Search Results for pattern

ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME Figure 7-10 ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME The pattern of expression of mismatch repair (MMR) proteins showed loss of MLH1 and PMS2 and retained expression of MSH2 and MSH6. More about this image found in ADRENAL CORTICAL CARCINOMA IN A PATIENT WITH LYNCH SYNDROME The pattern of...

ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND Figure 12-24 ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of growth shows a well-developed glandular arrangement of tumor cells. B: Metastatic poorly differentiated adenocarcinoma has a sinusoidal pattern, with growth More about this image found in ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of gro...

ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Figure 6-11 ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may be extremely variable, with patterns including the solid (A), “insular” (B), or large trabecular (C), frequently present within the same lesion. More about this image found in ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may ...

SINUSOIDAL AND VASCULAR INVASION IN ADRENAL CORTICAL CARCINOMA Figure 6-21 SINUSOIDAL AND VASCULAR INVASION IN ADRENAL CORTICAL CARCINOMA Patterns of vascular invasion in ACC include sinusoidal invasion (A) and angioinvasion with tumor cells in vascular channels associated with fibrin thrombi (B). More about this image found in SINUSOIDAL AND VASCULAR INVASION IN ADRENAL CORTICAL CARCINOMA Patterns of...

ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Figure 6-28 ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin pattern as highlighted by silver staining techniques, either in the form of “quantitative” changes (large nests disrupting the regular alveolar pattern More about this image found in ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin...

BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Figure 6-34 BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic beta-catenin expression in ACC may be focal with a “clonal” pattern or more frequently, diffuse as in the figure. Membrane pattern is visible in peritumoral non More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...

PRIMARY ADRENAL HEMANGIOMA Figure 12-7 PRIMARY ADRENAL HEMANGIOMA A: The subcortical area has a delicate capillary pattern, while more central areas are cavernous and have nonendothelial supporting cells. Fibrin thrombi are also present. B: The more cavernous pattern, with dilated vascular More about this image found in PRIMARY ADRENAL HEMANGIOMA A: The subcortical area has a delicate capillar...

ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-39 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells in a diffuse pattern of growth with prominent nucleoli. More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells i...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-32 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Preserved reticulin pattern, as highlighted by silver staining. More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...

INVASIVE ADRENAL CORTICAL CARCINOMA Figure 6-20 INVASIVE ADRENAL CORTICAL CARCINOMA Extra-adrenal extension with invasion of the periadrenal fat, both as large nodules (A) and as an infiltrative “Indian file” pattern (B). More about this image found in INVASIVE ADRENAL CORTICAL CARCINOMA Extra-adrenal extension with invasion ...

URINARY BLADDER PARAGANGLIOMA Figure 9-18 URINARY BLADDER PARAGANGLIOMA This paraganglioma shows extensive superficial growth beneath the mucosa. The tumor is a potential mimic of urothelial carcinoma because of its growth pattern and pale eosinophilic to clear cytoplasm. More about this image found in URINARY BLADDER PARAGANGLIOMA This paraganglioma shows extensive superfici...

CAROTID BODY PARAGANGLIOMA Figure 9-24 CAROTID BODY PARAGANGLIOMA A: The almost entirely spindle cell composition of this paraganglioma raises the possibility of mesenchymal and other spindle cell neoplasms. B: Reticulin stain highlights the spindle cell pattern. More about this image found in CAROTID BODY PARAGANGLIOMA A: The almost entirely spindle cell composition...

ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Figure 5-22 ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Areas of this adrenal adenoma show an ill-defined spindle cell pattern. More conventional histology was present in other fields. More about this image found in ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Areas of this adrenal ...

ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT Figure 6-27 ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circumscribed within the adrenal (A). It has a pure storiform architectural pattern (B) and consists of spindle cells (B) expressing SF1 (C) and Melan-A (D). More about this image found in ADRENAL CORTICAL CARCINOMA: SARCOMATOID VARIANT This tumor is well-circums...

PHEOCHROMOCYTOMA: PERIPHERY Figure 8-17 PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely variable, with some showing clear encapsulation (A) and others lacking a capsule, and instead showing interdigitation with the surrounding adrenal cortex (B). Both patterns are seen More about this image found in PHEOCHROMOCYTOMA: PERIPHERY The periphery of these tumors is extremely var...

VAGAL PARAGANGLIOMA Figure 9-16 VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arrangement of tumor cells may suggest a vascular tumor in the differential diagnosis. B: A different area of the same tumor shows a solid growth pattern with prominent perivascular More about this image found in VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arr...

LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-38 LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy specimen is largely replaced by metastatic ACC. The tumor is mottled tan-yellow. B: Metastatic ACC disrupts the liver parenchyma and has a large nesting pattern. More about this image found in LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy spec...

UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...

ADRENAL HEMANGIOMA Figure 12-8 ADRENAL HEMANGIOMA The well-developed features of anastomosing adrenal hemangioma include a prominent frame work of non endothelial supporting cells creating a “spleen-like” pattern of vascular channels lined by hobnail endothelial cells and containing occasional More about this image found in ADRENAL HEMANGIOMA The well-developed features of anastomosing adrenal hem...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-16 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Heterogeneous architectural patterns with diffuse and pseudonodular lesions from the adrenal More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...