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Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: NUCLEAR ATYPIA Figure 6-17 ADRENAL CORTICAL CARCINOMA: NUCLEAR ATYPIA A–C: Pleomorphic cells are variably present, including multinucleated large cells. More about this image found in ADRENAL CORTICAL CARCINOMA: NUCLEAR ATYPIA A–C: Pleomorphic cells are vari...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ANAPLASTIC NEUROBLASTOMA Figure 11-15 ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic nuclei. More about this image found in ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic ...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA Figure 8-26 PHEOCHROMOCYTOMA Some tumors have significant nuclear pleomorphism. More about this image found in PHEOCHROMOCYTOMA Some tumors have significant nuclear pleomorphism.
Images
Published: 01 December 2024
MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA Figure 9-23 MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA The presence of nuclear pleomorphism, together with artifactual cytoplasmic vacuolization and clearing in this paraganglioma, may suggest adenocarcinoma as a diagnosis. More about this image found in MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA The presence of nuclear pleomorp...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-23 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged pleomorphic nuclei are seen in some cells, which are markedly different than the nuclei of adjacent tumor cells. A few cells also contain finely granula... More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged...
Images
in Hereditary Predisposition to Adrenal Cortical Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Figure 7-8 ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Nine-month-old boy with 8-cm right adrenal tumor. No signs of hormonal overproduction. Resection specimen shows nuclear pleomorphism and incre... More about this image found in ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Ni...
Images
Published: 01 December 2024
ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-40 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A: The oncocytic adrenal cortical adenoma weighed 12 g and measured 3 cm. It was discovered incidentally on abdominal CT scan in a 67-year-old man who underwent surgical resection of a colonic adenocarci... More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE A: The oncocytic adrenal cortical...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMARY ADRENAL MELANOMA Figure 12-19 PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pain; imaging studies revealed a right adrenal mass; the patient had no evidence of melanoma in any other site following rigorous investigation using a multidisciplinary approach. Part of... More about this image found in PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pa...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged pleomorphic nuclei are seen in some cells, which are markedly different than the nuclei of adjacent tumor cells. A few cells also contain finely granular brown lipofuscin pigment. ATYPICAL CELLS IN ADRENAL CORTICAL ADENOMA Figure 5-24...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cytoplasmic invaginations ( fig. 8-25 ). Some tumors exhibit significant nuclear pleomorphism ( fig. 8-26 ), forming bizarre giant hyperchromatic nuclei and sometimes multinucleated cells ( figs. 8-27 , 8-28 ). Occasional tumors have prominent mitotic figures ( fig. 8-29 ). PHEOCHROMOCYTOMA Figure 8-20...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) PARAGANGLIOMA Figure 9-23 MIDDLE EAR (JUGULOTYMPANIC) PARAGANGLIOMA The presence of nuclear pleomorphism, together with artifactual cytoplasmic vacuolization and clearing in this paraganglioma, may suggest adenocarcinoma as a diagnosis. CAROTID BODY PARAGANGLIOMA Figure 9-24 CAROTID BODY PARAGANGLIOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical lesions are mistakenly diagnosed as malignant based upon cytologic atypia and nuclear pleomorphism ( 40 ). BILATERAL ORCHIECTOMY SPECIMENS FROM A 25-YEAR-OLD MALE WITH SALT-LOSING FORM OF 21-HYDROXYLASE DEFICIENCY Figure 2-14 BILATERAL ORCHIECTOMY SPECIMENS FROM A 25-YEAR-OLD MALE WITH SALT...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be distinguished from oncocytic changes characterized by deeper eosinophilia and a finely granular appearance Nuclear grade To be assessed based on the presence and size of nucleoli Nuclear pleomorphism is nonspecific and usually found in ACC mimics such as pheochromocytoma Mitotic index and atypical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... degrees of differentiation. The least differentiated cell, the neuroblast, has a relatively small, hyperchromatic, round nucleus with little pleomorphism and scant cytoplasm. Sometimes, the dispersed chromatin gives the impression of stippling or speckling of the nucleus, and rarely, nuclear inclusions...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... immunodeficiency virus (HIV) positive ( 52 ). MPNSTs can exhibit spindle cell, epithelioid, or pleomorphic morphology, mimicking a variety of other malignant tumors ( fig. 12-17 ). High-grade MPNSTs may show limited or absent expression of S-100 protein and SOX10. A feature recently reported...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... are limited to the fetal cortex. They may be as large as 120 μm in diameter and show marked nucleomegaly with pleomorphism and hyperchromasia. Nuclei of megalic cells may contain over 25 times the normal amount of DNA ( 45 ). Characteristically, there are no identifiable mitotic figures. CYTOMEGALY...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be an admixture of cells with more lipid-rich, vacuolated cytoplasm. Some nodules contain abundant lipid-rich cells that may show some “ballooning.” Nuclear hyperchromasia and pleomorphism are uncommon, although occasionally cells are binucleated or multinucleated, or have enlarged hyperchromatic nuclei...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be considered ( 77 ). ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Figure 7-8 ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Nine-month-old boy with 8-cm right adrenal tumor. No signs of hormonal overproduction. Resection specimen shows nuclear pleomorphism...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of the neoplasm. NASOPHARYNGEAL CARCINOMA Figure 8-12 NASOPHARYNGEAL CARCINOMA Strong epithelial positivity is seen on EBV-encoded small RNA (EBER) in situ hybridization (ISH), confirming the EBV association of the tumor. EBV-infected B-lymphoid cells are usually large, can have pleomorphic or multilobated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-10
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... arenavirus due to its distribution in Africa. On electron microscopy, the virus has a variable size, pleomorphic morphology, and internal granularity (representing host cell ribosomes), from which it derives its name (from Etruscan word “arena” = sand) ( fig. 10-6 ). The viral RNA segments have...
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