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Figure 3-11

KERATINIZING NASOPHARYNGEAL CARCINOMA A,B: Keratinizing nasopharyngeal car...

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in Nasopharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
KERATINIZING NASOPHARYNGEAL CARCINOMA Figure 3-11 KERATINIZING NASOPHARYNGEAL CARCINOMA A,B: Keratinizing nasopharyngeal carcinomas are often Epstein-Barr virus (EBV) negative and show similar histologic features to keratinizing squamous cell carcinomas in other head and neck anatomic sites. More about this image found in KERATINIZING NASOPHARYNGEAL CARCINOMA A,B: Keratinizing nasopharyngeal car...
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Figure 1-31

SINONASAL KERATINIZING SQUAMOUS CELL CARCINOMA Numerous irregular nests wi...

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in Sinonasal Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
cell carcinoma in any other anatomic site. More about this image found in SINONASAL KERATINIZING SQUAMOUS CELL CARCINOMA Numerous irregular nests wi...
Book Chapter

Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
...EMBRYOLOGY, HISTOLOGY, AND ANATOMY The neck is a complex, vital structure with numerous tissue types including skin, muscle, bone, vasculature, nerves, and organs, making it one of the most complex anatomic sites in the human body ( 1 ). It is critical for movement, metabolism, breathing...
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Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... are generated at the primary site ( 18 ). Some primary tumors can be exophytic, sometimes causing ball valve phenomenon and respiratory compromise. Primary tumor symptoms also include dysphagia and odynophagia. Nodal disease involves levels II and III (mid and upper jugular) in over 95 percent of patients ( 19...
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Book Chapter

Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
..., all basically point to voice trauma as the cause for nodule formation ( 20 ). Supporting this explanation is the fact that vocal cord nodules occur at the junction of the anterior and middle thirds of the cords ( fig. 6-6 ), which is the site of maximal vibration with phonation ( 19 ). Why...
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Book Chapter

Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... cutaneous adnexal structures. They arise in the nasopharynx or other upper aerodigestive tract sites. General Features. Hairy polyps are typically congenital, exophytic lesions that have been referred to by a variety of names (dermoid, teratoma, hamartoma, and choristoma) ( 12 ), although given...
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Book Chapter

Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... cases. In the United States in 2024, it is estimated that 58,450 new cases of OSCC will occur in these three anatomic sites, accounting for 2.9 percent of all new cancer cases ( https://seer.cancer.gov/statfacts/html/oralcav.html ). Although the overall number of oral cavity cancers is decreasing...
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Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
..., and Indonesia. It can involve virtually any site of the upper respiratory tract, but usually affects the nasal cavity and nasopharynx ( 25 ). Gross Findings. The rhinitic/exudative stage of rhinoscleroma has a nonspecific clinical appearance. The florid/proliferative stage results in friable nasal polyps...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... Ear The histologic features of the inner ear are much more integrated into functionality, and few surgical pathology specimens are submitted from these sites. The membranous labyrinth has two parts: the sacculocochlear and the utriculovestibular sections, joined by the ductus reuniens, and enclosed...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... associated with small nerves, both perineurally and intraneurally. Odontogenic epithelium has been reported to be neurotrophic but not all the epithelium of neuroepithelial structures is odontogenic in origin, and there are other theories of origin for the epithelium, particularly in sites where odontogenic...
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Images
Figure 6-39

SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), br...

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in Adrenal Cortical Carcinoma > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-39 SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), brain (C), and skin (a surgically excised nodule on the scalp, D) metastases from ACC. More about this image found in SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), br...
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Figure 9-1

SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distributi...

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in Paraganglia and Paragangliomas > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
SITES OF PARAGANGLIOMA DEVELOPMENT Figure 9-1 SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distribution of extra-adrenal chromaffin tissue in neonates (A) and prevalent sites of sympathetic paragangliomas reported up to 1965 (B) in a classic illustration. Arrow added More about this image found in SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distributi...
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Figure 1-15

Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the...

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in Physiology, Development, and Anatomy of the Adrenal Glands > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
Ki-67 IN FETAL ADRENAL GLAND Figure 1-15 Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the definitive zone, which is the major site of cortical cell generation. Scattered individual stained cortical cells are also present in the provisional zone, along with aggregates More about this image found in Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the...
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Figure 8-4

GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A)...

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in Pheochromocytoma and Adrenal Medullary Hyperplasia > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
metastasized to the pleura, celiac axis lymph node, and multiple skeletal sites. (Courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A)...
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Figure 12-19

PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pa...

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in Other Adrenal Neoplasms and Tumor-Like Lesions > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMARY ADRENAL MELANOMA Figure 12-19 PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pain; imaging studies revealed a right adrenal mass; the patient had no evidence of melanoma in any other site following rigorous investigation using a multidisciplinary approach. Part More about this image found in PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pa...
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Other Adrenal Neoplasms and Tumor-Like Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., or metastases to the adrenal gland from distant sites. There are also a few case reports of both endocrine and nonendocrine tumors potentially related to the adrenal gland developmentally, either by steroidogenic lineage or by proximity to the adrenogenital/gonadal ridge (see chapter 1 ). Non-neoplastic causes...
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Congenital Disorders of the Adrenal Gland

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is most often found in the upper abdomen or anywhere along the path of descent of the gonads. This anatomic localization is due to the close embryologic spatial relationship between the gonadal ridge and adrenal glands (see chapter 1 ). In rare cases, adrenal heterotopia occurs in bizarre anatomic sites...
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Book Chapter

Paraganglia and Paragangliomas

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... diagnosis of many types of tumor that occur in different parts of the body ( 10 ). SITES OF PARAGANGLIOMA DEVELOPMENT Figure 9-1 SITES OF PARAGANGLIOMA DEVELOPMENT The relationship between the distribution of extra-adrenal chromaffin tissue in neonates (A) and prevalent sites of sympathetic...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... at the time of diagnosis. Common sites of metastasis are lung, liver, and lymph nodes, and less frequently, bone ( 39 ). Systemic symptoms also may be present ( 40 ), including prominent weight loss, intermittent low-grade fever (possibly related to extensive tumor necrosis), and anorexia. Hypoglycemia...
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Book Chapter

Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...NEUROBLASTOMA AND GANGLIONEUROBLASTOMA Neuroblastoma (NBL) is a primitive neoplasm of neuroectodermal origin that arises in anatomic sites corresponding to the distribution of the sympathoadrenal autonomic nervous system. It is subdivided into three subtypes: undifferentiated, poorly...
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