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INTRADUCTAL TUBULOPAPILLARY NEOPLASM  Immunolabeling is <span class="search-highlight">positive</span> for MUC1 (...
Published: 01 March 2023
INTRADUCTAL TUBULOPAPILLARY NEOPLASM Figure 6-60 INTRADUCTAL TUBULOPAPILLARY NEOPLASM Immunolabeling is positive for MUC1 (left) and MUC6 (right). More about this image found in INTRADUCTAL TUBULOPAPILLARY NEOPLASM Immunolabeling is positive for MUC1 (...
Images
SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM  Immunolabeling is <span class="search-highlight">positive</span> for...
Published: 01 March 2023
SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Figure 13-19 SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Immunolabeling is positive for CK18 (left) and CD99 (right). More about this image found in SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Immunolabeling is positive for...
Images
INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM  Immunolabeling for MUC6 is diffus...
Published: 01 March 2023
INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Figure 6-51 INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Immunolabeling for MUC6 is diffusely positive. More about this image found in INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Immunolabeling for MUC6 is diffus...
Images
AUTOIMMUNE PANCREATITIS, TYPE 1  The periductal infiltrate has increased nu...
Published: 01 March 2023
AUTOIMMUNE PANCREATITIS, TYPE 1 Figure 15-17 AUTOIMMUNE PANCREATITIS, TYPE 1 The periductal infiltrate has increased numbers of IgG4-positive plasma cells. More about this image found in AUTOIMMUNE PANCREATITIS, TYPE 1 The periductal infiltrate has increased nu...
Images
ACINAR CELL CARCINOMA  Immunolabeling for chromogranin shows scattered posi...
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-24 ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered positive cells that make up less than 30 percent of the neoplasm. More about this image found in ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered posi...
Images
PANCREATOBLASTOMA  The immunolabeling of squamoid nests is somewhat variabl...
Published: 01 March 2023
PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...
Images
DUODENAL GASTRINOMA  The small tumor involves the duodenal submucosa (left)...
Published: 01 March 2023
DUODENAL GASTRINOMA Figure 12-74 DUODENAL GASTRINOMA The small tumor involves the duodenal submucosa (left), a more common location than the pancreas. Immunolabeling for gastrin is diffusely positive (right). More about this image found in DUODENAL GASTRINOMA The small tumor involves the duodenal submucosa (left)...
Images
SOLID PSEUDOPAPILLARY NEOPLASM  Immunolabeling for β-catenin shows diffuse ...
Published: 01 March 2023
SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-20 SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse aberrant nuclear positivity (left). There is loss of membranous E-cadherin expression (right). More about this image found in SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse ...
Images
MIXED DUCTAL-NEUROENDOCRINE CARCINOMA  Immunolabeling for synaptophysin (le...
Published: 01 March 2023
MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Figure 12-88 MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Immunolabeling for synaptophysin (left) is positive in the neuroendocrine component, whereas carcinoembryonic antigen (right) labels the glandular component. More about this image found in MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Immunolabeling for synaptophysin (le...
Images
UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES  A: This carcinoma has rh...
Published: 01 March 2023
UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES Figure 8-17 UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rhabdoid features. B,C: Immuno labeling for CK19 is positive (B), while INI1 is lost (C). More about this image found in UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rh...
Images
ACINAR CELL CARCINOMA  Staining with periodic acid–Schiff (PAS) with diasta...
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-21 ACINAR CELL CARCINOMA Staining with periodic acid–Schiff (PAS) with diastase digestion reveals intense, granular positivity in cases with numerous zymogen granules (left), but other cases show only faint staining (right). More about this image found in ACINAR CELL CARCINOMA Staining with periodic acid–Schiff (PAS) with diasta...
Images
DIFFUSE (PP) ISLETS  Left: Lobular pancreatic tissue from the posterior hea...
Published: 01 March 2023
DIFFUSE (PP) ISLETS Figure 15-68 DIFFUSE (PP) ISLETS Left: Lobular pancreatic tissue from the posterior head contains large diffuse islets with a trabecular architecture with irregular contours, mimicking an infiltrating neuroendocrine tumor. Right: Immunolabeling for pancreatic polypeptide (PP)... More about this image found in DIFFUSE (PP) ISLETS Left: Lobular pancreatic tissue from the posterior hea...
