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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 53-1 GENES IMPLICATED IN CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA MDM2 CDKN2A/B PDGFRA PDGFRB EGFR PIK3CA ACOX2 FH CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch55
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...PULMONARY ARTERY INTIMAL SARCOMA: RADIOLOGIC FEATURES Figure 55-1 PULMONARY ARTERY INTIMAL SARCOMA: RADIOLOGIC FEATURES This computerized tomography (CT) angiogram shows a luminal filling defect (yellow arrow) extending from the main pulmonary artery (PA) into the left pulmonary artery (Ao...
Images
DERMAL CLEAR CELL <span class="search-highlight">SARCOMA</span>  There is a nodule in the dermis, which simulates...
Published: 01 February 2024
DERMAL CLEAR CELL SARCOMA Figure 15-9 DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates the appearance of a nodular melanoma, but molecular analysis revealed a EWSR1-ATF1 gene fusion. More about this image found in DERMAL CLEAR CELL SARCOMA There is a nodule in the dermis, which simulates...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-like melanoma   Neurotropic and/or desmoplastic melanoma   Spitzoid melanoma   Nevoid melanoma  Misc. primary malignant tumors with neurocristic/melanocytic differentiation   Clear cell sarcoma   Dermal melanocytic tumor with CRTC1-TRIM11 fusion  Metastatic melanoma...
Images
UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nonmelanocytic neoplasms. Depending on the diagnostic problem (e.g., metastatic melanoma versus poorly differentiated carcinoma, lymphoma, or sarcoma) a set of antibodies to melanocytic differentiation antigens, as well as epithelial, lymphoid, and mesenchymal markers, may be necessary for a precise diagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... cell cytologic features, simulating a primitive small round cell sarcoma or neuroendocrine carcinoma ( 4 , 5 ). Mitotic figures and apoptotic bodies are common in small cell melanoma. A diagnostic error is unlikely if there is associated melanoma in situ, but there is potential for confusion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Acral nevus  Acral lentigo  Clear cell sarcoma Molecular Genetic Findings  Genomic complexity common  BRAF, NRAS, NF1, TERT mutations less common than in sun-exposed melanomas ACRAL MELANOMA Figure 14-1 ACRAL MELANOMA A: There is a large pigmented patch on the heel. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... distinction from scars and fibromas ( 16 ). They are also invaluable for the distinction of amelanotic DM (pure or mixed) from other spindle cell carcinomas and sarcomas. DESMOPLASTIC MELANOMA Figure 16-9 DESMOPLASTIC MELANOMA A: Amelanotic invasive spindle cell proliferation. B: The tumor cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are positive for BRAFV 600E or NRAS or diffusely express PRAME or HMB-45. AST versus Clear Cell Sarcoma versus Other Tumors. On occasion, a clear cell sarcoma (CCS) populates the epidermis and simulates the appearance of a Spitz tumor ( 51 ). Cytogenetic or mRNA sequence studies documenting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... analysis using a break-apart probe for EWSR1 can be used to distinguish them from clear cell sarcoma. Differential Diagnosis.  Blue Nevus versus Melanocytosis. Histopathologically, the common BN differs from melanocytosis by a greater concentration of melanocytes and associated stromal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... neurovascular bundles. LMM needs to be distinguished from LM colliding with other tumors, such as atypical fibroxanthoma, pleomorphic dermal sarcoma, or poorly differentiated carcinoma. Ancillary studies are usually necessary to exclude a collision scenario from an amelanotic pleomorphic or undifferentiated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-12
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... these entities when located elsewhere than is available about them in the breast. PRIMARY BREAST SARCOMAS General Features. With the single exception of angiosarcoma (discussed in chapter 11 ), primary sarcomas of the breast are vanishingly rare. Indeed, it is imperative that metaplastic carcinoma...
Images
CARDIAC SYNOVIAL <span class="search-highlight">SARCOMA</span>: BIPHASIC TYPE  Left: Biphasic synovial <span class="search-highlight">sarcoma</span> wi...
Published: 15 November 2023
CARDIAC SYNOVIAL SARCOMA: BIPHASIC TYPE Figure 56-13 CARDIAC SYNOVIAL SARCOMA: BIPHASIC TYPE Left: Biphasic synovial sarcoma with scattered epithelioid cells forms glandular structures in a background of malignant spindle cells. Right: This biphasic synovial sarcoma has a predominately epithelio... More about this image found in CARDIAC SYNOVIAL SARCOMA: BIPHASIC TYPE Left: Biphasic synovial sarcoma wi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... sarcomas of the breast (other than angiosarcoma) are so rare that it is thought that many of the reported cases represent examples of metaplastic carcinoma with heterologous mesenchymal differentiation rather than primary sarcomas ( 44 ). The characteristic features, immunoprofile, and molecular genetics...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-09
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... are primary breast carcinomas. Typical primary tumor types include lymphoma, rhabdomyosarcoma, medulloblastoma, neuroblastoma, medullary carcinoma of the thyroid gland, and Ewing sarcoma/primitive neuroectodermal tumor ( 33 ). Alveolar rhabdomyosarcoma appears to have a particular propensity to metastasize...
Images
CARDIAC SYNOVIAL <span class="search-highlight">SARCOMA</span>  The cellularity is uniform and in a vascular stro...
Published: 15 November 2023
CARDIAC SYNOVIAL SARCOMA Figure 56-11 CARDIAC SYNOVIAL SARCOMA The cellularity is uniform and in a vascular stroma that mimics angiosarcoma, although the cells of synovial sarcoma are more monomorphic than those seen with other sarcomas. More about this image found in CARDIAC SYNOVIAL SARCOMA The cellularity is uniform and in a vascular stro...
Images
AORTIC INTIMAL <span class="search-highlight">SARCOMA</span>  The tumor forms a near-perfect cast of the aortic a...
Published: 15 November 2023
AORTIC INTIMAL SARCOMA Figure 55-10 AORTIC INTIMAL SARCOMA The tumor forms a near-perfect cast of the aortic arch in this endarterectomy specimen, with extension into the arch vessels. The sarcoma itself has a gelatinous quality and was causing almost total obstruction. More about this image found in AORTIC INTIMAL SARCOMA The tumor forms a near-perfect cast of the aortic a...
Images
PERICARDIAL METASTASIS  Metastatic clear cell <span class="search-highlight">sarcoma</span> fills the pericardial...
Published: 15 November 2023
PERICARDIAL METASTASIS Figure 27-2 PERICARDIAL METASTASIS Metastatic clear cell sarcoma fills the pericardial space and likely involves the posterior myocardium. More about this image found in PERICARDIAL METASTASIS Metastatic clear cell sarcoma fills the pericardial...
Images
METASTASIS BY VENOUS EXTENSION  Osteogenic <span class="search-highlight">sarcoma</span> metastasized from the de...
Published: 15 November 2023
METASTASIS BY VENOUS EXTENSION Figure 52-4 METASTASIS BY VENOUS EXTENSION Osteogenic sarcoma metastasized from the deep leg veins through the inferior vena cava and is now within the right ventricle (RV) forming a tumor embolus (yellow arrow). More about this image found in METASTASIS BY VENOUS EXTENSION Osteogenic sarcoma metastasized from the de...