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HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: At low power, most tumo...
Available to PurchasePublished: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-54 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: At low power, most tumors are solid nests and sheets of basaloid cells. B: Cribriform growth is noted in some cases, seen here on the bottom right. More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: At low power, most tumo...
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HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tu...
Available to PurchasePublished: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-55 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tumor type, with a predominance of myoepithelial cells that exhibit varying degrees of cytoplasmic clearing (A) and spindling (B). C,D: Ducts are usually present More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tu...
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HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: Cases often exhibit sca...
Available to PurchasePublished: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-56 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: Cases often exhibit scattered, markedly atypical cells, and mitotic rates are typically high. B: Most cases show squamous dysplasia of the overlying epithelium. This dysplasia consists More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: Cases often exhibit sca...
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HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...
Available to PurchasePublished: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-57 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature of the tumor is demonstrated. Myoepithelial cells stain for markers like smooth muscle actin (A), and the ductal elements are positive for CD117 (B). C,D More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...
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TEFLON GRANULOMA A,B: Axial and coronal CT scans showing a 2.1-cm hyperden...
Available to PurchasePublished: 01 June 2025
TEFLON GRANULOMA Figure 6-21 TEFLON GRANULOMA A,B: Axial and coronal CT scans showing a 2.1-cm hyperdense solid mass with focal calcification involving the right true vocal cord and related to prior Teflon injection. (Photos courtesy of Dr. M. B. Cunnane, Boston, MA) More about this image found in TEFLON GRANULOMA A,B: Axial and coronal CT scans showing a 2.1-cm hyperden...
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UNIQUE ANATOMY OF THE RETICULATED TONSILLAR CRYPT EPITHELIUM There is an i...
Available to PurchasePublished: 01 June 2025
the epithelium. These features make the distinction of in situ carcinoma from invasive carcinoma almost impossible, and more likely irrelevant, as tumors may spread without invasion beyond the basement membrane. (Modified from fig. 7 from Westra WH. The morphologic profile of HPV-related head and neck squamous More about this image found in UNIQUE ANATOMY OF THE RETICULATED TONSILLAR CRYPT EPITHELIUM There is an i...
Book Chapter
Oropharynx
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... spread without invasion beyond the basement membrane. (Modified from fig. 7 from Westra WH. The morphologic profile of HPV-related head and neck squamous carcinoma: implications for diagnosis, prognosis, and clinical management. Head Neck Pathol 2012;6(Suppl 1):S48-54.) The specialized reticulated crypt...
Book Chapter
Sinonasal Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... in the ethmoidal labyrinth. They are divided into anterior, middle, and posterior groups. The frontal sinuses are in the frontal bone adjacent to the anterior cranial fossa and orbits. The sphenoid sinuses are within the sphenoid bone and are closely related to the internal carotid arteries, optic chiasm...
Book Chapter
Hypopharynx, Larynx, and Trachea
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... ulcers are treated conservatively, with voice rest and no other intervention, at least initially, for presumed voice trauma-related lesions. If gastroesophageal reflux is suspected, this may be treated. Reflux is occasionally “silent” at presentation and the contact ulcer is the presenting symptom, which...
Book Chapter
Ear and Temporal Bone
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... to each other by the thin basilar membrane with the organ of Corti superimposed. The anatomy of the organ of Corti is complex and not specifically related to any pathology specimens submitted for review but contains hair cells in inner (one row) and outer (three rows) rows surrounded by supporting cells...
Book Chapter
Neck
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
..., are related to numerous genes for pseudohypoxia ( 13 ). The dominant involved protein is the succinate dehydrogenase enzyme (SDH), a multiprotein complex consisting of subunits A through D and an important component of the Krebs cycle and electron transport chain in mitochondria ( 21 ). Clinical Features...
Book Chapter
Nasopharynx
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... the presence of mesodermal and ectodermal elements, dermoid may be the most appropriate classification ( 12 ). These lesions were first reported in 1918 by Brown-Kelley ( 13 ). The specific designation as a hairy polyp is related to the histologic presence of cutaneous adnexal structures, including hair...
Book Chapter
Oral Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
..., the increased number of reported cases is related to oropharyngeal SCC, specifically in White males ( 8 ). The only site in the oral cavity that shows an increased incidence of OSCC is the lateral border of the tongue and this is true for both genders and all ethnicities ( 9 ). Estimated new cases in 2024...
Book Chapter
Jaw
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... other odontogenic cysts or neoplasms. Degenerating dental lamina is frequently seen in the follicles of teeth that are extracted and submitted for pathologic interpretation ( fig. 5-9 ). The number of rests are age related and may be sufficiently numerous to be misdiagnosed as an odontogenic tumor...
Book Chapter
Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... tumors is characterized by the production of dopamine, with or without norepinephrine. Mutations of Krebs cycle-related genes, including members of the SDH complex or fumarate hydratase (FH), are implicated primarily in dopamine production, often referred to as “immature biochemical phenotype...
Images
PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Some pheochromo...
Available to Purchase
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Figure 8-34 PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Some pheochromocytomas in patients with SDHx-related disease have abundant granular eosinophilic cytoplasm. More about this image found in PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Some pheochromo...
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PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with reta...
Available to Purchase
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: SDHB STAINING Figure 8-43 PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with retained positivity in the stroma serving as an internal control provides strong evidence of SDHX-related disease and should prompt genetic investigation. B: The presence of intact More about this image found in PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with reta...
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VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associat...
Available to Purchase
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING Figure 8-45 VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associated with VHL-related disease; it may be diffuse or focal as in this case. More about this image found in VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associat...
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PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is a...
Available to Purchase
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: INHIBIN STAINING Figure 8-44 PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is associated with any hypoxic pathway disease, including SDHx- and VHL-related disease and can be confirmed by staining for SDHB and CAIX. More about this image found in PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is a...
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FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA A,B: The histologic fe...
Available to Purchase
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA Figure 8-46 FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA A,B: The histologic features of FH-related pheochromocytoma are not distinctive. C,D: Immunohistochemical staining for FH shows loss of cytoplasmic reactivity with retained More about this image found in FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA A,B: The histologic fe...
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