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Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE Figure 6-29 ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE A: Tumor cells contain sparse lipid droplets; some have small, irregular microvillous extensions of cytoplasm along the cell border. The cells contain ample mitochondria and smooth endoplasmic More about this image found in ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE A: Tumor cells contain sparse l...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
GANGLIONEUROMA Figure 11-40 GANGLIONEUROMA Gross image of bisected tumor 9 cm in diameter, with a smooth, glistening, tan-yellow surface. The tumor is well-circumscribed on the outer aspect. More about this image found in GANGLIONEUROMA Gross image of bisected tumor 9 cm in diameter, with a smoo...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ZONA FASCICULATA Figure 1-48 ZONA FASCICULATA Features associated with steroidogenesis include abundant smooth endoplasmic reticulum (top arrow), which may form a complex network of anastomosing tubules, mitochondria with tubular cristae (bottom arrow), and lipid droplets (bottom of field). More about this image found in ZONA FASCICULATA Features associated with steroidogenesis include abundant...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
DORSAL ASPECT OF FETAL ADRENAL GLANDS Figure 1-17 DORSAL ASPECT OF FETAL ADRENAL GLANDS The dorsal surface of both adrenal glands from a 35-week premature infant shows a ridge (or crista) and a relatively smooth cortical surface. Each gland weighed 3 g. More about this image found in DORSAL ASPECT OF FETAL ADRENAL GLANDS The dorsal surface of both adrenal g...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Figure 1-45 DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Distinctive arcades of interrupted smooth muscle form the wall of the central adrenal vein and its tributaries. The vein is surrounded More about this image found in DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Disti...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Figure 1-46 PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Where smooth muscle is deficient, chromaffin or cortical cells may come into close proximity with the vascular space and can form More about this image found in PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Whe...
Images
Published: 01 December 2024
ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 4-27 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile smooth borders that compress adjacent adrenal parenchyma and expand the adrenal capsule. B: The borders of the adenoma are sharply demarcated from the adjacent More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile ...
Images
Published: 01 December 2024
and prominent smooth endoplasmic reticulum are seen. Clusters of dense granules probably represent primary lysosomes. More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: The tumor cells contain sm...
Images
Published: 01 December 2024
ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-47 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have much smooth endoplasmic reticulum and a few lipid droplets, which vary in size. Microvillous cytoplasmic extensions are evident along the cell borders. Mitochondria More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have muc...
Images
in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
vasculature, with both smooth muscle and endothelial components. B: The paraganglioma, diagnosed 6 years later, has no unusual features. C,D: Staining for FH shows loss in the pheochromocytoma (C) and the paraganglioma (D). More about this image found in PHEOCHROMOCYTOMA AND PARAGANGLIOMA ASSOCIATED WITH GERMLINE FUMARATE HYDRAT...
Images
Published: 01 December 2024
arrow). A nodule is composed of lipid-rich cells (black arrow) and the small hyperplastic nodule protrudes into the vascular lumen between discontinuous bundles of smooth muscle (white arrowhead). More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Transverse section throug...
Images
Published: 01 December 2024
of the nuclear membrane. B: Cristae of mitochondria have a tubular or vesicular profile typical of steroid-producing cells. There is prominent smooth endoplasmic reticulum as well as a few free polyribosomes. More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: A nuclear pseudoinclusion ...
Images
Published: 01 December 2024
cells with chromaffin cells, and both the cortex and medulla have a close anatomic relationship with the vascular space due to discontinuity of smooth muscle in tributaries of the central adrenal vein vessel walls. More about this image found in NODULAR ADRENAL GLAND Diagram of a transverse section shows cortical extru...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
lipid droplets and abundant smooth endoplasmic reticulum. In the zona reticularis (C), cells are relatively depleted of lipid droplets. Lysosomes and lipofuscin granules are prominent, corresponding to the brown pigment seen in routine light microscopy. More about this image found in ULTRASTRUCTURAL CORRELATES OF CORTICAL ZONATION At low magnification, cell...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
and ballooned clear cells interspersed with spindle cells. C: Clear cells and spindle cells stain for smooth muscle actin. D: Clear cells and spindle cells stain for HMB-45. More about this image found in VARIED APPEARANCES OF ADRENAL PECOMA A: Sharply circumscribed areas of eos...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ADRENAL MYELOLIPOMA This tumor consists almost entirely of hematopoietic cells. A peripheral rim of normal adrenal cortex is present at right. The contour of adrenal myelolipoma is smooth, wavy, or irregular, and may show intermingling of cortical cells with elements of the myelolipoma. Microscopically...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... for the increased weight ( 37 ). Adrenal Gland Gross Anatomy In newborns, the adrenal glands have a relatively smooth capsular surface ( fig. 1-17 ). The gland may appear dark red to brown on transverse section due to a combination of regression of fetal cortex, congestion, and increased density of vascular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... smooth endoplasmic reticulum. In the presence of nuclear pseudoinclusions, these are due to an irregularity in the nuclear membrane, with indentation and infolding of cell cytoplasm, often with the same complement and density of cellular organelles. Mitochondria may be prominent, and are usually round...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... a close anatomic relationship with the vascular space due to discontinuity of smooth muscle in tributaries of the central adrenal vein vessel walls. Prior to the availability of computerized tomography (CT) scanning and other sensitive imaging techniques, the “nonfunctioning” nodular adrenal gland...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with the liver) ( 79 ). Table 6-1 IMAGING CHARACTERISTICS OF BENIGN VERSUS MALIGNANT ADRENAL MASSES a Characteristic Likely Benign Suspicious for Malignancy Size Small (<4 cm) Large (>4 cm) Shape Round or oval Irregular Margins Smooth Irregular Texture Homogeneous...
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