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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of steroid-producing cells ( 2 ), serves as a marker for steroid-producing tumors, and interacts in normal development with beta-catenin, which is frequently dysregulated in adrenal cortical carcinomas ( 3 ). PHYSIOLOGY Adrenal Cortex The adrenal cortex plays vital roles via the actions of three major...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... stained for chromogranin A. The term parasympathetic paraganglia is an anatomic designation indicating an association with a classic parasympathetic nerve rather than a physiologic definition implying a role in antagonizing sympathetic nervous system functions. With the exception of the carotid bodies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in many aspects of adrenal physiology ( 6 ). Some children with ACC have peculiar clinical and pathologic characteristics, which are described later in this chapter. In adult patients, a broad age-span peak in the 5th and 6th decades is observed, although ACC can occur at any age. There does not appear...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ATPase 3 (PMCA3). Mutations are found in the transmembrane domain M4 and lead to reduced calcium export, which is due to the loss of the physiologic pump functions, and increased intracellular calcium signaling due to the depolarization-activated Ca2+ channels or to an increase in calcium...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... anatomic variation ( 116 ). Also, although chromaffin cells in some normal adult rodent adrenal glands proliferate in response to physiologic signals ( 117 ), the same has not been demonstrated for normal human chromaffin cells in vivo or in vitro. True reactive hyperplasia is rare. Medullary expansion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... magnification image of a fresh hematoma. B: Hemorrhagic necrosis of overlying adrenal cortex. The susceptibility of the adrenal gland to massive hemorrhage is attributed to its vascular supply and pivotal role in physiologic response to stress; likened to a “vascular dam,” any rise in adrenal venous pressure...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... are divided into type 1 and 2 depending on the fragments created by proteinase digestion. The pathogenesis of prion disease is complex and incompletely understood, although research has shed much light on how these misfolded proteins derail normal physiology. The “protein only” hypothesis proposes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Control   2017 ; 75 : 1 - 13 . 4. Radoshevich   L , Cossart   P . Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis . Nat Rev Microbiol   2018 ; 16 : 32 - 46 . 5. Brouwer   MC , van de Beek   D , Heckenberg   SG , Spanjaard   L , de...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...   A . Tularemia: history, epidemiology, pathogen physiology and clinical manifestations . Ann N Y Acad Sci   2007 ; 1105 : 1 - 29 . 12. Tuncer   E , Onal   B , Simsek   G , et al . Tularemia: potential role of cytopathology in differential diagnosis of cervical lymphadenitis: multicenter...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., pain, and fatigability, usually involving muscles affected by the prior acute infection. The cause is postulated to be physiologic senescence of the innervation of muscles already partly denervated by the prior poliovirus infection ( 37 ). Pathologic Findings The most comprehensive autopsy studies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-26
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... Hernandez   J , Lackner   A , Aye   P , et al . Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis . Infect Immun   2007 ; 75 : 1137 - 43 . 36. Godwin   TA . Cryptosporidiosis in the acquired...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in Physiology/Medicine in 2008 ( 36 ). HUMAN PAPILLOMAVIRUS (HPV) Figure 9-33 HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain (courtesy of the CDC PHIL) and schematic (right) of HPV structure (left). B: Schematic of HPV genome (not to scale). C: Schematic of mechanism of E6...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... invade tissues, it causes disease by significantly altering the gastric acid secretory physiology. The enzyme urease is crucial for the bacterium’s survival in the harsh acidic environment of the stomach, while a cytotoxin-associated gene product (CagA) and a pore-forming protein (vacuolating cytotoxin...
Images
Published: 15 November 2023
COMPLICATIONS INDICATIVE OF FAILING FONTAN PHYSIOLOGY Figure 38-8 COMPLICATIONS INDICATIVE OF FAILING FONTAN PHYSIOLOGY Left: Protein-losing enteropathy. Small bowel with dilated lymphatic (arrow) in an adolescent, 4 years post-Fontan for hypoplastic left heart syndrome. Sloughed mucosa is due to... More about this image found in COMPLICATIONS INDICATIVE OF FAILING FONTAN PHYSIOLOGY Left: Protein-losing...
Images
Published: 15 November 2023
NONSPECIFIC CHRONIC INFLAMMATION Figure 24-6 NONSPECIFIC CHRONIC INFLAMMATION A chronic inflammatory infiltrate within fibrosis or scar should not be regarded as rejection. The prominent physiologic contraction bands do not reflect ischemic injury. More about this image found in NONSPECIFIC CHRONIC INFLAMMATION A chronic inflammatory infiltrate within ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Sclerosing adenosis and other adenoses discussed in this chapter are a collection of benign breast lesions characterized by an increase in the number of acini above physiologic norms, such as during pregnancy and lactation. In most types of adenosis, the lobulocentric growth pattern is maintained...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch04
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... in the virtue of moderation . JACC Electrophysiol   2017 ; 3 : 921 - 8 . 23. Abel   ED , Doenst   T . Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy . Cardiovasc Res   2011 ; 90 : 234 - 42 . 24. van de Schoor   FR , Aengevaeren   VL , Hopman   MT...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... rare ( 85 ) JPH2 Junctophilin 2 rare ( 86 ) ALPK3 Alpha-kinase 3 rare ( 87 ) FHOD3 Formin homology 2 domain containing 3 rare ( 88 ) Table 15-3 CLINICAL CHARACTERISTICS DISTINGUISHING PHYSIOLOGIC FROM PATHOLOGIC HYPERTROPHY Physiologic Pathologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch20
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., it is difficult to determine whether increased left ventricular mass is a physiologic (adaptive) or pathologic sequela. Clinically, electrocardiographic changes (e.g., P-wave dispersion, left axis deviation of 45 degrees or more) have been reported to have some specificity for true hypertensive heart disease ( 26...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch38
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of lymphocytes, plasma cells, and neutrophils in the lamina propria No blunting of intestinal villi Table 38-7 FINDINGS IN LUNG TISSUE FROM PATIENTS WITH FONTAN-RELATED PLASTIC BRONCHITIS AND CHRONIC FONTAN PHYSIOLOGY Microscopic Findings Large bronchial casts (with plastic bronchitis) Dilated...