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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...There are numerous inflammatory and reactive processes that involve the breast. Many of these are processes, or are in response to conditions, that may occur in any organ of the body and have similar morphologic features to those same diseases elsewhere. However, there are some entities...
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LYMPHOVASCULAR SPACE INVASION  A: An hematoxylin and eosin (H&E) stain ...
Published: 01 January 2024
LYMPHOVASCULAR SPACE INVASION Figure 8-4 LYMPHOVASCULAR SPACE INVASION A: An hematoxylin and eosin (H&E) stain demonstrates nests of tumor cells in lymphovascular spaces arrayed around a normal terminal duct lobular unit. In cases of diagnostic uncertainty, such as this example, immunostains ... More about this image found in LYMPHOVASCULAR SPACE INVASION A: An hematoxylin and eosin (H&E) stain ...
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BIOPSY SITE WITH DISPLACED EPITHELIUM  A: A benign proliferative lesion wit...
Published: 01 January 2024
BIOPSY SITE WITH DISPLACED EPITHELIUM Figure 2-7 BIOPSY SITE WITH DISPLACED EPITHELIUM A: A benign proliferative lesion with adjacent biopsy site and displaced epithelial elements. B: High power shows the epithelial nests and glands embedded in a reactive, spindle cell stroma with admixed histio... More about this image found in BIOPSY SITE WITH DISPLACED EPITHELIUM A: A benign proliferative lesion wit...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... . Nevoid malignant melanoma: morphologic patterns and immunohistochemical reactivity . J Cutan Pathol   1995 ; 22 : 502 - 17 . 7. Kossard   S , Wilkinson   B . Small cell (naevoid) melanoma: a clinicopathologic study of 131 cases . Australas J Dermatol   1997 ; 38 ( Suppl 1 ): S54 - 8...
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BENIGN PAPILLARY MESOTHELIAL PROLIFERATION  Above: <span class="search-highlight">Reactive</span> changes of the ...
Published: 15 November 2023
BENIGN PAPILLARY MESOTHELIAL PROLIFERATION Figure 27-13 BENIGN PAPILLARY MESOTHELIAL PROLIFERATION Above: Reactive changes of the pericardium include benign papillary proliferations that grossly manifest as little whiskers on the pericardial surface. Right: Histologically, they consist of papill... More about this image found in BENIGN PAPILLARY MESOTHELIAL PROLIFERATION Above: Reactive changes of the ...
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CARDIAC INFLAMMATORY MYOFIBROBLASTIC TUMOR  The lesional cells are <span class="search-highlight">reactive</span>...
Published: 15 November 2023
CARDIAC INFLAMMATORY MYOFIBROBLASTIC TUMOR Figure 50-5 CARDIAC INFLAMMATORY MYOFIBROBLASTIC TUMOR The lesional cells are reactive with antibodies directed against smooth muscle actin. More about this image found in CARDIAC INFLAMMATORY MYOFIBROBLASTIC TUMOR The lesional cells are reactive...
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CARDIAC PARAGANGLIOMA  The tumor cell nests are strongly <span class="search-highlight">reactive</span> with anti...
Published: 15 November 2023
CARDIAC PARAGANGLIOMA Figure 56-26 CARDIAC PARAGANGLIOMA The tumor cell nests are strongly reactive with antibodies directed against chromogranin. More about this image found in CARDIAC PARAGANGLIOMA The tumor cell nests are strongly reactive with anti...
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CARDIAC SYNOVIAL SARCOMA: IMMUNOHISTOCHEMISTRY  A–C: The tumor cells are di...
Published: 15 November 2023
CARDIAC SYNOVIAL SARCOMA: IMMUNOHISTOCHEMISTRY Figure 56-15 CARDIAC SYNOVIAL SARCOMA: IMMUNOHISTOCHEMISTRY A–C: The tumor cells are diffusely reactive with antibodies directed against CD99 (A) and exhibit more focal reactivity with antibodies directed against EMA (B) and pancytokeratin (C). The e... More about this image found in CARDIAC SYNOVIAL SARCOMA: IMMUNOHISTOCHEMISTRY A–C: The tumor cells are di...
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CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM  A,B: Spindle cell (A) and epith...
