DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Figure 6-6 DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Parenchymal organs, such as the adrenal gland, liver, and others, can be involved. Note the prominent necrosis and hemorrhage (A), as well as multiple intranuclear viral inclusions (B). (Courtesy of t... More about this image found in DISSEMINATED HUMAN HERPESVIRUS 1 INFECTION Parenchymal organs, such as the...

LEGIONNAIRES’ DISEASE Figure 12-9 LEGIONNAIRES’ DISEASE The etiologic bacterial organisms are seen with Steiner silver (A) and immunohistochemical (B) stains. (A: courtesy of the CDC IDPB; B: courtesy of the CDC PHIL) More about this image found in LEGIONNAIRES’ DISEASE The etiologic bacterial organisms are seen with Stei...

BORDETELLA PERTUSSIS ORGANISMS Figure 12-19 BORDETELLA PERTUSSIS ORGANISMS Gram (A) and immunohistochemical (B) stains of tracheobronchial respiratory epithelium. (Courtesy of the CDC IDPB) More about this image found in BORDETELLA PERTUSSIS ORGANISMS Gram (A) and immunohistoch...

RENAL TUBERCULOSIS WITH MULTIDRUG RESISTANT (MDR) ORGANISMS Figure 12-62 RENAL TUBERCULOSIS WITH MULTIDRUG RESISTANT (MDR) ORGANISMS Macroscopic parenchymal destruction with secondary hydronephrosis (A). A granulomatous focus (B) contains acid-fast bacilli (C). (A: courtesy of Dr. C. Ellis, Emory... More about this image found in RENAL TUBERCULOSIS WITH MULTIDRUG RESISTANT (MDR) ORGANISMS Macroscopic pa...

SEPTICEMIC PLAGUE Figure 14-22 SEPTICEMIC PLAGUE Intravascular organisms in skeletal muscle are seen with an H&E stain (A) and Y. pestis immunohistochemistry (B). (Courtesy of the CDC IDPB) More about this image found in SEPTICEMIC PLAGUE Intravascular organisms in skeletal muscle are seen with...

MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

COCCIDIOIDES SPP Figure 21-9 COCCIDIOIDES SPP Organisms range from immature (A,B) to mature (C) spherules; endospores are highlighted on a Grocott silver stain (D). (D: courtesy of the CDC PHIL) More about this image found in COCCIDIOIDES SPP Organisms range from immature (A,B) to m...

MUCORMYCOSIS Figure 21-38 MUCORMYCOSIS Angioinvasion by fungal organisms (A), with secondary thrombosis, necrosis, and hemorrhage (B,C), is characteristic. More about this image found in MUCORMYCOSIS Angioinvasion by fungal organisms (A), with secondary thrombo...

MUCORALES ORGANISMS Figure 21-39 MUCORALES ORGANISMS Coagulative and hemorrhagic necrosis (A). A prominent granulomatous response (B) directed against the fungi is rarely present. More about this image found in MUCORALES ORGANISMS Coagulative and hemorrhagic necrosis ...

MUCORALES ORGANISMS Figure 21-41 MUCORALES ORGANISMS PAS stain of mucormycosis in skin biopsy. Hypahae are lightly stained in pink, while spores are dark, pink and round (A). Spores and arthroconidia (brick-like structures) are observed in B. More about this image found in MUCORALES ORGANISMS PAS stain of mucormycosis in skin bio...

DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND CANDIDA SPP Figure 21-44 DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND CANDIDA SPP Striking difference in hyphal diameter and morphology of Mucorales (top) and Candida (bottom right). More about this image found in DUAL FUNGAL INFECTION BY MUCORALES ORGANISMS AND C...

DISSEMINATED ADIASPIROMYCOSIS INVOLVING THE KIDNEY Figure 21-49 DISSEMINATED ADIASPIROMYCOSIS INVOLVING THE KIDNEY Organisms have a much thicker sporangial wall and smaller endospores when compared to R. seeberi. (Courtesy of M. Robledo, Universidad of Antioquia, Medellín, Columbia) More about this image found in DISSEMINATED ADIASPIROMYCOSIS INVOLVING THE KIDNEY Organisms have a much t...

ESOPHAGEAL CANDIDIASIS Figure 22-9 ESOPHAGEAL CANDIDIASIS These fungal organisms were only identified after careful examination of numerous PAS-stained levels, due to their scant and focal nature. More about this image found in ESOPHAGEAL CANDIDIASIS These fungal organisms were only identified after c...

MICROSPORIDIOSIS Figure 22-18 MICROSPORIDIOSIS Electron microscopic features of microsporidian organisms at different magnifications. A: Enterocytozoon bieneusi meront (arrow) in the superficial enterocyte cytoplasm shows characteristic focally lamellar electrondense material and numerous inters... More about this image found in MICROSPORIDIOSIS Electron microscopic features of microsporidian organisms...

G. DUODENALIS ORGANISMS Figure 26-20 G. DUODENALIS ORGANISMS G. duodenalis organisms may occasionally be identified in the stomach (arrow), usually in the setting of achlorhydria, and may be mistaken for mucin droplets by the unwary (A: H&E, B: methylene blue stain. Courtesy of Dr. H. Venbrux, Camp Hill, PA) More about this image found in G. DUODENALIS ORGANISMS G. duodenalis or...

CRYPTOSPORIDIUM ORGANISMS Figure 26-28 CRYPTOSPORIDIUM ORGANISMS Cryptosporidium organisms may easily be missed if they are scant, as in this colonic biopsy. More about this image found in CRYPTOSPORIDIUM ORGANISMS Cryptosporidium...

CRYPTOSPORIDIUM ORGANISMS Figure 26-30 CRYPTOSPORIDIUM ORGANISMS The compact, round, basophilic and “stuck-on” appearance of cryptosporidial organisms differentiates them from mucin blebs at a morphologic level. More about this image found in CRYPTOSPORIDIUM ORGANISMS The compact, round, basophilic ...

CYSTOISOSPORA BELLI ORGANISMS Figure 26-34 CYSTOISOSPORA BELLI ORGANISMS Numerous intracytoplasmic Cystoisospora belli organisms, some surrounded by a prominent clear halo (due to their location in a paracytophorous vacuole), are readily identifiable in the surface enterocytes. More about this image found in CYSTOISOSPORA BELLI ORGANISMS Numerous intracytoplasmic ...

CYSTOISOSPORA BELLI ORGANISMS Figure 26-35 CYSTOISOSPORA BELLI ORGANISMS A: In the small intestine, large sexual forms (arrow) of the organism are readily identified. B,C: Macrogametocytes typically contain a large nucleolus (B), while microgamonts show numerous peripheral small nuclei (arrows) (C). D: Asexual forms (arrow) are small by comparison. Note the associated eosinophils. More about this image found in CYSTOISOSPORA BELLI ORGANISMS A: In the small intestine, ...