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Images
Published: 01 December 2024
ABDOMINAL PARAGANGLIOMA Figure 9-11 ABDOMINAL PARAGANGLIOMA This paraganglioma from the abdomen at the origin of the superior mesenteric artery shows a groove (arrow) where the specimen abutted the artery. Bulging areas of fleshy pink-gray and pink-tan tissue contrast with slightly retracted area... More about this image found in ABDOMINAL PARAGANGLIOMA This paraganglioma from the abdomen at the origin ...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON Figure 3-14 ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON A: The liver of H. P., with the diseased supra-renal capsules in situ. B,C: Sections of the diseased supra-renal capsules. (From his monograph, On the Constitutional an... More about this image found in ORIGINAL DESCRIPTION OF ADDISON DISEASE BY THOMAS ADDISON A: The liver of ...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY Figure 11-17 UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was originally diagnosed as malignant rhabdoid tumor on the basis of morphology and loss of BRG1 immunostaining, until resection showed foci of ganglion cell d... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was or...
Images
Published: 01 December 2024
PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-24 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macronodule and a larger pale yellow nodule with small areas of necrosis are seen. The patient was part of a family pedigree with the complex of myxomas, spotty pigmenta... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Organization (WHO) classification of tumors of endocrine origin ( 13 ). They are now the second most common adrenal incidentaloma, after cortical adenomas in some series ( 14 ). While most myelolipomas arise in the adrenal gland, extra-adrenal locations have been reported, including liver, kidney, spleen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical carcinoma (ACC) is a malignant neoplasm originating from the steroidogenic epithelial cells of the adrenal cortex. EPIDEMIOLOGY ACC accounts for the majority of deaths attributable to primary adrenal neoplasia, but it is a rare disease, meeting the criteria for an “orphan...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...NEUROBLASTOMA AND GANGLIONEUROBLASTOMA Neuroblastoma (NBL) is a primitive neoplasm of neuroectodermal origin that arises in anatomic sites corresponding to the distribution of the sympathoadrenal autonomic nervous system. It is subdivided into three subtypes: undifferentiated, poorly...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... or survival ( 4 ). In adults, the adrenal cortex provides about 1 percent of biologically important androgens in men (most are of testicular origin), and roughly half of all androgens in women ( 11 ). Steroid biosynthesis in the adrenal gland is regulated predominantly by pituitary-derived adrenocorticotropic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... features underpinning these conditions, with a critical role in the multidisciplinary team ( 1 ). CUSHING SYNDROME Cushing syndrome is a systemic disorder originally described by Harvey Cushing in 1932 ( 2 ) and caused by excess glucocorticoids that result in alterations in the structure...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... the staging workup of a patient with a known malignancy elsewhere ( fig. 4-2 ) ( 7 ). Adrenal “incidentalomas” are reported in around 5 percent of people subjected to imaging studies ( 7 – 9 ), although not all adrenal incidentalomas are of cortical origin. Moreover, the exact prevalence of sporadic nodular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and postnatal development, sympathetic paraganglia are most often associated with nerve fibers and ganglia of the preaortic sympathetic plexuses, including the celiac, mesenteric, hypogastric, renal, and gonadal plexuses ( figs. 9-1A , 9-2 ). The organ of Zuckerkandl, at the origin of the inferior mesenteric...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical origin, the description of functional characteristics, and the distinction of adenoma from carcinoma ( 49 ). This last aspect is discussed in chapter 6 . Primary Adrenal Cortical Origin Several biomarkers have been proposed to confirm adrenal cortical origin. However, the specificity...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... was described by Wiedemann in 1964 ( 51 ) and by Beckwith in 1969 ( 52 ). The major anatomic features are congenital abdominal wall defects, macroglossia, lateralized somatic hypertrophy, and visceral overgrowth, and BWS was therefore originally described as exomphalos-macroglossia-gigantism (EMG...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., the weight can vary and tumors may weigh up to several hundred grams. There is no preferential localization or origin in either the head or the body of the gland, the tail, or the wings, despite the variable amounts of normal medulla in these areas. PHEOCHROMOCYTOMA Figure 8-5 PHEOCHROMOCYTOMA A: The cut...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... tissue push into the cortex without frank invasion. D: Another patient with MEN2 has multiple nodules arising on intervening diffuse hyperplasia. Neurofibromatosis Type 1 Neurofibromatosis type 1 (NF1), originally called von Recklinghausen disease, is an autosomal dominant disorder caused...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Brazil, the TP53 p.R337H variant was identified in about 0.3 percent of the population ( 84 , 85 ). Despite the original hypothesis that this variant acts in an adrenal tissue specific manner, other tumors are associated with it in the Brazilian population, such as choroid plexus carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., geographically constrained fungus that is endemic to Southeast Asia and considered an acquired immunodeficiency syndrome (AIDS)-defining opportunistic infection. It was originally isolated from bamboo rats and can infect other immunocompromised individuals, including those with an underlying malignancy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... during the last pandemic in 1894. Historically, three plague pandemics are on record. The first occurred during the Roman era in the 6th century and appears to have originated in Africa or Central Asia. The second, known as the “black death,” occurred during the 14th century and had its origins in China...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... as the great imitator or mimicker, due to its protean clinical manifestations. The renowned physician and father of modern medicine, Sir William Osler, once remarked that the physician who knew syphilis, knew medicine. The precise origin of syphilis is still debated and two main hypotheses exist. Either...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of original first-line drugs (such as chloramphenicol, ampicillin, and co-trimoxazole) is limited by the emergence of widespread multidrug resistance ( 61 ). CHOLERA General Considerations, Including Etiology and Synonyms Cholera is a noninvasive GIT infection caused by the curved, flagellated...
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