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Figure 1-141
Published: 01 June 2025
OLFACTORY NEUROBLASTOMA Figure 1-141 OLFACTORY NEUROBLASTOMA A: A silver impregnation Grimelius stain highlights the cytoplasmic neurosecretory granules. (Courtesy of Dr. L. Grimelius, Stockholm, Sweden) B: S-100 protein reacts with the peripheral supporting sustentacular cells. C,D More about this image found in OLFACTORY NEUROBLASTOMA A: A silver impregnation Grimelius stain highlight...
Images
Figure 6-68
Published: 01 June 2025
ADENOSQUAMOUS CARCINOMA Figure 6-68 ADENOSQUAMOUS CARCINOMA A,B: A mucicarmine stain highlights the intracellular and intraluminal mucin. C: The squamous portions of the adenosquamous carcinoma are positive for p40. More about this image found in ADENOSQUAMOUS CARCINOMA A,B: A mucicarmine stain highlights the intracellu...
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Figure 4-59
Published: 01 June 2025
MUCOSAL MELANOMA Figure 4-59 MUCOSAL MELANOMA A: There is strong and diffuse nuclear staining for SOX10. B: MART 1 (Melan-A103) shows variably reactive cytoplasmic staining. C: HMB-45 cytoplasmic staining highlights the radial growth phase, similar to lentiginous cutaneous melanoma. D: Strong More about this image found in MUCOSAL MELANOMA A: There is strong and diffuse nuclear staining for SOX10...
Images
Figure 6-19
Published: 01 June 2025
AMYLOIDOSIS Figure 6-19 AMYLOIDOSIS A: The amyloid material stains strongly orange with a Congo red special stain. B: Congo red staining under polarized light shows foci of apple green birefringence. More about this image found in AMYLOIDOSIS A: The amyloid material stains strongly orange with a Congo re...
Images
Figure 6-71
Published: 01 June 2025
HEAD AND NECK PARAGANGLIOMA Figure 6-71 HEAD AND NECK PARAGANGLIOMA Immunohistochemical stains are positive for GATA3 (A), INSM1 (B), chromogranin (C), and S-100 protein in sustentacular cells (D); SDHB is retained within chief cells (E). More about this image found in HEAD AND NECK PARAGANGLIOMA Immunohistochemical stains are positive for GA...
Images
Figure 8-92
Published: 01 June 2025
PARAGANGLIOMA Figure 8-92 PARAGANGLIOMA Cytology findings show moderate cellularity with a background of blood. A: Clusters and single cells are seen. (Papanicolaou stain) B: There are polygonal, spindled, and isolated pleomorphic cells in this smear. (Diff Quik stain) C: Polygonal cells More about this image found in PARAGANGLIOMA Cytology findings show moderate cellularity with a backgroun...
Images
Figure 7-39
Published: 01 June 2025
staining even in the thinner areas of tumor lining. B: In a branchial cleft cyst, p16 immunohistochemistry shows patchy, somewhat weaker staining in some cyst lining cells without the block-like, strong nuclear and cytoplasmic staining that is seen with in HPV-associated oropharyngeal SCC. More about this image found in METASTATIC SQUAMOUS CELL CARCINOMA VERSUS BRANCHIAL CLEFT CYST A: p16 immu...
Images
Figure 7-44
Published: 01 June 2025
LIPOMA Figure 7-44 LIPOMA A: This FNA of a lipoma shows large uniform adipocytes with small, round and regular nuclei. (Papanicolaou stain) B: A spindle cell lipoma from the posterior neck shows uniform bland spindled cells, as well as focal ropey collagen; mast cells are often found More about this image found in LIPOMA A: This FNA of a lipoma shows large uniform adipocytes with small, ...
Images
Figure 1-41
Published: 01 June 2025
SINONASAL UNDIFFERENTIATED CARCINOMA Figure 1-41 SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely positive for pancytokeratin. B: Squamous markers like p40 are negative, or at most, focally positive. Diffuse staining excludes sinonasal undifferentiated carcinoma. C More about this image found in SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely posit...
