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retinoblastoma

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of a so-called small blue round cell tumor, where the differential diagnosis includes lymphoblastic lymphoma, rhabdomyosarcoma, Ewing sarcoma and related sarcoma types, and in rare instances, Wilms tumor, desmoplastic round cell tumor, medulloblastoma, synovial sarcoma, retinoblastoma, small cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the inhibition of apoptosis. The E7 proteins interact with the host tumor suppressor retinoblastoma (Rb) protein, resulting in the release of Rb-bound E2F transcription factor and other proteins. This allows cell proliferation by activation of cyclins A and E. E7 also blocks two cyclin-dependent kinase...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of expression of menin, the protein product of MEN1, is found in about 40 percent of PanNETs, with generally concordant expression in primary and metastatic foci ( 267 ). Expression of retinoblastoma 1 (Rb1) is retained in most PanNETs ( 233 ). There is abnormal expression of p53 in only 3 to 4 percent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-2
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... and E7 inactivate the retinoblastoma protein (Rb1). Interpretation of p16 staining requires attention to whether the staining is present in both nucleus and cytoplasm, and whether the staining is localized, heterogeneous, or diffuse in distribution. In the lower female genital tract, p16 is used...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
...: clinicopathologic analysis of 13 cases . Am J Surg Pathol   2010 ; 34 : 707 – 14 . 300. Chen   BJ , Mariño-Enríquez   A , Fletcher   CD , Hornick   JL . Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-10
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... of the testis, although alveolar rhabdomyosarcoma ( 23 , 24 ), embryonal rhabdomyosarcoma ( fig. 10-19 ) ( 25 ), medulloblastoma ( 24 ), retinoblastoma ( 5 ), and others may also be seen. In one study almost 4 percent of males with neuroblastoma had testicular metastases ( 26 ). EMBRYONAL RHABDOMYOSARCOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases . Am J Surg Pathol   2010 ; 34 : 707 - 14 . 318. Chen   BJ , Mariño-Enríquez   A , Fletcher   CD , Hornick   JL . Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... suppressor of T-cell activation (VISTA), in epithelioid subtypes; VISTA gene expression is also assessable using immunohistochemistry ( 220 ). CDKN2A is a critical tumor suppressor gene that controls the cell cycle in the retinoblastoma pathway. Loss of its protein product, p16...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-02
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... Osteosarcoma Retinoblastoma Retinoblastoma AD RB1 180200 Osteosarcoma Baller-Gerold syndrome Craniosynostosis, radial aplasia AR RECQL4 218600 Osteosarcoma RAPADILINO syndrome Radial and patellar aplasia, absent thumb, dislocation of joints, facial features, cleft palate...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 9
Published: 01 November 2021
10.55418/9781933477176-3
ISBN-10: 1-933477-17-2
ISBN: 978-1-933477-17-6
... , Tsukamoto   K , Tochigi   H . Leiomyosarcoma of the bladder eighteen years after cyclophosphamide therapy for retinoblastoma . Urol Int   1993 ; 51 : 49 - 53 . 781. Young   RH , Proppe   KH , Dickersin   GR , Scully   RE . Myxoid leiomyosarcoma of the urinary bladder . Arch...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-05
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... or environmental cause. A minority of tumors develops in the setting of a genetic cancer predisposition syndrome such as Li-Fraumeni syndrome, hereditary retinoblastoma, Rothmund-Thompson type 2, Werner syndrome, Bloom syndrome, RAPADILINO syndrome, Baller-Gerold syndrome, OSLAM syndrome, hereditary familial...
Images
EXTRAOCULAR EXTENSION OF <span class="search-highlight">RETINOBLASTOMA</span>  Extension of <span class="search-highlight">retinoblastoma</span> in the...
Published: 01 February 2021
EXTRAOCULAR EXTENSION OF RETINOBLASTOMA Figure 9-24 EXTRAOCULAR EXTENSION OF RETINOBLASTOMA Extension of retinoblastoma in the stroma of conjunctiva and some intralymphatic tumor. Empty spaces represent silicon oil filtered from the intraocular space into the stroma (silicon oil was used during v... More about this image found in EXTRAOCULAR EXTENSION OF RETINOBLASTOMA Extension of retinoblastoma in the...
Images
<span class="search-highlight">RETINOBLASTOMA</span>: IMMUNOHISTOCHEMISTRY  A: Synaptophysin antibody is an excel...
Published: 01 February 2021
RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY Figure 9-21 RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY A: Synaptophysin antibody is an excellent marker for retinoblastoma because it stains the cytoplasm of the tumor cells consistently (compare staining in the tumor at the top with staining in the underlying retina). Synaptophysin highlights the synaptic regions of the retina and the outer segments of rod-type photoreceptors. B: Retinoblastoma protein is negative. The RB gene is mutated and not producing the protein. C: The retina in a patient with sporadic retinoblastoma shows positive nuclear staining with RB protein antibody. More about this image found in RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY A: Synaptophysin antibody is an excel...
