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HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-54 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: At low power, most tumors are solid nests and sheets of basaloid cells. B: Cribriform growth is noted in some cases, seen here on the bottom right. More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: At low power, most tumo...

HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-55 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tumor type, with a predominance of myoepithelial cells that exhibit varying degrees of cytoplasmic clearing (A) and spindling (B). C,D: Ducts are usually present More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tu...

HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-56 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: Cases often exhibit scattered, markedly atypical cells, and mitotic rates are typically high. B: Most cases show squamous dysplasia of the overlying epithelium. This dysplasia consists More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A: Cases often exhibit sca...

HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-57 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature of the tumor is demonstrated. Myoepithelial cells stain for markers like smooth muscle actin (A), and the ductal elements are positive for CD117 (B). C,D More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...

TEFLON GRANULOMA Figure 6-21 TEFLON GRANULOMA A,B: Axial and coronal CT scans showing a 2.1-cm hyperdense solid mass with focal calcification involving the right true vocal cord and related to prior Teflon injection. (Photos courtesy of Dr. M. B. Cunnane, Boston, MA) More about this image found in TEFLON GRANULOMA A,B: Axial and coronal CT scans showing a 2.1-cm hyperden...

the epithelium. These features make the distinction of in situ carcinoma from invasive carcinoma almost impossible, and more likely irrelevant, as tumors may spread without invasion beyond the basement membrane. (Modified from fig. 7 from Westra WH. The morphologic profile of HPV-related head and neck squamous More about this image found in UNIQUE ANATOMY OF THE RETICULATED TONSILLAR CRYPT EPITHELIUM There is an i...

PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Figure 8-34 PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Some pheochromocytomas in patients with SDHx-related disease have abundant granular eosinophilic cytoplasm. More about this image found in PHEOCHROMOCYTOMA: ONCOCYTIC CHANGE IN SDHX-RELATED DISEASE Some pheochromo...

PHEOCHROMOCYTOMA: SDHB STAINING Figure 8-43 PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with retained positivity in the stroma serving as an internal control provides strong evidence of SDHX-related disease and should prompt genetic investigation. B: The presence of intact More about this image found in PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with reta...

VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING Figure 8-45 VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associated with VHL-related disease; it may be diffuse or focal as in this case. More about this image found in VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associat...

PHEOCHROMOCYTOMA: INHIBIN STAINING Figure 8-44 PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is associated with any hypoxic pathway disease, including SDHx- and VHL-related disease and can be confirmed by staining for SDHB and CAIX. More about this image found in PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is a...

FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA Figure 8-46 FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA A,B: The histologic features of FH-related pheochromocytoma are not distinctive. C,D: Immunohistochemical staining for FH shows loss of cytoplasmic reactivity with retained More about this image found in FUMARATE HYDRATASE (FH)-ASSOCIATED PHEOCHROMOCYTOMA A,B: The histologic fe...