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Images
Published: 01 December 2024
SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-30 SF1 IN ADRENAL CORTICAL CARCINOMA Diffuse SF1-positive nuclear staining (A) highlights single neoplastic cells invading the periadrenal adipose tissue (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA Diffuse SF1-positive nuclear staining (A...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: INHIBIN STAINING Figure 8-44 PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is associated with any hypoxic pathway disease, including SDHx- and VHL-related disease and can be confirmed by staining for SDHB and CAIX. More about this image found in PHEOCHROMOCYTOMA: INHIBIN STAINING The presence of inhibin positivity is a...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING Figure 8-45 VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associated with VHL-related disease; it may be diffuse or focal as in this case. More about this image found in VHL-ASSOCIATED PHEOCHROMOCYTOMA: CAIX STAINING CAIX positivity is associat...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS Figure 8-39 PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show strong nuclear and cytoplasmic positivity in sustentacular cells, identified easily even if the tumor cells also show diffuse reactivity. B: The nuclei of sustentacular cel... More about this image found in PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show ...
Images
in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
SDH-DEFICIENT PARAGANGLIOMA Figure 10-5 SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained positivity in vascular endothelium serving as an internal positive control. More about this image found in SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient w...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between chr... More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...
Images
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Figure 9-36 CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalous immunoreactivity for keratins is present in this paraganglioma stained with antibody cocktail AE1/AE3. The tumor was diffusely positive for synapto... More about this image found in CAROTID BODY PARAGANGLIOMA WITH ANOMALOUS KERATIN EXPRESSION Focal anomalo...
Images
Published: 01 December 2024
ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm. This appearance is often associated with SDHB mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse expression to absent expression in a small region of the tumor. D: Immunohistochemical stain for S-100 protein shows heterogeneous distribution of sustentacular cells in adjacent areas of tumor. E: Immunohistochemical stain for glial fibrillary acidic protein (GFAP) shows a small focus of GFAP-positive sustentacular cells in a tumor in which S-100 protein-positive cells were much more numerous. More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...
Images
Published: 01 December 2024
ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-51 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Diffuse nonpolarized CYP11B2-positive immunohistochemistry is compared to adjacent cortex devoid of aldosterone-producing cells. More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Diffuse nonpolarized CYP11B...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA Figure 11-27 UNDIFFERENTIATED NEUROBLASTOMA This tumor could not be diagnosed by morphology only, but was shown to be a NB on the basis of positive cytoplasmic staining of chromogranin A (shown here), synaptophysin, and tyrosine hydroxylase, and nuclear staining of ... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA This tumor could not be diagnosed by morpho...
Images
Published: 01 December 2024
SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-31 SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cortical carcinoma in this transbronchial fine needle aspiration biopsy of a perihilar lymph node (A) is supported by positive nuclear staining for SF1 (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cort...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL INVOLVEMENT BY LYMPHOMA Figure 12-28 ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, replaces much of the adrenal gland, with only a few small nests of pale-staining cortical cells present in this field. B: Immunostain for CD20 is diffusely positive. More about this image found in ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, rep...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: 68GA DOTATATE SCAN Figure 8-51 PHEOCHROMOCYTOMA: 68GA DOTATATE SCAN Multifocal osteolytic skeletal lesions demonstrate dotatate avidity consistent with a somatostatin receptor-positive tumor. There is also activity in the retroperitoneum showing recurrent disease around the resection margin of the primary tumor. More about this image found in PHEOCHROMOCYTOMA: 68GA DOTATATE SCAN Multifocal osteolytic skel...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUSING ACROMEGALY Figure 8-41 PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUSING ACROMEGALY The presentation of this patient with acromegaly prompted staining of the tumor for GHRH; the tumor is di... More about this image found in PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUS...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA: SDHB STAINING Figure 8-43 PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with retained positivity in the stroma serving as an internal control provides strong evidence of SDHX-related disease and should prompt genetic investigation. B: The presence of intact reactivity for SDHB suggests that the tumor is not related to SDHx mutation. More about this image found in PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with reta...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Figure 1-14 S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positive cells are present at the periphery of a small neuroblastic aggregate (right), while others are associated with scattered more mature-appearing cells with clear c... More about this image found in S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positiv...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
GATA3 IN NORMAL ADRENAL MEDULLA Figure 1-51 GATA3 IN NORMAL ADRENAL MEDULLA GATA3 is expressed in normal and neoplastic adrenal medulla and extra-adrenal paraganglia but not adrenal cortex. It is a valuable marker for diagnosis but is widely ex pressed in various tissues and must be considered in... More about this image found in GATA3 IN NORMAL ADRENAL MEDULLA GATA3 is expressed in normal and neoplasti...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION Figure 11-16 UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stage 3 NB in a 5-year-old girl was not pretreated and showed this peculiar undifferentiated spindle cell morphology without presence of neuropil, ga... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH SPINDLE CELL DIFFERENTIATION This stag...
Images
Published: 01 December 2024
URINARY BLADDER PARAGANGLIOMA Figure 9-35 URINARY BLADDER PARAGANGLIOMA A: This extensively invasive urinary bladder paraganglioma deep within the bladder wall is a potential mimic of prostatic or urothelial carcinoma. B: Diffuse expression of tyrosine hydroxylase confirms the identity of the tu... More about this image found in URINARY BLADDER PARAGANGLIOMA A: This extensively invasive urinary bladder...
Images
Published: 01 December 2024
PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION Figure 9-42 PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION The liver was infiltrated by tumor cells from a 10-cm partly intrahepatic and partly extrahepatic mass. The mass was a known recurrence of an extrahepatic tumor, and the intrahepatic co... More about this image found in PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION The liver was infiltrate...
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