MYELOID SARCOMA (CHLOROMA) Figure 13-39 MYELOID SARCOMA (CHLOROMA) This myeloid sarcoma mimics a primary pancreatic carcinoma because it encases the pancreatic duct. More about this image found in MYELOID SARCOMA (CHLOROMA) This myeloid sarcoma mimics a primary pancreati...

EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Figure 13-35 EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Immunolabeling for CD99. More about this image found in EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Immunolabeling for CD99.

EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Figure 13-32 EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR The bulky, yellow to tan cut surface of this tumor has a multinodular periphery. More about this image found in EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR The bulky, yellow to tan cut...

EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Figure 13-33 EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR This small round blue cell neoplasm forms a solid, cellular mass of primitive and undifferentiated cells. Infiltrated pancreatic parenchyma is seen at the periphery. More about this image found in EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR This small round blue cell n...

EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR Figure 13-34 EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR On cytology, there are small round cells with uniform chromatin and inconspicuous nucleoli (H&E stain). More about this image found in EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR On cytology, there are small...

ALVEOLAR SOFT PART SARCOMA Figure 3-61 ALVEOLAR SOFT PART SARCOMA Left: The tumor typically shows a nested architecture on low-power examination. Right: At high magnification, the tumor cells are noncohesive, imparting a sac-like (alveolar) appearance. The tumor cells are large with round atypic... More about this image found in ALVEOLAR SOFT PART SARCOMA Left: The tumor typically shows a nested archit...

NTRK-REARRANGED SARCOMA Figure 3-62 NTRK-REARRANGED SARCOMA The tumor, which has a tan, fleshy appearance, involves the superficial aspect of the cervical wall and protrudes into the canal. More about this image found in NTRK-REARRANGED SARCOMA The tumor, which has a tan, flesh...

NTRK-REARRANGED SARCOMA Figure 3-63 NTRK-REARRANGED SARCOMA A: On low-power magnification, the tumor may have a variable appearance, ranging from patternless to areas with somewhat fascicular growth. B,C: The neoplastic spindle cells often surround and envelop native endocervical glands (B) and sometimes produce intraglandular polypoid projections (C). D: The tumor cell population can show variable atypia. In this example, there is only mild nuclear pleomorphism; note the prominent vascular hyalinization. E: The neoplastic cells are usually positive for S-100 protein, although the extent and intensity can be variable. F: Pan-TRK is typically diffusely positive, although this result is not specific. More about this image found in NTRK-REARRANGED SARCOMA A: On low-power magnification, th...

NTRK-REARRANGED SARCOMA Figure 3-63 NTRK-REARRANGED SARCOMA A: On low-power magnification, the tumor may have a variable appearance, ranging from patternless to areas with somewhat fascicular growth. B,C: The neoplastic spindle cells often surround and envelop native endocervical glands (B) and sometimes produce intraglandular polypoid projections (C). D: The tumor cell population can show variable atypia. In this example, there is only mild nuclear pleomorphism; note the prominent vascular hyalinization. E: The neoplastic cells are usually positive for S-100 protein, although the extent and intensity can be variable. F: Pan-TRK is typically diffusely positive, although this result is not specific. More about this image found in NTRK-REARRANGED SARCOMA A: On low-power magnification, th...

SMARC-DEFICIENT UTERINE SARCOMA Figure 3-64 SMARC-DEFICIENT UTERINE SARCOMA The tumor grows in sheets and is composed of large epithelioid cells with vesicular nuclei and prominent nucleoli. Mitoses are abundant. More about this image found in SMARC-DEFICIENT UTERINE SARCOMA The tumor grows in sheets...

COL1A1::PDGFB REARRANGED SARCOMA Figure 3-65 COL1A1::PDGFB REARRANGED SARCOMA Left: Similar to dermatofibrosarcoma protuberans (DFSP), these tumors often have storiform growth. Right: The neoplastic cells are short, spindled, and monotonous. More about this image found in COL1A1::PDGFB REARRANGED SARCOMA Left: Similar to dermato...

MYELOID SARCOMA (“CHLOROMA”) Figure 3-73 MYELOID SARCOMA (“CHLOROMA”) Left: This tumor is characterized by diffuse infiltration of the cervical wall by sheets of round cells. Right: At higher magnification, the population is composed of immature cells with a high nuclear to cytoplasmic ratio, so... More about this image found in MYELOID SARCOMA (“CHLOROMA”) Left: This tumor is characterized by diffuse ...

KAPOSI SARCOMA Figure 5-80 KAPOSI SARCOMA Left: The lesion usually has a nodular or plaque-like appearance. Right: It is formed by bland spindle cells surrounding poorly formed vessels; the stroma has slit-like spaces, associated with red blood cell extravasation and hemosiderin deposition. More about this image found in KAPOSI SARCOMA Left: The lesion usually has a nodular or plaque-like appea...

SYNOVIAL SARCOMA Figure 5-83 SYNOVIAL SARCOMA Left: This biphasic tumor contains a monomorphic spindle cell population (left aspect) admixed with a well-formed glandular component consisting of monotonous cuboidal or columnar cells (right aspect). Right: The glandular component can be extensive,... More about this image found in SYNOVIAL SARCOMA Left: This biphasic tumor contains a monomorphic spindle ...

MYELOID SARCOMA Figure 5-92 MYELOID SARCOMA There is infiltrative proliferation of cells with high nuclear to cytoplasmic ratios and dense, hyperchromatic small nuclei. Immunohistochemistry is usually required to confirm the myeloid lineage of these cells. More about this image found in MYELOID SARCOMA There is infiltrative proliferation of cells with high nuc...

CIC-REARRANGED SARCOMA Figure 5-94 CIC-REARRANGED SARCOMA Left: The cellular proliferation is arranged in sheets with scant hyalinized stroma. Right: The tumor cells have moderate amounts of pale cytoplasm and round atypical nuclei with prominent nucleoli. More about this image found in CIC-REARRANGED SARCOMA Left: The cellular proliferation i...

MYOEPITHELIAL-LIKE TUMOR Figure 5-78 MYOEPITHELIAL-LIKE TUMOR This vulvar neoplasm associated with SMARCB1 loss is well circumscribed but contains a similar epithelioid population as seen in SMARCB1-deficient sarcomas. In this example the epithelioid cells are organized in a vaguely storiform arr... More about this image found in MYOEPITHELIAL-LIKE TUMOR This vulvar neoplasm associated with SMARCB1 loss...