinoma. Somatically derived trophoblastic ( fig. 5-10 ) or yolk sac tumor have been reported ( 28a , 28b ). TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Figure 5-10 TROPHOBLASTIC DIFFERENTIATION IN HIGH-GRADE SEROUS CARCINOMA Transdifferentiation, with formation...
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Book Chapter

Germ Cell Tumors

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-13
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... teratoma (squamous epithelium, cartilage), embryoid bodies, intermediate trophoblasts, and enteric glands that may have goblet cells. Yolk sac tumors have hyaline bodies, lack a lymphocytic infiltrate, and have more nuclear variation than dysgerminomas. The morphologic spectrum of yolk sac tumors...
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Book Chapter

Other Carcinomas, Miscellaneous Tumors, and Tumor-Like Conditions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... Gynecol Pathol   2016 ; 35 : 167 - 75 . 24. Ordi   J , Romagosa   C , Tavassoli   FA , et al   CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the di agnosis of mesonephric, trophoblastic, and clear cell tumors . Am J Surg Pathol   2003 ; 27...
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Images
Figure 3-94

PLACENTAL SITE NODULE Left: This lesion has a vague lobulated outline and ...

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in Tumors and Tumor-Like Lesions of the Cervix > Tumors of the Cervix, Vagina, and Vulva
Published: 01 February 2023
PLACENTAL SITE NODULE Figure 3-94 PLACENTAL SITE NODULE Left: This lesion has a vague lobulated outline and is associated with dense chronic inflammation; it is, however, noninfiltrative. Right: The lesion is composed of epithelioid polygonal trophoblastic cells with uniform hyperchromatic More about this image found in PLACENTAL SITE NODULE Left: This lesion has a vague lobulated outline and ...
Book Chapter

Classification and Biomarkers of Lower Female Genital Tract Neoplasia

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-2
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... homologue p63 . Gynecol Oncol   2001 ; 80 : 30 - 6 . 30. Shih   IM , Kurman   RJ . p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations . Am J Surg Pathol   2004 ; 28 : 1177 - 83 . 31...
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Book Chapter

Adenocarcinoma Variants

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ). The absence of atypical cells distinguishes these lesions from undifferentiated carcinomas with osteoclast-like giant cells. The neoplastic conditions associated with giant cells include Hodgkin lymphoma, large cell lymphoma, trophoblastic neoplasms, malignant fibrous histiocytoma, undifferentiated carcinoma...
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Book Chapter

Tumors and Tumor-Like Lesions of the Cervix

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... with dense chronic inflammation; it is, however, noninfiltrative. Right: The lesion is composed of epithelioid polygonal trophoblastic cells with uniform hyperchromatic round nuclei and eosinophilic cytoplasm, surrounded by a homogeneous extracellular matrix. DECIDUAL CHANGE Figure 3-95 DECIDUAL CHANGE...
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Book Chapter

Tumors and Tumor-Like Lesions of the Vagina

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... . Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis . Gynecol Oncol   2002 ; 84 : 416 - 9 . 261. Ng   HJ , Aly   EH . Vaginal metastases from colorectal cancer . Int J Surg   2013 ; 11 : 1048 - 55 . 262. Zhu   XD , Wang   J , You...
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Images
Figure 4-158

EPITHELIOID TROPHOBLASTIC TUMOR Left: Pleomorphic trophoblastic cells are ...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
EPITHELIOID TROPHOBLASTIC TUMOR Figure 4-158 EPITHELIOID TROPHOBLASTIC TUMOR Left: Pleomorphic trophoblastic cells are in a hyalinized to fibrous stroma with only a small amount of remnant fibrinoid material (top). A muscular artery is seen at center. Right: In this case, the vessels are small More about this image found in EPITHELIOID TROPHOBLASTIC TUMOR Left: Pleomorphic trophoblastic cells are ...
Images
Figure 4-161

HYBRID TROPHOBLASTIC TUMOR (UNCLASSIFIED TROPHOBLASTIC AND MALIGNANT GLANDU...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
HYBRID TROPHOBLASTIC TUMOR (UNCLASSIFIED TROPHOBLASTIC AND MALIGNANT GLANDULAR TUMOR OF TESTIS) Figure 4-161 HYBRID TROPHOBLASTIC TUMOR (UNCLASSIFIED TROPHOBLASTIC AND MALIGNANT GLANDULAR TUMOR OF TESTIS) Nests of eosinophilic trophoblastic cells (left) that were positive for hCG, inhibin More about this image found in HYBRID TROPHOBLASTIC TUMOR (UNCLASSIFIED TROPHOBLASTIC AND MALIGNANT GLANDU...
Images
Figure 2-249

POSTCHEMOTHERAPY TROPHOBLAST CELLS A small linear cluster of trophoblast c...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
POSTCHEMOTHERAPY TROPHOBLAST CELLS Figure 2-249 POSTCHEMOTHERAPY TROPHOBLAST CELLS A small linear cluster of trophoblast cells is seen in a hyalinized stroma. This likely represents a tiny amount of epithelioid trophoblast tumor, but in this limited amount, we generally do not designate More about this image found in POSTCHEMOTHERAPY TROPHOBLAST CELLS A small linear cluster of trophoblast c...
Images
Figure 4-143

CHORIOCARCINOMA There is a spectrum of malignant trophoblastic cells from ...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
CHORIOCARCINOMA Figure 4-143 CHORIOCARCINOMA There is a spectrum of malignant trophoblastic cells from relatively small to large, mostly mononucleated forms. Other areas had the usual appearance. More about this image found in CHORIOCARCINOMA There is a spectrum of malignant trophoblastic cells from ...
Images
Figure 4-157

EPITHELIOID TROPHOBLASTIC TUMOR A: There are cohesive nests of predominant...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
EPITHELIOID TROPHOBLASTIC TUMOR Figure 4-157 EPITHELIOID TROPHOBLASTIC TUMOR A: There are cohesive nests of predominantly mononucleated, squamoid cells with copious eosinophilic cytoplasm and pleomorphic hyperchromatic nuclei. B: Pleomorphic intermediate trophoblastic cells with clear to pale More about this image found in EPITHELIOID TROPHOBLASTIC TUMOR A: There are cohesive nests of predominant...
Images
Figure 4-159

EPITHELIOID TROPHOBLASTIC TUMOR Clumps and bands of the characteristic cel...

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in Germ Cell Neoplasia in Situ and Tumors Derived from Germ Cell Neoplasia in Situ > Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
EPITHELIOID TROPHOBLASTIC TUMOR Figure 4-159 EPITHELIOID TROPHOBLASTIC TUMOR Clumps and bands of the characteristic cells line a space filled with degenerated and necrotic tumor cells, a likely transitional phase to cystic trophoblastic tumor. More about this image found in EPITHELIOID TROPHOBLASTIC TUMOR Clumps and bands of the characteristic cel...