Images
ANTERIOR CHAMBER INVASION BY <span class="search-highlight">RETINOBLASTOMA</span>  A: Cut surface of the eye with...
Published: 01 February 2021
ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA Figure 9-30 ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA A: Cut surface of the eye with retinoblastoma that has invaded the anterior chamber (AC), angle (*) posterior chamber (between iris and ciliary body [CB]), and anterior vitreous. B: Histologic cor... More about this image found in ANTERIOR CHAMBER INVASION BY RETINOBLASTOMA A: Cut surface of the eye with...
Images
<span class="search-highlight">RETINOBLASTOMA</span> WITH POST-LAMINAR OPTIC NERVE INVASION  Left: The optic nerv...
Published: 01 February 2021
RETINOBLASTOMA WITH POST-LAMINAR OPTIC NERVE INVASION Figure 10-12 RETINOBLASTOMA WITH POST-LAMINAR OPTIC NERVE INVASION Left: The optic nerve is diffusely infiltrated by retinoblastoma in all the segments: optic nerve head or prelaminar, laminar (LC) and post-laminar nerve. The nerve expands tow... More about this image found in RETINOBLASTOMA WITH POST-LAMINAR OPTIC NERVE INVASION Left: The optic nerv...
Images
ROSETTES: <span class="search-highlight">RETINOBLASTOMA</span> VS RETINAL DYSPLASIA  Left: The rosettes of retino...
Published: 01 February 2021
ROSETTES: RETINOBLASTOMA VS RETINAL DYSPLASIA Figure 9-14 ROSETTES: RETINOBLASTOMA VS RETINAL DYSPLASIA Left: The rosettes of retinoblastoma are arranged in ringlets that are only one cell layer deep. Right: The rosettes of retinal dysplasia are more than one cell layer thick. In heterotopic bra... More about this image found in ROSETTES: RETINOBLASTOMA VS RETINAL DYSPLASIA Left: The rosettes of retino...
Images
<span class="search-highlight">RETINOBLASTOMA</span>: SUBRETINAL TUMOR SEEDS  A: Enucleated eye after removal of ...
Published: 01 February 2021
RETINOBLASTOMA: SUBRETINAL TUMOR SEEDS Figure 9-10 RETINOBLASTOMA: SUBRETINAL TUMOR SEEDS A: Enucleated eye after removal of the superior calotte shows total retinal detachment (R) with subretinal fluid/exudate (*) and a retinoblastoma growing from the retina into the subretinal space (right). B... More about this image found in RETINOBLASTOMA: SUBRETINAL TUMOR SEEDS A: Enucleated eye after removal of ...
Images
DIFFERENTIATION IN <span class="search-highlight">RETINOBLASTOMA</span>  A: Flexner-Wintersteiner rosettes, typic...
Published: 01 February 2021
DIFFERENTIATION IN RETINOBLASTOMA Figure 9-15 DIFFERENTIATION IN RETINOBLASTOMA A: Flexner-Wintersteiner rosettes, typically seen in retinoblastoma, are composed of neoplastic cells with long cytoplasmic processes that converge upon a central lumen. The lumen appears to be bordered by basement me... More about this image found in DIFFERENTIATION IN RETINOBLASTOMA A: Flexner-Wintersteiner rosettes, typic...
Images
<span class="search-highlight">RETINOBLASTOMA</span>: CYTOPATHOLOGIC FEATURES  Left: Touch imprint of retinoblast...
Published: 01 February 2021
RETINOBLASTOMA: CYTOPATHOLOGIC FEATURES Figure 9-17 RETINOBLASTOMA: CYTOPATHOLOGIC FEATURES Left: Touch imprint of retinoblastoma shows the presence of medium-sized cells with scant cytoplasm and hyperchromatic nuclei featuring salt and pepper type chromatin. A mitosis (circle) is easily found in... More about this image found in RETINOBLASTOMA: CYTOPATHOLOGIC FEATURES Left: Touch imprint of retinoblast...
Images
IRIS NEOVASCULARIZATION AND NEOVASCULAR GLAUCOMA IN <span class="search-highlight">RETINOBLASTOMA</span>  Left: A...
Published: 01 February 2021
IRIS NEOVASCULARIZATION AND NEOVASCULAR GLAUCOMA IN RETINOBLASTOMA Figure 9-16 IRIS NEOVASCULARIZATION AND NEOVASCULAR GLAUCOMA IN RETINOBLASTOMA Left: An eye with retinoblastoma (posterior to the lens) and anterior synechia, adhesions of the iris (*) to the cornea. A neovascular membrane, not vi... More about this image found in IRIS NEOVASCULARIZATION AND NEOVASCULAR GLAUCOMA IN RETINOBLASTOMA Left: A...