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COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-<span class="search-highlight">POSITIVE</span> MELANOCYTES  A: Compound...
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow) and intrade... More about this image found in COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound...
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MELANOCYTIC NEVUS WITH PLASMACYTOID AND ONCOCYTIC FEATURES  The nucleus of ...
Published: 01 February 2024
MELANOCYTIC NEVUS WITH PLASMACYTOID AND ONCOCYTIC FEATURES Figure 3-15 MELANOCYTIC NEVUS WITH PLASMACYTOID AND ONCOCYTIC FEATURES The nucleus of the melanocyte is positioned eccentrically (arrows). The cytoplasm is abundant and contains eosinophilic granular material. More about this image found in MELANOCYTIC NEVUS WITH PLASMACYTOID AND ONCOCYTIC FEATURES The nucleus of ...
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BIOPSY CLIP SITE  In this scanning magnification image, a <span class="search-highlight">positive</span> lymph no...
Published: 01 January 2024
BIOPSY CLIP SITE Figure 14-3 BIOPSY CLIP SITE In this scanning magnification image, a positive lymph node is seen on the left, and on the right is histologic evidence of the biopsy clip site, which must be identified and documented in any case in which preoperative lymph node sampling has occurre... More about this image found in BIOPSY CLIP SITE In this scanning magnification image, a positive lymph no...
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SPITZ NEVUS MISDIAGNOSED AS NEVOID MELANOMA  A: Silhouette of a raised nodu...
Published: 01 February 2024
SPITZ NEVUS MISDIAGNOSED AS NEVOID MELANOMA Figure 17-12 SPITZ NEVUS MISDIAGNOSED AS NEVOID MELANOMA A: Silhouette of a raised nodule with consumption of the epidermis. B: The tumor cells are diffusely positive for NTRK1; no cytogenetic aberration rearrangement was found. C: There is some, albe... More about this image found in SPITZ NEVUS MISDIAGNOSED AS NEVOID MELANOMA A: Silhouette of a raised nodu...
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PIGMENTED EPITHELIOID MELANOCYTOMA  A: Silhouette of a heavily pigmented co...
Published: 01 February 2024
PIGMENTED EPITHELIOID MELANOCYTOMA Figure 11-4 PIGMENTED EPITHELIOID MELANOCYTOMA A: Silhouette of a heavily pigmented compound tumor from the back of a 22-year-old male. There is associated epidermal hyperplasia. B: Epithelioid to ovoid cells are present, with a vesicular chromatin pattern and ... More about this image found in PIGMENTED EPITHELIOID MELANOCYTOMA A: Silhouette of a heavily pigmented co...
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MELANOMA WITH PLEXIFORM GROWTH  A: Asymmetric silhouette of a melanoma with...
Published: 01 February 2024
MELANOMA WITH PLEXIFORM GROWTH Figure 21-3 MELANOMA WITH PLEXIFORM GROWTH A: Asymmetric silhouette of a melanoma with conventional features in its superficial portion and a deep pigmented plexiform invasive tumor component. B: The superficial part of the tumor contains atypical cells in the epid... More about this image found in MELANOMA WITH PLEXIFORM GROWTH A: Asymmetric silhouette of a melanoma with...
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COMBINED BAP1-INACTIVATED MELANOCYTIC NEVUS  A: Silhouette of a predominant...
Published: 01 February 2024
COMBINED BAP1-INACTIVATED MELANOCYTIC NEVUS Figure 10-8 COMBINED BAP1-INACTIVATED MELANOCYTIC NEVUS A: Silhouette of a predominantly intradermal melanocytic nevus. B: There is a dual population of melanocytes with small conventional melanocytes present at the periphery of the lesion (thin arrow)... More about this image found in COMBINED BAP1-INACTIVATED MELANOCYTIC NEVUS A: Silhouette of a predominant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are immunoreactive for S-100 protein. In mixed DM, the nondesmoplastic tumor component, especially if it displays an epithelioid cell morphology, may be positive for Mart1/Melan-A, tyrosinase, MITF, or HMB-45. A rare undifferentiated DM may be negative for, or only minimally positive, for all melanocyte markers...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...)  Irregular surface lesion positive by ABCD criteria (asymmetric, irregular borders, multiple colors, diameter > 6 mm) Histopathologic Findings  Usually asymmetric silhouette  Melanoma in situ displaying nests and/or pagetoid melanocytes  Invasive tumor cells displaying cytologic atypia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with chromogen and lead to a false-positive staining result. When there is heavy pigmentation of keratinocytes, it is advantageous to use red chromogen and/or antibodies that recognize nuclear antigens (MITF, SOX10) ( 17 ). Immunohistochemistry can also help distinguish LM or LMM from benign proliferations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytes may only express SOX10 or S-100 protein   Most ordinary nevi express p16, some only partially; a few are negative by IHC   Most nevi are negative for PRAME, but some are partially positive  Cytogenetics   Usually no aberrations; occasionally a few isolated aberrations may be found...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow) and intradermal melanocytes (short arrow) are negative...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are negative for PRAME (preferentially expressed antigen in melanoma), but in some lesions, especially pigmented Spitz nevi, a significant or even predominant portion of tumor cells label for PRAME ( 36 ). Most Spitz nevi are negative for gp100 (HMB-45), but pigmented lesions may be positive. Loss...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nevus and differential labeling (nevus positive, atypical tumor cells positive for PRAME). Immunohistochemistry for PRKAR1A helps distinguish a melanoma from pigmented epithelioid melanocytoma (PEM) ( 14 ) or melanotic schwannian neoplasms ( 15 ). MOLECULAR GENETIC FINDINGS GNAQ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... pigmented plexiform invasive tumor component. B: The superficial part of the tumor contains atypical cells in the epidermis and dermis, some in mitosis (arrow). C: The deep plexiform component displays marked nuclear atypia (arrow). This tumor was associated with a positive sentinel lymph node...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., but unlike other nevi, are also usually positive for gp100 (HMB-45) ( 3 , 4 ). Most harbor mutations in GNAQ and GNA11, while mutations of CYSTLTR2 or PLCB4 or gene fusions involving GRIM1 or PRKCA are less common ( 2 , 5 – 11 ). DERMAL MELANOCYTOSES Dermal melanocytoses...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... VERSUS SPITZ MELANOMA Spitzoid Melanoma Spitz Melanoma Spitzoid Histology Spitzoid Histology Immunohistochemical Findings: Immunohistochemical Findings:  May be positive for BRAF V600E  Negative for BRAF V600E  May be positive for ALK, NTRK1, ROS1 Molecular Genetic Aberrations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with an increased risk for local recurrence, particularly if the surgical margins are positive or narrow ( 10 ). In such instances, radiotherapy may reduce the incidence of local recurrence. Regression. Regression refers to observations that the body’s immune system can attack and destroy tumor. Histologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (preferentially expressed antigen in melanoma) is a better ancillary method since melanomas tend to be strongly and diffusely immunoreactive, while most persistent nevi express PRAME only in a minor subpopulation, usually at the dermoepidermal junction. However, there are false-negative and false-positive test...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Molecular Genetic:   Genomic aberrations are common (cytogenetic tests are often positive)   NRAS mutations and noncoding mutations are common a Classic type of nevoid melanoma (melanoma simulating a small acquired or congenital nevus). CLINICAL FEATURES Nevoid melanomas occur at any...