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situ
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Images
Published: 01 September 2024
VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY Figure 1-5 VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A,B) staining of an adrenal spindle cell neoplasm in an immunocompromised patient. Epstein-Barr virus encoded RNA (EBER) in situ hybridization (ISH) ... More about this image found in VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A...
Images
Published: 01 September 2024
EPSTEIN-BARR INFECTION (EBV) Figure 9-13 EPSTEIN-BARR INFECTION (EBV) EBER in situ hybridization of EBV infection in LIP. More about this image found in EPSTEIN-BARR INFECTION (EBV) EBER in situ hybridization of EBV infection i...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Images
Published: 01 September 2024
NASOPHARYNGEAL CARCINOMA Figure 8-12 NASOPHARYNGEAL CARCINOMA Strong epithelial positivity is seen on EBV-encoded small RNA (EBER) in situ hybridization (ISH), confirming the EBV association of the tumor. More about this image found in NASOPHARYNGEAL CARCINOMA Strong epithelial positivity is seen on EBV-encod...
Images
Published: 01 September 2024
BABESIA SPP Figure 27-9 BABESIA SPP Detection of Babesia spp. using an immunohistochemical assay in an aspirate (A) and in situ hybridization in a formalin-fixed, paraffin-embedded sample (B). (Courtesy of the CDC IDPB) More about this image found in BABESIA SPP Detection of Babesia spp. us...
Images
Published: 01 September 2024
BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA Figure 27-11 BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA A peripheral blood smear shows a morphology indistinguishable from Plasmodium falciparum (malaria). In this case, babesiosis was suspected due to a negative rapid malaria test, and confirmed with in situ hybridization. More about this image found in BABESIA SPP DIFFERENTIAL DIAGNOSIS WITH MALARIA A periphe...
Images
Published: 01 September 2024
HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...
Images
Published: 01 September 2024
HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... improved over the ensuing decades, the latter half of the 20th century saw the rapid development in laboratory ancillary techniques for the diagnosis of microorganisms in tissue. These techniques include electron microscopy, immunohistochemistry, and in situ hybridization, and significantly augment...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-27
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and associated small hemorrhages of the deep viscera. Parasites can be detected in aspirates and tissue sections using either immunohistochemistry or in situ hybridization (ISH) ( fig. 27-9 ). BABESIA SPP Figure 27-9 BABESIA SPP Detection of Babesia spp. using an immunohistochemical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... visible HIV virus, often within germinal centers (i.e., virus within follicle dendritic reticulum cells), thus resembling HIV persistent generalized lymphadenopathy (PGL) ( fig. 9-12D ). Also in some cases, EBV in lymphoid cells is seen via EBV-encoded RNA (EBER) in situ hybridization ( fig. 9-13 ). Cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... should also be undertaken, taking into account the phase of disease since the etiologic pathogen is not always identifiable in the blood. Immunohistochemistry and molecular testing (including in situ hybridization) can be performed on EMB (fresh and formalin-fixed paraffin-embedded) cardiac tissue. Other...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... a differentiated squamous cell, basaloid, or undifferentiated carcinomatous component with an associated desmoplastic stroma and striking mononuclear inflammatory cell infiltrate, hence the term “lymphoepithelial carcinoma” ( fig. 8-11 ). EBV is detected in the neoplastic epithelium by in situ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... scattered prominent immunoblasts (C). (Courtesy of the CDC IDPB) Hantavirus antigens are demonstrated immunohistochemically in endothelial cells at many sites, including the lung, kidney, and spleen ( fig. 4-22 ), as well as in dendritic cells in the spleen and lymph nodes. In situ hybridization confirms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... index, HIV infection, intravenous (IV) drug use, and individuals on hemodialysis, hospitalized patients on ventilators or with catheters in situ, and those with other immune deficiencies. Certain ethnic backgrounds, including African and indigenous Australian and Pacific island populations have a higher...
Images
Published: 01 February 2024
MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS Figure 12-8 MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ with asymmetric and broad growth of melanocytes as nests and solitary units at the dermoepidermal junction associated with inflammation. B: Melanoma in situ i... More about this image found in MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ w...
Images
Published: 01 February 2024
MELANOMA IN SITU Figure 12-3 MELANOMA IN SITU Junctional nests of varying size and shape are present in association with numerous solitary units of melanocytes in the spinous cell layer. More about this image found in MELANOMA IN SITU Junctional nests of varying size and shape are present in...
Images
Published: 01 February 2024
MELANOMA IN SITU Figure 12-4 MELANOMA IN SITU This lesion is predominantly composed of solitary units of melanocytes at all layers of the epidermis. More about this image found in MELANOMA IN SITU This lesion is predominantly composed of solitary units o...
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Published: 01 February 2024
MELANOMA IN SITU Figure 12-5 MELANOMA IN SITU The melanoma is predominantly composed of junctional nests (thick arrow) with only a few solitary units of melanocytes in the spinous cell layer (thin arrows). More about this image found in MELANOMA IN SITU The melanoma is predominantly composed of junctional nest...
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