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Images
Published: 01 September 2024
KAPOSI SARCOMA Figure 8-16 KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous characteristic violaceous plaques. (Courtesy of L. M. Gomez, Department of Dermatology, Pontifica Bolivariana University, Medellín, Colombia) B: Palatal mucosa with KS lesions. (Courtesy of the C... More about this image found in KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous ...
Images
Published: 01 September 2024
KAPOSI SARCOMA Figure 8-20 KAPOSI SARCOMA Strong diffuse endothelial marker positivity, including CD34 (illustrated), is typical of Kaposi sarcoma. More about this image found in KAPOSI SARCOMA Strong diffuse endothelial marker positivity, including CD3...
Images
Published: 01 September 2024
MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Figure 8-24 MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient with HIV where there is HHV8-associated Kaposi sarcoma (A) and Castleman disease (B). More about this image found in MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient wi...
Images
Published: 01 September 2024
PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA Figure 8-17 PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA The dermis appears “busy,” with a subtle vasoformative proliferation composed of somewhat jagged vessels, usually most obvious in the vicinity of native blood vessels and skin appendages. More about this image found in PATCH STAGE OF CUTANEOUS KAPOSI SARCOMA The dermis appears “busy,” with a ...
Images
Published: 01 September 2024
PLAQUE STAGE KAPOSI SARCOMA Figure 8-18 PLAQUE STAGE KAPOSI SARCOMA The early haphazard spindle cell proliferation, extravasated erythrocytes, and abundant extracellular and intracellular hyaline globules, representing effete red blood cells (arrows), are seen at high power. More about this image found in PLAQUE STAGE KAPOSI SARCOMA The early haphazard spindle cell proliferation...
Images
Published: 01 September 2024
EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA Figure 8-19 EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell proliferation with slit-like spaces, some containing erythrocytes. Note the cellular appearance and relatively scant mitotic activity. More about this image found in EARLY NODULAR STAGE OF CUTANEOUS KAPOSI SARCOMA There is a spindle cell pr...
Images
Published: 01 September 2024
KAPOSI SARCOMA Figure 8-21 KAPOSI SARCOMA HHV8 latency-associated nuclear antigen (LANA) immunohistochemical assay shows typical punctate nuclear staining. More about this image found in KAPOSI SARCOMA HHV8 latency-associated nuclear antigen (LANA) immunohistoc...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... predominant transmission via saliva. The virus was first identified and also noted to resemble other herpesviruses in 1964 by Epstein, Achong, and Barr, in their search for an etiologic pathogen of cases of “jaw sarcoma” in African patients collected by Denis P. Burkitt ( 14 ). Epidemiology It is estimated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-20
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... number of yeasts. Inflammatory pseudotumors consisting of histiocytic and myofibroblastic cells with interspersed collagen and fungal yeasts have been documented in incompletely treated patients (especially those with HIV) and can histologically mimic a sarcoma ( fig. 20-7 ) ( 14 ). CRYPTOCOCCAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... The syndrome included weight loss, respiratory distress, pneumocystis pneumonia, cryptococcal meningitis, Kaposi sarcoma, and other signs of immune suppression ( 1 ). This new disease was initially referred to as gay-related immune deficiency syndrome (GRIDS) and seemed to cause death by destroying the immune...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... sarcoma virus (KSHV or HHV8, discussed in chapter 7 ). The name herpes is derived from the Greek word for crawl or creep and early descriptions of the disease have been ascribed to Hippocrates ( 1 ). All human herpesviruses have a similar structure and consist of four layers: the core (containing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... (tuberculosis or leprosy), and parasites, as well as neoplasms such as primary cutaneous malignancies (epithelial, hematolymphoid, and mesenchymal tumors, including lymphoma and Kaposi sarcoma) and skin metastases. Pathologic Findings Excised skin lesions usually grossly reveal nodular gray to tan tissue...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 53-1 GENES IMPLICATED IN CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA MDM2 CDKN2A/B PDGFRA PDGFRB EGFR PIK3CA ACOX2 FH CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch55
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...PULMONARY ARTERY INTIMAL SARCOMA: RADIOLOGIC FEATURES Figure 55-1 PULMONARY ARTERY INTIMAL SARCOMA: RADIOLOGIC FEATURES This computerized tomography (CT) angiogram shows a luminal filling defect (yellow arrow) extending from the main pulmonary artery (PA) into the left pulmonary artery (Ao...
Images
Published: 01 February 2024
DERMAL CLEAR CELL SARCOMA Figure 15-9 DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates the appearance of a nodular melanoma, but molecular analysis revealed a EWSR1-ATF1 gene fusion. More about this image found in DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-like melanoma Neurotropic and/or desmoplastic melanoma Spitzoid melanoma Nevoid melanoma Misc. primary malignant tumors with neurocristic/melanocytic differentiation Clear cell sarcoma Dermal melanocytic tumor with CRTC1-TRIM11 fusion Metastatic melanoma...
Images
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nonmelanocytic neoplasms. Depending on the diagnostic problem (e.g., metastatic melanoma versus poorly differentiated carcinoma, lymphoma, or sarcoma) a set of antibodies to melanocytic differentiation antigens, as well as epithelial, lymphoid, and mesenchymal markers, may be necessary for a precise diagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... cell cytologic features, simulating a primitive small round cell sarcoma or neuroendocrine carcinoma ( 4 , 5 ). Mitotic figures and apoptotic bodies are common in small cell melanoma. A diagnostic error is unlikely if there is associated melanoma in situ, but there is potential for confusion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Acral nevus Acral lentigo Clear cell sarcoma Molecular Genetic Findings Genomic complexity common BRAF, NRAS, NF1, TERT mutations less common than in sun-exposed melanomas ACRAL MELANOMA Figure 14-1 ACRAL MELANOMA A: There is a large pigmented patch on the heel. B...
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