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Images
Figure 4-38
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-38 OSTEOBLASTOMA A: The osteoblastoma is confined by a layer of reactive sub periosteal bone. The tumor is solid and composed of inter connecting trabeculae of woven bone. B: Islands of cellular tumor contain mineralized bone, well-defined by subperiosteal reactive bone More about this image found in OSTEOBLASTOMA A: The osteoblastoma is confined by a layer of reactive sub ...
Images
Figure 5-34
Published: 01 October 2021
OSTEOBLASTOMA-LIKE OSTEOSARCOMA Figure 5-34 OSTEOBLASTOMA-LIKE OSTEOSARCOMA Left: Osteoblastoma-like osteosarcoma grows with an infiltrative pattern, encasing preexisting bone. Right: Neoplastic bone is rimmed by plump osteoblasts. The intertrabecular spaces contain loose connective tissue More about this image found in OSTEOBLASTOMA-LIKE OSTEOSARCOMA Left: Osteoblastoma-like osteosarcoma grow...
Images
Figure 4-45
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-45 OSTEOBLASTOMA Ki-67 immunohistochemical stain of conventional osteoblastoma shows that many tumor cells are positive. More about this image found in OSTEOBLASTOMA Ki-67 immunohistochemical stain of conventional osteoblastom...
Images
Figure 4-40
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-40 OSTEOBLASTOMA A: A sheet-like deposit of woven bone is seen. B: Neoplastic rimming osteoblasts are of medium size with abundant eosinophilic to amphophilic cytoplasm. Many nuclei are polarized away from the bone-forming surface. Scattered osteoclasts are present More about this image found in OSTEOBLASTOMA A: A sheet-like deposit of woven bone is seen. B: Neoplasti...
Images
Images
Figure 4-42
Published: 01 October 2021
OSTEOBLASTOMA WITH CARTILAGE Figure 4-42 OSTEOBLASTOMA WITH CARTILAGE Left: Nodule of well-formed hyaline cartilage abuts neoplastic bone. Right: In areas, the cartilage merges with the tumor bone. More about this image found in OSTEOBLASTOMA WITH CARTILAGE Left: Nodule of well-formed hyaline cartilage...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-04
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... as a portion of the matrix. OSTEOID OSTEOMA Figure 4-30 OSTEOID OSTEOMA Scattered tumor cells have positive nuclear staining for FOS. OSTEOBLASTOMA Figure 4-31 OSTEOBLASTOMA Left: Frontal radiograph of the spine showing loss of normal outline of the left T11 pedicle (white arrow), indicative...
Images
Figure 4-44
Published: 01 October 2021
OSTEOBLASTOMA WITH PSEUDOMALIGNANT CHANGE Figure 4-44 OSTEOBLASTOMA WITH PSEUDOMALIGNANT CHANGE Left: Neoplastic osteoblasts have enlarged hyperchromatic nuclei. Right: The nuclear enlargement, hyperchromasia, smudging, and vacuolization in pseudomalignant change is hypothesized to be related More about this image found in OSTEOBLASTOMA WITH PSEUDOMALIGNANT CHANGE Left: Neoplastic osteoblasts hav...
Images
Figure 4-31
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-31 OSTEOBLASTOMA Left: Frontal radiograph of the spine showing loss of normal outline of the left T11 pedicle (white arrow), indicative of destruction of the pedicle by tumor. Right: Sagittal fat-suppressed T2-weighted MRI shows an expansile, well-defined mass with fluid More about this image found in OSTEOBLASTOMA Left: Frontal radiograph of the spine showing loss of normal...
Images
Figure 4-35
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-35 OSTEOBLASTOMA Left: Frontal radiograph shows an intramedullary lytic and sclerotic lesion that extends through the cortex, displaces the periosteum, and has deposited a rim of reactive bone. The margins are difficult to appreciate. Right: Coronal fat suppressed T2 More about this image found in OSTEOBLASTOMA Left: Frontal radiograph shows an intramedullary lytic and s...
