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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...HUMAN HERPESVIRUS 1, 2, AND 3 INFECTIONS General Considerations, Including Etiology and Synonyms Human herpesviruses (HHV) 1, 2, and 3 are neurotropic double-stranded DNA viruses of the alpha Herpesviridae family, which most frequently infect the skin but can also affect...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...NECROTIZING FASCIITIS AND NECROTIZING SKIN INFECTIONS General Considerations, Including Etiology and Synonyms Bacterial infections of the skin and soft tissue encompass a spectrum of conditions, ranging from those that are confined and superficial (e.g., folliculitis) to the fulminant and life...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., certain species such as S. brasiliensis are geographically restricted. The fungus thrives in warm, humid climates and grows in soil, wood, and decaying vegetation. Wood splinters, thorns, and sphagnum moss are common sources of inoculation of this sapronotic infection into the skin. Consequently...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... disease is also known as kala-azar or “black illness” (due to associated skin discoloration), Dum Dum fever, and Assam fever. Numerous synonyms exist for cutaneous leishmaniasis, depending on the clinical presentation and geographic area. Solitary lesions are sometimes referred to as tropical, oriental...
Images
Published: 01 December 2024
SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-39 SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), brain (C), and skin (a surgically excised nodule on the scalp, D) metastases from ACC. More about this image found in SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), br...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and weakness. The skin becomes thin and pigmented striae are prominent. Easy bruising is common. One of the most common presenting features is insulin resistance and type 2 diabetes, often overlooked as a pivotal manifestation of glucocorticoid excess. Patients may develop hypertension, dyslipidemia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ( 16 , 17 ). It may also occur in the pediatric population, particularly in the first years of life, in strong association with the McCune-Albright syndrome. This syndrome (polyostotic fibrous dysplasia, café-au-lait skin spots, and precocious puberty) is a genetically mosaic disorder with populations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... syndrome FLCN Oncocytic adenoma (in case reports) <1% Skin hamartomas, pulmonary cysts, oncocytoid renal neoplasms (oncocytoma and renal cell carcinoma) Li-Fraumeni syndrome TP53 Carcinoma 3-5% (adults) 50-80% (children) Gliomas, breast and lung carcinomas, sarcomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... PLoS One 2017;12:e0185190.) Metastatic locations of NBL and GNBL have a wide range, but are frequently seen in bone marrow, bone, lymph nodes, and liver ( figs. 11-4 , 11-5 ). Multiple skin manifestations of NBL may result in the clinical picture of a “blueberry muffin baby.” Less frequent locations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal gland; no prior or current pigmented lesions of the skin, mucosal surfaces, or eye; no history of removal of pigmented skin or eye lesions; and failure to detect an extra-adrenal primary even by a thorough autopsy ( 58 ). An important entity in the differential diagnosis is pigmented...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., headaches, weakness Weight gain, central obesity, facial roundness, hirsutism, easy bruising, poor wound healing, red to purple skin striae, weakness, hyperglycemia, hypertension, osteoporosis, immunodeficiency Virilization or feminization Mainly incidental Age 4th-5th decade 4th-5th decade...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., and lymph nodes. Bone metastases are usually lytic. Rare sites of metastases include the brain and skin ( figs. 6-38 , 6-39 ). LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-38 LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy specimen is largely replaced by metastatic ACC...
Images
Published: 01 September 2024
EARLY MEASLES EXANTHEM Figure 4-28 EARLY MEASLES EXANTHEM Skin biopsy shows spongiosis, mild parakeratosis, and early keratinocyte necrosis (A). MeV immunohistochemistry (B) demonstrates positivity in epidermal squamous epithelium. (Courtesy of the CDC IDPB) More about this image found in EARLY MEASLES EXANTHEM Skin biopsy shows spongiosis, mild parakeratosis, a...
Images
Published: 01 September 2024
HUMAN HERPESVIRUSES 1 TO 3 SKIN LESIONS Figure 6-5 HUMAN HERPESVIRUSES 1 TO 3 SKIN LESIONS The histopathology of the three is similar and shows vesicle formation (A) and characteristic syncytial cells with nuclear inclusions (B,D). Herpes virus is confirmed using specific immunohistochemical stai... More about this image found in HUMAN HERPESVIRUSES 1 TO 3 SKIN LESIONS The histopathology of the three is...
Images
Published: 01 September 2024
MPOX Figure 6-11 MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: Early changes showing a lichenoid papillary dermal and perivascular mixed inflammatory cell infiltrate, which includes lymphocytes, macrophages, and rare eosinophils. Single dyskeratotic cells are visible i... More about this image found in MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: ...
Images
Published: 01 September 2024
MPOX Figure 6-11 MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: Early changes showing a lichenoid papillary dermal and perivascular mixed inflammatory cell infiltrate, which includes lymphocytes, macrophages, and rare eosinophils. Single dyskeratotic cells are visible i... More about this image found in MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: ...
Images
Published: 01 September 2024
KAPOSI SARCOMA Figure 8-16 KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous characteristic violaceous plaques. (Courtesy of L. M. Gomez, Department of Dermatology, Pontifica Bolivariana University, Medellín, Colombia) B: Palatal mucosa with KS lesions. (Courtesy of the C... More about this image found in KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous ...
Images
Published: 01 September 2024
EBOLA VIRUS IMMUNOHISTOCHEMISTRY Figure 10-4 EBOLA VIRUS IMMUNOHISTOCHEMISTRY A skin biopsy shows strong red positivity (A,B) and filamentous viral particles illustrated on transmission electron microscopy (C). (Courtesy of the CDC IDPB and the CDC PHIL) More about this image found in EBOLA VIRUS IMMUNOHISTOCHEMISTRY A skin biopsy shows strong red positivity...
Images
Published: 01 September 2024
MENINGOCOCCEMIA Figure 11-7 MENINGOCOCCEMIA Meningococcal skin lesion (A) with relatively inapparent bacterial organisms. Gram stain on heart tissue (B), in contrast, shows numerous, more obvious intracellular gram-negative cocci. (Courtesy of the CDC IDPB) More about this image found in MENINGOCOCCEMIA Meningococcal skin lesion (A) with relatively inapparent b...
Images
Published: 01 September 2024
SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA Figure 11-10 SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA A: Hematoxylin and eosin (H&E) stain (left) shows leukocytoclastic vasculitis. B: Scant intracellular cocci are seen with immunohistochemistry. (A,B: courtesy of the CDC IDPB) More about this image found in SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA A: Hematoxylin and eosin (H&am...
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