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STROMAL <span class="search-highlight">REACTION</span> TO RUPTURED CYST  A: A core needle biopsy specimen shows f...
Published: 01 January 2024
STROMAL REACTION TO RUPTURED CYST Figure 2-21 STROMAL REACTION TO RUPTURED CYST A: A core needle biopsy specimen shows fibroadipose tissue with a chronic inflammatory cell infiltrate and stromal fibrosis. B: High-power view demonstrates histiocytes, lymphocytes, and plasma cells; while not defin... More about this image found in STROMAL REACTION TO RUPTURED CYST A: A core needle biopsy specimen shows f...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Melanocytes may extend into follicles along epithelial stromal junction  Starburst giant cell  Associated lichenoid inflammatory reaction common Differential Diagnosis  Solar lentigo  Seborrheic keratosis  Lichenoid keratosis  Pigmented actinic keratosis  Lentiginous junctional nevus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... polymerase chain reaction (RT-PCR) to document EWSR1 rearrangement or EWSRI-ATF1 or EWSRI-CREB1 fusion. Metastatic Melanoma versus Nonmelanocytic Tumor. Amelanotic metastatic melanoma to the skin may also be confused with a number of nonmelanocytic tumors. Large...
Images
MICROGLANDULAR ADENOSIS  A few small glands with eosinophilic secretions in...
Published: 01 January 2024
MICROGLANDULAR ADENOSIS Figure 6-17 MICROGLANDULAR ADENOSIS A few small glands with eosinophilic secretions in the adipose tissue of the breast may be overlooked due to the lack of any stromal reaction. More about this image found in MICROGLANDULAR ADENOSIS A few small glands with eosinophilic secretions in...
Images
METASTATIC CARCINOMA  In this low-power image, the lymph node is seen to be...
Published: 01 January 2024
METASTATIC CARCINOMA Figure 14-4 METASTATIC CARCINOMA In this low-power image, the lymph node is seen to be completely replaced by metastatic carcinoma. The stromal reaction and nested growth pattern allow for easy identification. The extent of involvement constitutes a macrometastasis. More about this image found in METASTATIC CARCINOMA In this low-power image, the lymph node is seen to be...
Images
AMYLOIDOSIS: GIANT CELL <span class="search-highlight">REACTION</span>  Giant cell <span class="search-highlight">reaction</span> to interstitial amylo...
Published: 15 November 2023
AMYLOIDOSIS: GIANT CELL REACTION Figure 21-16 AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amyloid deposition, the significance of which is unknown. More about this image found in AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amylo...
Images
BIOPSY SITE  Biopsy marking devices produce varying morphologic responses, ...
Published: 01 January 2024
BIOPSY SITE Figure 15-10 BIOPSY SITE Biopsy marking devices produce varying morphologic responses, but in each instance, evidence of a tissue reaction, foreign body giant cells (A), and a chronic inflammatory cell infiltrate (B), in addition to locating the clip, is important to confirm excision ... More about this image found in BIOPSY SITE Biopsy marking devices produce varying morphologic responses, ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... In a later stage of an inflamed lentigo, there may be no more lymphocytes. Scattered melanophages may be the only evidence to indicate a prior inflammatory reaction. Lesions of ink spot lentigo are histopathologically characterized by small diameter (“narrow”) and intense hyperpigmentation of basilar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... systemic immunotherapy for melanoma or other cancers may become inflamed and are sometimes found with a variably dense inflammatory reaction and halo nevus-like changes ( 28 ). The color of nevi may fade. A combination of inflammation and fibrosis in variable proportions in a pattern suggesting regression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Imberti   GL , Parazzini   F , Gallus   S , La Vecchia   C . Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the Italian population: results of a collaborative case-control study . Cancer   2000 ; 88...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... inflammatory reaction pattern. Sometimes there is partial loss of melanocytes, a phenomenon referred to as “regression.” Inflammation or partial regression may correlate with a so-called “halo” phenomenon, which refers to the clinical finding of circumferential depigmentation or hypopigmentation around...
Images
SPONTANEOUS CORONARY ARTERY DISSECTION: ADVENTITIAL <span class="search-highlight">REACTION</span>  Chronic adven...
Published: 15 November 2023
SPONTANEOUS CORONARY ARTERY DISSECTION: ADVENTITIAL REACTION Figure 6-12 SPONTANEOUS CORONARY ARTERY DISSECTION: ADVENTITIAL REACTION Chronic adventitial inflammation is common in spontaneous coronary artery dissection (left), which often contains increased eosinophils (right). More about this image found in SPONTANEOUS CORONARY ARTERY DISSECTION: ADVENTITIAL REACTION Chronic adven...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... Until recently, the favored prosthesis was made of polyurethane, had a textured surface, and contained silicone; others have a smooth surface and/or contain saline ( 33 ). Several types of reaction occur in response to the presence of breast prostheses ( 34 ). In most women, a fibrous capsule forms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... or isolated tumor cells (ITCs) only.  pN0(i+): Malignant cells in regional lymph node(s) no greater than 0.2 mm (detected by hematoxylin and eosin [H&E] stain or immunohistochemistry [IHC] including ITCs).  pN0(mol+) – Positive molecular findings (reverse transcription polymerase chain reaction [RT...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., identification of the basement membrane layer is rarely utilized clinically, although it can be demonstrated with reticulin stains or with immunohistochemical reactions for laminin or type IV collagen ( 10 , 11 ). ACINI OF THE BREAST Figure 1-4 ACINI OF THE BREAST The inner epithelial cell layer and the outer...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... ( figs. 6-15 , 6-16 ). Surprisingly, there is no stromal reaction elicited by the proliferation, which can be deceptive, and leads to some cases of microglandular adenosis being subtle and easily overlooked even with the haphazard arrangement of the glands ( fig. 6-17 ). Within the glandular lumens...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... ). These are often the cases with the most pronounced stromal reaction and inflammation, which increases the challenge of evaluation. Microinvasion is discussed further in chapter 8 . DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR GRADE WITH MICROINVASION Figure 3-27 DUCTAL CARCINOMA IN SITU: HIGH NUCLEAR GRADE...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...), which is a reverse-transcriptase-polymerase gene reaction (RT-PCR)-based assay performed in a central laboratory which evaluates 21 genes generating a recurrence score (RS) stratifying patients with ER-positive/HER2-negative carcinoma into low, intermediate, and high risk of relapse groups. The assay...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-13
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... examination, the lesion may appear as an irregular and cystic mass. Retroareolar asymmetrical density and skin thickening may be observed on mammogram ( 3 , 5 ). Microscopic Findings. In many cases, there is an exuberant acute inflammatory reaction, with neutrophils and microabscess formation obscuring...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... and difficult to discern in sclerosing lesions, and the stroma may be altered, giving the appearance of a desmoplastic reaction. Clues to the underlying benign process include the lobulocentric growth pattern as opposed to an infiltrative one, and that the stroma is more fibrotic or elastotic rather than truly...