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Images
in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL PATHOLOGY IN VON HIPPEL-LINDAU (VHL) DISEASE Figure 10-4 ADRENAL PATHOLOGY IN VON HIPPEL-LINDAU (VHL) DISEASE A: The adrenal gland has multiple nodules that represent pheochromocytomas. B: The tumors have degenerate stroma with striking edema, focal hemorrhage, and hemosiderin deposition... More about this image found in ADRENAL PATHOLOGY IN VON HIPPEL-LINDAU (VHL) DISEASE A: The adrenal gland ...
Book
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMORDIA OF ADRENAL GLAND Figure 1-3 PRIMORDIA OF ADRENAL GLAND Schematic cross section of human embryo shows primordia of adrenal glands, which are located lateral to the base of the dorsal mesentery, separated from the gonadal primordium by the adrenal groove. (Fig. 1-3 from Lack EE, Kozakewic... More about this image found in PRIMORDIA OF ADRENAL GLAND Schematic cross section of human embryo shows p...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY Figure 1-16 AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The patients ranged from 30 weeks’ gestational age to 35 years. Vertical bars represent one standard deviation. There is a marked decrease in c... More about this image found in AVERAGE COMBINED WEIGHT OF ADRENAL GLANDS FROM 226 PATIENTS AT AUTOPSY The...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES Figure 6-19 ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures in varied shapes are a pathologic hallmark of ACC. More about this image found in ADRENAL CORTICAL CARCINOMA: ATYPICAL MITOSES A–C: Atypical mitotic figures...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... The complexity of hormone regulation can also result in hyperplasia of the adrenal cortex, which is secondary to neoplasms in other body sites. In some clinical scenarios, the adrenal glands are resected to prevent hormone excess even when the primary pathology is elsewhere, and the pathologist must assess...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in many aspects of adrenal physiology ( 6 ). Some children with ACC have peculiar clinical and pathologic characteristics, which are described later in this chapter. In adult patients, a broad age-span peak in the 5th and 6th decades is observed, although ACC can occur at any age. There does not appear...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with primary aldosteronism and Cushing syndrome enabled the development of a molecular classification that goes beyond pathology and allows a personalized approach to affected patients, including genetic screening for familial forms. A detailed description of hereditary conditions predisposing to adrenal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Institute of Pathology (AFIP) adrenal gland Fascicle and was intended to prevent confusion caused by promiscuous diagnoses of paraganglioma ( 6 ). Until recently, however, it did little to prevent inconsistent diagnoses of “pheochromocytoma” ( 7 ). Acceptance of the arbitrary distinction between...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal proliferations (including nodular diseases and tumors) can occur in the context of familial or syndromic diseases, with a wide variety of clinical presentations and molecular backgrounds ( Table 7-1 ). The main features and morphofunctional characteristics of pathologic lesions related...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... during embryogenesis and to function normally throughout life. A fundamental knowledge of normal adrenal function, development, and structure is essential to interpret the pathology and pathobiology of these complex organs. Familiarity with normal adrenal development from an anatomic standpoint...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-established immunohistochemical protocols, loss of protein expression can validate the significance of a molecular variant of uncertain significance (VUS). Pathology is also important in determining whether a second type of tumor in a patient with a pheochromocytoma or paraganglioma is actually part...
Images
Published: 01 September 2024
VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY Figure 1-5 VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A,B) staining of an adrenal spindle cell neoplasm in an immunocompromised patient. Epstein-Barr virus encoded RNA (EBER) in situ hybridization (ISH) ... More about this image found in VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in parasympathetic paraganglia are also known as “type 1” cells, “chief cells,” or “glomus cells,” and the sustentacular cells are also known as “type 2 cells.” “Glomus” is discouraged in pathology literature because the same name applies to cutaneous temperature sensors and their corresponding tumors, but it still...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., adrenal angiosarcomas can be extremely bloody lesions, and careful search may be required to identify tumor cells within pools of blood. Adrenal hemangiomas are extremely rare and most are discovered incidentally at autopsy. The files of the Armed Forces Institute of Pathology (AFIP) listed one...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... called cortical nodular disease, which is essentially multiple adenomas. In addition, not all cases undergo surgery, thus pathologic confirmation is not always available. Solitary adenomas occur at any age and in both sexes. Reports of large autopsy series have found adrenal adenomas greater than 2 to 5...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be achieved, and resection or debulking is performed following chemotherapy. Such resections frequently arrive piecemeal in the pathology laboratory and resection margins are not an issue with regard to pathology reporting. Instead, the amount of chemotherapy effect should be assessed upon gross morphology...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... They may be asymptomatic or associated with virilization, and can be difficult to detect in imaging studies ( 46 ). Pathologic Findings. On cross section, the larger tumors are unencapsulated, bulging, multinodular masses separated by prominent bands of fibrous connective tissue ( fig. 2-14...
Images
Published: 01 September 2024
CLINICAL AND PATHOLOGIC MANIFESTATIONS OF BURKHOLDERIA PSEUDOMALLEI INFECTION Figure 14-29 CLINICAL AND PATHOLOGIC MANIFESTATIONS OF BURKHOLDERIA PSEUDOMALLEI INFECTION More about this image found in CLINICAL AND PATHOLOGIC MANIFESTATIONS OF BURKHOLDERIA PSEUDOMALLEI...
Book
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
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