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pleomorphic

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 53-1 GENES IMPLICATED IN CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA MDM2 CDKN2A/B PDGFRA PDGFRB EGFR PIK3CA ACOX2 FH CARDIAC UNDIFFERENTIATED PLEOMORPHIC SARCOMA: IMMUNOHISTOCHEMICAL FEATURES...
Images
SPITZ MELANOMA WITH <em>MAP3K8</em> FUSION  The tumor cells display...
Published: 01 February 2024
SPITZ MELANOMA WITH MAP3K8 FUSION Figure 19-5 SPITZ MELANOMA WITH MAP3K8 FUSION The tumor cells display pleomorphic epithelioid cell features with distinct nucleoli. They are from an in-transit metastasis. More about this image found in SPITZ MELANOMA WITH MAP3K8 FUSION The tumor cells display...
Images
CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN)  There is a dense nod...
Published: 01 February 2024
CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) Figure 2-15 CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) There is a dense nodular aggregate of epithelioid melanocytes, but the aggregate blends with the nevus background, and marked pleomorphism and mitoses are absent. More about this image found in CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) There is a dense nod...
Images
SUPERFICIAL SPREADING MELANOMA, IN SITU AND INVASIVE  A: Asymmetric silhoue...
Published: 01 February 2024
SUPERFICIAL SPREADING MELANOMA, IN SITU AND INVASIVE Figure 12-9 SUPERFICIAL SPREADING MELANOMA, IN SITU AND INVASIVE A: Asymmetric silhouette of the tumor. B: Atypical melanocytes are present in the epidermis as junctional nests and solitary units in the spinous cell layer. C: The intradermal ... More about this image found in SUPERFICIAL SPREADING MELANOMA, IN SITU AND INVASIVE A: Asymmetric silhoue...
Images
SPITZ MELANOCYTOMA  A: Silhouette of a cellular tumor with extension into t...
Published: 01 February 2024
SPITZ MELANOCYTOMA Figure 7-23 SPITZ MELANOCYTOMA A: Silhouette of a cellular tumor with extension into the deep dermis and deep bulbous growth. B: Nests of plump spindle and epithelioid cells are present at the dermoepidermal junction and fascicles are seen in the dermis. C: Epithelioid melano... More about this image found in SPITZ MELANOCYTOMA A: Silhouette of a cellular tumor with extension into t...
Images
<span class="search-highlight">PLEOMORPHIC</span> APOCRINE LOBULAR CARCINOMA IN SITU  This example of <span class="search-highlight">pleomorphic</span>...
Published: 01 January 2024
PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU Figure 4-15 PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU This example of pleomorphic LCIS has abundant eosinophilic cytoplasm in addition to the pronounced nuclear pleomorphism and prominent nucleoli. More about this image found in PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU This example of pleomorphic...
Images
<span class="search-highlight">PLEOMORPHIC</span> LOBULAR CARCINOMA IN SITU  A: At low power, the acinus is expan...
Published: 01 January 2024
PLEOMORPHIC LOBULAR CARCINOMA IN SITU Figure 4-13 PLEOMORPHIC LOBULAR CARCINOMA IN SITU A: At low power, the acinus is expanded by a highly atypical, and dyshesive, epithelial proliferation with the significant nuclear pleomorphism. B,C: At intermediate and higher power, the nuclear pleomorphism... More about this image found in PLEOMORPHIC LOBULAR CARCINOMA IN SITU A: At low power, the acinus is expan...
Images
<span class="search-highlight">PLEOMORPHIC</span> LOBULAR CARCINOMA IN SITU  High power illustrates the nuclear p...
Published: 01 January 2024
PLEOMORPHIC LOBULAR CARCINOMA IN SITU Figure 4-14 PLEOMORPHIC LOBULAR CARCINOMA IN SITU High power illustrates the nuclear pleomorphism that characterizes this entity. Cytologic dyshesion is appreciated in this example. More about this image found in PLEOMORPHIC LOBULAR CARCINOMA IN SITU High power illustrates the nuclear p...
