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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). The genetic alterations are most often hereditary, giving rise to familial disease that can involve only PPGL formation, but usually is associated with other disorders. Some are nonhereditary disorders that cause syndromic manifestations. At least 20 genes have been implicated in familial disorders...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
BECKWITH-WIEDEMANN SYNDROME Figure 2-18 BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a 3-week-old infant with Beckwith-Wiedemann syndrome are enlarged and show redundant cerebriform folds of cortex with demarcation between adult or definitive cortex and regressing More about this image found in BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
BECKWITH-WIEDEMANN SYNDROME Figure 2-19 BECKWITH-WIEDEMANN SYNDROME Chromaffin cells forming a nodule protruding from the fetal cortex are inappropriately mature for this stage of development and have clear cytoplasm. There is a morphologic resemblance of the nodule to normal extra-adrenal More about this image found in BECKWITH-WIEDEMANN SYNDROME Chromaffin cells forming a nodule protruding f...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
CUSHING SYNDROME Figure 3-1 CUSHING SYNDROME The clinical features of this disorder (left) can be caused by pituitary adrenocorticotropic hormone (ACTH) excess (top right), ectopic ACTH causing massive adrenal hyperplasia (right middle), or primary adrenal disease (bottom right). (From Netter FH More about this image found in CUSHING SYNDROME The clinical features of this disorder (left) can be caus...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Figure 3-2 ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothalamic-pituitary-adrenal axis (upper left), pituitary-dependent Cushing disease (upper right), and ectopic ACTH syndrome. More about this image found in ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothala...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
CUSHING SYNDROME Figure 3-4 CUSHING SYNDROME Magnetic resonance image (MRI) of bilateral adrenal hyperplasia in a patient with ACTH-dependent Cushing syndrome due to ectopic ACTH secretion. More about this image found in CUSHING SYNDROME Magnetic resonance image (MRI) of bilateral adrenal hyper...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-6 ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically resected from a patient with ectopic ACTH syndrome due to a bronchial neuroendocrine tumor. The tumor had remained occult for several years. The right adrenal gland weighed 12 g and the left More about this image found in ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically res...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-9 ECTOPIC ACTH SYNDROME Adrenal cortical hyperplasia shows acidophilic cells expanding the zona fasciculata of the adrenal cortex. More about this image found in ECTOPIC ACTH SYNDROME Adrenal cortical hyperplasia shows acidophilic cells...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-10 ECTOPIC ACTH SYNDROME Large eosinophilic cells replace lipid-rich cells in the zona fasciculata of the adrenal cortex. More about this image found in ECTOPIC ACTH SYNDROME Large eosinophilic cells replace lipid-rich cells in...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-11 ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia from an adrenal metastasis of an ACTH-secreting lung neuroendocrine tumor. More about this image found in ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia fr...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME DUE TO PHEOCHROMOCYTOMA Figure 3-13 ECTOPIC ACTH SYNDROME DUE TO PHEOCHROMOCYTOMA A 51-year-old white female presented with hypertension, facial swelling, and hirsutism. There were elevated steroid metabolites in the urine which could not be suppressed with high-dose More about this image found in ECTOPIC ACTH SYNDROME DUE TO PHEOCHROMOCYTOMA A 51-year-old white female p...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-2 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME CT scan in basal phase (A) and poor uptake in the venous phase (B). (Courtesy of Prof. A. Veltri and Dr. F. Solitro, San Luigi Hospital, Turin, Italy) More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME CT scan in basal phase (A) an...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-4 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME US scan (A), CT scan (B, 20 HU), and magnetic resonance imaging (MRI) (“in” phase, C, and “out” phase, D) show a lipid-poor pattern in a 4.5-cm adenoma. (Courtesy of Prof. A. Veltri and Dr. F More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME US scan (A), CT scan (B, 20 H...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME Figure 5-7 ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME This adrenal cortical adenoma from a 32-year-old woman with Cushing syndrome measured 2.1 cm. The geographic to mottled zones of dark pigmentation are due to lipid depletion of neoplastic More about this image found in ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME This adrenal cortical adeno...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-8 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cortical adenoma is from a 33-year-old patient with Cushing syndrome. The tumor is yellow-orange on cross section and has vague lobulations. It measured 3.5 More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cor...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-9 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cortical adenoma is from a 35-year-old female with Cushing syndrome. The tumor has a confluent brown color due to cells with compact, lipid-de pleted More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cor...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-18 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clear (upper right) and compact cells (left). More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clea...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-20 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A reticulin stain highlights the regular architecture of the lesion. More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A reticulin stain highlights ...
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Published: 01 December 2024
ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-23 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged pleomorphic nuclei are seen in some cells, which are markedly different than the nuclei of adjacent tumor cells. A few cells also contain finely More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-25 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells have compact eosinophilic cytoplasm and contain eosinophilic hyaline globules. More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME The tumor cells ...
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