Search Results for pancreatoblastoma

PANCREATOBLASTOMA Figure 10-13 PANCREATOBLASTOMA In this patient with familial adenomatous polyposis (FAP), a morphologically classic pancreatoblastoma (left) is present and a tubular adenoma also involves the ampulla of Vater (right). More about this image found in PANCREATOBLASTOMA In this patient with familial adenomatous polyposis (FAP...

PANCREATOBLASTOMA Figure 10-8 PANCREATOBLASTOMA Immunolabeling for carcinoembryonic antigen (CEA). More about this image found in PANCREATOBLASTOMA Immunolabeling for carcinoembryonic antigen (CEA).

PANCREATOBLASTOMA Figure 10-7 PANCREATOBLASTOMA Immunolabeling for chymotrypsin (left) and synaptophysin (right). More about this image found in PANCREATOBLASTOMA Immunolabeling for chymotrypsin (left) and synaptophysin...

PANCREATOBLASTOMA Figure 10-5 PANCREATOBLASTOMA Left: Gland formation with columnar mucinous cells is rare. Right: The mucin is highlighted by mucicarmine staining. More about this image found in PANCREATOBLASTOMA Left: Gland formation with columnar mucinous cells is ra...

PANCREATOBLASTOMA Figure 10-12 PANCREATOBLASTOMA Ultrastructurally, the cells have acinar features, with round zymogen granules (left) and irregular fibrillary granules (right). More about this image found in PANCREATOBLASTOMA Ultrastructurally, the cells have acinar features, with ...

PANCREATOBLASTOMA Figure 10-11 PANCREATOBLASTOMA Immunolabeling for β-catenin shows a mosaic pattern due to focal aberrant nuclear labeling that is predominantly in the squamoid nests. More about this image found in PANCREATOBLASTOMA Immunolabeling for β-catenin shows a mosaic pattern due ...

PANCREATOBLASTOMA Figure 10-16 PANCREATOBLASTOMA Treatment effects include fibrosis (left) and infiltrates of foamy histiocytes (right), which can obscure the classic histologic features. More about this image found in PANCREATOBLASTOMA Treatment effects include fibrosis (left) and infiltrate...

PANCREATOBLASTOMA Figure 10-1 PANCREATOBLASTOMA Left: The neoplasm is well circumscribed, yellow to tan, and lobulated. Right: Areas of central fibrosis with necrosis and hemorrhage are present in the fleshy tumor. More about this image found in PANCREATOBLASTOMA Left: The neoplasm is well circumscribed, yellow to tan,...

PANCREATOBLASTOMA Figure 10-15 PANCREATOBLASTOMA Squamoid nests can be more apparent on cell block preparations (left), and these cells show nuclear immunolabeling for β-catenin (right). More about this image found in PANCREATOBLASTOMA Squamoid nests can be more apparent on cell block prepar...

PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...

PANCREATOBLASTOMA Figure 10-6 PANCREATOBLASTOMA Left: The stroma is often hypercellular, especially in pediatric cases. Right: Sometimes the degree of cellularity suggests that the stroma is also neoplastic; heterologous bone is present in this case. More about this image found in PANCREATOBLASTOMA Left: The stroma is often hypercellular, especially in p...

SURVIVAL WITH PANCREATOBLASTOMA Figure 10-17 SURVIVAL WITH PANCREATOBLASTOMA More than half of patients experience long-term survival in the pediatric age group. (Courtesy of Dr. N. N. Shukla, New York, NY) More about this image found in SURVIVAL WITH PANCREATOBLASTOMA More than half of patients experience long...

PANCREATOBLASTOMA Figure 10-10 PANCREATOBLASTOMA The nuclei in the squamoid nests show optically clear biotin inclusions (left) and therefore have nonspecific immunoreactivity for every antigen when biotin-based detection systems are used (right). More about this image found in PANCREATOBLASTOMA The nuclei in the squamoid nests show optically clear bi...

PANCREATOBLASTOMA Figure 10-2 PANCREATOBLASTOMA Left: At low power, the lobulated architecture is apparent. Fibrous bands separate the highly cellular lobules. Right: In an adult case, the fibrous bands are absent, but the lobularity persists, producing a geographic pattern. More about this image found in PANCREATOBLASTOMA Left: At low power, the lobulated architecture is appare...

PANCREATOBLASTOMA Figure 10-14 PANCREATOBLASTOMA Three-dimensional clusters of epithelioid cells with uniform nuclei are present (A). In air-dried preparations, the nuclei appear enlarged and overlapping (B). Solid nests show a hint of acinar formations at the periphery (C). (A: Thinprep; B More about this image found in PANCREATOBLASTOMA Three-dimensional clusters of epithelioid cells with uni...

PANCREATOBLASTOMA Figure 10-3 PANCREATOBLASTOMA A: Microscopic patterns include acini and solid sheets and nests; the acini have pinpoint to slightly dilated lumens (inset). B: Variable amounts of cytoplasm in different cells give rise to morphologic heterogeneity. C: Some cells in solid areas More about this image found in PANCREATOBLASTOMA A: Microscopic patterns include acini and solid sheets a...

PANCREATOBLASTOMA Figure 10-4 PANCREATOBLASTOMA A: Primitive-appearing small cells are adjacent to an ill-defined squamoid nest composed of polygonal cells with eosinophilic cytoplasm and central, larger nuclei. B: In other cases, the squamoid nests are more circumscribed; they lack acinar More about this image found in PANCREATOBLASTOMA A: Primitive-appearing small cells are adjacent to an il...

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-45 PANCREATIC NEUROENDOCRINE TUMOR Squamoid nests (left) simulate a pancreatoblastoma. Cytoplasmic asteroid bodies are seen (right). More about this image found in PANCREATIC NEUROENDOCRINE TUMOR Squamoid nests (left) simulate a pancreato...