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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-23
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... lesions, ulcers, and tender nodules. Lymphadenopathy is frequent in the drainage area. A chronic form associated with disseminated ulcerating subcutaneous nodules also exists ( fig. 23-3 ) ( 3 ). Osseous lesions typically affect the axial skeleton, appear osteolytic, and can be complicated by cyst...
Images
Published: 01 February 2024
MELANOMA WITH SARCOMATOID DIFFERENTIATION Figure 21-7 MELANOMA WITH SARCOMATOID DIFFERENTIATION A: Amelanotic spindle cell melanoma shows focally osseous differentiation. B: The same tumor also showed focal cartilaginous differentiation. More about this image found in MELANOMA WITH SARCOMATOID DIFFERENTIATION A: Amelanotic spindle cell melan...
Images
Published: 01 January 2024
METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS Figure 8-62 METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS In addition to the malignant spindle cells, this tumor has areas of osseous differentiation. More about this image found in METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS In addition t...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... WITH SARCOMATOID DIFFERENTIATION A: Amelanotic spindle cell melanoma shows focally osseous differentiation. B: The same tumor also showed focal cartilaginous differentiation. There are pitfalls related to overlaps in immunophenotype. Some melanomas, for example, may be positive for smooth muscle actin (SMA...
Images
Published: 15 November 2023
AORTIC INTIMAL SARCOMA: OSSEOUS DIFFERENTIATION Figure 55-13 AORTIC INTIMAL SARCOMA: OSSEOUS DIFFERENTIATION In this example, there are large areas of bland osteoid formation (left), interposed with areas of malignant spindle cells producing osteoid (right). More about this image found in AORTIC INTIMAL SARCOMA: OSSEOUS DIFFERENTIATION In this example, there are...
Images
Published: 15 November 2023
PULMONARY ARTERY INTIMAL SARCOMA: OSTEOCARTILAGENOUS DIFFERENTIATION Figure 55-7 PULMONARY ARTERY INTIMAL SARCOMA: OSTEOCARTILAGENOUS DIFFERENTIATION Left: This example exhibits cartilaginous differentiation, producing a chondroid matrix. Right: Areas of osteoid production and osseous differenti... More about this image found in PULMONARY ARTERY INTIMAL SARCOMA: OSTEOCARTILAGENOUS DIFFERENTIATION Left:...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... to represent a degenerative phenomenon, and should be recognized as such to avoid misclassification of the tumor as a malignant lesion. Rarely, heterologous elements are seen, including areas of smooth muscle, osseous, or cartilaginous differentiation ( fig. 11-8 ). Again, these features do not portend a worse...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... As the name suggests, this is a metaplastic carcinoma in which, in addition to the more obvious areas of epithelial differentiation, either glandular or squamous, there are admixed mesenchymal elements with osseous ( fig. 8-62 ), chondroid ( fig. 8-63 ), or rhabdomyoid differentiation ( 197 – 199...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch55
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... and osseous differentiation may also be seen. PULMONARY ARTERY INTIMAL SARCOMA: PAUCICELLULAR TYPE Figure 55-8 PULMONARY ARTERY INTIMAL SARCOMA: PAUCICELLULAR TYPE This example shows primary intimal collagen with only rare malignant cells throughout. AORTIC INTIMAL SARCOMA Figure 55-10 AORTIC INTIMAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch09
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of degenerative changes on TAVs, with a greater incidence of osseous and chondroid metaplasia. Epidemiology. The incidence of an unicuspid aortic valve (UAV) is low, ranging from 0.02 to 0.075 percent of patients referred for echocardiography ( 27 , 28 ). In multiple series of resected valves, they represent 2...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., or osseous matrix ( 59 , 62 ). BCL10, trypsin, and chymotrypsin are appropriate markers for demonstrating acinar differentiation. Synaptophysin and chromogranin A may also be positive in the elements with neuroendocrine differentiation ( 74 ). Only limited data are available regarding the molecular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... described in adenosarcoma include chondroid/chondrosarcomatous and osseous/osteoblastic differentiation. Sex-cord differentiation may be present but should not be considered a form of sarcomatous overgrowth and does not confer a worse prognosis ( 291 ). Ancillary Studies. Immunohistochemically, low-grade...
Images
Published: 01 August 2022
OSSEOUS METAPLASIA OF THE TESTIS Figure 11-133 OSSEOUS METAPLASIA OF THE TESTIS Left: An ossified nodule is present in the testis. Atrophic seminiferous tubules are seen at bottom. Right: The central zone of the nodule (top) consists of fibrin, likely reflecting a remote hematoma. More about this image found in OSSEOUS METAPLASIA OF THE TESTIS Left: An ossified nodule is present in th...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
...-JT syndrome is an autosomal dominant disorder caused by mutation of the CDC73 gene and is associated with hyperparathyroidism and a significant risk of parathyroid cancer. HPT-JT is also associated with fibro-osseous jaw tumors and renal cysts and hamartomas, but is not usually associated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
.... Metaplastic changes include myelolipomatous and osseous metaplasia. In contrast to functional adenomas associated with glucocorticoid production, the cortex adjacent to nonfunctional nodules is not atrophic. Degenerative or retrogressive changes, such as hyalinization, hemorrhage, and calcification, may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... is found in the osseous canal ( 124 , 125 ). In many cases of congenital absence of the anterior pituitary, posterior pituitary gland tissue may be present. Pituitary Hypoplasia Pituitary hypoplasia is the defective or incomplete development of the pituitary gland. It may occur as an isolated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-09
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... a prior history of some form of plasma cell neoplasia. Of these, approximately 50 percent have multiple myeloma, while roughly equal numbers of the remainder have single osseous or extramedullary plasmacytomas or both. Most have lesions at other sites when the testicular tumor is discovered, show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... with the androgen insensitivity syndrome. The testicular nodule is likely a Sertoli cell adenoma. Other rare lesions that may mimic neoplasms include: prostatic glands in the epididymis ( 313 ); osseous metaplasia of the epididymis ( 71 ) and testis ( 314 ), with one case of the latter that we personally observed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-09
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Fibro-osseous tumors of bone are defined by their two components: spindle cells that resemble fibroblasts and neoplastic bone. Most fibro-osseous tumors are benign; the exception is well-differentiated osteosarcoma, which is discussed in chapter 5 . They arise within the medullary cavity, except...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
10.55418/9781933477190-8
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... with enteric duplication cysts ( 111 – 114 ). Macroscopically, there is black pigmentation of the peritoneal membranes. Microscopy shows histiocytes containing abundant melanin. CHONDROID AND OSSEOUS METAPLASIA Osseous or chondroid metaplasia may rarely involve the peritoneal cavity, usually...
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