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Figure 4-15

CARCINOMA CUNICULATUM A: Cut surface of the gross surgical specimen from a...

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in Oral Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
CARCINOMA CUNICULATUM Figure 4-15 CARCINOMA CUNICULATUM A: Cut surface of the gross surgical specimen from a hemiglossectomy shows a deeply penetrating lesion arising from the posterior dorsal tongue. (Courtesy of Dr. K. Magliocca, Atlanta, GA) B: Low-power image shows invaginating keratin More about this image found in CARCINOMA CUNICULATUM A: Cut surface of the gross surgical specimen from a...
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Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... , 61 ). Grossly and microscopically, CC is characterized by a proliferation of well-differentiated epithelium with a predominately endophytic growth pattern, although an exophytic component may be present ( fig. 4-15A,B ). The hallmark of CC is the presence of deeply penetrating, keratin-filled...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... ) or into the wall, mural UA ( fig. 5-51C ). Initially, mural infiltration was still considered UA as long as the mural infiltration did not penetrate to or beyond the external margin of the “cyst.” UNICYSTIC AMELOBLASTOMA (UA) VARIANTS Figure 5-51 UNICYSTIC AMELOBLASTOMA (UA) VARIANTS A: Luminal variant where...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
.... A. M. Valsalva noted fixation of the stapes ( 700 ), later specifically called otosclerosis and recognized to produce deafness. The majority of cases are inherited by an autosomal dominant pattern with variable penetrance. The major gene loci involved are designated as otosclerosis (OTSC...
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Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... with smooth muscle walls. Mast cells are also common. The stroma shows nuclear β-catenin, as well as androgen receptor, with actins limited to the vessel walls ( 267 , 377 , 378 ). Lobular capillary hemangioma shows lobular growth around a central, penetrating vessel, with slit-like vessels and a rich...
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Familial and Syndrome-Related Pheochromocytoma and Paraganglioma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... 10-1 , tumors involving other tissues and organs. Most of these syndromes are autosomal dominant with variable penetrance, as they are due to transmission of an inactivated tumor suppressor gene that presumably requires a “second hit” to inactivate the normal allele. A single exception to this rule...
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Book Chapter

Hereditary Predisposition to Adrenal Cortical Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... novo mutations, and the penetrance approximates 100 percent ( 9 ). Macronodules may occur in PPNAD and classification as typical adenoma may result in misdiagnosis. Adrenal cortical carcinomas arising in PPNAD in the context of Carney complex are extremely rare but have been reported, with rapid local...
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Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... sections just outside the capsule. Small myelinated nerves penetrate the adrenal capsule, primarily on the posterior or dorsal surface. Extrusions of adrenal cortical tissue through the capsule and accessory cortical nodules are common in adrenal glands from adults and elderly persons, and can be a source...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of invasion or penetration into adjacent tissues by the tumor. Necrosis and hemorrhage are characteristic but may not be evident in some cases and need to be carefully sought during sampling. Necrotic areas appear pale tan or yellow-white, with a putty-like consistency. Calcifications and cystic degeneration...
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Adrenal Cortical Adenoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and contain eosinophilic hyaline globules. Complete penetration of the tumor capsule and venous invasion are absent. Clusters of cortical cells may be present outside the adrenal capsule at the periphery of the lesion, as also described in the normal adrenal gland (see chapter 1 ) and in adrenal cortical...
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Pheochromocytoma and Adrenal Medullary Hyperplasia

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... hyperplasia associated with an SDHB mutation . J Clin Oncol   2011 ; 29 : e200 - 2 . 122. Toledo   SP , Lourenco   DM   Jr , Sekiya   T , et al . Penetrance and clinical features of pheochromocytoma in a six-generation family carrying a germline TMEM127 mutation . J Clin Endocrinol Metab...
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Book Chapter

Deep Penetrating Nevus

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 9-1 FEATURES OF DEEP PENETRATING NEVUS Clinical Features  Brown or bluish-black macule or papule  Usually present in young individuals, but can occur at any age Histopathologic Findings  Symmetric silhouette, often in the shape of an inverted triangle (wedge-shaped...
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Book Chapter

Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-20
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... This allows the organism to cause pulmonary disease and disseminate hematogenously to other organs, sometimes involving multiple sites. Because the yeasts are able to penetrate the blood brain barrier, central nervous system (CNS) involvement is a particularly serious consequence of systemic spread. Other...
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Book Chapter

Systemic Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-27
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... Gametocyte fertilization then occurs within the mosquito gut, forming a motile zygote (ookinete) that penetrates the mosquito gut wall and multiplies to form sporozoites. These sporozoites migrate to the salivary glands, where they are, in turn, injected into the vertebrate host during a blood meal. To evade...
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Book Chapter

Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...; and can also cause disease in other mammals. Although the exact mode of transmission has not been determined, it is thought that infection is caused by penetrating trauma such as small skin wounds or an insect bite in individuals who have had contact with contaminated water sources. The disease also...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... organisms can survive in the environment for extended periods of time, due to the formation of spore-like particles ( 69 ). Other modes of C. burnetii transmission include ingestion and direct skin penetration, with infection occurring mainly during spring and summer months. The organism is now...
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Book Chapter

Systemic Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., particularly because of their central nervous system penetration. Importantly, both treatment and prophylaxis require antibiotic administration for 60 days. Since toxin production and release causes much of the pathology in anthrax, sterilization of blood cultures through antibiotic therapy may not be enough...
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Book Chapter

Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... are ubiquitous in the environment, particularly in soil and organic matter ( 48 ). The fungi usually cause disease through inhalation and passage to the lungs, or mechanical trauma with penetration of the skin. Sometimes, the traumatic incident is so minor as not to be remembered by the individual. Disease...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... uncoating of the capsid, which requires endosome acidification and removal of the vertex proteins ( 34 ). Interaction of the AdV penton protein (located at the base of the fiber protein) with various host proteins (primarily integrins) results in actin polymerization and subsequent cytoplasmic penetration...
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Book Chapter

Sexually Transmitted and Urogenital Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the blood brain barrier, probably inside monocytes, and enters the brain tissue. Virus is located mainly in microglial cells and newly recruited macrophages, and remains in the central nervous system (CNS) for the life of the patient. HAART penetrates into the brain and reduces the tissue and cerebrospinal...
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