GANGLIONEUROMA Figure 11-42 GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelinated nerve is present at one pole of a ganglion. The ganglion is probably incorporated secondarily in the tumor. B: A large bundle of myelinated nerve is present in this GN and is most likely se... More about this image found in GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelin...

PHEOCHROMOCYTOMA: CELLULARITY Figure 8-50 PHEOCHROMOCYTOMA: CELLULARITY Increased cellularity due to crowded small tumor cells is a histologic feature of aggressive pheochromocytomas. More about this image found in PHEOCHROMOCYTOMA: CELLULARITY Increased cellularity due to crowded small t...

SMALL BLUE ROUND CELL TUMOR Figure 11-11 SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to be undifferentiated NB. The cellular tumor is composed of undifferentiated cells with atypical nuclei and scant cytoplasm. No stroma or ganglion cell differentiation is present. More about this image found in SMALL BLUE ROUND CELL TUMOR Immunohistochemically, this tumor was shown to...

POORLY DIFFERENTIATED NEUROBLASTOMA Figure 11-28 POORLY DIFFERENTIATED NEUROBLASTOMA Very cellular tumor, composed of small blue round cells. The scattered small amount of neuropil indicates the neuroblastic nature of the lesion. More about this image found in POORLY DIFFERENTIATED NEUROBLASTOMA Very cellular tumor, composed of small...

JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA Figure 12-9 JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA A,B: Small juvenile hemangioma of the adrenal gland in a newborn. There were numerous cutaneous hemangiomas and a large vascular tumor of the liver with identical histology. The adrenal tumor is uniformly ... More about this image found in JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA A,B: Small juvenile hemangioma of ...

PRIMARY ADRENAL ADENOMATOID TUMOR Figure 12-14 PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces transition into cysts with a flattened lining. At top left, the tumor insinuates between and envelops small nests of adrenal cortical cells. B: Higher magnification of a more soli... More about this image found in PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces tran...

PRIMARY ADRENAL ADENOMATOID TUMOR Figure 12-14 PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces transition into cysts with a flattened lining. At top left, the tumor insinuates between and envelops small nests of adrenal cortical cells. B: Higher magnification of a more soli... More about this image found in PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces tran...

ADENOCARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-25 ADENOCARCINOMA METASTATIC TO ADRENAL GLAND A: Core needle biopsy of an adrenal mass in a patient with non-small cell lung carcinoma. The tumor replaces much of adrenal tissue, with only small nests of residual pale-staining cortical cells vi... More about this image found in ADENOCARCINOMA METASTATIC TO ADRENAL GLAND A: Core needle biopsy of an adr...

CHROMAFFIN CELLS IN ADRENAL MEDULLA Figure 1-49 CHROMAFFIN CELLS IN ADRENAL MEDULLA Portions of adjacent chromaffin cells with heterogeneous secretory granules. With fixation in glutaraldehyde and postfixation in osmium ( 58 ), norepinephrine-containing granules have small, uniformly dark dense c... More about this image found in CHROMAFFIN CELLS IN ADRENAL MEDULLA Portions of adjacent chromaffin cells ...

TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Figure 2-15 TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY A: Tumor cells are arranged in lobules and solid sheets, with some intervening fibrous stroma. A ... More about this image found in TESTICULAR ADRENAL REST TUMOR IN A PATIENT WITH SALT-LOSING FORM OF 21-HYDR...

PRIMARY ADRENAL ANGIOSARCOMA Figure 12-10 PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative architecture with sinusoidal growth between cords of vacuolated cortical cells. Acute inflammatory cells and eosinophils are also present. B: Primary adrenal angiosarcoma (same case as... More about this image found in PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative arch...

ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm. This appearance is often associated with SDHB mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse expression to absent expression in a small region of the tumor. D: Immunohistochemical stain for S-100 protein shows heterogeneous distribution of sustentacular cells in adjacent areas of tumor. E: Immunohistochemical stain for glial fibrillary acidic protein (GFAP) shows a small focus of GFAP-positive sustentacular cells in a tumor in which S-100 protein-positive cells were much more numerous. More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...

INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Figure 1-40 INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are present in several chromaffin cells. A few cells contain numerous small globules. More about this image found in INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are p...

MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Figure 12-17 MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle cells and epithelioid cells are present beneath a small area of residual adrenal cortex. More about this image found in MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle c...

POSTNATAL REGRESSION OF PROVISIONAL ADRENAL CORTEX Figure 1-26 POSTNATAL REGRESSION OF PROVISIONAL ADRENAL CORTEX This 3-week postnatal adrenal gland shows necrosis and debris in the central part of the gland and a small amount of residual provisional cortex beneath the developing zona fasciculat... More about this image found in POSTNATAL REGRESSION OF PROVISIONAL ADRENAL CORTEX This 3-week postnatal a...

ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT Figure 6-26 ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT A–C: Myxoid stromal changes are variably in extent and distribution. Neoplastic cells are usually small, grow in cords or thin trabeculae, and have less pronounced cytologic atypia. More about this image found in ADRENAL CORTICAL CARCINOMA: MYXOID VARIANT A–C: Myxoid stromal changes are...

ADRENAL INVOLVEMENT BY LYMPHOMA Figure 12-28 ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, replaces much of the adrenal gland, with only a few small nests of pale-staining cortical cells present in this field. B: Immunostain for CD20 is diffusely positive. More about this image found in ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, rep...

CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-19 CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA A: This adenoma consists of a homogeneous population of predominantly clear cells with marked atrophy of the adjacent cortex. B: The clear cells have uniform small round nuclei and abundant cytopl... More about this image found in CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA A: This adenoma consists of a ...

ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Figure 5-29 ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Some adenomas show focal or predominant areas with stromal changes, either as loose edematous stroma (A) or as more dense and collagenous depositions embedding small clusters of tumor cells (B). More about this image found in ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Some adenomas show focal or pred...

PHEOCHROMOCYTOMA: CYSTIC DEGENERATION Figure 8-9 PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-cm tumor most likely results from old hemorrhage or infarction and contains only thin blood-tinged fluid. The small cyst to its right contains degenerating blood. More about this image found in PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-...