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Book Chapter
Oropharynx
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... appearance of MEC in the oropharynx is similar to that in other head and neck anatomic sites, with varying amounts of epidermoid (squamoid), mucin-producing, and intermediate cells arranged in cystic, solid, and small nests in a fibrous stroma ( fig. 2-37 ). Frank keratinization is rare, but the epidermoid...
Book Chapter
Sinonasal Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... carcinoma is often infiltrated by inflammatory cells, especially neutrophils. D: Some cases have mature-appearing, deceptively bland areas that mimic inverted sinonasal papilloma. Immunohistochemical Findings. KSCC and NKSCC are diffusely positive for pancytokeratin as well as the squamoid markers p40...
Book Chapter
Oral Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... pleomorphic cells as well as singly dispersed cells. These cells characteristically have large nuclei, prominent nucleoli, and dense, pink (“squamoid”-appearing) cytoplasm on Papanicolaou staining. Molecular Genetic Findings. OSCC has marked genetic heterogeneity and genetic alterations that are found...
Book Chapter
Jaw
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... involving the subgemmal plexus ( 5 , 7 ). Neuroepithelial structures have also been reported in the jaws ( 6 ). The epithelium appears as small strands or islands without cytologic atypia in which the cells are squamoid but without keratinization. They have a tendency for cytoplasmic clearing. There are few...
Images
LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, a...
Available to PurchasePublished: 01 January 2024
LOW-GRADE ADENOSQUAMOUS CARCINOMA Figure 8-59 LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, and nests of epithelial cells are seen haphazardly placed in the stroma. Scattered lymphoid aggregates are present. B,C: Some nests have a squamoid appearance (B) and others More about this image found in LOW-GRADE ADENOSQUAMOUS CARCINOMA A: At low power, subtle cords, glands, a...
Images
SYRINGOMATOUS TUMOR A: At low power, predominantly solid nests of tumor ce...
Available to PurchasePublished: 01 January 2024
SYRINGOMATOUS TUMOR Figure 13-11 SYRINGOMATOUS TUMOR A: At low power, predominantly solid nests of tumor cells are seen percolating through the dermis of the nipple. B–D: Increasing magnification of areas of the tumor showing solid nests of tumor cells (B) with some squamoid features within More about this image found in SYRINGOMATOUS TUMOR A: At low power, predominantly solid nests of tumor ce...
Images
SQUAMOUS CELL CARCINOMA IN SITU A: At low power, sheets of malignant-appea...
Available to PurchasePublished: 01 January 2024
appears eosinophilic. There is a gradual transition between the more normal-appearing squamous cells and the malignant cells. C: At high power, more squamoid-appearing features are seen, including possible keratinization. This case had initially been diagnosed as Paget disease; upon secondary review More about this image found in SQUAMOUS CELL CARCINOMA IN SITU A: At low power, sheets of malignant-appea...
Images
METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Available to PurchasePublished: 01 January 2024
with the papilloma. B: At higher power, the greater stromal cellularity and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Images
METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Available to PurchasePublished: 01 January 2024
with the papilloma. B: At higher power, the greater stromal cellularity and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Images
CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery...
Available to PurchasePublished: 15 November 2023
CYSTIC ADVENTITIAL DISEASE Figure 31-21 CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery shows numerous cysts within the adventitial space. Right: High-power evaluation of the adventitial cysts shows blood and amorphous debris within the space surrounded by squamoid More about this image found in CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery...
Book Chapter
Nipple Disorders
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-13
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...-appearing squamous cells and the malignant cells. C: At high power, more squamoid-appearing features are seen, including possible keratinization. This case had initially been diagnosed as Paget disease; upon secondary review, the aforementioned features were noted, suggesting squamous cell carcinoma. A p63...
Book Chapter
Axillary Lymph Nodes
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... in subcapsular sinus Usually present as isolated cells or minute clusters (<0.2 mm) Cells have degenerated and/or squamoid morphology Presence of hemosiderin and macrophages favor artifactual displacement Nevus cell aggregate Variably sized aggregate of small cells in lymph node capsule Pale eosinophilic...
Book Chapter
Papillary Lesions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... and stromal cell atypia are more obvious. C: The cytologic atypia is striking at high power; in some areas the spindled cells are more epithelioid or squamoid in appearance. D: Mitotic activity is brisk. While the presence of a collagenous matrix admixed with many bland spindle cells suggests a diagnosis...
Book Chapter
Inflammatory and Reactive Conditions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... or slightly squamoid appearance of the cells or nests of cells situated in a reactive stroma. On occasion, however, it may be more challenging to determine whether or not a focus of bona fide invasive carcinoma or lymphovascular space invasion is present. In the absence of conventional invasive carcinoma away...
Book Chapter
Invasive Carcinomas of the Breast
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... haphazardly placed in the stroma. Scattered lymphoid aggregates are present. B,C: Some nests have a squamoid appearance (B) and others are more glandular (C). Taken together, the features are consistent with a diagnosis of low-grade adenosquamous carcinoma. SQUAMOUS CELL CARCINOMA Figure 8-60 SQUAMOUS CELL...
Book Chapter
Mesenchymal Lesions
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of cellular condensation into more squamoid or epithelioid aggregates) or foci of DCIS favor a diagnosis of metaplastic carcinoma. However, immunohistochemical studies may be needed to confirm the diagnosis as there can be considerable morphologic overlap; a panel should include keratins and p63...
Book Chapter
Connective Tissue Disorders
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch31
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Figure 31-21 CYSTIC ADVENTITIAL DISEASE Left: Elastic staining of this popliteal artery shows numerous cysts within the adventitial space. Right: High-power evaluation of the adventitial cysts shows blood and amorphous debris within the space surrounded by squamoid cells and inflammation/granulation...
Images
MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamo...
Available to PurchasePublished: 01 August 2023
MALIGNANT BRENNER TUMOR Figure 9-11 MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamoid cells in desmoplastic stroma is typical. A benign or borderline Brenner component should be present (not shown) to confirm Brenner lineage. Otherwise, squamous cell carcinoma More about this image found in MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamo...
Book Chapter
Brenner Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-09
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
.... MALIGNANT BRENNER TUMOR Figure 9-11 MALIGNANT BRENNER TUMOR Left: Irregularly shaped nests of malignant squamoid cells in desmoplastic stroma is typical. A benign or borderline Brenner component should be present (not shown) to confirm Brenner lineage. Otherwise, squamous cell carcinoma is a diagnostic...
Images
PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...
Available to PurchasePublished: 01 March 2023
PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...
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