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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with an increased risk for local recurrence, particularly if the surgical margins are positive or narrow ( 10 ). In such instances, radiotherapy may reduce the incidence of local recurrence. Regression. Regression refers to observations that the body’s immune system can attack and destroy tumor. Histologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of the intraepidermal melanocytes, i.e., confluency at the dermoepidermal junction, the presence of nests, and pagetoid spread. When a patient is then referred to a dermatologic surgeon for surgical excision, invasion is detected in the remainder of the excised tissue in 5 to 20 percent of the cases. Most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of trauma and treatment is important because sometimes the associated microscopic features simulate the appearance of a melanoma ( 1 – 5 ). Awareness of the clinical context, and in the case of a prior surgical procedure knowledge of the prior pathology, are essential to avoid misdiagnoses. TRAUMATIZED...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... not recommend it as a routine surgical procedure for children with a diagnosis of spitzoid melanoma. Given the lack of data that would argue otherwise, for adults with spitzoid and Spitz melanomas we recommend surgical management similar to that for conventional melanomas. REFERENCES REFERENCES 1. Kamino...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... surgical intervention. The situation is different, if the diagnosis of “nevus” is not certain due to the presence of atypical findings. In that case, as with other atypical melanocytic proliferations, conservative complete excision is a prudent course of action, especially if it can be done easily...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... as “nevus with atypical features” should prompt concerns about a possible melanoma, and further studies (e.g., deeper levels, PRAME or cytogenetic testing) or complete surgical removal of the lesion should be considered. Unbalanced genomic aberrations are usually not detected in common ordinary nevi ( 27...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... examinations. While nodular melanomas tend to present at a higher pathologic stage, after adjustment for stage, they have a prognosis comparable to other melanoma types. They are surgically managed like any other invasive melanoma, but one could argue that tumors with a circumscribed nodular growth pattern...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Deeper levels, PRAME stain, or cytogenetic testing should be considered for further diagnostic workup. Such lesions should be completely removed surgically. Most dysplastic nevi lack unbalanced genomic aberrations, but on occasion, a lesion has some gains or losses or is even associated with a positive...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... a nodular melanoma. Attention to anatomic site, extent of solar elastosis, and the predominant growth pattern of most of the lesion is needed for melanoma subtyping. TREATMENT AND PROGNOSIS Complete surgical excision is the treatment of choice for primary superficial spreading melanomas. The prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (history of a prior melanoma or not) is paramount for accurate staging. TREATMENT AND PROGNOSIS Surgery is the treatment of choice and surgical management is similar as for conventional melanomas. With regard to prognosis, there does not seem to be a significant difference between nevoid and conventional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., is associated with a shorter time for disease recurrence than a solitary metastasis ( 20 ). Solitary lesions are often managed surgically ( 21 ). Depending on the clinical manifestations (e.g., localized limb melanoma with numerous in-transit lesions confined to an extremity), isolated limb perfusion may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and metastases (more than a decade after the excision of the primary tumor) and subsequent death from metastatic melanoma after two decades. The pattern of recurrence is variable, but metastases first to the liver (similar to uveal melanoma) are common. Surgical excision with a rim of normal tissue around...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Surgical excision is the treatment of choice for most lesions. As for other melanomas, sentinel lymph node biopsy may be used for staging. Acral melanomas are associated with a worse prognosis than truncal and head and neck melanomas ( 33 – 38 ). This is in large part related to the fact that at the time...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... requires a multidisciplinary approach ( 2 , 26 , 27 ). Early and complete surgical excision is considered ( 28 ). Complete removal, however, is rarely feasible, especially for giant CMNs, where melanoma risk is also highest. Furthermore, removal of cutaneous CMN does not eliminate the risk of melanoma...
Images
PAPILLARY MUSCLE RUPTURE: <span class="search-highlight">SURGICAL</span> RESECTION  Acute papillary muscle ruptur...
Published: 15 November 2023
PAPILLARY MUSCLE RUPTURE: SURGICAL RESECTION Figure 8-11 PAPILLARY MUSCLE RUPTURE: SURGICAL RESECTION Acute papillary muscle rupture often necessitates mitral valve replacement, with removal of the native mitral valve. More about this image found in PAPILLARY MUSCLE RUPTURE: SURGICAL RESECTION Acute papillary muscle ruptur...
Images
LEFT VENTRICULAR TRUE ANEURYSM: <span class="search-highlight">SURGICAL</span> RESECTION  This aneurysmectomy spe...
Published: 15 November 2023
LEFT VENTRICULAR TRUE ANEURYSM: SURGICAL RESECTION Figure 8-18 LEFT VENTRICULAR TRUE ANEURYSM: SURGICAL RESECTION This aneurysmectomy specimen consists of a left ventricular wall with marked thinning, representing the expanded segment of remodeled left ventricle. More about this image found in LEFT VENTRICULAR TRUE ANEURYSM: SURGICAL RESECTION This aneurysmectomy spe...
Images
MYXOMATOUS MITRAL VALVE DISEASE: <span class="search-highlight">SURGICAL</span> SPECIMEN  Focal resection of the ...
Published: 15 November 2023
MYXOMATOUS MITRAL VALVE DISEASE: SURGICAL SPECIMEN Figure 10-11 MYXOMATOUS MITRAL VALVE DISEASE: SURGICAL SPECIMEN Focal resection of the valve (P2 segment, in this case) produces a thickened, rubbery portion of leaflet that is characteristic of myxomatous disease. More about this image found in MYXOMATOUS MITRAL VALVE DISEASE: SURGICAL SPECIMEN Focal resection of the ...
Images
<span class="search-highlight">SURGICAL</span> MYECTOMY PROCEDURE  Left: Excision of hypertrophic muscle can help...
Published: 15 November 2023
SURGICAL MYECTOMY PROCEDURE Figure 15-22 SURGICAL MYECTOMY PROCEDURE Left: Excision of hypertrophic muscle can help open the left ventricular outflow tract (yellow arrow), reducing the effect of systolic anterior motion of the mitral valve and improving left ventricular function. Right: Muscle r... More about this image found in SURGICAL MYECTOMY PROCEDURE Left: Excision of hypertrophic muscle can help...
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<span class="search-highlight">SURGICAL</span> ASCENDING AORTIC RESECTIONS  Segmental (left) and partial (above) ...
Published: 15 November 2023
SURGICAL ASCENDING AORTIC RESECTIONS Figure 28-20 SURGICAL ASCENDING AORTIC RESECTIONS Segmental (left) and partial (above) aortic resection. More about this image found in SURGICAL ASCENDING AORTIC RESECTIONS Segmental (left) and partial (above) ...
Images
ATRIAL SEPTAL DEFECTS: INTERVENTIONAL CLOSURES  A: <span class="search-highlight">Surgical</span> patch closure (...
Published: 15 November 2023
ATRIAL SEPTAL DEFECTS: INTERVENTIONAL CLOSURES Figure 35-9 ATRIAL SEPTAL DEFECTS: INTERVENTIONAL CLOSURES A: Surgical patch closure (arrow), with residual volume hypertrophy of the right ventricle, in an adult (four-chamber view). B: Excision of the valve of the fossa ovalis during surgical patc... More about this image found in ATRIAL SEPTAL DEFECTS: INTERVENTIONAL CLOSURES A: Surgical patch closure (...