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SPITZ NEVUS  Cytologically, the tumor cells have a plump <span class="search-highlight">spindle</span> cell appea...
Published: 01 February 2024
SPITZ NEVUS Figure 7-12 SPITZ NEVUS Cytologically, the tumor cells have a plump spindle cell appearance and are often polygonal in shape with pink cytoplasm. The nuclei are enlarged and there is an open chromatin pattern. More about this image found in SPITZ NEVUS Cytologically, the tumor cells have a plump spindle cell appea...
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PIGMENTED <span class="search-highlight">SPINDLE</span> CELL NEVUS  Intraepidermal whorls of slender pigmented sp...
Published: 01 February 2024
PIGMENTED SPINDLE CELL NEVUS Figure 7-19 PIGMENTED SPINDLE CELL NEVUS Intraepidermal whorls of slender pigmented spindle cells contain small oval bland nuclei. More about this image found in PIGMENTED SPINDLE CELL NEVUS Intraepidermal whorls of slender pigmented sp...
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PIGMENTED <span class="search-highlight">SPINDLE</span> CELL NEVUS  Clefts are present between junctional nests o...
Published: 01 February 2024
PIGMENTED SPINDLE CELL NEVUS Figure 7-20 PIGMENTED SPINDLE CELL NEVUS Clefts are present between junctional nests of melanocytes and adjacent epidermal keratinocytes. This nevus had a confirmed NTRK3 fusion. More about this image found in PIGMENTED SPINDLE CELL NEVUS Clefts are present between junctional nests o...
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SCLEROSING BLUE NEVUS  A: Small amelanotic fibrosing <span class="search-highlight">spindle</span> cell lesion in...
Published: 01 February 2024
SCLEROSING BLUE NEVUS Figure 8-8 SCLEROSING BLUE NEVUS A: Small amelanotic fibrosing spindle cell lesion in the superficial dermis. B: The spindle cells are strongly and diffusely immunoreactive for Melan-A. C: The tumor cells display cytologically bland fibroblast-like features, simulating a f... More about this image found in SCLEROSING BLUE NEVUS A: Small amelanotic fibrosing spindle cell lesion in...
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SCLEROSING AND CELLULAR BLUE NEVUS  A: Sclerosing <span class="search-highlight">spindle</span> cell nodule is in...
Published: 01 February 2024
SCLEROSING AND CELLULAR BLUE NEVUS Figure 8-9 SCLEROSING AND CELLULAR BLUE NEVUS A: Sclerosing spindle cell nodule is in the dermis. Most of the superficial part of the tumor is paucicellular, typical of a sclerosing BN, but its lower half contains areas of hypercellularity. B: Paucicellular fib... More about this image found in SCLEROSING AND CELLULAR BLUE NEVUS A: Sclerosing spindle cell nodule is in...
Images
DEEP PENETRATING NEVUS  Nests of pigmented <span class="search-highlight">spindle</span> and epithelioid melanocy...
Published: 01 February 2024
DEEP PENETRATING NEVUS Figure 9-7 DEEP PENETRATING NEVUS Nests of pigmented spindle and epithelioid melanocytes are surrounded by bipolar spindle cells (arrows). This feature has been referred to as “ball in mitt.” Multinucleated cells (arrowhead) are also present. More about this image found in DEEP PENETRATING NEVUS Nests of pigmented spindle and epithelioid melanocy...
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DESMOPLASTIC MELANOMA  Invasive amelanotic <span class="search-highlight">spindle</span> cell melanoma cells are ...
Published: 01 February 2024
DESMOPLASTIC MELANOMA Figure 16-2 DESMOPLASTIC MELANOMA Invasive amelanotic spindle cell melanoma cells are seen in the dermis. There is no associated melanoma in situ. More about this image found in DESMOPLASTIC MELANOMA Invasive amelanotic spindle cell melanoma cells are ...
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DESMOPLASTIC MELANOMA  A: Amelanotic invasive <span class="search-highlight">spindle</span> cell proliferation.  ...
