S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Figure 1-14 S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positive cells are present at the periphery of a small neuroblastic aggregate (right), while others are associated with scattered more mature-appearing cells with clear c... More about this image found in S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positiv...

SUSTENTACULAR CELLS Figure 1-42 SUSTENTACULAR CELLS Immunohistochemical stains for S-100 protein (A) or SOX10 (B) show numerous sustentacular cells around and within groups of chromaffin cells. More about this image found in SUSTENTACULAR CELLS Immunohistochemical stains for S-100 protein (A) or SO...

PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS Figure 8-39 PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show strong nuclear and cytoplasmic positivity in sustentacular cells, identified easily even if the tumor cells also show diffuse reactivity. B: The nuclei of sustentacular cel... More about this image found in PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show ...

CAROTID BODY PARAGANGLIOMA Figure 9-37 CAROTID BODY PARAGANGLIOMA Immunohistochemical stains for S-100 protein and SOX10 outline the nested architecture in carotid body paraganglioma. More about this image found in CAROTID BODY PARAGANGLIOMA Immunohistochemical stains for S-100 protein an...

ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm. This appearance is often associated with SDHB mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse expression to absent expression in a small region of the tumor. D: Immunohistochemical stain for S-100 protein shows heterogeneous distribution of sustentacular cells in adjacent areas of tumor. E: Immunohistochemical stain for glial fibrillary acidic protein (GFAP) shows a small focus of GFAP-positive sustentacular cells in a tumor in which S-100 protein-positive cells were much more numerous. More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...

NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS Figure 9-3 NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS A: Normal paraganglia (arrows) in close proximity to lymph nodes. In a patient with a hereditary paraganglioma syndrome, this anatomic rel... More about this image found in NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS ...

SATELLITE CELLS OF ADRENAL MEDULLARY GANGLION Figure 1-43 SATELLITE CELLS OF ADRENAL MEDULLARY GANGLION Immunohistochemical stain for S-100 protein highlights both sustentacular cells and satellite cells in a group of medullary ganglion cells. More about this image found in SATELLITE CELLS OF ADRENAL MEDULLARY GANGLION Immunohistochemical stain fo...

ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME Figure 7-10 ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME The pattern of expression of mismatch repair (MMR) proteins showed loss of MLH1 and PMS2 and retained expression of MSH2 and MSH6. More about this image found in ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME The pattern of...

TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Figure 1-13 TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Most of the medullary progenitor cells in this image express TH. Because TH is a cytosolic enzyme, it can often detect ability to produce catecholamines in immature or poorly ... More about this image found in TYROSINE HYDROXYLASE IN DEVELOPING FETAL ADRENAL GLAND Most of the medulla...

CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Figure 9-36 CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalous immunoreactivity for keratins is present in this paraganglioma stained with antibody cocktail AE1/AE3. The tumor was diffusely positive for synapto... More about this image found in CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalo...

PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Figure 8-53 PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical stain for S-100 protein shows intratumoral variation in density of sustentacular cells in a pheochromocytoma from a patient with MEN2A (same patient as figure 8-3... More about this image found in PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical sta...

COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...

COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...

NORMAL CAROTID BODY Figure 9-7 NORMAL CAROTID BODY A: This developing carotid body in an early second trimester stillborn fetus (same case as in figs. 9-3 and 9-4 ), shows more complex architecture and greater admixture of cell types than the abdominal paraganglia. B: Tyrosine hydroxylase exp... More about this image found in NORMAL CAROTID BODY A: This developing carotid body in an early second tri...

PULMONARY PARAGANGLIOMA Figure 9-32 PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initially interpreted as an epithelial pulmonary NET. The patient was found to have a hereditary SDHC mutation. No other primary tumors were found and this tumor contained abundant sustentacular cells. In view of the clinical and histologic findings and the low metastasis frequency associated with SDHC mutation, the tumor was consistent with a primary pulmonary paraganglioma. B: High magnification shows nested architecture and cells of varied sizes. C: S-100 protein highlights sustentacular cells. More about this image found in PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initia...

MESENTERIC PARAGANGLIOMA Figure 9-14 MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and clear cells was incidentally discovered in an asymptomatic patient with no other tumors. Fat invasion, poorly defined irregular cell nests, and diffuse growth are putative risk factors f... More about this image found in MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and ...

CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...

CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...