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NASOPHARYNGEAL CARCINOMA Figure 3-13 NASOPHARYNGEAL CARCINOMA A: Ancillary in situ hybridization is positive for EBER. B–D: There is diffuse immunohistochemical reactivity for CK5/6 (B), p40 (C), and p63 (D). E: Nasopharyngeal carcinomas often demonstrate positive membranous immunoreactivity More about this image found in NASOPHARYNGEAL CARCINOMA A: Ancillary in situ hybridization is positive fo...

SQUAMOUS CELL CARCINOMA IN SITU Figure 6-37 SQUAMOUS CELL CARCINOMA IN SITU A: The epithelium is replaced by full-thickness atypia. B: High-magnification view shows the marked nuclear atypia and scattered mitoses. C: Severe keratinizing atypia involves the full thickness of the epithelium More about this image found in SQUAMOUS CELL CARCINOMA IN SITU A: The epithelium is replaced by full-thic...

MINIMALLY-INVASIVE SQUAMOUS CELL CARCINOMA Figure 6-46 MINIMALLY-INVASIVE SQUAMOUS CELL CARCINOMA SCC in situ of the true cord with very small foci of early invasive keratinizing-type carcinoma. More about this image found in MINIMALLY-INVASIVE SQUAMOUS CELL CARCINOMA SCC in situ of the true cord wi...

in situ hybridization. More about this image found in CONDYLOMA ACUMINATUM A: Condyloma acuminatum presents as an exophytic broa...

OLFACTORY NEUROBLASTOMA Figure 1-135 OLFACTORY NEUROBLASTOMA A–C: The neoplastic cells of ONB are generally small (A), with scant to lightly staining cytoplasm (B), occasionally showing spindling or irregular outlines (C). D: An “in situ” or intraepithelial growth may be seen (black arrow More about this image found in OLFACTORY NEUROBLASTOMA A–C: The neoplastic cells of ONB are generally sma...

with severe (high grade) dysplasia or squamous cell carcinoma (SCC) in situ, particularly on frozen sections. More about this image found in IMMATURE SQUAMOUS METAPLASIA In immature squamous metaplasia with hyperpla...

secondary to irritation. Most cases harbor low-risk human papillomavirus (HPV) as demonstrated by RNA in situ hybridization (inset). More about this image found in EXOPHYTIC SINONASAL PAPILLOMA A: Koilocytic changes, i.e., nuclear enlarge...

nasopharyngeal carcinoma. B: This tumor type is positive for Epstein-Barr virus (EBV), best demonstrated by in situ hybridization for EBV-encoded small RNA (EBER). More about this image found in SINONASAL LYMPHOEPITHELIAL CARCINOMA A: Tumor cells have ill-defined cell ...

: The tumors are diffusely positive for p16 (C), and are positive for high-risk HPV by RNA in situ hybridization (D). More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...

malignant. D,E: Plasmacytomas are positive for CD138 (D) and MUM1 (E). F: In situ hybridization for kappa and lambda demonstrates monoclonality. More about this image found in PLASMACYTOMA A: The submucosa is infiltrated by sheets of inflammatory cel...

ERYTHROLEUKOPLAKIA Figure 4-17 ERYTHROLEUKOPLAKIA A: Ill-defined area in the anterior floor of the mouth (black arrows) shows carcinoma in situ (CIS) on biopsy. B: CIS presents as speckled leukoplakia with a central granular area. C: Discrete area of leukoplakia (black arrow) with more More about this image found in ERYTHROLEUKOPLAKIA A: Ill-defined area in the anterior floor of the mouth ...

: Strong nuclear and cytoplasmic immunoreactivity for p16, with a striking demarcation of the staining. D: HPV16 is positive by RNA in situ hybridization. More about this image found in HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophi...

NK/T-CELL LYMPHOMA Figure 1-181 NK/T-CELL LYMPHOMA A,B: The neoplastic lymphoma cells show an NK-cell phenotype with CD56 (A) and CD3-e (B) strongly staining the cells. C: EBER in situ hybridization is universally present, seen in the neoplastic cells in a destroyed vessel wall. D,E More about this image found in NK/T-CELL LYMPHOMA A,B: The neoplastic lymphoma cells show an NK-cell phen...

contains cohesive clusters of nonkeratinizing squamous cell carcinoma in a background of lymphocytes and debris. C,D: An immunohistochemical stain for p16 is strongly positive (C), and in situ hybridization for high-risk HPV (D) is also positive. More about this image found in METASTATIC HPV-ASSOCIATED SQUAMOUS CELL CARCINOMA A: The FNA shows crowded...

: Synaptophysin stains the neuroblastoma cells (C), which are also highlighted by membranous CD56 (D). E: Calretinin yields strong nuclear and cytoplasmic reactivity in the neoplastic cells. F: A pancytokeratin stain reacts with the surface epithelial cells that surround in situ olfactory neuroblastoma cells More about this image found in OLFACTORY NEUROBLASTOMA A: A silver impregnation Grimelius stain highlight...

the epithelium. These features make the distinction of in situ carcinoma from invasive carcinoma almost impossible, and more likely irrelevant, as tumors may spread without invasion beyond the basement membrane. (Modified from fig. 7 from Westra WH. The morphologic profile of HPV-related head and neck squamous More about this image found in UNIQUE ANATOMY OF THE RETICULATED TONSILLAR CRYPT EPITHELIUM There is an i...