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Figure 1-12

LIMITED ROSAI-DORFMAN DISEASE A: In an otherwise normal-appearing inflamma...

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in Sinonasal Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
LIMITED ROSAI-DORFMAN DISEASE Figure 1-12 LIMITED ROSAI-DORFMAN DISEASE A: In an otherwise normal-appearing inflammatory polyp, there are multiple scattered aggregates of inflammatory cells. B: On high power, each of the nodules has the classic appearance of Rosai-Dorfman disease. More about this image found in LIMITED ROSAI-DORFMAN DISEASE A: In an otherwise normal-appearing inflamma...
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Figure 1-43

NEUROENDOCRINE CARCINOMA, NOT OTHERWISE SPECIFIED A: This tumor was positi...

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in Sinonasal Cavity > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
NEUROENDOCRINE CARCINOMA, NOT OTHERWISE SPECIFIED Figure 1-43 NEUROENDOCRINE CARCINOMA, NOT OTHERWISE SPECIFIED A: This tumor was positive for neuroendocrine markers, and showed rosettes. B: It does not have classic cellular features of either small cell or large cell neuroendocrine carcinoma. More about this image found in NEUROENDOCRINE CARCINOMA, NOT OTHERWISE SPECIFIED A: This tumor was positi...
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Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... could be entertained. Recognizing the pathologic context (i.e., organizing fibrin within an otherwise typical sinonasal polyp) is most useful in avoiding this pitfall. The fibrotic nature and occasional nasopharyngeal location of antrochoanal polyps sometimes suggest angiofibroma. Both lesions typically...
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Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... as a single, surrogate test in patients for whom things otherwise line up typically for an HPV-associated tumor, namely, that the tumor arises in the palatine tonsil or base of tongue, is occurring in a geographic area with a high attributable fraction of HPV association (such as the United States or Canada...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... findings are seen in age-matched controls, and the cartilage may be normal in cases that otherwise match the clinical and dermatologic findings ( 61 , 62 ). Also called Winkler disease after the dermatologist, Dr. Max Winkler, who described it originally, it also goes by the terms nodule of Winkler...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... a cytologically bland “ameloblastoma” metastasizes ( fig. 5-17 ). AMELOBLASTOMA IN A LYMPH NODE Figure 5-17 AMELOBLASTOMA IN A LYMPH NODE The tumor is cytologically bland. Primary Intraosseous Carcinoma, Not Otherwise Specified (NOS) Definition.  Primary intraosseous carcinoma (PIOC...
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Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... until proven otherwise. Inflammatory myofibroblastic tumors (IMT) are uncommon but can be seen in the glottic region of the larynx where they enter the differential diagnosis with keratin-negative SCSCC. Molecular testing is helpful: alterations in ALK, ROS1, or NTRK favor IMT since...
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Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... stromal cells, and are circumscribed ( 144 ). For deep lesions (deep to fascia), the diagnosis of a mature adipose tissue tumor is well-differentiated liposarcoma until proven otherwise, and if the morphologic features are not diagnostic, FISH for MDM2 amplification should be performed. Myxoid...
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Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
..., verruca vulgaris, and condyloma acuminatum. Condyloma acuminatum generally is much larger (more than 1 cm) than SP, but is otherwise essentially the same lesion ( 104 ). Verruca vulgaris is uncommon intraorally, with similar features to the cutaneous counterpart. As the name implies, multifocal epithelial...
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Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be recognized by the bright yellow color. Otherwise, they are usually pale white to brown on the outside. On cut surface, they may be gray-white to tan and mostly firm, sometimes with a vaguely nodular aspect. Consistency depends on the composition of the tumor, with mature schwannian stroma of GNBL intermixed...
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Adrenal Cortical Nodular Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-producing nodules or micronodules within an otherwise histologically normal zona glomerulosa ( fig. 4-28 ). Nodules and micronodules may be detected by CYP11B2 immunohistochemical staining ( fig. 4-29 ). MULTIPLE ALDOSTERONE-PRODUCING NODULES Figure 4-28 MULTIPLE ALDOSTERONE-PRODUCING NODULES Right...
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Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ) distinguish with high sensitivity and specificity benign from malignant lesions in a group of otherwise indeterminate adrenal tumors. Importantly, such an approach has been shown to possess a higher mean accuracy compared to a morphology-based evaluation by experienced radiologists ( 114 ). Radiomic features...
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Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ( 38 ). Adrenal Cytomegaly. Adrenal cytomegaly has been reported in 0.8 percent of pediatric autopsies ( 45 ) and occasionally in older patients ( 45 ). It is usually an incidental finding in glands that are otherwise grossly normal, and may be focal or diffuse ( fig. 1-27 ). Affected cells...
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Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-20
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and otherwise healthy individuals, sampled primary lung lesions grossly may merely reveal a circumscribed focus of fibrosis. If fungal yeasts are abundant, an exudate, consolidation, or mass with mucinous consistency (gelatinous form of cryptococcosis) may be noted as a result of the organism’s mucoid capsule...
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Introduction and Methods

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... colonoscopy he has an ulceration 10 cm proximal to the anastomotic site. The patient noticed blood spotting of the stool for the last 3 weeks. He is otherwise well and tumor recurrence free. Biopsies of the ulcerated area are submitted for histology and microbiologic studies, together with a stool sample...
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Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... The papule enlarges to form a nodule, which ulcerates over the ensuing months ( fig. 28-2 ). The ulceration is usually shallow and tends to occur less often in multiple lesions. Typically, the patients are otherwise well and the skin involvement, although sometimes itchy, is not associated with the pain...
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Liver and Gastrointestinal Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... constitutional symptoms, such as headache, occur. Most infections, especially in otherwise healthy individuals, are self-limiting. Severe diarrhea leading to pronounced dehydration, hypovolemic shock, and even death, as well as recurrent and chronic infections, are much more frequent in resource-limited regions...
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Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in otherwise healthy infants and children . N Engl J Med   2004 ; 350 : 443 - 50 . 62. Kim   HW , Canchola   JG , Brandt   CD , et al . Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine . Am J Epidemiol   1969 ; 89 : 422 - 34...
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Gastrointestinal Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... mucosal injury EAEC Acute nonmucoid, nonbloody/watery diarrhea, vomiting, abdominal pain, and low-grade fever Can be associated with chronic diarrhea, wasting, and postinfectious irritable bowel syndrome Usually prominent surface epithelial coating by straight gram-negative bacilli Otherwise normal...
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Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... fluorescence under a Wood lamp; e geophilic; f encompasses tinea faciei; g diaper dermatitis is a clinical variant among infants; NOS = not otherwise specified. Table 24-4 DERMATOPHYTIC CONDITIONS AND THEIR CLINICAL FEATURES, DIFFERENTIAL DIAGNOSES, AND POTENTIAL COMPLICATIONS...
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