DUCTAL ADENOCARCINOMA Figure 7-9 DUCTAL ADENOCARCINOMA Poorly differentiated carcinoma with a haphazard growth pattern and predominantly solid nests. More

DUCTAL ADENOCARCINOMA Figure 7-21 DUCTAL ADENOCARCINOMA Poorly differentiated ductal adenocarcinoma with minimal gland formation. More

DUCTAL ADENOCARCINOMA, POORLY DIFFERENTIATED Figure 7-39 DUCTAL ADENOCARCINOMA, POORLY DIFFERENTIATED Three-dimensional, papillary cluster with highly irregular hyperchromatic nuclei (Papanicolaou). More

DUCTAL ADENOCARCINOMA, POORLY DIFFERENTIATED Figure 7-40 DUCTAL ADENOCARCINOMA, POORLY DIFFERENTIATED Enlarged, multilobated nuclei have markedly prominent nucleoli (Papanicolaou). More

MEDULLARY CARCINOMA Figure 8-14 MEDULLARY CARCINOMA Syncytial growth of poorly differentiated cells with a pushing border (left) and associated lymphocytes (right). More

UNDIFFERENTIATED CARCINOMA Figure 8-18 UNDIFFERENTIATED CARCINOMA The neoplastic cells are poorly cohesive (left: direct smear; right: Diff Quik stain). More

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-61 PANCREATIC NEUROENDOCRINE TUMOR Left: Small, poorly cohesive plasmacytoid cells in a G1 PanNET (hematoxylin and eosin [H&E] stain). Right: Coarse chromatin and well-defined cytoplasm in a G1 PanNET (H&E stain). More

FOLLICULAR LYMPHOMA Figure 14-7 FOLLICULAR LYMPHOMA Cytologically, there is a diffuse, poorly cohesive population of small to medium-sized cells with little cytoplasm and peripherally clumped chromatin (Papanicolaou stain). More

MUCINOUS CYSTIC NEOPLASM WITH ASSOCIATED INVASIVE ADENOCARCINOMA Figure 5-19 MUCINOUS CYSTIC NEOPLASM WITH ASSOCIATED INVASIVE ADENOCARCINOMA Some invasive carcinomas are poorly differentiated or sarcomatoid. More

PERIVASCULAR EPITHELIOID CELL TUMOR (PEComa) Figure 13-10 PERIVASCULAR EPITHELIOID CELL TUMOR (PEComa) On smears, the cells have delicate, poorly defined cytoplasm. Nuclear enlargement can be pronounced (Diff Quik stain). More

MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Figure 12-87 MIXED DUCTAL-NEUROENDOCRINE CARCINOMA Left: The neuroendocrine component is poorly differentiated, large cell type, and the adenocarcinoma component resembles conventional ductal adenocarcinoma, with simple mucinous glands. Right: Mucicarmine st... More

DUCTAL ADENOCARCINOMA Figure 7-5 DUCTAL ADENOCARCINOMA A: Gross cross-section of an adenocarcinoma in the body of the pancreas with a normal downstream pancreatic duct (left), a small cancer (center), and dilatation of the upstream pancreatic duct (right). B: Gross cross-section of an adenocarci... More

POORLY DIFFERENTIATED NONKERATINIZING SQUAMOUS CELL CARCINOMA Figure 3-23 POORLY DIFFERENTIATED NONKERATINIZING SQUAMOUS CELL CARCINOMA This tumor is nested, in keeping with an epithelial malignancy, but it lacks keratinization or overt squamous differentiation. Distinction from other poorly diff... More

INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED Figure 4-9 INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED This tumor may be difficult to recognize as a squamous cell carcinoma since there is no keratinization or overt squamous architecture. A p63 stain may help to confirm the dia... More

KAPOSI SARCOMA Figure 5-80 KAPOSI SARCOMA Left: The lesion usually has a nodular or plaque-like appearance. Right: It is formed by bland spindle cells surrounding poorly formed vessels; the stroma has slit-like spaces, associated with red blood cell extravasation and hemosiderin deposition. More

HPV-INDEPENDENT SQUAMOUS NEOPLASIA OF THE CERVIX Figure 3-30 HPV-INDEPENDENT SQUAMOUS NEOPLASIA OF THE CERVIX This rare example of a squamous intraepithelial lesion of the cervix was worrisome for HSIL but was negative for p16 (left). The lesion was associated with a poorly differentiated invasiv... More