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Figure 6-40
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-40 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy associated with virilization, classified as benign behavior by means of the Wieneke score. The cut surface was homogeneously brown, with no evidence of necrosis More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy...
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Figure 6-41
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-41 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progressively higher magnification. It lacks necrosis and signs of invasion and showed low mitotic and proliferation indexes. Final Wieneke score was 0. (Same case as fig. 6 More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progre...
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Figure 6-42
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-42 PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and vascular invasion (B,C). Increased mitotic activity and rare atypical mitotic figures were also found. Cytologic atypia was mild as it is usually in pediatric adrenal cortical More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and va...
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Figure 6-43
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-43 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1 (A). Ki-67 index (B) was 5 percent, whereas p53 was expressed in rare nuclei (C). (Same case as figs. 6-40 and 6-41 .) More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1...
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Figure 6-44
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-44 PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a malignant pediatric adrenal cortical tumor. (Same case as fig. 6-42 .) More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a m...
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Book
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... pediatric adrenal cortical tumors than those living in industrial and large urban regions ( 14 ). ACC is associated with a significant history of previous or subsequent associated cancers, thus suggesting heterogeneous underlying cancer predisposition mechanisms. In a recent epidemiologic study, 9 percent...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) and negative staining for PAX2 and PAX8 identifies adrenal tissue in most cases ( fig. 2-5 ) ( 16 ). An unusual example in a dysplastic pediatric kidney is shown in figure 2-6 . ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY Figure 2-5 ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY A: Uncircumscribed...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., both cell types, i.e., Schwann cell progenitor cells and neural crest progenitor cells, are potentially implicated as cells of origin. Epidemiology NBL and GNBL are the most common extracranial solid tumors in infancy and childhood, with an incidence of 9.7 cases per million in the entire pediatric...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... 7-8 ) ( 74 ). Rare pediatric adrenal tumors with morphologic parameters consistent with a benign lesion are also on record ( 76 ). In the presence of adrenal cortical carcinoma in children negative for TP53 germline testing, the presence of mosaic TP53 alterations should...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... neoplasm is more frequent in adrenal cortical carcinoma; thus malignancy should be suspected in the presence of pronounced virilization in a woman and feminization of a man. Virilization is the most frequent hormonal manifestation of functioning adrenal cortical adenomas in the pediatric age group ( 25...
Images
Figure 13-6
Published: 01 September 2024
PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION Figure 13-6 PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: Endoscopic biopsy histology shows normal/near normal colon mucosa with nonspecific histologic alterations, including mild goblet cell depletion, focal lamina More about this image found in PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: E...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of the tumor cells. In children, these composite tumors tend to behave like conventional pediatric neuroblastoma with respect to metastatic potential and clinical course, while in adults they are more indolent, and if completely excised usually do not metastasize even after years of follow-up ( 108 ). In light...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Pediatric 5th-6th decade M/F Slight male predominance Female predominance Female predominance Equal Potential precursor lesions Aldosterone-producing cell clusters Unknown Unknown Unknown Size Usually <2 cm 3-4 cm Usually <3 cm (mostly case reports, only) 3-4 cm Peculiar...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be found on imaging, at autopsy, or during the histopathologic examination of adrenalectomy specimens undertaken for other reasons ( 6 ). They may be more common in elderly and hypertensive patients, but they rare in the pediatric population. NODULAR ADRENAL GLAND Figure 4-1 NODULAR ADRENAL GLAND...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ( 38 ). Adrenal Cytomegaly. Adrenal cytomegaly has been reported in 0.8 percent of pediatric autopsies ( 45 ) and occasionally in older patients ( 45 ). It is usually an incidental finding in glands that are otherwise grossly normal, and may be focal or diffuse ( fig. 1-27 ). Affected cells...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and leiomyosarcomas are very rare tumors associated with the adrenal vein or its tributaries. Fewer than 20 adrenal leiomyomas had been reported up to about 2013, occurring in both children and adults ( 36 ). The tumors were bilateral in 2 of 4 pediatric patients and 3 of 12 adults. Approximately 30 cases...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...   A , Millo   C , et al . Superiority of 68Ga-DO-TATATE over 18F-FDG and anatomic imaging in the detection of succinate dehydrogenase mutation (SDHx )-related pheochromocytoma and paraganglioma in the pediatric population . Eur J Nucl Med Mol Imaging   2018 ; 45 : 787 - 97 . 19...
Book Chapter
Book cover for Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...   B , Peitzsch   M , et al . Characteristics of pediatric vs adult pheochromocytomas and paragangliomas . J Clin Endocrinol Metab   2017 ; 102 : 1122 - 32 . 54. Wen   J , Li   HZ , Ji   ZG , Mao   QZ , Shi   BB , Yan   WG . A decade of clinical experience with extra...