Published: 01 February 2024
DESMOPLASTIC MELANOMA Figure 16-9 DESMOPLASTIC MELANOMA A: Amelanotic invasive spindle cell proliferation. B: The tumor cells are immunoreactive for S-100 protein. More about this image found in DESMOPLASTIC MELANOMA A: Amelanotic invasive spindle cell proliferation. ...
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MELANOMA WITH SARCOMATOID DIFFERENTIATION  A: Amelanotic <span class="search-highlight">spindle</span> cell melan...
Published: 01 February 2024
MELANOMA WITH SARCOMATOID DIFFERENTIATION Figure 21-7 MELANOMA WITH SARCOMATOID DIFFERENTIATION A: Amelanotic spindle cell melanoma shows focally osseous differentiation. B: The same tumor also showed focal cartilaginous differentiation. More about this image found in MELANOMA WITH SARCOMATOID DIFFERENTIATION A: Amelanotic spindle cell melan...
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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant <span class="search-highlight">spindle</span>...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Images
DEEP PENETRATING NEVUS  A: Symmetric wedge-shaped silhouette of a pigmented...
Published: 01 February 2024
DEEP PENETRATING NEVUS Figure 9-1 DEEP PENETRATING NEVUS A: Symmetric wedge-shaped silhouette of a pigmented tumor involving dermis and superficial subcutis. B: Short fascicles of pigmented spindle and epithelioid melanocytes with bland nuclear features are seen in association with melanophages.... More about this image found in DEEP PENETRATING NEVUS A: Symmetric wedge-shaped silhouette of a pigmented...
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NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA  A: Punch biopsy with an intraderma...
Published: 01 February 2024
NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA Figure 16-10 NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intradermal spindle cell proliferation. B: Cytologically bland spindle cells with Schwannian (neurofibroma-like) features. C: The biopsy of the locally persistent tumor shows mel... More about this image found in NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intraderma...
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MELANOMA ASSOCIATED WITH A CELLULAR BLUE NEVUS  A: There is an expansile no...
Published: 01 February 2024
MELANOMA ASSOCIATED WITH A CELLULAR BLUE NEVUS Figure 18-6 MELANOMA ASSOCIATED WITH A CELLULAR BLUE NEVUS A: There is an expansile nodule composed of compact spindle cells with no intervening fibrous stroma. It is (on one side) surrounded by cellular areas with aggregates of melanocytes separated... More about this image found in MELANOMA ASSOCIATED WITH A CELLULAR BLUE NEVUS A: There is an expansile no...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or mid-dermis only  Plexiform growth pattern common  Usually pigmented  Range of cytologic features (spindle, ovoid, and epithelioid)  Random nuclear atypia (enlarged nuclei, hyperchromatism, pseudoinclusions)  Curvilinear spindle cells around groups of melanocytes  Mitoses rare...
Images
COMBINED NEUROTIZED NEVUS  There is a mixed population of nests of small co...
Published: 01 February 2024
COMBINED NEUROTIZED NEVUS Figure 10-12 COMBINED NEUROTIZED NEVUS There is a mixed population of nests of small conventional epithelioid melanocytes (arrow) and fusiform spindle cells. More about this image found in COMBINED NEUROTIZED NEVUS There is a mixed population of nests of small co...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... JUNCTIONAL SPITZ NEVUS Small circumscribed lesion has junctional nests of varying size and shape. Clefts are seen between the nests of melanocytes and the adjacent hyperplastic epidermis. JUNCTIONAL SPITZ NEVUS Figure 7-5 JUNCTIONAL SPITZ NEVUS Nests of spindle and epithelioid cells seem to float...
Images
DESMOPLASTIC MELANOMA WITH MYXOID STROMA  Combined conventional and desmopl...
Published: 01 February 2024
DESMOPLASTIC MELANOMA WITH MYXOID STROMA Figure 16-3 DESMOPLASTIC MELANOMA WITH MYXOID STROMA Combined conventional and desmoplastic melanoma with fusiform amelanotic spindle cells is associated with a myxoid stroma. More about this image found in DESMOPLASTIC MELANOMA WITH MYXOID STROMA Combined conventional and desmopl...