INTRADUCTAL TUBULOPAPILLARY NEOPLASM Figure 6-60 INTRADUCTAL TUBULOPAPILLARY NEOPLASM Immunolabeling is positive for MUC1 (left) and MUC6 (right). More about this image found in INTRADUCTAL TUBULOPAPILLARY NEOPLASM Immunolabeling is positive for MUC1 (...

SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Figure 13-19 SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Immunolabeling is positive for CK18 (left) and CD99 (right). More about this image found in SCLEROSING EPITHELIOID MESENCHYMAL NEOPLASM Immunolabeling is positive for...

INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Figure 6-51 INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Immunolabeling for MUC6 is diffusely positive. More about this image found in INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM Immunolabeling for MUC6 is diffus...

AUTOIMMUNE PANCREATITIS, TYPE 1 Figure 15-17 AUTOIMMUNE PANCREATITIS, TYPE 1 The periductal infiltrate has increased numbers of IgG4-positive plasma cells. More about this image found in AUTOIMMUNE PANCREATITIS, TYPE 1 The periductal infiltrate has increased nu...

ACINAR CELL CARCINOMA Figure 9-24 ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered positive cells that make up less than 30 percent of the neoplasm. More about this image found in ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered posi...

PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...

DUODENAL GASTRINOMA Figure 12-74 DUODENAL GASTRINOMA The small tumor involves the duodenal submucosa (left), a more common location than the pancreas. Immunolabeling for gastrin is diffusely positive (right). More about this image found in DUODENAL GASTRINOMA The small tumor involves the duodenal submucosa (left)...

SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-20 SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse aberrant nuclear positivity (left). There is loss of membranous E-cadherin expression (right). More about this image found in SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse ...

MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Figure 12-88 MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Immunolabeling for synaptophysin (left) is positive in the neuroendocrine component, whereas carcinoembryonic antigen (right) labels the glandular component. More about this image found in MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Immunolabeling for synaptophysin (le...

UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES Figure 8-17 UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rhabdoid features. B,C: Immuno labeling for CK19 is positive (B), while INI1 is lost (C). More about this image found in UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rh...

ACINAR CELL CARCINOMA Figure 9-21 ACINAR CELL CARCINOMA Staining with periodic acid–Schiff (PAS) with diastase digestion reveals intense, granular positivity in cases with numerous zymogen granules (left), but other cases show only faint staining (right). More about this image found in ACINAR CELL CARCINOMA Staining with periodic acid–Schiff (PAS) with diasta...

DIFFUSE (PP) ISLETS Figure 15-68 DIFFUSE (PP) ISLETS Left: Lobular pancreatic tissue from the posterior head contains large diffuse islets with a trabecular architecture with irregular contours, mimicking an infiltrating neuroendocrine tumor. Right: Immunolabeling for pancreatic polypeptide (PP)... More about this image found in DIFFUSE (PP) ISLETS Left: Lobular pancreatic tissue from the posterior hea...

ANATOMY OF THE DEVELOPING PANCREAS Figure 1-1 ANATOMY OF THE DEVELOPING PANCREAS Left: The dorsal pancreatic bud appears first as a bud caudal to the stomach. The smaller ventral pancreatic bud arises from the base of the hepatic diverticulum. Neither bud expresses the sonic hedgehog (SHH) gene whereas the adjacent foregut does. Right: Rotation of the duodenum to the right carries the ventral bud to a position posterior to the dorsal bud, and the two primitive buds fuse to form the pancreas. The dorsal bud gives rise to the cephalad portion of the head, the body, and the tail, whereas the ventral bud gives rise to the caudal portion of the head and the uncinate process. The main pancreatic duct (of Wirsüng) is formed by the union of the distal portion of the dorsal pancreatic duct and the ventral pancreatic duct. The proximal portion of the dorsal pancreatic duct forms the accessory duct of Santorini. (Artwork by Jennifer Parsons Brumbaugh, M.A.) More about this image found in ANATOMY OF THE DEVELOPING PANCREAS Left: The dorsal pancreatic bud appears...

MICROANATOMY OF THE VAGINA Figure 1-13 MICROANATOMY OF THE VAGINA A: Normal glycogenated squamous mucosa. B: Atrophic squamous mucosa with occasional scattered MIB1-positive nuclei (inset). C: In contrast, maturing mucosa displays abundant MIB1-positive nuclei in the suprabasal cells (inset). More about this image found in MICROANATOMY OF THE VAGINA A: Normal glycogenated squamous mucosa. B: Atr...

SQUAMOCOLUMNAR JUNCTION (SCJ) Figure 1-8 SQUAMOCOLUMNAR JUNCTION (SCJ) A: This landmark demarcates the junction of the mature squamous mucosa and endocervical columnar epithelium. B: SCJ cells merging with an immature epithelium are strongly CK7 positive. C: In this example, a p16 immunostain h... More about this image found in SQUAMOCOLUMNAR JUNCTION (SCJ) A: This landmark demarcates the junction of ...