RABIES VIRAL INCLUSIONS Figure 3-12 RABIES VIRAL INCLUSIONS Neurons show the round intracytoplasmic rabies viral inclusions, known as Negri bodies (arrows). More about this image found in RABIES VIRAL INCLUSIONS Neurons show the round intracytoplasmic rabies vir...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-27 SUBACUTE SCLEROSING PANENCEPHALITIS Microglial clusters at high power show central cellular debris due to cell destruction; this is known as neuronophagia if it occurs in areas of neuronal loss. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Microglial clusters at high power show...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-28 SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show more striking diffuse microgliosis than tight localized microglial clusters, as illustrated here in the cortex of an SSPE case at autopsy. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Many cases of viral encephalitis show ...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-31 SUBACUTE SCLEROSING PANENCEPHALITIS Multiple neurons (arrows) show characteristic nuclear inclusions, which can be confirmed by measles virus immunohistochemistry. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Multiple neurons (arrows) show charact...

PULMONARY COVID-19 Figure 4-10 PULMONARY COVID-19 A: Initial changes show some intra-alveolar fibrin with focal early hyaline membrane formation, scattered intra-alveolar red blood cells, and focal mild interstitial lymphocyte infiltration. B: Low-power view of patchy intra-alveolar fibrin with ... More about this image found in PULMONARY COVID-19 A: Initial changes show some intra-alveolar fibrin with...

CYTOMEGALOVIRUS (CMV) COLITIS Figure 5-17 CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon shows a patchy hemorrhagic mucosa and scattered well-circumscribed deep ulcers. (Courtesy of Dr. A. E. van der Hoven, University of Pretoria, Pretoria, South Africa) More about this image found in CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon show...

LSIL Figure 9-36 LSIL A: A normal intermediate cell is indicated (arrow). Other cells show features of LSIL with nuclear enlargement, coarse chromatin, nuclear membrane irregularities, perinuclear halo (“koilocyte”), and multinucleation (SurePath cytology, Papanicolaou stain). B: Condyloma with ... More about this image found in LSIL A: A normal intermediate cell is indicated (arrow). Other cells show ...

PNEUMOCOCCAL MENINGITIS Figure 12-4 PNEUMOCOCCAL MENINGITIS A: Gross findings show a purulent subarachnoidal exudate. (Courtesy of the CDC PHIL) B,C: Microscopy shows a dense leptomeningeal neutrophil infiltration (B) and immunohistochemical staining (C) confirms the presence of large numbers of S. pneumoniae organisms in the infiltrate. (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in PNEUMOCOCCAL MENINGITIS A: Gross findings show a purulent subarachnoidal e...

STREPTOCOCCUS PNEUMONIAE Figure 12-5 STREPTOCOCCUS PNEUMONIAE Colonies on blood agar show alpha hemolysis (A), lysis after exposure to bile (B), and lack of growth around optochin (C). More about this image found in STREPTOCOCCUS PNEUMONIAE Colonies on blood agar show alph...

STAPHYLOCOCCUS AUREUS Figure 12-15 STAPHYLOCOCCUS AUREUS Colonies show typical beta (complete) hemolysis on blood agar. More about this image found in STAPHYLOCOCCUS AUREUS Colonies show typical beta (complet...

BORRELIA SPP PATHOGENESIS Figure 15-6 BORRELIA SPP PATHOGENESIS Blue arrows show vector and bacterial factors while red arrows show host factors. More about this image found in BORRELIA SPP PATHOGENESIS Blue arrows show vector and bac...

NONTUBERCULOUS MYCOBACTERIAL COLONIES Figure 15-29 NONTUBERCULOUS MYCOBACTERIAL COLONIES Cultures show the different morphologic characteristics of nontuberculous mycobacterial colonies. (Courtesy of the CDC PHIL) More about this image found in NONTUBERCULOUS MYCOBACTERIAL COLONIES Cultures show the different morpholo...

ACANTHAMOEBA SPP Figure 25-18 ACANTHAMOEBA SPP On culture, protozoal trophozoites show bacterial engulfment. (Courtesy of the CDC PHIL) More about this image found in ACANTHAMOEBA SPP On culture, protozoal trophozoites show ...

TRICHOMONAS Figure 30-4 TRICHOMONAS Cervical cytology smears show clusters of neutrophils, reactive squamous epithelial changes (with vague perinuclear halos), and interspersed T. vaginalis organisms (arrows) (A,B). Note the nondescript appearance of the parasites against the granular smear background (C). More about this image found in TRICHOMONAS Cervical cytology smears show clusters of neu...

CREUTZFELDT-JAKOB DISEASE Figure 2-2 CREUTZFELDT-JAKOB DISEASE Whole brain specimen shows prominent cerebral and cerebellar atrophy. More about this image found in CREUTZFELDT-JAKOB DISEASE Whole brain specimen shows prominent cerebral an...

EARLY POLIOMYELITIS Figure 3-16 EARLY POLIOMYELITIS CNS histology shows hypercellularity due to microgliosis (circled). More about this image found in EARLY POLIOMYELITIS CNS histology shows hypercellularity due to microglios...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-29 SUBACUTE SCLEROSING PANENCEPHALITIS The white matter in SSPE shows vacuolization, myelin pallor, mild hypercellularity due to reactive astrocytosis, and perivascular lymphocytic cuffing; this should not be mistaken for a gemistocytic astrocytoma/neo... More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS The white matter in SSPE shows vacuoli...

JC VIRUS GRANULE CELL NEURONOPATHY Figure 3-43 JC VIRUS GRANULE CELL NEURONOPATHY Coronal T1-weighted MRI scan shows less frequent type of PML, JC virus granule cell neuronopathy. Note the severe damage to the cerebellar hemisphere (lower right of the image). More about this image found in JC VIRUS GRANULE CELL NEURONOPATHY Coronal T1-weighted MRI scan shows less...

INFLUENZA VIRUS Figure 4-1 INFLUENZA VIRUS Schematic illustration of the influenza virus, showing its antigenic structure. More about this image found in INFLUENZA VIRUS Schematic illustration of the influenza virus, showing its...

ADENOVIRUS PNEUMONITIS IN A CHILD Figure 4-12 ADENOVIRUS PNEUMONITIS IN A CHILD Autopsy specimen shows congestion and vaguely circumscribed paler areas of consolidation. (Courtesy of Dr. L. S. de Haas, University of Pretoria, Pretoria, South Africa) More about this image found in ADENOVIRUS PNEUMONITIS IN A CHILD Autopsy specimen shows congestion and va...