Search Results for rejection

MILD CELL-MEDIATED REJECTION (GRADE 1R) Figure 24-3 MILD CELL-MEDIATED REJECTION (GRADE 1R) Perivascular lymphocytic infiltrates are usually obvious at both low-power (left) and high-power (right) microscopy. More about this image found in MILD CELL-MEDIATED REJECTION (GRADE 1R) Perivascular lymphocytic infiltrat...

MODERATE CELL-MEDIATED REJECTION (GRADE 2R) Figure 24-4 MODERATE CELL-MEDIATED REJECTION (GRADE 2R) The lymphocytic infiltrate extends beyond the perivascular territory into the interstitium and is associated with multifocal myocyte injury. Only a single focus of injury is shown here (black More about this image found in MODERATE CELL-MEDIATED REJECTION (GRADE 2R) The lymphocytic infiltrate ext...

SEVERE CELL-MEDIATED REJECTION (GRADE 3R) Figure 24-5 SEVERE CELL-MEDIATED REJECTION (GRADE 3R) A: There is an extensive interstitial and endocardial lymphocytic infiltrate, evident even at low power. B: The copious lymphocytes begin to replace the myocardium. C: Multifocal myocyte injury More about this image found in SEVERE CELL-MEDIATED REJECTION (GRADE 3R) A: There is an extensive interst...

ANTIBODY-MEDIATED REJECTION (pAMR 1 [H+]) Figure 24-7 ANTIBODY-MEDIATED REJECTION (pAMR 1 [H+]) Left: Endothelial cell swelling and intravascular mononuclear cells make the myocardium appear “busy” and more cellular than normal. Right: The nature of this cellularity becomes evident at high More about this image found in ANTIBODY-MEDIATED REJECTION (pAMR 1 [H+]) Left: Endothelial cell swelling ...

ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) Figure 24-8 ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) A,B: C4d (A) and C3D (B) immunofluorescence show diffuse and strong capillary endothelial reactivity. C: Diffuse and strong capillary endothelial C4d reactivity may also be seen More about this image found in ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) A,B: C4d (A) and C3D (B) immunof...

NONSPECIFIC CHRONIC INFLAMMATION Figure 24-6 NONSPECIFIC CHRONIC INFLAMMATION A chronic inflammatory infiltrate within fibrosis or scar should not be regarded as rejection. The prominent physiologic contraction bands do not reflect ischemic injury. More about this image found in NONSPECIFIC CHRONIC INFLAMMATION A chronic inflammatory infiltrate within ...

that closely mimic rejection and Quilty effect. C: In situ hybridization for Epstein-Barr virus (L26) confirms the nature of the infiltrate. More about this image found in POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD) A: Two discrete gross ...

LATE ACUTE CELLULAR REJECTION Figure 11-14 LATE ACUTE CELLULAR REJECTION Late acute cellular rejection is often characterized by lobular hepatitis, in addition to the typical bile duct changes of early acute cellular rejection. Interface hepatitis is well developed in this example. More about this image found in LATE ACUTE CELLULAR REJECTION Late acute cellular rejection is often chara...

CHRONIC REJECTION Figure 11-17 CHRONIC REJECTION Foam cell arteriopathy in chronic rejection, with subintimal accumulation of lipid-laden macrophages in a branch of the hepatic artery. Such changes are rarely seen on biopsy because the medium-sized arteries affected are not sampled. More about this image found in CHRONIC REJECTION Foam cell arteriopathy in chronic rejection, with subint...

ACUTE CELLULAR REJECTION Figure 4-36 ACUTE CELLULAR REJECTION A small granuloma is present next to a central vein in a case of otherwise typical acute cellular rejection. More about this image found in ACUTE CELLULAR REJECTION A small granuloma is present next to a central ve...

EARLY CHRONIC REJECTION Figure 11-15 EARLY CHRONIC REJECTION Slight mononuclear portal inflammatory infiltrate in early chronic rejection, with distorted attenuated bile duct. More about this image found in EARLY CHRONIC REJECTION Slight mononuclear portal inflammatory infiltrate ...

ACUTE CELLULAR REJECTION Figure 11-11 ACUTE CELLULAR REJECTION Endotheliitis involving hepatic venule in acute cellular rejection. Lymphocytes have burrowed under the endothelial cells, which are discontinuous and show a hobnail appearance. More about this image found in ACUTE CELLULAR REJECTION Endotheliitis involving hepatic venule in acute c...

ACUTE CELLULAR REJECTION Figure 11-12 ACUTE CELLULAR REJECTION Isolated central perivenulitis without involvement of portal tracts is a manifestation of acute cellular rejection more common in children. The inflammatory infiltrate consists of mostly mononuclear cells and is centered around More about this image found in ACUTE CELLULAR REJECTION Isolated central perivenulitis without involvemen...

ACUTE CELLULAR REJECTION Figure 11-9 ACUTE CELLULAR REJECTION The inflammatory infiltrate involves the portal tracts and hepatic venules. More about this image found in ACUTE CELLULAR REJECTION The inflammatory infiltrate involves the portal t...

ACUTE ANTIBODY-MEDIATED REJECTION Figure 11-8 ACUTE ANTIBODY-MEDIATED REJECTION There is linear circumferential expression of CD4D in portal vessels. More about this image found in ACUTE ANTIBODY-MEDIATED REJECTION There is linear circumferential expressi...

EARLY CHRONIC REJECTION Figure 11-16 EARLY CHRONIC REJECTION Reactive, distorted bile ducts with irregular spacing of biliary epithelial cells, without ductular reaction. More about this image found in EARLY CHRONIC REJECTION Reactive, distorted bile ducts with irregular spac...