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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...As with any field in pathology, appropriate specimen processing is critical to tissue evaluation. Breast tissue, in particular, due to its inherently fatty composition requires special attention to adequate fixation prior to processing in order to ensure optimal microscopic examination and accuracy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of metastatic disease. Their outlook for 10-year survival ranges from 75 percent to nearly 100 percent depending on associated clinical and pathologic factors. To best stratify risk assessment for patients, it is important to carefully assess and record these parameters. This chapter focuses on the prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nevus-like, other a DPN = deep penetrating nevus. While nodular melanoma is not a distinct pathologic-genomic entity, it is clinically a very useful melanoma subcategory. Nodular melanomas are more difficult to diagnose clinically than other conventional melanomas, especially in the absence...
Images
<span class="search-highlight">PATHOLOGIC</span> INTIMAL THICKENING  Left: The coronary artery demonstrates signi...
Published: 15 November 2023
PATHOLOGIC INTIMAL THICKENING Figure 5-5 PATHOLOGIC INTIMAL THICKENING Left: The coronary artery demonstrates significant luminal narrowing, but without a necrotic core. Right: Abundant extracellular lipid can be seen with rare microcalcifications. More about this image found in PATHOLOGIC INTIMAL THICKENING Left: The coronary artery demonstrates signi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the line is subject to ongoing investigations and evolving paradigms, trying to find the right balance between molecular and pathologic aberrations and a clinically meaningful tumor classification. Designating tumors as melanomas because of cytogenetic aberrations does not serve patients well if most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The melanocytic nevus commonly referred to as dysplastic is a fairly common acquired lesion with clinical and pathologic features intermediate between an ordinary nevus and superficial spreading melanoma. Other terms for this nevus include melanocytic nevus with architectural disorder...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., however, a small subset of spitzoid melanocytic tumors for which no definitive distinction between nevus and melanoma can be made even by experts in melanocyte pathology. Those lesions are generally referred to as atypical Spitz tumor ( 10 , 11 ). According to recent proposals, if knowledge...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of trauma and treatment is important because sometimes the associated microscopic features simulate the appearance of a melanoma ( 1 – 5 ). Awareness of the clinical context, and in the case of a prior surgical procedure knowledge of the prior pathology, are essential to avoid misdiagnoses. TRAUMATIZED...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or NRAS mutations. Instead, they commonly have structural rearrangements leading to kinase fusions or harbor HRAS mutations ( 27 ). More details on the pathologic findings of Spitz melanomas are provided in chapter 19 . Nodular Melanomas of Giant/Large Congenital Nevus Subtype. Large/giant...
Images
EBSTEIN ANOMALY  Surgical <span class="search-highlight">pathology</span> specimens show the spectrum of distorti...
Published: 15 November 2023
EBSTEIN ANOMALY Figure 39-16 EBSTEIN ANOMALY Surgical pathology specimens show the spectrum of distortion of the anterior leaflet and portions of the septal and posterior leaflets. Specimens are from an adolescent (A), from a young adult (B), from a young adult, showing the atrial aspect (C) and ... More about this image found in EBSTEIN ANOMALY Surgical pathology specimens show the spectrum of distorti...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and pathologically as melanoma . Pathology   2004 ; 36 : 419 - 27 . 8. Yeh   I , Lang   UE , Durieux   E , Tee   MK , et al . Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi . Nat Commun   2017 ; 8 : 644 . 9. de la Fouchardière...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (a rare variant of spindle cell melanoma) . Cancer   1971 ; 28 : 914 - 36 . 2. Busam   KJ . Desmoplastic melanoma . Clin Lab Med   2011 ; 31 : 321 - 30 . 3. Busam   KJ . Desmoplastic melanoma . In: Busam   KJ , Gerami   P , Scolyer   RA , eds. Pathology of melanocytic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are observed, complete excision is a prudent course of action. While most combined nevi have no clinical significance other than that they can be confused with melanoma clinically and pathologically, the documentation of a BAP1-inactivation may have further implications. While most lesions are sporadic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with and/or simulating a nevus . In: Busam   KJ , Gerami   P , Scolyer   RA , eds. Pathology of melanocytic tumors . Philadelphia : Elsevier ; 2019 : 226 - 34 . 4. Borgenvik   TL , Karlsvik   TM , Ray   S , Fawzy   M , James   N . Blue nevus-like and blue nevus-associated melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Scolyer   R , eds. Pathology of melanocytic tumors . Philadelpha : Elsevier ; 2018 ; 168 - 80 . 3. Arrington   JH   3rd , Reed   RJ , Ichinose   H , Krementz   ET . Plantar lentiginous melanoma: a distinctive variant of human cutaneous malignant melanoma . Am J Surg Pathol   1977...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Dense inflammatory infiltrates are usually absent ( 13 ). A dermal component showing the ordinary features of CMN is typically reassuring. Atypical PN can be difficult to distinguish from melanoma. Clinical and pathologic parameters are important for diagnosis. Clinical features concerning for melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ACQUIRED MELANOCYTIC NEVI a Nevus Variant Pathology Unna nevus Polypoid or sessile lesion with papillomatous silhouette Intradermal or predominantly dermal compound nevus Usually confined to (usually expanded) papillary dermis Adventitial involvement common Miescher nevus Smooth...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... WHO classification of skin tumors , 4th ed. Lyon : IARC ; 2018 : 76 - 9 . 3. Gerami   P . Superficial spreading melanoma . In: Busam   KJ , Gerami   P , Scolyer   RA , eds. Pathology of melanocytic tumors . Philadelphia : Elsevier ; 2019 : 158 - 67 . 4. Naldi   L...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... found using immunotherapy. REFERENCES REFERENCES 1. Scolyer   RA , Lezcano   C , Busam   KJ . Metastatic melanoma . In: Busam   KJ , Gerami   P , Scolyer   RA , eds. Pathology of melanocytic tumors . Philadelphia : Elsevier ; 2019 : 314 - 29 . 2. Kornberg   R...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...   RA , eds. Pathology of melanocytic tumors . Philadelphia : Elsevier ; 2019 : 140 - 57 . 13. Kilinc-Karaarslan   I , Akalin   T , Ozdemir   F . Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression . Arch Dermatol   2009 ; 145 : 725 - 6...