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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... as of the trigeminal nerve (periorbital region, forehead, temple, cheek, and nose), as well as conjunctiva, retina, periorbital soft tissue, and nasal mucosa. The condition usually presents unilaterally at birth or in childhood, but delayed onset in adolescence may occur. Approximately 0.01 to 0.03 percent of Asians...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch42
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... changes of the retina) a Table 1 from reference 48 . b The diagnosis is established with 2 major criteria + 1 minor criterion or 1 major criterion + 3 minor criteria. CARDIAC FIBROMA: MAGNETIC RESONANCE IMAGING Figure 42-1 CARDIAC FIBROMA: MAGNETIC RESONANCE IMAGING This large cardiac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Lindau   A . Studien Uber Kleinhirncysten. Bau, Pathogenese und Beziehungen zur Angiomatosis Retinae . Acta Pathol Microbiol Scand   1926 ; 1 : 1 - 128 . 9. Compagno   J , Oertel   JE . Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... microtumors, other tumors von Hippel-Lindau syndrome VHL Pancreatic microtumors and/or PanNETs, duodenal microtumors, SCNs Hemangioblastomas (CNS, retina, peripheral nerve), kidney (clear cell RCC), pheochromocytomas and paragangliomas, epididymal tumors, other tumors Neurofibromatosis type...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... literature, many as single case reports ( 146 – 154 ). MNTI is considered of neural crest origin and exhibits both neuroblastic and retinal-like epithelial differentiation that resembles the retinal pigmented epithelium and recapitulates the early embryologic development of the retina. The pathogenesis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch09
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
...ANATOMY AND HISTOLOGY Of the three coats of the eye (corneoscleral, uveal, and retinal), the retina is the inner-most and represents the neurosensory layer. The retina is located in the posterior portion of the eye and lies between the gelatinous vitreous body and the choroid, the vascular layer...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-11
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... ). It is suggested to represent a dysembryogenic neoplasm that recapitulates the retina at 5 weeks of gestation ( 62 ). It has previously been referred to by a variety of names including congenital melanoma, melanotic adamantinoma, retinal anlage tumor, melanotic progonoma, and pigmented epulis of infancy. Clinical...
Images
SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY <span class="search-highlight">RETINA</span>  Start...
Published: 01 February 2021
SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Figure 8-3 SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Starting from the bottom of the figure, first seen is the densely eosinophilic sclera. The loose fibrovascular connective tissue between the sclera ... More about this image found in SCLERA, CHOROID, RETINAL PIGMENT EPITHELIUM, AND NEUROSENSORY RETINA Start...
Images
MACROSCOPIC ANATOMY AND HISTOLOGY OF THE <span class="search-highlight">RETINA</span>  Left: Macroscopic view und...
Published: 01 February 2021
MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Figure 9-1 MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Left: Macroscopic view under stereoscopic dissecting microscope. Note the inner most portion the transparent translucent vitreous body, the white translucent neurosensory retina with the red... More about this image found in MACROSCOPIC ANATOMY AND HISTOLOGY OF THE RETINA Left: Macroscopic view und...
Images
ASTROCYTOMA OF THE <span class="search-highlight">RETINA</span>  There are fascicles of cytologically bland spind...
Published: 01 February 2021
ASTROCYTOMA OF THE RETINA Figure 9-31 ASTROCYTOMA OF THE RETINA There are fascicles of cytologically bland spindle-shaped astrocytes in a loose background. The cells have abundant eosinophilic cytoplasm and no atypia. This area was seen in the inner layers of the retina (nerve fiber layer expande... More about this image found in ASTROCYTOMA OF THE RETINA There are fascicles of cytologically bland spind...
Images
HEMANGIOBLASTOMA OF THE <span class="search-highlight">RETINA</span>  Left: Capillary sized vessels depicted here...
Published: 01 February 2021
HEMANGIOBLASTOMA OF THE RETINA Figure 9-32 HEMANGIOBLASTOMA OF THE RETINA Left: Capillary sized vessels depicted here by CD31 stain are surrounded by bland-appearing stromal cells. Right: Stromal cells are distinctive for vacuolated cytoplasm and small nuclei alternating with other cells without the vacuoles, all surrounding vessels. Approximately 50 percent of VHL affected patients develop retinal hemangioblastoma ( 34 ). More about this image found in HEMANGIOBLASTOMA OF THE RETINA Left: Capillary sized vessels depicted here...
Images
COMBINED HAMARTOMA OF THE <span class="search-highlight">RETINA</span> AND RETINAL PIGMENT EPITHELIUM (CHR-RPE)  ...
Published: 01 February 2021
COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM (CHR-RPE) Figure 9-34 COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM (CHR-RPE) Glial and retinal tissue and single cells, cords, and tubules of retinal pigment epithelium (RPE) form this mass located adjacent to the ... More about this image found in COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM (CHR-RPE) ...
Images
PRIMARY VITREORETINAL LYMPHOMA  A: The <span class="search-highlight">retina</span> is infiltrated by large lymph...
Published: 01 February 2021
PRIMARY VITREORETINAL LYMPHOMA Figure 11-2 PRIMARY VITREORETINAL LYMPHOMA A: The retina is infiltrated by large lymphoma cells with extensive necrosis of outer layers (bottom) and retinal pigment epithelium (pigmented cells). B: Mostly necrotic retina with perivascular viable large lymphoma cell... More about this image found in PRIMARY VITREORETINAL LYMPHOMA A: The retina is infiltrated by large lymph...