Published: 15 November 2023
CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM Figure 54-10 CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epithelioid (B) angiosarcoma. C,D: ERG reactivity within spindle cell angiosarcoma (C) and epithelioid angiosarcoma (D). E,F: CD31 reactivity in spindle cell angiosarcoma... More about this image found in CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epith...
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CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM  A,B: Spindle cell (A) and epith...
Published: 15 November 2023
CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM Figure 54-10 CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epithelioid (B) angiosarcoma. C,D: ERG reactivity within spindle cell angiosarcoma (C) and epithelioid angiosarcoma (D). E,F: CD31 reactivity in spindle cell angiosarcoma... More about this image found in CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epith...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-09
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... the ETV6::NTRK3 gene fusion (see below) ( 25 ). Paradoxically, perhaps, GCDFP-15 is not reactive ( 26 ). Differential Diagnosis. Given the well-circumscribed and nested arrangement of the tumor, often with an apparently cribriform architectural pattern and rather monotonous nuclei, low-grade ductal...
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CARDIAC ROSAI-DORFMAN DISEASE: IMMUNOHISTOCHEMISTRY  The histiocytes are di...
Published: 15 November 2023
CARDIAC ROSAI-DORFMAN DISEASE: IMMUNOHISTOCHEMISTRY Figure 57-16 CARDIAC ROSAI-DORFMAN DISEASE: IMMUNOHISTOCHEMISTRY The histiocytes are diffusely reactive with antibodies directed against CD163 (left) and also show reactivity with S-100 protein (right). More about this image found in CARDIAC ROSAI-DORFMAN DISEASE: IMMUNOHISTOCHEMISTRY The histiocytes are di...
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CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES ...
Published: 15 November 2023
CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES Figure 53-13 CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES A smooth muscle actin stain shows reactivity primarily within the tumor vasculature and focal reactivity in the lesional cells. More about this image found in CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES ...
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ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+])  A,B: C4d (A) and C3D (B) immunof...
Published: 15 November 2023
ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) Figure 24-8 ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) A,B: C4d (A) and C3D (B) immunofluorescence show diffuse and strong capillary endothelial reactivity. C: Diffuse and strong capillary endothelial C4d reactivity may also be seen with immunohistochemis... More about this image found in ANTIBODY-MEDIATED REJECTION (pAMR 1 [I+]) A,B: C4d (A) and C3D (B) immunof...
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CAPILLARIES AND LYMPHATICS: IMMUNOHISTOCHEMICAL DIFFERENTIATION  A,B: Capil...
Published: 15 November 2023
CAPILLARIES AND LYMPHATICS: IMMUNOHISTOCHEMICAL DIFFERENTIATION Figure 33-16 CAPILLARIES AND LYMPHATICS: IMMUNOHISTOCHEMICAL DIFFERENTIATION A,B: Capillary endothelial reactivity with antibodies directed against CD34 (A) and CD31 (B); these also can be positive in lymphatic endothelium. C: Speci... More about this image found in CAPILLARIES AND LYMPHATICS: IMMUNOHISTOCHEMICAL DIFFERENTIATION A,B: Capil...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... Axillary lymph nodes may show a variety of other changes, mostly reactive, but occasionally neoplastic, of which to be aware as these processes can be a diagnostic pitfall or can be overlooked in the search for metastatic foci. LYMPH NODE METASTASIS Pathologic Staging. The principal reason axillary lymph...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... proliferation of soft tissue. It has long been thought to be a reactive, self-limited process, however, recent studies indicate that nodular fasciitis is a clonal proliferation harboring a fusion gene involving USP6. Nodular fasciitis can be a mimic for carcinoma clinically, radiologically, and even...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... In cases of diagnostic uncertainty, such as this example, immunostains can be helpful. B: A D2-40 immunostain highlights the lymphatic endothelial cells. Significant cross-reactivity with myoepithelial cells is present. C: A p63 immunostain is negative, confirming that the cells lining the involved...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... will highlight lymphovascular endothelial cells, but note cross-reactivity with myoepithelial cell antigens a DCIS = ductal carcinoma in situ; LCIS = lobular carcinoma in situ; HMWCK = high molecular weight cytokeratin; ER = estrogen receptor; SMMHC = smooth muscle myosin heavy chain; TDLU = terminal...