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Figure 4-21

HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophi...

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in Oral Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA Figure 4-21 HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophilic parakeratin overlying epithelium shows full-thickness dysplasia. B: Numerous karyorrhectic cells (black arrows) and apoptotic cells (blue arrows). C More about this image found in HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophi...
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Figure 7-22

METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARC...

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in Neck > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARCINOMA Figure 7-22 METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARCINOMA Metastasis to a cervical lymph node showing a thin lining epithelium with smooth surface and scattered ciliated cells. More about this image found in METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARC...
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Figure 2-5

CYSTIC METASTASIS Axial view computerized tomography (CT) scan of the neck...

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in Oropharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
CYSTIC METASTASIS Figure 2-5 CYSTIC METASTASIS Axial view computerized tomography (CT) scan of the neck shows cystic metastases (asterisks) from a human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC). More about this image found in CYSTIC METASTASIS Axial view computerized tomography (CT) scan of the neck...
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Figure 6-48

NONKERATINIZING SQUAMOUS CELL CARCINOMA An uncommon nonkeratinizing SCC of...

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in Hypopharynx, Larynx, and Trachea > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
NONKERATINIZING SQUAMOUS CELL CARCINOMA Figure 6-48 NONKERATINIZING SQUAMOUS CELL CARCINOMA An uncommon nonkeratinizing SCC of the larynx recapitulates many of the features of oropharyngeal SCC. These do not share the same strong correlation with high risk human papillomavirus or the clear More about this image found in NONKERATINIZING SQUAMOUS CELL CARCINOMA An uncommon nonkeratinizing SCC of...
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Figure 1-19

EXOPHYTIC SINONASAL PAPILLOMA A: Koilocytic changes, i.e., nuclear enlarge...

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in Sinonasal Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
secondary to irritation. Most cases harbor low-risk human papillomavirus (HPV) as demonstrated by RNA in situ hybridization (inset). More about this image found in EXOPHYTIC SINONASAL PAPILLOMA A: Koilocytic changes, i.e., nuclear enlarge...
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Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
...EMBRYOLOGY, ANATOMY, AND HISTOLOGY The oropharynx, more than any other area of the anatomically complex head and neck, has shaped pathology in the past 50 years through the influence of high-risk human papillomavirus (HPV). The unique anatomy makes the oropharynx particularly suited for HPV...
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Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... is a benign, papillomatous neoplasm of squamous epithelium arising in the larynx, trachea, oropharynx, and oral cavity, and occasionally in the other head and neck mucosal sites, that is usually related to low-risk human papillomavirus (HPV) ( 49 – 52 ). General Features. Squamous papillomas arise...
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Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... Fanconi anemia, Li-Fraumeni syndrome, and dyskeratosis congenita ( 16 , 20 ). Although human papillomavirus (HPV), in particular, type 16, is a well-recognized etiology in oropharyngeal SCC, less than 3 percent of OSCCs are HPV associated ( 3 , 21 ). Proliferative verrucous leukoplakia (PVL) is a distinct...
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Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... evaluated in the differential diagnosis with cystic metastatic SCC. It is usually positive but often shows a patchy distribution in the superficial portion of the squamous lining. Unlike metastatic human papillomavirus (HPV)-associated SCC, which usually shows strong and diffuse nuclear and cytoplasmic...
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Book Chapter

Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... entity but rather distinct neoplasms is now supported by emerging molecular data: OSP harbors KRAS mutations, ISP usually harbors EGFR mutations, and ESP is strongly associated with low-risk human papillomavirus (HPV) infection ( 37 – 39 ). The etiology of sinonasal papillomas...
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Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
..., particularly of the nonkeratinizing type, are positive for high-risk human papillomavirus (HPV), especially in nonendemic areas, but further studies are needed to define the precise role of HPV in this disease ( 48 , 49 ). Clinical Features. In nonendemic areas, NPC tends to show a bimodal distribution...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... is not the result of human papillomavirus (HPV) infection ( 53 , 54 ). Verrucous carcinoma can also arise in these cysts ( 55 ). Immunohistochemical Findings. Since PIOCs arise from odontogenic epithelium, CK19 is a sensitive marker for odontogenic origin, although malignant tumors may lose some reactivity ( 56...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... decreases, there is an inverse relationship to the degree of pleomorphism and tumor grade. In poorly differentiated, nonkeratinizing, and basaloid tumors ( fig. 8-49 ), the possibility of viral-induced (human papillomavirus [HPV], Epstein-Barr virus [EBV]) or translocation driven etiology (BRD4...
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Images
Figure 9-33

HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain...

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in Sexually Transmitted and Urogenital Infections > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
HUMAN PAPILLOMAVIRUS (HPV) Figure 9-33 HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain (courtesy of the CDC PHIL) and schematic (right) of HPV structure (left). B: Schematic of HPV genome (not to scale). C: Schematic of mechanism of E6- and E7-mediated HPV More about this image found in HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain...
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Sexually Transmitted and Urogenital Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... papillomavirus and cervical cancer . Lancet . 2007 ; 370 : 890 - 907 . 44. Schiffman   M , Wentzensen   N . From human papillomavirus to cervical cancer . Obstet Gynecol   2010 ; 116 : 177 - 85 . 45. Krishnamurti   U , Unger   ER . Pathobiology of human papillomaviruses in human...
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Figure 7-33

METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOM...

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in Endometrioid Tumors > Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOMA Figure 7-33 METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOMA A: Many examples demonstrate a characteristically repetitive cribriform pattern or papillary architecture (not shown). B More about this image found in METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOM...
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Figure 16-34

METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOM...

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in Neoplasms of the Fallopian Tube and Broad Ligament > Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOMA COLONIZING TUBAL MUCOSA Figure 16-34 METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOMA COLONIZING TUBAL MUCOSA The lesion may resemble STIC or high-grade serous carcinoma at low-power More about this image found in METASTATIC HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ENDOCERVICAL ADENOCARCINOM...
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Secondary Tumors

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-15
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... ) Positive in 50% of cases ( 25 ) Negative Negative Positive in 50% of cases ( 25 ) Negative (loss) in 55% ( 76 ) Rare cases (10%) strong diffuse ( 25 ) a Data from references 25 and 74 through 78 . b HPV = human papillomavirus. Prognosis. It is now clear from molecular studies that low...
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Hereditary Cancer Syndromes

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-03
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... the diagnosis. Tumors affecting the ovary include sex cord tumor with annular tubules (SCTAT), rare Sertoli cell tumors, and metastatic human papillomavirus (HPV)-independent endocervical gastric-type adenocarcinomas. Thirty-six percent of SCTATs are attributable to PJS ( 36 ) and are occasionally...
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Mucinous Ovarian Tumors

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-08
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... should be considered. P16 should also be added to begin excluding a metastasis of an endocervical adenocarcinoma. If the tumor is diffusely and strongly positive for p16 then a molecular analysis for high-risk human papillomavirus (HPV) should be performed. Other tumors can masquerade as mucinous tumors...
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