Images
<span class="search-highlight">PLEOMORPHIC</span> WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU  A: Intermediat...
Published: 01 January 2024
PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU Figure 4-17 PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU A: Intermediate-power image shows adjacent areas of classic (right side of image) and pleomorphic LCIS (central and left side of image). B: High power shows the lar... More about this image found in PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU A: Intermediat...
Images
<span class="search-highlight">PLEOMORPHIC</span> LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA  A lobule...
Published: 01 January 2024
PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA Figure 4-18 PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule is expanded by atypical, dyshesive epithelial cells with large pleomorphic nuclei. Present in the stroma adjacent to this focus are several scat... More about this image found in PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule...
Images
INVASIVE LOBULAR CARCINOMA, <span class="search-highlight">PLEOMORPHIC</span> TYPE  The nuclei are large, and var...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE Figure 8-38 INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and vary considerably in size and shape, sufficient for a diagnosis of pleomorphic lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and var...
Images
INVASIVE LOBULAR CARCINOMA, <span class="search-highlight">PLEOMORPHIC</span> TYPE  A focus of lymphovascular spa...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE Figure 8-39 INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE A focus of lymphovascular space invasion. More about this image found in INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE A focus of lymphovascular spa...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... lymph node. SPITZ MELANOMA WITH MAP3K8 FUSION Figure 19-5 SPITZ MELANOMA WITH MAP3K8 FUSION The tumor cells display pleomorphic epithelioid cell features with distinct nucleoli. They are from an in-transit metastasis. Along with a spitzoid cytology, microscopic features also suggest...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... likened to a “fried egg” ( fig. 11-3 ). The epithelioid cell may be multinucleated, display nuclear pleomorphism, and resemble a Reed-Sternberg cell. The cytoplasm is heavily pigmented with fine melanin granules. The epithelioid melanocytes are usually admixed with variable proportions of pigmented...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Histopathologic Findings  Fascicles of spindle cells with tumor overgrowth (loss of intervening fibrous bands)  Expansile aggregates of atypical epithelioid cells  Nuclear pleomorphism  Mitoses  Necrosis (variable)  Dual population of atypical melanocytes associated with benign melanocytes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... pigmented, containing fine melanin granules. The nuclei vary in size and appearance. Some melanocytes display enlarged pleomorphic hyperchromatic nuclei or pseudonuclear inclusions ( fig. 9-6 ). Mitoses are usually absent or rare (usually 2 or less per mm2). DEEP PENETRATING NEVUS Figure 9-6...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... cells. Since the lesions we recognize as LCIS have expanded, the above definition refers to what is now called “classic LCIS” or just LCIS. Pleomorphic LCIS and florid LCIS comprise newer lesions and have been referred to as “nonclassic” or “variant” forms of LCIS, although the use of the specific...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of epithelioid melanocytes, but the aggregate blends with the nevus background, and marked pleomorphism and mitoses are absent. CMN WITH MID AND DEEP DERMAL PN Figure 2-16 CMN WITH MID AND DEEP DERMAL PN A: There is an amelanotic cellular nodule in the dermis and subcutis. B: The associated nevus shows bland...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...: Atypical melanocytes are present in the epidermis as junctional nests and solitary units in the spinous cell layer. C: The intradermal melanocytes lack maturation and display nuclear pleomorphism. MELANOMA IN SITU WITH FOCAL MICROINVASION Figure 12-10 MELANOMA IN SITU WITH FOCAL MICROINVASION Rare...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... by LMM. Some LMMs display a nested or dermal nevus-like growth pattern, simulating a melanocytic nevus. Other tumors are pleomorphic and/or infiltrative, with an obviously malignant appearance. Many invasive tumor cells are paucimelanotic; some are amelanotic, desmoplastic, neurotropic, or a combination...