Images
Figure 3-5
Published: 01 June 2025
cytoplasm and a plasmacytoid shape (C); rare mitoses are present. D: Nuclei are oval, with finely granular chromatin. E: The tumor cells are present in a collagenized background. F: There is strong diffuse cytoplasmic staining for synaptophysin. G: Keratin AE1/AE3 shows a prominent dot-like staining More about this image found in ECTOPIC PITUITARY ADENOMA (PitNET) INVOLVING NASOPHARYNX A: Low-magnificat...
Images
Figure 3-5
Published: 01 June 2025
cytoplasm and a plasmacytoid shape (C); rare mitoses are present. D: Nuclei are oval, with finely granular chromatin. E: The tumor cells are present in a collagenized background. F: There is strong diffuse cytoplasmic staining for synaptophysin. G: Keratin AE1/AE3 shows a prominent dot-like staining More about this image found in ECTOPIC PITUITARY ADENOMA (PitNET) INVOLVING NASOPHARYNX A: Low-magnificat...
Images
Figure 5-59
Published: 01 June 2025
CALCIFYING EPITHELIAL ODONTOGENIC TUMOR Figure 5-59 CALCIFYING EPITHELIAL ODONTOGENIC TUMOR Birefringence of the amyloid protein, ODAM (Congo red stain). More about this image found in CALCIFYING EPITHELIAL ODONTOGENIC TUMOR Birefringence of the amyloid prote...
Images
Figure 2-33
Published: 01 June 2025
OROPHARYNGEAL SMALL CELL CARCINOMA Figure 2-33 OROPHARYNGEAL SMALL CELL CARCINOMA Immunohistochemistry for chromogranin-A shows only focal, punctate paranuclear staining. More about this image found in OROPHARYNGEAL SMALL CELL CARCINOMA Immunohistochemistry for chromogranin-A...
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Figure 6-92
Published: 01 June 2025
GRANULAR CELL TUMOR Figure 6-92 GRANULAR CELL TUMOR An S-100 protein immunostain shows the characteristic diffuse, strong cytoplasmic and nuclear staining. More about this image found in GRANULAR CELL TUMOR An S-100 protein immunostain shows the characteristic ...
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Figure 6-81
Published: 01 June 2025
LARGE CELL NEUROENDOCRINE CARCINOMA Figure 6-81 LARGE CELL NEUROENDOCRINE CARCINOMA The carcinoma shows markedly elevated staining with Ki-67 (A) and is positive for synaptophysin (B). More about this image found in LARGE CELL NEUROENDOCRINE CARCINOMA The carcinoma shows markedly elevated ...
Images
Figure 7-57
Published: 01 June 2025
MYXOID LIPOSARCOMA Figure 7-57 MYXOID LIPOSARCOMA A,B: The aspirate shows adipocytes, some with atypical nuclei, in a myxoid background with occasional blood vessels. (Diff Quik stain) More about this image found in MYXOID LIPOSARCOMA A,B: The aspirate shows adipocytes, some with atypical ...
Images
Figure 7-54
Published: 01 June 2025
CHORDOMA Figure 7-54 CHORDOMA A,B: Loosely cohesive groups of polygonal cells with elongated to oval nuclei and small distinct nucleus. There is a mild amount of nuclear pleomorphism. (Papanicolaou stain) More about this image found in CHORDOMA A,B: Loosely cohesive groups of polygonal cells with elongated to...
Images
Figure 1-127
Published: 01 June 2025
BIPHENOTYPIC SINONASAL SARCOMA Figure 1-127 BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity for both S-100 protein (A) and SMA (B), although the extent of staining is variable. More about this image found in BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity...
Images
Figure 6-75
Published: 01 June 2025
NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-75 NEUROENDOCRINE TUMOR, GRADE 1 Ki-67 immunohistochemistry shows little positive nuclear staining (less than 5 percent of cells). More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 Ki-67 immunohistochemistry shows little posi...
Images
Figure 1-14
Published: 01 June 2025
RHINOSCLEROMA Figure 1-14 RHINOSCLEROMA A: The diagnostic microscopic finding of rhinoscleroma is the “Mikülicz cell,” large histiocytes with ample clear, vacuolated cytoplasm. B: Rod-shaped bacilli are demonstrated by Warthin-Starry staining. More about this image found in RHINOSCLEROMA A: The diagnostic microscopic finding of rhinoscleroma is th...