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Figure 1-121
Published: 01 June 2025
SPINDLE CELL/SCLEROSING RHABDOMYOSARCOMA Figure 1-121 SPINDLE CELL/SCLEROSING RHABDOMYOSARCOMA A,B: Eosinophilic tumor cells with mildly pleomorphic nuclei are arranged as alternating fascicles, resembling leiomyosarcoma. C,D: Desmin is strongly positive (C), and myogenin is typically focal (D). More about this image found in SPINDLE CELL/SCLEROSING RHABDOMYOSARCOMA A,B: Eosinophilic tumor cells wit...
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Figure 5-21
Published: 01 June 2025
SCLEROSING ODONTOGENIC CARCINOMA Figure 5-21 SCLEROSING ODONTOGENIC CARCINOMA Highly destructive osteolytic lesion of the anterior maxilla. Only one other reported case has root resorption. More about this image found in SCLEROSING ODONTOGENIC CARCINOMA Highly destructive osteolytic lesion of t...
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Figure 5-22
Published: 01 June 2025
SCLEROSING ODONTOGENIC CARCINOMA Figure 5-22 SCLEROSING ODONTOGENIC CARCINOMA Thin strands of single cells in a densely sclerotic fibrous stroma. More about this image found in SCLEROSING ODONTOGENIC CARCINOMA Thin strands of single cells in a densely...
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Figure 5-23
Published: 01 June 2025
SCLEROSING ODONTOGENIC CARCINOMA Figure 5-23 SCLEROSING ODONTOGENIC CARCINOMA Cytokeratin immunohistochemistry highlights the epithelial component. More about this image found in SCLEROSING ODONTOGENIC CARCINOMA Cytokeratin immunohistochemistry highligh...
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Figure 5-24
Published: 01 June 2025
SCLEROSING ODONTOGENIC CARCINOMA Figure 5-24 SCLEROSING ODONTOGENIC CARCINOMA Cytologically bland tumor cells with cytoplasmic clearing in a densely sclerotic stroma. More about this image found in SCLEROSING ODONTOGENIC CARCINOMA Cytologically bland tumor cells with cyto...
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Figure 7-9
Published: 01 June 2025
SCLEROSING PARAGANGLIOMA Figure 7-9 SCLEROSING PARAGANGLIOMA Some paragangliomas have dense, collagenized stroma relative to the amount of actual tumor cells. This can lead to diagnostic challenges given the similarity to other lesions. The stroma obscures the typical nested pattern More about this image found in SCLEROSING PARAGANGLIOMA Some paragangliomas have dense, collagenized stro...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... metastasis occurs infrequently, most often to lung ( 59 ). Sclerosing Odontogenic Carcinoma Definition.  Sclerosing odontogenic carcinoma (SOC) is a primary carcinoma of the jaw characterized by cytologically bland infiltrating strands of epithelium within a sclerotic fibrous stroma. General...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... by the darker brown areas here, are common. Microscopic Findings. Tumors are nodular but unencapsulated ( fig. 7-3 ). Most are circumscribed, but some are more infiltrative, occasionally with prominent, hyalinized stroma around the infiltrating nests (“sclerosing paraganglioma”) ( 24 , 25 ). The classic growth...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... are not detected. Nodular sclerosing classic Hodgkin lymphoma shows much heavier sclerosing fibrosis, as well as the characteristic Reed-Sternberg cells or lacunar cells, which are CD15 and CD30 immunoreactive. Organisms are lacking. Sarcomas are usually much more cellular, have a specific architectural...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... with dental rolls, and other sclerosing or binding/pressure remedies ( 100 , 106 , 107 , 115 , 118 ). Incision and drainage with curettage generally does not work well and is associated with infection, auricular chondritis, and further deformity. Needle aspiration alone has limited value, but is effective...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... nuclei ( figs. 6-98 , 6-99 ). However, sclerosing areas can be seen, either partially or completely, where adipocytic differentiation is absent (“sclerosing well-differentiated liposarcoma”). Mitoses are rare to absent and necrosis is not identified. Occasional lipoblasts are found, but their numbers...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma . Virchows Arch   2011 ; 459 : 117 - 8 . 124. Gnepp   DR . Salivary gland tumor “wishes” to add to the next WHO tumor classification: sclerosing polycystic adenosis, mammary analogue secretory carcinoma, cribriform adenocarcinoma...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... positive ( fig. 4-69C ). MEC variants include oncocytic, sclerosing, and Warthin-like, although these variants are uncommon in the oral cavity ( 230 ). Features of high-grade tumors are necrosis, perineural invasion, a less than 20 percent intracystic component, mitoses, and anaplasia ( 224 , 228...
Images
Figure 9-19
Published: 01 December 2024
CAROTID BODY SCLEROSING PARAGANGLIOMA Figure 9-19 CAROTID BODY SCLEROSING PARAGANGLIOMA A: Sclerosing paragangliomas have been reported as a distinct entity that can mimic infiltrating carcinoma. This sharply circumscribed example shows extensive sclerosis, which is very dense at top right. B More about this image found in CAROTID BODY SCLEROSING PARAGANGLIOMA A: Sclerosing paragangliomas have be...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... percent of cases. Sclerosis was found to correlate with hereditary tumor predisposition, and was especially associated with SDHx mutations ( 75 ). Sclerosing paraganglioma, characterized by extensive sclerosis resulting in a pseudoinfiltrative pattern of tumor cells ( fig. 9-19...
Images
Figure 3-22
Published: 01 September 2024
LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Figure 3-22 LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Whole mount section of autopsy brain shows marked atrophy, secondary ventricular enlargement (hydrocephalus ex vacuo), and mild meningeal fibrosis. Note the gaping space More about this image found in LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Whole mount secti...
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Figure 3-23
Published: 01 September 2024
SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-23 SUBACUTE SCLEROSING PANENCEPHALITIS Whole mount autopsy brain section changes several years after clinical onset of symptoms, showing the small size of the brainstem at the level of the medulla (A), compared to medulla from an age-matched control More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Whole mount autopsy brain section chan...
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Figure 3-24
Published: 01 September 2024
SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-24 SUBACUTE SCLEROSING PANENCEPHALITIS In late stages of disease, there is meningeal fibrosis and usually scanty mononuclear cells. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS In late stages of disease, there is me...
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Figure 3-25
Published: 01 September 2024
SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-25 SUBACUTE SCLEROSING PANENCEPHALITIS At autopsy, perivascular mononuclear cell cuffing (without vasculitis) is often more conspicuous than meningeal inflammation. Violaceous smudged viral inclusions can be found within neuronal nuclei (arrow More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS At autopsy, perivascular mononuclear c...
Images
Figure 3-26
Published: 01 September 2024
SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-26 SUBACUTE SCLEROSING PANENCEPHALITIS Microglial clusters (arrows) are present in the pons, a nonspecific finding that is seen in many forms of viral encephalitis. More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS Microglial clusters (arrows) are prese...