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Book Chapter
Neck
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... impression of a paraganglioma. In addition, since most head and neck paragangliomas are nonsecreting, FNA is considered less problematic than core biopsy. Cytologic samples are generally cellular, and composed of loose clusters of cells as well as scattered dispersed cells. Individual cells are polygonal...
Book Chapter
Oral Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... of tumor invasion, particularly in tongue cancer, is an important prognostic indicator. The depth of invasion is measured from the reconstructed basement membrane to the deepest point of invasion. Accurate measurement of depth of invasion can be problematic, especially in the presence of extratumoral...
Book Chapter
Sinonasal Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... M . Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic . Mod Pathol 1998 ; 11 : 65 - 71 . 717. Shmookler BM , Enzinger FM , Brannon RB . Orofacial synovial sarcoma: a clinicopathologic study of 11 new...
Book Chapter
Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... at diagnosis and the extent of disease ( Table 11-2 ) ( 40 ). This staging system was problematic because it did not allow pretreatment classification. Table 11-2 THE INTERNATIONAL NEUROBLASTOMA STAGING SYSTEM (INSS) a Stage 1 Localized tumor with complete gross excision, with or without...
Book Chapter
Adrenal Cortical Carcinoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in hot-spots. Most ACCs have mitotic counts beyond the cut-off for malignancy, but cases with low mitotic activity exist, and the assessment of the mitotic index in such cases may be more problematic and less reproducible. Phos-pho-histone-H3 immunohistochemistry may help highlight mitoses in carcinomas...
Book Chapter
Overview
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in the environment (making nosocomial spread in hospitals problematic) is Candida auris ( 7 ). The fungus is a yeast that does not produce hyphae or pseudohyphae. Its biochemical identification was initially problematic because it was placed with other Candida spp (in particular, the C...
Book Chapter
Gastrointestinal Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... diagnosis problematic Therapy may precipitate immune reconstitution inflammatory syndrome (IRIS) WHIPPLE DISEASE Figure 13-35 WHIPPLE DISEASE At endoscopy, enteric mucosa has multiple small yellow patches and plaques. (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) WHIPPLE DISEASE Figure...
Book Chapter
Skin and Soft Tissue
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... In 2014, the Food and Drug Administration (FDA) also approved the oral agent miltefosine for treatment of cutaneous, mucosal, and visceral leishmaniasis. Treatment of immunocompromised patients, particularly those with HIV infection, is problematic and often requires multiple courses of treatment...
Book Chapter
Systemic Infections
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-27
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of cases reported. In parts of the world where malaria is endemic, the distinction between babesiosis and malaria may be problematic, as both protozoans infect erythrocytes and have a similar microscopic morphology. Human-to-human transmission of Babesia spp can occur transplacentally and via...
Book Chapter
Gastrointestinal Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-22
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of their typical morphology. Careful correlation with relevant microbiologic findings is thus always indicated. The morphologic diagnosis of Candida and Candida-like yeasts can be problematic in skin and nail infections, where dermatophytes and Malasezzia spp. (pityriasis versicolor...
Book Chapter
Systemic Infections
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the exposure occurred. This can make diagnosis problematic, since the disease may manifest outside an endemic area. Confirming that the patient has a tick bite is useful for diagnosis, although such a bite mark or history is not always apparent in infected individuals. As identification of the vector...
Book Chapter
Central Nervous System
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in the hemolymphatic stage of the disease ( fig. 25-10 ). The diagnostic yield is greatly increased if serial specimens are examined, and enhanced by concentration techniques. In problematic cases, examination of Giemsa-stained bone marrow aspirates sometimes allows identification of organisms when...
Book Chapter
Skin and Soft Tissue
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and are referred to as sclerotic (“copper penny” or Medlar) bodies ( fig. 24-27 ). Muriform cells are usually found in the epidermis with transepidermal expulsion. Due to the widespread presence of these fungi in the environment, prevention of infection is problematic, although the wearing of protective clothing...
Book Chapter
Respiratory Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... by Rhinosporidium seeberi, an infectious agent with a problematic taxonomy largely due to the fact that it cannot be cultured ( 89 ). It was formerly considered to be a fungus, but molecular typing using 18S ribosomal DNA methodology has reclassified the organism as an aquatic protistan (eukaryote) parasite...
Book Chapter
Respiratory Tract
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... Unless the culture is pure, attributing the disease process to Actinomyces spp may be problematic. Correlation with the pathology specimen to confirm the presence of sulfur granules and a tissue inflammatory response is thus imperative. PCR assays can also be used to identify the bacteria from...
Images
INK TRACKING Ink readily tracks into the crevices of breast specimens. Ext...
Available to Purchase
in Pathologic Evaluation and Reporting of Breast and Axillary Lymph Node Specimens
> Tumors of the Mammary Gland
Published: 01 January 2024
INK TRACKING Figure 15-7 INK TRACKING Ink readily tracks into the crevices of breast specimens. Extra care is required to prevent this occurrence, which is particularly problematic if there is a tumor close to the specimen margin. More about this image found in INK TRACKING Ink readily tracks into the crevices of breast specimens. Ext...
Images
INFILTRATING MARGIN A: H&E stain of a grade 1 invasive breast carcinom...
Available to PurchasePublished: 01 January 2024
INFILTRATING MARGIN Figure 8-14 INFILTRATING MARGIN A: H&E stain of a grade 1 invasive breast carcinoma, NST. The infiltrative margin is a helpful clue to the malignant nature of a proliferation composed of small glands. B: In problematic cases, myoepithelial cell markers, such as p63 More about this image found in INFILTRATING MARGIN A: H&E stain of a grade 1 invasive breast carcinom...
Images
PAPILLARY LESION WITH INFARCTION A: At low power, an area of papillary duc...
Available to PurchasePublished: 01 January 2024
” of fibrovascular cores are discernable; however, accurate categorization of the epithelial component is problematic. More about this image found in PAPILLARY LESION WITH INFARCTION A: At low power, an area of papillary duc...
Book Chapter
Melanocytic Nevi of Special Sites
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., conservative complete excision is a prudent course of action. However, it does not need to be the default option. Considering that surgery can be difficult and functionally or cosmetically problematic, if there is sufficient diagnostic confidence among experienced colleagues that a lesion with atypical...
Book Chapter
Nevoid Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... diagnosis. Ancillary studies (e.g., immunohistochemistry, cytogenetics) are recommended for problematic cases to minimize misdiagnosis (or underdiagnosis) of melanoma. Historically, immunohistochemistry for HMB-45 and Ki-67 has been used to aid in the distinction of nevi from melanoma ( 3 , 6 ). Diffuse...
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