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<span class="search-highlight">PRIMARY</span> BLUE MELANOMA  An expansile tumor nodule is present in the subcutis...
Published: 01 February 2024
PRIMARY BLUE MELANOMA Figure 18-7 PRIMARY BLUE MELANOMA An expansile tumor nodule is present in the subcutis. The tumor carried a GNAQ 209L mutation. By clinical history, the patient had a blue nevus for many years, which had changed. More about this image found in PRIMARY BLUE MELANOMA An expansile tumor nodule is present in the subcutis...
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<span class="search-highlight">PRIMARY</span> DE NOVO PEDIATRIC MELANOMA  A: Ulcerated pigmented melanoma from a ...
Published: 01 February 2024
PRIMARY DE NOVO PEDIATRIC MELANOMA Figure 20-2 PRIMARY DE NOVO PEDIATRIC MELANOMA A: Ulcerated pigmented melanoma from a child with no associated nevus remnant. B: Sheets of tumor cells are present with no evidence of maturation. More about this image found in PRIMARY DE NOVO PEDIATRIC MELANOMA A: Ulcerated pigmented melanoma from a ...
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BLUE NEVUS-LIKE MELANOMA METASTASIS (IN-TRANSIT METASTASIS FROM A <span class="search-highlight">PRIMARY</span> A...
Published: 01 February 2024
BLUE NEVUS-LIKE MELANOMA METASTASIS (IN-TRANSIT METASTASIS FROM A PRIMARY ACRAL MELANOMA) Figure 22-8 BLUE NEVUS-LIKE MELANOMA METASTASIS (IN-TRANSIT METASTASIS FROM A PRIMARY ACRAL MELANOMA) A: The silhouette of the tumor simulates a blue nevus. B: An epithelioid tumor cell is seen in mitosis (... More about this image found in BLUE NEVUS-LIKE MELANOMA METASTASIS (IN-TRANSIT METASTASIS FROM A PRIMARY A...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma can affect the skin not only as a primary tumor, but also as a metastatic tumor deposit. Metastatic melanoma has not originated at the site where it is found, but represents secondary growth after intravascular, intralymphatic or potentially perivascular spread. CLINICAL FEATURES Melanoma...
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SATELLITE METASTASIS  A: A small subcutaneous tumor nodule (arrow) is separ...
Published: 01 February 2024
SATELLITE METASTASIS Figure 22-2 SATELLITE METASTASIS A: A small subcutaneous tumor nodule (arrow) is separated from the primary tumor by normal adipose tissue. B: The nodule is composed of atypical tumor cells similar to the primary melanoma. More about this image found in SATELLITE METASTASIS A: A small subcutaneous tumor nodule (arrow) is separ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...There are two microscopically descriptive scenarios for nodular melanoma. One is a primary dermal invasive melanoma without associated in situ melanoma; the other is a primary invasive melanoma accompanied by in situ melanoma that does not extend peripherally beyond the invasive tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...PROGNOSTIC FACTORS Once a diagnosis of melanoma has been established, it is important for the pathologist to provide prognostic information for patients and their clinical care team. At the time of diagnosis approximately 90 percent of individuals with primary cutaneous melanoma have no evidence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter discusses unusual morphologic variants of primary cutaneous melanomas that have not been discussed elsewhere in the Fascicle. The purpose of commenting on these variants is for the practicing pathologist to be aware of the morphologic spectrum of melanomas, and to consider...
Images
MELANOMA IN-TRANSIT METASTASIS  A: Several red papules are present near a s...
Published: 01 February 2024
MELANOMA IN-TRANSIT METASTASIS Figure 22-1 MELANOMA IN-TRANSIT METASTASIS A: Several red papules are present near a scar from the prior excision of the primary melanoma. One papule (arrow) was biopsied. B: The biopsy revealed an intradermal nodule of melanoma. C: The tumor cells are amelanotic ... More about this image found in MELANOMA IN-TRANSIT METASTASIS A: Several red papules are present near a s...
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EPIDERMOTROPIC METASTATIC MELANOMA  A: Metastatic melanoma is present in th...
Published: 01 February 2024
EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-7 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopatholo... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...
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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
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SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS  A: Asym...
Published: 01 February 2024
SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS Figure 20-1 SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asymmetric silhouette of the lesion of a teenager shows an ulcerated nodular growth on the right side and a plaque lesion of a compound nevus on the left. B: Compound melanocytic nevus with bland cytologic features. C: In situ and invasive melanoma are characterized by architectural disorder and nuclear atypia. D: The primary invasive melanoma contains sheets of atypical melanocytes, some of which are in mitosis. E: Metastatic melanoma in the sentinel lymph node. F: The tumor cells homogenously express BRAF V600E. More about this image found in SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asym...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... setting fits (e.g., scalp lesion with a clinical history of changing blue nevus and no prior history of melanoma elsewhere), a diagnosis of primary blue melanoma can still be established or at least favored. PRIMARY BLUE MELANOMA Figure 18-7 PRIMARY BLUE MELANOMA An expansile tumor nodule is present...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ). In Southeast Asia, for example, more than half of the primary cutaneous melanomas occur at acral sites, with subungual melanoma accounting for 10 to 20 percent ( 11 – 13 ). In the United States, 2 to 3 percent of melanomas are acral ( 11 ). CLINICAL FEATURES Acral melanoma occurs across a wide age range...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of a compound nevus on the left. B: Compound melanocytic nevus with bland cytologic features. C: In situ and invasive melanoma are characterized by architectural disorder and nuclear atypia. D: The primary invasive melanoma contains sheets of atypical melanocytes, some of which are in mitosis. E: Metastatic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... sheet-like aggregates of melanophages. The lesion may be associated with spontaneous or treatment-related tumor regression or primary or metastatic melanoma. In contrast to PEM, the pigment-laden macrophages of tumoral melanosis tend to be smaller, with smaller nuclei with inconspicuous nucleoli. Large...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with fibrous dysplasia and endocrinopathy), and café-au-lait macules. Melanotic macules may also represent a paraneoplastic process ( 12 ). PRIMARY ACQUIRED MELANOSIS Primary acquired melanosis (PAM) without atypia is a term for a conjunctival pigmentary alteration characterized by hyperpigmentation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... diagnosis of BN. Tumoral melanosis associated with primary or metastatic melanoma or other pigmented tumors is characterized by the presence of dense aggregates of melanophages. It may be confused with an epithelioid BN. While the melanin is typically finely granular within melanocytes, it tends...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... a nodular melanoma. Attention to anatomic site, extent of solar elastosis, and the predominant growth pattern of most of the lesion is needed for melanoma subtyping. TREATMENT AND PROGNOSIS Complete surgical excision is the treatment of choice for primary superficial spreading melanomas. The prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytes. Strong and diffuse immunoreactivity for PRAME can assist in establishing a diagnosis of melanoma. FISH may also be useful. Primary Nevoid Melanoma versus Cutaneous Metastasis. On rare occasion, a melanoma metastasis to the dermis is confused with a primary nevoid melanoma. Clinical context...