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osteoblastoma
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Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-38 OSTEOBLASTOMA A: The osteoblastoma is confined by a layer of reactive sub periosteal bone. The tumor is solid and composed of inter connecting trabeculae of woven bone. B: Islands of cellular tumor contain mineralized bone, well-defined by subperiosteal reactive bone. ... More
Images
Published: 01 October 2021
OSTEOBLASTOMA-LIKE OSTEOSARCOMA Figure 5-34 OSTEOBLASTOMA-LIKE OSTEOSARCOMA Left: Osteoblastoma-like osteosarcoma grows with an infiltrative pattern, encasing preexisting bone. Right: Neoplastic bone is rimmed by plump osteoblasts. The intertrabecular spaces contain loose connective tissue with ... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-45 OSTEOBLASTOMA Ki-67 immunohistochemical stain of conventional osteoblastoma shows that many tumor cells are positive. More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-40 OSTEOBLASTOMA A: A sheet-like deposit of woven bone is seen. B: Neoplastic rimming osteoblasts are of medium size with abundant eosinophilic to amphophilic cytoplasm. Many nuclei are polarized away from the bone-forming surface. Scattered osteoclasts are present on the ... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-37 OSTEOBLASTOMA Curetted tumor is composed of fragments of red-tan tissue. More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-04
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... as a portion of the matrix. OSTEOID OSTEOMA Figure 4-30 OSTEOID OSTEOMA Scattered tumor cells have positive nuclear staining for FOS. OSTEOBLASTOMA Figure 4-31 OSTEOBLASTOMA Left: Frontal radiograph of the spine showing loss of normal outline of the left T11 pedicle (white arrow), indicative...
Images
Published: 01 October 2021
OSTEOBLASTOMA WITH CARTILAGE Figure 4-42 OSTEOBLASTOMA WITH CARTILAGE Left: Nodule of well-formed hyaline cartilage abuts neoplastic bone. Right: In areas, the cartilage merges with the tumor bone. More
Images
Published: 01 October 2021
OSTEOBLASTOMA WITH PSEUDOMALIGNANT CHANGE Figure 4-44 OSTEOBLASTOMA WITH PSEUDOMALIGNANT CHANGE Left: Neoplastic osteoblasts have enlarged hyperchromatic nuclei. Right: The nuclear enlargement, hyperchromasia, smudging, and vacuolization in pseudomalignant change is hypothesized to be related to... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-31 OSTEOBLASTOMA Left: Frontal radiograph of the spine showing loss of normal outline of the left T11 pedicle (white arrow), indicative of destruction of the pedicle by tumor. Right: Sagittal fat-suppressed T2-weighted MRI shows an expansile, well-defined mass with fluid-f... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-35 OSTEOBLASTOMA Left: Frontal radiograph shows an intramedullary lytic and sclerotic lesion that extends through the cortex, displaces the periosteum, and has deposited a rim of reactive bone. The margins are difficult to appreciate. Right: Coronal fat suppressed T2-weigh... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-39 OSTEOBLASTOMA A: Needle biopsy specimen shows aggregates of tumor well delineated from subperiosteal reactive bone. B: Haphazardly oriented trabeculae of woven bone are prominently rimmed by plump osteoblasts. The intertrabecular tissue is composed of loose vascular con... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-36 OSTEOBLASTOMA A: Lateral radiograph of the elbow shows a mixed lytic and sclerotic lesion arising from the proximal ulna and extending into the adjacent soft tissues. Associated osteopenia is present. B: Axial T2-weighted MRI shows multiple fluid-fluid levels (ABC-like ... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-34 OSTEOBLASTOMA A: Axial CT image shows a large tumor of the occiput that is delineated peripherally by a thin rim of reactive bone. Most of the tumor is low in attenuation. An area of high attenuation represents neoplastic bone. B: Axial T2-weighted MRI shows that much o... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-32 OSTEOBLASTOMA A: Axial CT image of the cervical spine shows an expansile well-defined mixed sclerotic and lytic tumor of the left pedicle and spinous process. B: Frontal radiograph of the knee shows a mildly expansile, well-defined lytic lesion involving the distal femo... More
Images
Published: 01 October 2021
OSTEOBLASTOMA Figure 4-33 OSTEOBLASTOMA A: Oblique radiograph of the hip shows a mixed lytic and sclerotic lesion involving the lesser trochanter. The periphery of the tumor is not surrounded by a rim of reactive bone. B: Coronal reformatted CT image shows a heterogeneous ill-defined lesion cent... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-02
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... cell tumor of bone (H3F3A) Chondroblastoma (H3F3B) Altered signaling: Translocations resulting in gene over-expression Aneurysmal bone cyst (USP6) Chondromyxoid fibroma (GRM1) Osteoblastoma (FOS) Specific amplifications...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-05
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... in this osteosarcoma are positive for keratin. This phenomenon is a diagnostic pitfall, particularly in middle aged and elderly populations. OSTEOBLASTOMA-LIKE OSTEOSARCOMA Figure 5-34 OSTEOBLASTOMA-LIKE OSTEOSARCOMA Left: Osteoblastoma-like osteosarcoma grows with an infiltrative pattern, encasing preexisting bone...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-01
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
..., and biologic potential of the neoplasm. Some benign tumors have a low rate of recurrence following curettage or en bloc resection, such as nonossifying fibroma, fibrous dysplasia, osteochondroma, and enchondroma, while the rate of recurrence of more aggressive lesions such as chondroblastoma, osteoblastoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-15
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... that includes lymphocytes, neutrophils, eosinophils, and plasma cells. Most also exhibit intratumoral hemorrhage, reactive woven bone, and varying numbers of osteoclast-like giant cells ( figs. 15-78 , right; 15-80C ). Sometimes the reactive woven bone is prominent and mimics osteoblastoma ( figs. 15-78...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
DOI:
10.55418/9781933477138-14
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... cell tumor of bone, chondroblastoma, fibrous dysplasia, chondromyxoid fibroma, and osteoblastoma; however, it also can be seen in malignant tumors such as osteosarcoma. Aneurysmal bone cyst needs to be thoroughly sampled microscopically, especially the solid component of the tumor, to exclude...
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