Search Results for positive

INVERTED SINONASAL PAPILLOMA, LOW-RISK HPV POSITIVE Figure 1-22 INVERTED SINONASAL PAPILLOMA, LOW-RISK HPV POSITIVE This inverted papilloma has the typical growth pattern (A), but exhibits prominent koilocytic changes in the epithelium (B). Papillomas with this appearance typically harbor low More about this image found in INVERTED SINONASAL PAPILLOMA, LOW-RISK HPV POSITIVE This inverted papillom...

OLFACTORY CARCINOMA Figure 1-45 OLFACTORY CARCINOMA A,B: Synaptophysin (A) and INSM1 (B) are positive. C: S-100 protein stains in a distinctly sustentacular pattern. D: Pancytokeratin is far more diffuse than is acceptable for olfactory neuroblastoma, however. More about this image found in OLFACTORY CARCINOMA A,B: Synaptophysin (A) and INSM1 (B) are positive. C:...

NASOPHARYNGEAL CARCINOMA Figure 3-13 NASOPHARYNGEAL CARCINOMA A: Ancillary in situ hybridization is positive for EBER. B–D: There is diffuse immunohistochemical reactivity for CK5/6 (B), p40 (C), and p63 (D). E: Nasopharyngeal carcinomas often demonstrate positive membranous immunoreactivity More about this image found in NASOPHARYNGEAL CARCINOMA A: Ancillary in situ hybridization is positive fo...

MULTIFOCAL EPITHELIAL HYPERPLASIA Figure 4-35 MULTIFOCAL EPITHELIAL HYPERPLASIA A HIV-positive male with multifocal epithelial hyperplasia of the lips (black arrows) and a concomitant condyloma acuminatum (white arrow). More about this image found in MULTIFOCAL EPITHELIAL HYPERPLASIA A HIV-positive male with multifocal epit...

PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY Figure 4-78 PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY A: A 32-year-old HIV-positive male has multiple hemorrhagic and ulcerated swellings of the gingiva. B: The lymphoma contains an admixture of immunoblast-like cells and medium-sized to large More about this image found in PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY A: A 32-year-old HIV-positive ma...

HEAD AND NECK PARAGANGLIOMA Figure 6-71 HEAD AND NECK PARAGANGLIOMA Immunohistochemical stains are positive for GATA3 (A), INSM1 (B), chromogranin (C), and S-100 protein in sustentacular cells (D); SDHB is retained within chief cells (E). More about this image found in HEAD AND NECK PARAGANGLIOMA Immunohistochemical stains are positive for GA...

CERUMINOUS ADENOMA Figure 8-71 CERUMINOUS ADENOMA A: All the neoplastic cells are strongly positive with pancytokeratin. B: The luminal cells tend to be highlighted with CK7 specifically. C: The basal-myoepithelial cells are highlighted by p63. D: GATA3 highlights the luminal-glandular cells More about this image found in CERUMINOUS ADENOMA A: All the neoplastic cells are strongly positive with ...

SINONASAL UNDIFFERENTIATED CARCINOMA Figure 1-41 SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely positive for pancytokeratin. B: Squamous markers like p40 are negative, or at most, focally positive. Diffuse staining excludes sinonasal undifferentiated carcinoma. C More about this image found in SINONASAL UNDIFFERENTIATED CARCINOMA A: This tumor type is diffusely posit...

BIPHENOTYPIC SINONASAL SARCOMA Figure 1-127 BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity for both S-100 protein (A) and SMA (B), although the extent of staining is variable. More about this image found in BIPHENOTYPIC SINONASAL SARCOMA This tumor type invariably shows positivity...

NASOPHARYNGEAL ANGIOFIBROMA Figure 3-31 NASOPHARYNGEAL ANGIOFIBROMA Stromal cells show strong nuclear positivity for β-catenin (A) and scattered stromal cells are positive for androgen receptor (B). More about this image found in NASOPHARYNGEAL ANGIOFIBROMA Stromal cells show strong nuclear positivity f...

HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-57 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature of the tumor is demonstrated. Myoepithelial cells stain for markers like smooth muscle actin (A), and the ductal elements are positive for CD117 (B). C,D More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...

INTESTINAL-TYPE ADENOCARCINOMA Figure 1-47 INTESTINAL-TYPE ADENOCARCINOMA A,B: CK7 is consistently negative (A), while CK20 is positive (B). C,D: Intestinal markers such as CDX2 (C) and SATB2 (D) are also positive in this tumor. More about this image found in INTESTINAL-TYPE ADENOCARCINOMA A,B: CK7 is consistently negative (A), whil...

PARAGANGLIOMA Figure 8-93 PARAGANGLIOMA Several immunohistochemistry studies aid in the diagnosis: chromogranin-positive paraganglia (A); synaptophysin-positive paraganglia (B); S-100 protein sustentacular cells (note dendritic cells in metaplastic squamous epithelium adjacent) (C); and intact More about this image found in PARAGANGLIOMA Several immunohistochemistry studies aid in the diagnosis: c...

RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT Figure 5-197 RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT A: Strong and diffuse staining with AE1/AE3. B: The spindle cells are desmin positive while the surface epithelium is negative. C: The tumor is strongly positive for MyoD1 More about this image found in RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT A: Strong and d...

MIDDLE EAR NEUROENDOCRINE TUMOR Figure 8-103 MIDDLE EAR NEUROENDOCRINE TUMOR The neoplastic cells are variably reactive with a number of different immunohistochemical markers: pancytokeratin shows most of the cells positive, although some are nonreactive (A); CK7 highlights the inner luminal More about this image found in MIDDLE EAR NEUROENDOCRINE TUMOR The neoplastic cells are variably reactive...

GLOMANGIOPERICYTOMA Figure 1-105 GLOMANGIOPERICYTOMA Various immunohistochemistry findings help to support the diagnosis. A: Strong, delicate SMA cytoplasmic reaction. B: Nuclear β-catenin stains all of the neoplastic cells. C,D: CD34 is usually negative (C), but may be positive (D) depending More about this image found in GLOMANGIOPERICYTOMA Various immunohistochemistry findings help to support ...

contains cohesive clusters of nonkeratinizing squamous cell carcinoma in a background of lymphocytes and debris. C,D: An immunohistochemical stain for p16 is strongly positive (C), and in situ hybridization for high-risk HPV (D) is also positive. More about this image found in METASTATIC HPV-ASSOCIATED SQUAMOUS CELL CARCINOMA A: The FNA shows crowded...

NEUROENDOCRINE TUMOR, GRADE 1 Figure 6-74 NEUROENDOCRINE TUMOR, GRADE 1 This tumor is strongly and diffusely positive for chromogranin-A. More about this image found in NEUROENDOCRINE TUMOR, GRADE 1 This tumor is strongly and diffusely positiv...

NEUROENDOCRINE TUMOR, GRADE 2 Figure 6-77 NEUROENDOCRINE TUMOR, GRADE 2 The neuroendocrine tumor is immunohistochemically positive for keratins (A), synaptophysin (B), and chromogranin (C). More about this image found in NEUROENDOCRINE TUMOR, GRADE 2 The neuroendocrine tumor is immunohistochemi...

ADENOSQUAMOUS CARCINOMA Figure 6-68 ADENOSQUAMOUS CARCINOMA A,B: A mucicarmine stain highlights the intracellular and intraluminal mucin. C: The squamous portions of the adenosquamous carcinoma are positive for p40. More about this image found in ADENOSQUAMOUS CARCINOMA A,B: A mucicarmine stain highlights the intracellu...