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Book Chapter
Spitzoid and Spitz Melanomas
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 19-1 FEATURES OF SPITZOID VERSUS SPITZ MELANOMA Spitzoid Melanoma Spitz Melanoma Spitzoid Histology Spitzoid Histology Immunohistochemical Findings: Immunohistochemical Findings: May be positive for BRAF V600E Negative for BRAF V600E May be positive for ALK, NTRK1...
Images
SPITZOID LENTIGO The melanocytes associated with this macular hyperpigment...
Available to PurchasePublished: 01 February 2024
SPITZOID LENTIGO Figure 1-5 SPITZOID LENTIGO The melanocytes associated with this macular hyperpigmentation show large epithelioid features. More about this image found in SPITZOID LENTIGO The melanocytes associated with this macular hyperpigment...
Images
CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm...
Available to PurchasePublished: 01 February 2024
CONVENTIONAL MELANOMA WITH SPITZOID FEATURES Figure 19-1 CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm with a predominant nested growth pattern. B: The tumor cells carry a NRAS Q61R mutation and are uniformly immunoreactive with the antibody SP174. C More about this image found in CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm...
Images
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...
Available to PurchasePublished: 01 February 2024
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...
Images
SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...
Available to PurchasePublished: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional lymph node. More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...
Images
SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lac...
Available to PurchasePublished: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-6 SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lack of maturation and tongue-like projections at the base. B: The tumor is composed of fusiform melanocytes, many of which are in mitosis. C: Tumor cells are present More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lac...
Images
ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than m...
Available to PurchasePublished: 01 February 2024
ATYPICAL SPITZ TUMOR Figure 7-22 ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than most Spitz nevi. There is limited maturation. B: The tumor cells display spitzoid features and nuclear atypia. More about this image found in ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than m...
Book Chapter
Spitz Nevi, Spitz Melanocytomas, and Atypical Spitz Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Epithelioid Spitz nevus Predominance of large epithelioid melanocytes with open nuclear chromatin pattern Pagetoid Spitz nevus Small diameter circumscribed lesion with several suprabasilar spitzoid melanocytes Pigmented spindle cell nevus of Reed Sharply circumscribed pigmented lesion with densely...
Images
HALO SPITZ NEVUS A: The silhouette of the lesion shows a dense band-like l...
Available to PurchasePublished: 01 February 2024
HALO SPITZ NEVUS Figure 7-14 HALO SPITZ NEVUS A: The silhouette of the lesion shows a dense band-like lymphocytic infiltrate in the superficial dermis. B: A few scattered large epithelioid (spitzoid) melanocytes are present in the lymphocytic infiltrate. More about this image found in HALO SPITZ NEVUS A: The silhouette of the lesion shows a dense band-like l...
Book Chapter
Combined Melanocytic Nevi/Melanocytomas
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 10-1 VARIANTS OF COMBINED NEVI Combined deep penetrating nevus Combined inverted type A nevus Combined blue nevus Combined spitzoid nevus a Combined desmoplastic nevus Combined neurotized nevus Combined balloon cell nevus Combined pigmented epithelioid...
Book Chapter
Pediatric Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... TW , et al . Spitz melanoma is a distinct subset of spitzoid melanoma . Mod Pathol 2020 ; 33 : 1122 - 34 . 27. Wiesner T , He J , Yelensky R , et al . Kinase fusions are frequent in Spitz tumours and spitzoid melanomas . Nat Commun 2014 ; 5 : 3116 . 28...
Book Chapter
Melanotic Macule
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... There is a slight increase in the density of solitary units of melanocytes associated with hyperpigmented keratinocytes. SPITZOID LENTIGO Figure 1-5 SPITZOID LENTIGO The melanocytes associated with this macular hyperpigmentation show large epithelioid features. SOLAR LENTIGO Figure 1-1 SOLAR LENTIGO...
Book Chapter
Nodular Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 15-1 VARIANTS OF NODULAR MELANOMA Nodular melanoma, in situ and invasive De novo Associated with a melanocytic nevus Various phenotypes: epithelioid, fusiform, nevoid, spitzoid, desmoplastic plexiform (DPN-like) a , other Nodular melanoma, invasive only...
Book Chapter
Superficial Spreading Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Differential immunoreactivity for PRAME can help in difficult cases. Clinical context also is also important to assess the odds of melanoma versus nevus. A spitzoid lesion on the extremity of a teenager is more likely a Spitz nevus than a spitzoid neoplasm associated with marked solar elastosis in an elderly...
Book Chapter
Nevoid Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... also be seen with other benign melanocytic neoplasms. Maturation may even be absent in some lesions, such as deep penetrating nevi. Recognition of the class of melanocytic tumors (Spitz versus spitzoid) is important to appropriately balance the constellation of microscopic findings for the final...
Book Chapter
Blue Nevus-Related Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... group of tumors, including pigmented plexiform (deep penetrating nevus-like) melanomas, miscellaneous pigmented neoplasms with spitzoid and/or some blue nevus-like features, and PEM. In our experience, lesions reported as pigment-synthesizing melanoma reflect a mixture of bonafide malignant melanomas...
Book Chapter
Acral Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., desmoplastic, nevoid, spitzoid, or blue nevus associated. While acral melanoma likely has a similar incidence across different ethnicities ( 5 ), it is the most common variant of melanoma affecting individuals of Asian, Hispanic, or African ethnic origin ( 6 – 10 ). In Southeast Asia, for example, more than...
Book Chapter
Desmoplastic Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... tend to have a few nests with spitzoid or epithelioid cell features, usually in the superficial dermis. Ancillary studies may be of some assistance in distinguishing sclerosing nevi from DM. Desmoplastic Spitz nevi tend to strongly express p16 ( 34 ), and some are associated with HRAS...
Book Chapter
Mesenchymal Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 7
Published: 01 September 2021
10.55418/9781933477121-2
ISBN-10: 1-933477-12-1
ISBN: 978-1-933477-12-1
... HISTIOCYTOMA Figure 2-35 EPITHELIOID FIBROUS HISTIOCYTOMA Homogeneous expression of ALK by neoplastic cells. Molecular Genetic Findings . Most cases tested show ALK gene rearrangements, and characteristic fusion genes have been described ( 33 – 35 ). Differential Diagnosis . Spitzoid neoplasms...