Images
ANATOMY OF THE DEVELOPING PANCREAS  Left: The dorsal pancreatic bud appears...
Published: 01 March 2023
ANATOMY OF THE DEVELOPING PANCREAS Figure 1-1 ANATOMY OF THE DEVELOPING PANCREAS Left: The dorsal pancreatic bud appears first as a bud caudal to the stomach. The smaller ventral pancreatic bud arises from the base of the hepatic diverticulum. Neither bud expresses the sonic hedgehog (SHH) gene whereas the adjacent foregut does. Right: Rotation of the duodenum to the right carries the ventral bud to a position posterior to the dorsal bud, and the two primitive buds fuse to form the pancreas. The dorsal bud gives rise to the cephalad portion of the head, the body, and the tail, whereas the ventral bud gives rise to the caudal portion of the head and the uncinate process. The main pancreatic duct (of Wirsüng) is formed by the union of the distal portion of the dorsal pancreatic duct and the ventral pancreatic duct. The proximal portion of the dorsal pancreatic duct forms the accessory duct of Santorini. (Artwork by Jennifer Parsons Brumbaugh, M.A.) More about this image found in ANATOMY OF THE DEVELOPING PANCREAS Left: The dorsal pancreatic bud appears...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-03
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... classification for TNM staging . Ann Surg Oncol   2015 ; 22 ( Suppl 3 ): S1187 - 95 . 14. Elshaer   M , Gravante   G , Kosmin   M , Riaz   A , Al-Bahrani   A . A systematic review of the prognostic value of lymph node ratio, number of positive nodes and total nodes examined in pancreatic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of IgG4-positive plasma cells. AUTOIMMUNE PANCREATITIS-ASSOCIATED REACTIVE FIBROINFLAMMATORY PSEUDOTUMOR Figure 15-18 AUTOIMMUNE PANCREATITIS-ASSOCIATED REACTIVE FIBROINFLAMMATORY PSEUDOTUMOR The extensive storiform fibrosis in this case formed a mass. Note the lymphocytic venulitis (top left, arrow...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... be focal clear cell change (right). ACINAR CELL CARCINOMA Figure 9-21 ACINAR CELL CARCINOMA Staining with periodic acid–Schiff (PAS) with diastase digestion reveals intense, granular positivity in cases with numerous zymogen granules (left), but other cases show only faint staining (right). ACINAR CELL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). PANCREATOBLASTOMA Figure 10-10 PANCREATOBLASTOMA The nuclei in the squamoid nests show optically clear biotin inclusions (left) and therefore have nonspecific...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... Cytomorphology Immunophenotype Acinar cell carcinoma Solid and acinar patterns Granular eosinophilic cytoplasm, prominent nucleoli Trypsin, BCL10 positive; chromogranin A and synaptophysin usually focally positive Solid pseudopapillary neoplasm Solid and cystic with degenerative changes Loosely...
Images
MICROANATOMY OF THE VAGINA  A: Normal glycogenated squamous mucosa.  B: Atr...
Published: 01 February 2023
MICROANATOMY OF THE VAGINA Figure 1-13 MICROANATOMY OF THE VAGINA A: Normal glycogenated squamous mucosa. B: Atrophic squamous mucosa with occasional scattered MIB1-positive nuclei (inset). C: In contrast, maturing mucosa displays abundant MIB1-positive nuclei in the suprabasal cells (inset). More about this image found in MICROANATOMY OF THE VAGINA A: Normal glycogenated squamous mucosa. B: Atr...
Images
SQUAMOCOLUMNAR JUNCTION (SCJ)  A: This landmark demarcates the junction of ...
Published: 01 February 2023
SQUAMOCOLUMNAR JUNCTION (SCJ) Figure 1-8 SQUAMOCOLUMNAR JUNCTION (SCJ) A: This landmark demarcates the junction of the mature squamous mucosa and endocervical columnar epithelium. B: SCJ cells merging with an immature epithelium are strongly CK7 positive. C: In this example, a p16 immunostain h... More about this image found in SQUAMOCOLUMNAR JUNCTION (SCJ) A: This landmark demarcates the junction of ...