Images
RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY  A: Synaptophysin antibody is an excel...
Published: 01 February 2021
RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY Figure 9-21 RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY A: Synaptophysin antibody is an excellent marker for retinoblastoma because it stains the cytoplasm of the tumor cells consistently (compare staining in the tumor at the top with staining in the underlying retina). Synaptophysin highlights the synaptic regions of the retina and the outer segments of rod-type photoreceptors. B: Retinoblastoma protein is negative. The RB gene is mutated and not producing the protein. C: The retina in a patient with sporadic retinoblastoma shows positive nuclear staining with RB protein antibody. More about this image found in RETINOBLASTOMA: IMMUNOHISTOCHEMISTRY A: Synaptophysin antibody is an excel...
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COATS DISEASE  A: A sectioned eye with Coats disease features an extensive ...
Published: 01 February 2021
COATS DISEASE Figure 9-22 COATS DISEASE A: A sectioned eye with Coats disease features an extensive subretinal proteinaceous exudate (*) with small shiny cholesterol crystals and tan-yellow material (hemorrhage) in the most anterior portion of the exudate. The insert shows the leukocoria/ xanthoc... More about this image found in COATS DISEASE A: A sectioned eye with Coats disease features an extensive ...
Images
POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA  A: <em>Top left:</em>...
Published: 01 February 2021
POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA Figure 9-23 POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA A: Top left: Systemic chemotherapy produces regression of the tan-gray lesion (RT) with large chunky calcifications (Ca++). In this eye there are also chorioretinal scars (circle) left by local treatment (laser or cryotherapy). A, top right: histopathology of the regressed tumor (RT) shows a retinocytoma-like lesion with neuronal or photoreceptor differentiation and an absence of mitoses or apoptosis. A, bottom left: chunky large calcifications (Ca++) in the regressed tumor. A, bottom right: histopathology of the same area with large chunky calcifications (Ca++) in a gliotic tissue. B: Radiotherapy effect in an eye with retinoblastoma. B, top left: the pupil-optic nerve section of this eye with a regressed tumor (RT) features calcifications and a funnel-shaped, totally detached retina at the center. B, bottom left: postradiation treatment shows areas of vitreous, retinal, and subretinal hemorrhages (*) with a detached retina and extensively calcified tumor (Ca++). B, right panel: epiretinal and tumor neovascular membrane. C: Effects after intra-arterial chemotherapy. C, left panel: gross photograph of a chorioretinal scar with RPE migration into the retina. C, right panel: histologic section of the same area with the RPE migration encircled. In eyes that have undergone local therapy, including laser photocoagulation, cryotherapy, or plaque radiation, large areas of chorioretinal scarring with RPE dispersion and proliferation into the retina are seen. Retinal atrophy and gliotic attachment to the RPE layer. D: A mostly regressed tumor with several multinucleated foreign body type cells (arrows) with fiber-like blue-gray material in the cytoplasm. D, top right: high-power view of a foreign body-type giant cell in the choroid. D, bottom right: polarization discloses birefringent polarizable foreign material (arrow). More about this image found in POST-TREATMENT EFFECT IN EYES WITH RETINOBLASTOMA A: Top left:...
Images
RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS  A: Central pupil-optic nerve section...
Published: 01 February 2021
RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS Figure 9-7 RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS A: Central pupil-optic nerve section of an eye with endophytic retinoblastoma that grows from the retina into the vitreous and seeds the head of the optic nerve with tumor. B: High magnification of an endophyt... More about this image found in RETINOBLASTOMA: DUST-TYPE TUMOR SEEDS A: Central pupil-optic nerve section...
Images
SECONDARY INVOLVEMENT OF THE UVEAL TRACT  The ciliary body (CB), choroid (C...
Published: 01 February 2021
SECONDARY INVOLVEMENT OF THE UVEAL TRACT Figure 11-13 SECONDARY INVOLVEMENT OF THE UVEAL TRACT The ciliary body (CB), choroid (Ch), and retina are involved by non-Hodgkin B-cell chronic lymphocytic leukemia/chronic lymphocytic lymphoma with extraocular extension into the inferior oblique muscle (... More about this image found in SECONDARY INVOLVEMENT OF THE UVEAL TRACT The ciliary body (CB), choroid (C...
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INTERIOR OF THE EYE  A: Cutting the first calotte allows the pathologist to...
Published: 01 February 2021
INTERIOR OF THE EYE Figure 1-8 INTERIOR OF THE EYE A: Cutting the first calotte allows the pathologist to visualize the interior of the eye. At the top, the cornea, anterior chamber, and lens are without pathologic alteration. The pathology appears in the posterior portion of the eye with a detac... More about this image found in INTERIOR OF THE EYE A: Cutting the first calotte allows the pathologist to...
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HISTOLOGY OF THE OPTIC NERVE  A: Axons of the ganglion cells located in the...
Published: 01 February 2021
HISTOLOGY OF THE OPTIC NERVE Figure 10-2 HISTOLOGY OF THE OPTIC NERVE A: Axons of the ganglion cells located in the ganglion cell layer (GCL) of the retina continue into the optic nerve. In the GCL, there are also astrocytes surrounding vessels and extending into the nerve fiber layer (NFL), seen... More about this image found in HISTOLOGY OF THE OPTIC NERVE A: Axons of the ganglion cells located in the...