Images
Figure 4-39
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-39 OSTEOBLASTOMA A: Needle biopsy specimen shows aggregates of tumor well delineated from subperiosteal reactive bone. B: Haphazardly oriented trabeculae of woven bone are prominently rimmed by plump osteoblasts. The intertrabecular tissue is composed of loose vascular More about this image found in OSTEOBLASTOMA A: Needle biopsy specimen shows aggregates of tumor well del...
Images
Figure 4-36
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-36 OSTEOBLASTOMA A: Lateral radiograph of the elbow shows a mixed lytic and sclerotic lesion arising from the proximal ulna and extending into the adjacent soft tissues. Associated osteopenia is present. B: Axial T2-weighted MRI shows multiple fluid-fluid levels (ABC-like More about this image found in OSTEOBLASTOMA A: Lateral radiograph of the elbow shows a mixed lytic and s...
Images
Figure 4-34
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-34 OSTEOBLASTOMA A: Axial CT image shows a large tumor of the occiput that is delineated peripherally by a thin rim of reactive bone. Most of the tumor is low in attenuation. An area of high attenuation represents neoplastic bone. B: Axial T2-weighted MRI shows that much More about this image found in OSTEOBLASTOMA A: Axial CT image shows a large tumor of the occiput that is...
Images
Figure 4-32
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-32 OSTEOBLASTOMA A: Axial CT image of the cervical spine shows an expansile well-defined mixed sclerotic and lytic tumor of the left pedicle and spinous process. B: Frontal radiograph of the knee shows a mildly expansile, well-defined lytic lesion involving the distal More about this image found in OSTEOBLASTOMA A: Axial CT image of the cervical spine shows an expansile w...
Images
Figure 4-33
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-33 OSTEOBLASTOMA A: Oblique radiograph of the hip shows a mixed lytic and sclerotic lesion involving the lesser trochanter. The periphery of the tumor is not surrounded by a rim of reactive bone. B: Coronal reformatted CT image shows a heterogeneous ill-defined lesion More about this image found in OSTEOBLASTOMA A: Oblique radiograph of the hip shows a mixed lytic and scl...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-02
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... cell tumor of bone (H3F3A) Chondroblastoma (H3F3B)  Altered signaling:   Translocations resulting in gene over-expression Aneurysmal bone cyst (USP6) Chondromyxoid fibroma (GRM1) Osteoblastoma (FOS)   Specific amplifications...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-05
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... that are polyhedral and contain abundant cytoplasm. Right: In clear cell osteosarcoma, the neoplastic cells have abundant clear cytoplasm. OSTEOBLASTOMA-LIKE OSTEOSARCOMA Figure 5-34 OSTEOBLASTOMA-LIKE OSTEOSARCOMA Left: Osteoblastoma-like osteosarcoma grows with an infiltrative pattern, encasing preexisting bone...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-01
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
..., osteochondroma, and enchondroma, while the rate of recurrence of more aggressive lesions such as chondroblastoma, osteoblastoma, aneurysmal bone cyst, and giant cell tumor is 10 to 20 percent. The prognosis of patients with sarcoma also depends on the specific type, size, location, grade, and stage of the tumor...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-14
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... in benign tumors, the most common tumors of which are giant cell tumor of bone, chondroblastoma, fibrous dysplasia, chondromyxoid fibroma, and osteoblastoma; however, it also can be seen in malignant tumors such as osteosarcoma. Aneurysmal bone cyst needs to be thoroughly sampled microscopically, especially...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-03
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... ( 11 ). A solid or thick periosteal reaction suggests a slow-growing nonaggressive lesion, from which the bone has time to wall off. Examples of a benign periosteal reaction include slow-growing tumors, such as osteoid osteoma, osteoblastoma, and fracture callus formation ( fig. 3-18 ). A lamellated...