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Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... appearance of MEC in the oropharynx is similar to that in other head and neck anatomic sites, with varying amounts of epidermoid (squamoid), mucin-producing, and intermediate cells arranged in cystic, solid, and small nests in a fibrous stroma ( fig. 2-37 ). Frank keratinization is rare, but the epidermoid...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... carcinoma is often infiltrated by inflammatory cells, especially neutrophils. D: Some cases have mature-appearing, deceptively bland areas that mimic inverted sinonasal papilloma. Immunohistochemical Findings. KSCC and NKSCC are diffusely positive for pancytokeratin as well as the squamoid markers p40...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... pleomorphic cells as well as singly dispersed cells. These cells characteristically have large nuclei, prominent nucleoli, and dense, pink (“squamoid”-appearing) cytoplasm on Papanicolaou staining. Molecular Genetic Findings. OSCC has marked genetic heterogeneity and genetic alterations that are found...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... involving the subgemmal plexus ( 5 , 7 ). Neuroepithelial structures have also been reported in the jaws ( 6 ). The epithelium appears as small strands or islands without cytologic atypia in which the cells are squamoid but without keratinization. They have a tendency for cytoplasmic clearing. There are few...
Images
Figure 8-59
Published: 01 January 2024
LOW-GRADE ADENOSQUAMOUS CARCINOMA Figure 8-59 LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, and nests of epithelial cells are seen haphazardly placed in the stroma. Scattered lymphoid aggregates are present. B,C: Some nests have a squamoid appearance (B) and others More about this image found in LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, a...
Images
Figure 13-11
Published: 01 January 2024
SYRINGOMATOUS TUMOR Figure 13-11 SYRINGOMATOUS TUMOR A: At low power, predominantly solid nests of tumor cells are seen percolating through the dermis of the nipple. B–D: Increasing magnification of areas of the tumor showing solid nests of tumor cells (B) with some squamoid features within More about this image found in SYRINGOMATOUS TUMOR A: At low power, predominantly solid nests of tumor ce...
Images
Figure 13-18
Published: 01 January 2024
appears eosinophilic. There is a gradual transition between the more normal-appearing squamous cells and the malignant cells. C: At high power, more squamoid-appearing features are seen, including possible keratinization. This case had initially been diagnosed as Paget disease; upon secondary review More about this image found in SQUAMOUS CELL CARCINOMA IN SITU A: At low power, sheets of malignant-appea...
Images
Figure 7-12
Published: 01 January 2024
with the papilloma. B: At higher power, the greater stromal cellularity and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Images
Figure 7-12
Published: 01 January 2024
with the papilloma. B: At higher power, the greater stromal cellularity and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Images
Figure 31-21
Published: 15 November 2023
CYSTIC ADVENTITIAL DISEASE Figure 31-21 CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery shows numerous cysts within the adventitial space. Right: High-power evaluation of the adventitial cysts shows blood and amorphous debris within the space surrounded by squamoid More about this image found in CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-13
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...-appearing squamous cells and the malignant cells. C: At high power, more squamoid-appearing features are seen, including possible keratinization. This case had initially been diagnosed as Paget disease; upon secondary review, the aforementioned features were noted, suggesting squamous cell carcinoma. A p63...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... in subcapsular sinus Usually present as isolated cells or minute clusters (<0.2 mm) Cells have degenerated and/or squamoid morphology Presence of hemosiderin and macrophages favor artifactual displacement Nevus cell aggregate Variably sized aggregate of small cells in lymph node capsule Pale eosinophilic...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous matrix admixed with many bland spindle cells suggests a diagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... or slightly squamoid appearance of the cells or nests of cells situated in a reactive stroma. On occasion, however, it may be more challenging to determine whether or not a focus of bona fide invasive carcinoma or lymphovascular space invasion is present. In the absence of conventional invasive carcinoma away...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... haphazardly placed in the stroma. Scattered lymphoid aggregates are present. B,C: Some nests have a squamoid appearance (B) and others are more glandular (C). Taken together, the features are consistent with a diagnosis of low-grade adenosquamous carcinoma. SQUAMOUS CELL CARCINOMA Figure 8-60 SQUAMOUS CELL...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of cellular condensation into more squamoid or epithelioid aggregates) or foci of DCIS favor a diagnosis of metaplastic carcinoma. However, immunohistochemical studies may be needed to confirm the diagnosis as there can be considerable morphologic overlap; a panel should include keratins and p63...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch31
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Figure 31-21 CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery shows numerous cysts within the adventitial space. Right: High-power evaluation of the adventitial cysts shows blood and amorphous debris within the space surrounded by squamoid cells and inflammation/granulation...
Images
Figure 9-11
Published: 01 August 2023
MALIGNANT BRENNER TUMOR Figure 9-11 MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamoid cells in desmoplastic stroma is typical. A benign or borderline Brenner component should be present (not shown) to confirm Brenner lineage. Otherwise, squamous cell carcinoma More about this image found in MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamo...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-09
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
.... MALIGNANT BRENNER TUMOR Figure 9-11 MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamoid cells in desmoplastic stroma is typical. A benign or borderline Brenner component should be present (not shown) to confirm Brenner lineage. Otherwise, squamous cell carcinoma is a diagnostic...
Images
Figure 10-9
Published: 01 March 2023
PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...