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Images
Published: 01 March 2023
PANCREATIC NEUROENDOCRINE TUMOR Figure 12-47 PANCREATIC NEUROENDOCRINE TUMOR Immunolabeling for Ki-67 allows grading as low grade (G1), with 1 percent of nuclei labeling (A); intermediate grade (G2), with 9 percent labeling (B); or high grade (G3), with 30 percent labeling (C). A G3 PanNET (D) sh... More about this image found in PANCREATIC NEUROENDOCRINE TUMOR Immunolabeling for Ki-67 allows grading as...
Images
Published: 01 March 2023
PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE Figure 12-83 PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE The Ki-67 labeling index is 90 percent. More about this image found in PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE The Ki-67 labeling in...
Images
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-24 ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered positive cells that make up less than 30 percent of the neoplasm. More about this image found in ACINAR CELL CARCINOMA Immunolabeling for chromogranin shows scattered posi...
Images
Published: 01 March 2023
MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-43 MIXED ACINAR-NEUROENDOCRINE CARCINOMA The morphology (A) is homogeneous but there is immunolabeling for both trypsin (B) and synaptophysin (C) in more than 30 percent of the cells. More about this image found in MIXED ACINAR-NEUROENDOCRINE CARCINOMA The morphology (A) is homogeneous bu...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ( 17 ). These neoplasms exceed kidney and lung metastases in many series that include the hematolymphoid neoplasms, comprising 7 to 47 percent of pancreatic metastases in an EUS-FNA series and 7 to 19 percent in an autopsy series ( 8 , 11 , 17 , 23 , 25 , 61 , 62 ). Non-Hodgkin lymphoma is the most...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...) and synaptophysin (C) in more than 30 percent of the cells. MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-44 MIXED ACINAR-NEUROENDOCRINE CARCINOMA Double immunohistochemical labeling for trypsin (blue reaction product) and synaptophysin (brown reaction product) shows the relationship of the two cells types...
Images
Published: 01 March 2023
MIXED DUCTAL ADENOCARCINOMA-PanNET Figure 12-90 MIXED DUCTAL ADENOCARCINOMA-PanNET Most of the neoplasm consists of a conventional PanNET, with focal morphologically distinct mucinous glands representing a ductal adenocarcinoma component (A,B). The PanNET component expresses chromogranin A (C) an... More about this image found in MIXED DUCTAL ADENOCARCINOMA-PanNET Most of the neoplasm consists of a conv...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... asteroid bodies are seen (right). PANCREATIC NEUROENDOCRINE TUMOR Figure 12-47 PANCREATIC NEUROENDOCRINE TUMOR Immunolabeling for Ki-67 allows grading as low grade (G1), with 1 percent of nuclei labeling (A); intermediate grade (G2), with 9 percent labeling (B); or high grade (G3), with 30 percent...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... results are not specific enough for a definitive diagnosis. Unfortunately, a definitive cytology diagnosis is also often elusive, possible in only 10 percent by EUS-FNA ( 60 ). Retrospective analysis has shown up to 20 percent of EUS-guided aspirates contain identifiable serous cells ( 61 ). Successful...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ( 216 ). The symptoms are similar to those of IPMNs. Gross Findings. ITPNs are mainly (45 percent) located in the pancreatic head, followed by the body and tail (32 percent); 23 percent involve the entire gland ( 216 ). The tumors are solid, fleshy, nodular masses of a mean size of 4.5 cm (range, 0.5...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... VARIATIONS The Endocrine Pancreas Endocrine cells comprise only 1 to 2 percent of the mass of the adult pancreas; 90 percent of these cells are organized in richly innervated, highly vascularized, small collections called the islets of Langerhans. Single endocrine cells are also scattered throughout...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... presented with metastases and an additional 15 percent developed them later in their course ( 19 ). Fifteen of the 35 patients (43 percent) died from their disease, after a mean of 17 months. Review of more recent follow-up data paints a somewhat more optimistic picture, however ( 79 ). In the pediatric age...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., cancers with microsatellite instability respond exceptionally well to immunotherapy ( 300 ). Prognosis. The 5-year survival rate for patients diagnosed with pancreatic cancer is only 11 percent ( fig. 7-47 ) ( 382 ). This represents only a minimal improvement over the 5 percent 5-year survival rate...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... mutations are highly suggestive of IPMNs ( 55 ). In one study of cyst fluid, absence of CTNNB1 or GNAS mutations, chromosome 3 LOH, or aneuploidy of chromosome 1q or 22q identified MCNs with 100 percent sensitivity and 75 percent specificity ( 55 ). Importantly, the degree of aneuploidy...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...). In children, the most common presentation is vomiting or a palpable mass; some patients are asymptomatic. Adults present most commonly with abdominal or back pain (40 percent). Aspiration findings of teratoma may be nonspecific. The contents of a dermoid cyst include mature squamous epithelial cells...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... from 0.3 percent of pancreatic neoplasms submitted to a referral center, to about 10 percent of pancreatic non-neuroendocrine neoplasms seen at autopsy ( 96 – 99 ). Men are affected more often than women, with a male to female ratio of 1.2-2.0 to 1.0 ( 98 ). The mean age at diagnosis is about 65 years...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... cysts range from 1.2 to 17.0 cm (mean, 4.7 cm); they may be unilocular (40 percent) or multilocular (60 percent) ( 158 ). They are well circumscribed and sharply demarcated from the adjacent pancreas ( fig. 15-52 ), sometimes even appearing to be peripancreatic. The cyst wall is usually only 1- to 3-mm...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-11
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... patients who presented initially with nonmetastatic solid pseudopapillary neoplasms revealed recurrence in only 69 cases (2.6 percent) ( 219 ). For the 10 to 15 percent of patients with metastatic disease, long-term survival is also common, and it may be years before the growth of metastases causes...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-16
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... nitrogen and store at -80° C to preserve the DNA, mRNA, and protein. The entire specimen can then be fixed in 10 percent buffered formalin overnight for best results with further dissection and sectioning for histology. Tissue Sections. The purpose of histologic evaluation of any specimen is for diagnosis...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-02
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., and pancreatic neuroendocrine carcinomas (PanNECs), which are poorly differentiated, is maintained. PanNETs are now recognized occasionally to demonstrate high proliferation rates (Ki-67 over 20 percent or mitotic rate over 20 per 2 mm2), which fall within the high-grade (grade 3) range. Because...
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