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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-33 ACINAR CELL CARCINOMA Treatment-related changes include fibrosis and aggregates of foamy histiocytes. More
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in Embryology and Anatomy of the Lower Female Genital Tract
> Tumors of the Cervix, Vagina, and Vulva
Published: 01 February 2023
SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX Figure 1-4 SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX SCJ-associated high-grade squamous intraepithelial lesion (A). SCJ-associated adenocarcinoma in situ (B), and isolated adenocarcinoma in... More
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... younger patients (under 35 years) tend to have an inherited genetic etiology ( 3 , 5 ). Chronic pancreatitis has various etiologies. As stated, most cases in the Western world are associated with long-term alcohol abuse, and usually also cigarette smoking ( 3 , 5 ). Less common causes are related...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... percent present with distant metastases ( 5 ). Traditionally, PanNETs are separated into functioning (i.e., syndromic) and nonfunctioning (i.e., nonsyndromic) groups based upon the occurrence of a clinical syndrome related to the secretion of hormones by the neoplasm ( 6 ). Functioning PanNETs are defined...
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Published: 01 February 2023
SEBACEOUS CELL CARCINOMA Figure 5-38 SEBACEOUS CELL CARCINOMA Similar to basaloid squamous cell carcinoma, this tumor has a predominant nested and basaloid epithelial cell population (A); vacuolated cells (aka sebocytes), which are appreciable at higher magnification, help establish the diagnosis... More
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Published: 01 February 2023
HPV-ASSOCIATED ADENOCARCINOMA, MUCINOUS TYPE Figure 3-41 HPV-ASSOCIATED ADENOCARCINOMA, MUCINOUS TYPE In this tumor type, most cells (50% or more) contain intracytoplasmic mucin. Mucin can be of endocervical-type (left) or feature intestinal differentiation (right). Rarely, signet ring cell morph... More
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... is present within the cysts. Hypercellular stroma of the type found in mucinous cystic neoplasms is not found in lymphangiomas. The lymphatic endothelial lining cells immunolabel for CD31, factor VIII-related antigen, ERG, and D2-40. Negative markers include calretinin and pancytokeratin, while CD34 is often...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ). Similar to the related entity pancreatoblastoma, some cases of acinar cell carcinoma have occurred in patients with familial adenomatous polyposis ( 43 , 44 ), supporting a genetic relationship between these entities, although the Beck-with-Wiedemann syndrome, which is also associated...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of pancreatic cancer ( 70 , 72 , 79 , 101 – 103 ). The ATM gene codes for a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) family. The protein functions in DNA damage repair and also has functions activated by oxidative stress ( 104 – 106 ). Germline mutations in the p16...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... lymphatics. The interlobular lymphatics may travel with or independent of blood vessels ( 94 ). Approximately 55 percent of interlobular lymphatics are closely related to the accompanying artery and vein, 25 percent are separated from other structures by a significant amount of connective tissue, and 20...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-11
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... neoplasm) ( 32 – 36 ), pancreas divisum ( 37 ), situs inversus ( 38 ), urogenital abnormalities ( 39 , 40 ), congenital diaphragmatic (Bochdalaek) hernia ( 41 ), sickle cell trait ( 42 ), autoimmune (IgG4-related) pancreatitis ( 43 ), and neutrophilic dermatosis secondary to granulocyte colony stimulating...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... as well as WNT pathway effector genes. Overexpression of IGF2, cell cycle-related genes, and stem cell regulator genes is also observed ( 27 , 33 ). Pancreatic multipotent progenitor cells and human embryonic stem cells have similar gene expression profiles to pancreatoblastoma, supporting...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ( 52 ). The background pancreatic tissue can show PanIN or even an intraductal papillary mucinous neoplasm ( 53 ), and ducts with mucinous epithelium can be closely related to the neoplastic serous cysts, especially in the macrocystic variant, which is less sharply circumscribed. Immunohistochemical...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... presentation of patients with main duct IPMNs is usually related to intermittent obstruction of the pancreatic duct caused by the tenacious mucin and/or papillary projections produced by the neoplasm. The resulting symptoms are often those of chronic pancreatitis, including episodes of abdominal pain, weight...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-16
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Remember to fill the camera viewfinder as much as possible with the lesion and related adjacent tissue. Some find that fixing the cut section to be photographed in formalin for 2 or 3 minutes helps reduce unwanted shine and reflections. The cut surface of the pancreas and lesion should be examined...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... imaging for an unrelated indication. Patients with larger MCNs may present with vague abdominal symptoms such as epigastric pain and a sense of abdominal fullness related to compression of surrounding organs ( 10 , 15 ). Less commonly, patients have nausea and vomiting, diarrhea, anorexia, and weight loss...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... S , et al Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk . Mod Pathol 2015 ; 28 : 994 - 1000 . 16. Fujimura M , Ostrow RS , Okagaki T . Implication of human papillomavirus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... and basaloid epithelial cell population (A); vacuolated cells (aka sebocytes), which are appreciable at higher magnification, help establish the diagnosis (B). Tumor cells are strongly positive for p16, the overexpression of which is not related to HPV infection (C). Tumor cells show patchy staining...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-1
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... cephalad to the SCJ. SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX Figure 1-4 SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX SCJ-associated high-grade squamous intraepithelial lesion (A). SCJ-associated adenocarcinoma in situ (B), and isolated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... interface. A related phenomenon, crypt involvement by HSIL, is also recognized by its regular distribution of nests without loss of polarity at the stromal epithelial interface. Buried epithelium in prior biopsy site is associated with granulation tissue, hemosiderin deposition, and other...
